Dacarbazine, also known as imidazole carboxamide, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma.

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Dacarbazine is a cell-cycle non-specific antineoplastic that is thought to function as an alkylating agent after it has been activated in the liver.
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Package leaet: Information for the patient

What is the most important information I should know about dacarbazine? norepinephrine supplements
Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease.
Avoid eating anything for 4 to 6 hours before your injection. This may help prevent severe nausea or vomiting.
Dacarbazine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

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PACKAGE LEAFLET: INFORMATION FOR THE USER

PACKAGE LEAFLET: INFORMATION (Norepinephrine) Concentrate taking, or have recently taken or might determine the correct
FOR THE USER 4. Possible side effects take any other dose for you. After the initial dose your
Noradrenaline (Norepinephrine) 1mg/ml 5. How to store Noradrenaline medicines. doctor will assess your response and
Concentrate for Solution for Infusion (Norepinephrine) Concentrate A number of medicines are known to adjust the dose
Noradrenaline (as noradrenaline tartrate) 6. Contents of the pack and other increase the toxic effects of accordingly.
Read all of this leaflet carefully before information noradrenaline, such as: If you are given more or forget to take
you start using this medicine because it • monoamine oxidase inhibitors Noradrenaline (Norepinephrine)
contains important information for you. 1. What Noradrenaline (antidepressants) Concentrate:
(Norepinephrine) Concentrate is and • tricyclic antidepressants It is unlikely that you will receive too
what it is used for • linezolid (an antibiotic) much or too little of this medicine, as this
Noradrenaline (Norepinephrine) • anaesthetics (especially anaesthetic medicine will be
Concentrate for Solution for Infusion is gases) given to you in hospital. However, talk to
used in an emergency to increase blood • adrenergic-serotoninergic medicines, your doctor or nurse if you have any
pressure to normal levels. e.g. used in the treatment of asthma and concerns.
heart Symptoms of overdose are severe high
2. What you need to know before you conditions. blood pressure, slow heartbeat, violent
are given Noradrenaline Pregnancy, breast-feeding and fertility headache, light
(Norepinephrine) Concentrate If you are pregnant or breast-feeding, sensitivity, pain in the chest, pale colour,
Do not take Noradrenaline think you may be pregnant or are intense sweating and vomiting.
(Norepinephrine) Concentrate planning to have a baby, ask
• if you are allergic to noradrenaline your doctor or pharmacist for advice 4. Possible side effects
• Keep this leaflet. You may need to read preparations or to any of the other before taking this medicine. Like all medicines, this medicine can
it again. ingredients of this medicine ( listed in Noradrenaline (Norepinephrine) cause side effects, although not
• If you have any further questions, section 6). Concentrate may harm the unborn baby. everybody gets them.
please ask your doctor or pharmacist. Tell your doctor if any of the above Your doctor will decide if you should be Tell your doctor immediately if you
• This medicine has been prescribed for applies to you before this medicine is given experience:
you. Do not pass it on to others. It may used. Noradrenaline (Norepinephrine) • sudden itchy rash (hives), swelling of
harm them, even if their signs of illness Warnings and precautions Concentrate. the hands, feet, ankles, face, lips, mouth
are the same as yours. Talk to your doctor or pharmacist before Noradrenaline (Norepinephrine) or throat
• If you get any side effects, talk to your taking Noradrenaline (Norepinephrine) Concentrate contains sodium (which may cause difficulty in swallowing
doctor or pharmacist. This includes any Concentrate if you have: The 2 ml ampoule contains 6.7 mg or breathing), feeling that you are going
possible side effects not listed in this • diabetes sodium, and the 4 ml ampoule contains to faint.
leaflet. See section 4. • high blood pressure 13.3 mg sodium. Take • pain and/or swelling at the injection site
The name of this medicinal product is • an over-active thyroid into consideration if you are on a low- Tell your doctor as soon as possible if
Noradrenaline (Norepinephrine) 1 mg/ml • low levels of oxygen in the blood sodium diet. you experience
Concentrate for Solution for Infusion but • high levels of carbon dioxide in the • slow heart rate
it will be referred to as Noradrenaline blood 3. How to use Noradrenaline • abnormal heart rhythm
(Norepinephrine) Concentrate throughout • clots or obstructions in the blood (Norepinephrine) Concentrate • breathing difficulties
this leaflet. vessels supplying the heart, intestines, or Noradrenaline (Norepinephrine) • anxiety
other parts of the body Concentrate will be given to you in • headaches
What is in this leaflet: • low blood pressure following a heart hospital by a doctor or nurse. It • cold extremities
1. What Noradrenaline attack is first diluted and then infused into a • pain in the extremities
(Norepinephrine) Concentrate is and • a type of angina (chest pain) called vein. Your doctor will monitor your blood
what it is used for Prinzmetal’s angina. The recommended dose of pressure and blood volume.
2. What you need to know before you • are elderly Noradrenaline (Norepinephrine) Reporting of side effects
use Noradrenaline (Norepinephrine) Concentrate will depend on your medical If you get any side effects, talk to your
Concentrate Other medicines and Noradrenaline condition. The usual dose is between 0.4 doctor or pharmacist. This includes any
3. How to use Noradrenaline Tell your doctor or pharmacist if you are and 0.8 mg per hour. Your doctor will possible side effects

not listed in this leaflet. concentrate for solution for infusion. The Either add 2 ml of concentrate to 48 ml chlorpheniramine, chlorothiazide,
solution is a clear glucose 5% solution (or sodium chloride nitrofurantoin, novobiocin, phenytoin,
5. How to store Noradrenaline colourless or yellowish solution. 9 mg/ml (0.9%) with sodium bicarbonate, sodium iodide,
(Norepinephrine) Concentrate It may be supplied in packs of 5 x 2 ml glucose 5% solution) for administration streptomycin.
Keep this medicine out of the sight and ampoules or 5 x 4 ml ampoules. by syringe pump, or add 20 ml of Dilution instructions
reach of children concentrate to 480 ml Dilute before use with glucose 5%
Do not store above 25°C Marketing Authorisation Holder glucose 5% solution (or sodium chloride solution or sodium chloride 9 mg/ml
Do not use this medicine after the expiry 9 mg/ml (0.9%) with glucose 5% solution) (0.9%) with glucose 5 %
date which is stated on the carton after Manufactured in India by: for administration solution.
EXP. The expiry TAJ PHARMACEUTICALS LTD. by drip counter. In both cases the final Either add 2 ml of concentrate to 48 ml
date refers to the last day of that month. Mumbai, India concentration of the infusion solution is glucose 5% solution (or sodium chloride
From a microbiological point of view, the at SURVEY NO.188/1 TO 189/1,190/1 40 mg/litre 9 mg/ml (0.9%) with
product should be used immediately after TO 4, ATHIYAWAD, DABHEL, DAMAN- noradrenaline base (which is equivalent glucose 5% solution) for administration
dilution. 396210 (INDIA) to 80 mg/litre noradrenaline tartrate). by syringe pump, or add 20 ml of
Do not use this medicine if the solution is Dilutions other than 40 concentrate to 480 ml
brown in colour. This leaflet was last revised in May mg/litre noradrenaline base may also be glucose 5% solution (or sodium chloride
Do not throw away any medicines via 2019. used. If dilutions other than 40 mg/litre 9 mg/ml (0.9%) with glucose 5% solution)
wastewater. Ask your pharmacists how to noradrenaline base for administration
throw away ------------------------------------------------------- are used, check the infusion rate by drip counter. In both cases the final
medicines you no longer use. These ------------------------------------------------------- calculation carefully before starting concentration of the infusion solution is
measures will help protect the -- treatment. 40 mg/litre
environment. Noradrenaline (Norepinephrine) 1 mg/ml The product is compatible with PVC noradrenaline base (which is equivalent
Concentrate for Solution for Infusion infusion bags. to 80 mg/litre noradrenaline tartrate).
6. Contents of the pack and other The following information is intended for Any unused product or waste material Dilutions other than 40
information healthcare professionals only: should be disposed of in accordance with mg/litre noradrenaline base may also be
What Noradrenaline (Norepinephrine) For intravenous use. local requirements. used. If dilutions other than 40 mg/litre
contains Dilute before use. noradrenaline base
The active substance is noradrenaline Administer as a diluted solution via a ------------------------------------------------------- are used, check the infusion rate
(as noradrenaline tartrate). central venous catheter. ------------------------------------------------------- calculation carefully before starting
1 ml concentrate for solution for infusion The infusion should be at a controlled -- treatment.
contains 2 mg noradrenaline tartrate rate using either a syringe pump or an Noradrenaline (Norepinephrine) 1 mg/ml The product is compatible with PVC
equivalent to 1 mg infusion pump or a drip Concentrate for Solution for Infusion infusion bags.
noradrenaline base. counter. The following information is intended for Any unused product or waste material
1 ampoule of 2 ml contains 4 mg Incompatibilities healthcare professionals only: should be disposed of in accordance with
noradrenaline tartrate equivalent to 2 mg Infusion solutions containing For intravenous use. local requirements.
noradrenaline base. noradrenaline tartrate have been Dilute before use.
1 ampoule of 4 ml contains 8 mg reported to be incompatible with the Administer as a diluted solution via a
noradrenaline tartrate equivalent to 4 mg following substances: alkalis and central venous catheter.
noradrenaline base. oxidising agents, barbiturates, The infusion should be at a controlled
The other ingredients are: chlorpheniramine, chlorothiazide, rate using either a syringe pump or an
• sodium chloride nitrofurantoin, novobiocin, phenytoin, infusion pump or a drip
• sodium hydroxide (for pH adjustment) sodium bicarbonate, sodium iodide, counter.
• hydrochloric acid (for pH adjustment) streptomycin. Incompatibilities
• Water for Injections. Dilution instructions Infusion solutions containing
What Noradrenaline (Norepinephrine) Dilute before use with glucose 5% noradrenaline tartrate have been
Concentrate looks like and contents of solution or sodium chloride 9 mg/ml reported to be incompatible with the
the pack: (0.9%) with glucose 5 % following substances: alkalis and
This medicinal product is presented as a solution. oxidising agents, barbiturates,

Dacarbazine, also known as imidazole carboxamide, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. For Hodgkin's it is often used together with vinblastine, bleomycin, and doxorubicin. It is given by injection into a vein.
Dacarbazine for injection 200 mg/vial is reconstituted with 19.7 mL of sterile water for injection, USP. Dacarbazine for injection 500 mg/vial is reconstituted with 49.25 mL of sterile water for injection, USP. The resulting solution contains 10 mg/mL of dacarbazine having a
pH of 3.0 to 4.0.
Dacarbazine is a cell-cycle non-specific antineoplastic that is thought to function as an alkylating agent after it has been activated in the liver.
Dacarbazine for Injection, dacarbazine injection brand name, dacarbazine side effects, dacarbazine infusion time, dacarbazine indication, What is dacarbazine used for?, What is DTIC chemotherapy?, How is dacarbazine administered?, Dacarbazine, dacarbazine dose,
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Injection BP, dacarbazine, dacarbazine injection, dacarbazine injection brand name, dacarbazine indication, dacarbazine melanoma, dacarbazine warnings, dacarbazine cost, Dacarbazine for Injection,
What is the most important information I should know about dacarbazine?
Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease.
Avoid eating anything for 4 to 6 hours before your injection. This may help prevent severe nausea or vomiting.
Dacarbazine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Dacarbazine, also known as imidazole carboxamide, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. For Hodgkin's it is often used together with vinblastine, bleomycin, and doxorubicin. It is given by injection into a vein.
Dacarbazine for injection 200 mg/vial is reconstituted with 19.7 mL of sterile water for injection, USP. Dacarbazine for injection 500 mg/vial is reconstituted with 49.25 mL of sterile water for injection, USP. The resulting solution contains 10 mg/mL of dacarbazine having a
pH of 3.0 to 4.0.
Dacarbazine is a cell-cycle non-specific antineoplastic that is thought to function as an alkylating agent after it has been activated in the liver.
Dacarbazine for Injection, dacarbazine injection brand name, dacarbazine side effects, dacarbazine infusion time, dacarbazine indication, What is dacarbazine used for?, What is DTIC chemotherapy?, How is dacarbazine administered?, Dacarbazine, dacarbazine dose,
dacarbazine warnings, dacarbazine melanoma, dacarbazine cost, dacarbazine + resistance, dacarbazine solubility, dacarbazine hypersensitivity reaction, dacarbazine pill, Dacarbazine for Injection BP, DACARBAZINE FOR INJECTION BP 600MG, Dacarbazine for
Injection BP, dacarbazine, dacarbazine injection, dacarbazine injection brand name, dacarbazine indication, dacarbazine melanoma, dacarbazine warnings, dacarbazine cost, Dacarbazine for Injection,
What is the most important information I should know about dacarbazine?
Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease.
Avoid eating anything for 4 to 6 hours before your injection. This may help prevent severe nausea or vomiting.
Dacarbazine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).