2. Calculation of Apigenin 7 Glucoside content: 
‐It was observed in HPLC chromatogram that about 52% content is apig‐7‐
glucoside.  

‐so total apig‐7‐glucoside content was  52% of the recovered extract  

‐ It can be expressed in terms of apig‐7‐gluco present in per gram dry chamomile . 

  

 
 

 
 CHAMOMILE
Kingdom: Plantae
Class: Magnoliopsida
Order: Asterales
Family: Asteraceae
Genus: Matricaria, Anthemis
GermanChamomile)
Matricaria recutita -GermanChamomile)
(Anthemis nobilis – Roman Chamomile)

Disc/ tubular
florets

Roman Chamomile
Ray/ Ligulate
florets

 
Plant contains
0.24%–1.9% volatile oil,

Secondary metabolites
…..include 28 terpenoids, 36 flavonoids. Both alpha-bisabolol , bisabolol
oxides A and B and chamazulene or azulenesse, farnesene and spiro-ether
quiterpene lactones, glycosides, hydroxycoumarins, flavanoids (apigenin,
luteolin, patuletin, and quercetin ), coumarins (herniarin and
umbelliferone), terpenoids, and mucilage.

Major constituents of Chamomile and their action

Constituents Class Medical Properties
Chamazulence Cyclic sesquiterpene Anti‐inflammatory
α‐bisabolol Cyclic sesquiterpene Anti‐inflammatory, antispasmodic
Bisabolol oxide IsomericCyclic sesquiterpene Anti‐inflammatory, antispasmodic
Spiroether Polyine antispasmodic
Chrysoplenin Alkylated flavonoid Anti‐inflammatory, antispasmodic
Chrysoplenol Alkylated flavonoid Anti‐inflammatory, antispasmodic
Jaceidin Alkylated flavonoid Anti‐inflammatory, antispasmodic
Apigenin Flavones Antispasmodic,anti‐inflammatory,
antitumorigenic,
 

Use of Chamomile based on traditional Practice or theory

Abdominalbloating, abortifacient, abrasions, abscesses, acne, anorexia, antibacterial,
anticoagulant, antifungal, antiinflammatory, antioxidant, antipruritic, antispasmodic,
antiseptic, anxiety, aromatic, arthritis, asthma, back pain, bedsores, bladder disorders,
blood purification, bruises, burns, canker sores, carpal tunnel syndrome, catarrh,
chicken pox, constipation, contact dermatitis, convulsions, cough, Crohn's disease,
croup, cystitis, delirium tremens (DTs), diaper rash, diaphoretic, diuretic (increasing
urination), diverticulitis, dry skin, dysmenorrheal (painful menstruation), ear infections,
eye disorders (blocked tear ducts), eye infections, fatty liver, fever, fistula healing, flu-like
symptoms, frostbite, gallstones, gingivitis, glomerulonephritis, gout, gum irritation, hay
fever, headaches, heartburn, heat rash, hives, hemorrhoids, hepatic disorders, hives,
hypoglycemia (low blood sugar), hysteria, impetigo, inflammatory conditions, insect bites,
insomnia, intestinal cramps, irregular menstrual cycles, irritable bowel syndrome, kidney
disorders, leg ulcers, liver disorders, low back pain, malaria, mastitis (breast
inflammation), menopause, menstrual cramps, menstrual disorders, morning sickness,
morphine withdrawal, motion sickness, muscle strength, nasal inflammation, nausea,
nervous stomach, neuralgia (nerve pain), nightmares, oral hygiene (mouthwash),
osteoporosis, parasites/worms, peptic ulcers, perineal trauma, poison ivy, psoriasis, post-
natal depression rash (heat), respiratory inflammatory, restlessness, rheumatism,
Roehmheld's syndrome, sciatica, sea sickness, seizure disorder, sinusitis, stomach
cramps, sunburn, sunstroke, teething pain (mouth rinse), tension, tics, toothache, travel
sickness, tuberculosis, ulcerative colitis, ulcers, uterine disorders, uterine stimulant,
uterine tonic, vaginal infections, viral infection (flu-like symptoms), viral infection (polio),
vomiting, vomiting/nausea during pregnancy.(123)

Genuinely called as “ capable of any thing”

 
 US FDA in 1998 categorized it as (GRAS) Generally recognized as safe
Food or dietary supplement

It has been already included in the Pharmacopoeia of 26 countries

Chamomile is used
*as one of the world’s most popular herbal teas and about a
million cups are consumed every day
*applied topically in skin and mucous membrane inflammations
and skin diseases
* inhaled for respiratory tract inflammations or irritations
* used in baths as to treat ano-genital inflammation
* used internally for GI spasms and inflammatory diseases and
sleep disorder
However, clinical trials supporting any use of chamomile are
limited and need more expansion.

(NOTE: Do not use distilled oils directly on skin without first diluting
adequately with olive or sweet almond oils.)

 
Uses based on scientific evidence

Clinical Trials for establishing the potential of Chamomile

Colic / Diarrhea in children
Gastrointestinal conditions
Hemorrhagic cystitis (bladder irritation with bleeding)
Hemorrhoids
Eczema
Infantile colic
Mucositis from cancer treatment (mouth ulcers/irritation)
Quality of life in cancer patients
Skin inflammation
Sleep aid / sedation
Vaginitis (inflammation of the vagina)
Wound healing
Post-operative sore throat/hoarseness due to intubation

Complementary and Alternative Medicine (NCCAM)

Treatment of Functional Abdominal Pain in Children: Evaluation of
Relaxation/Guided Imagery and Chamomile Tea as Therapeutic Modalities
This study has been completed.
ClinicalTrials.gov Identifier: NCT00010933

 
 Preparations of Chamomile used for Treatment.
Standardized Extract (Standardized extracts are technically and scientifically
advanced herbal products. Standardization of an extract assures specific
measurable levels of the important compounds that give the product their
beneficial activity in the body)
Tea
Infusion
Lotion
Tincture
Poultice
Bath additive
Herb Beers
. Gargle Inhalation
Chamomile Wine
Dry powder of Heads
Chamomile Vapor Bath
Homeopathic Medicine
Veterinary Use of chamomile
Aromatherapy and as massage oil: (NOTE: Do not use distilled oils directly on
skin without first diluting adequately with olive or sweet almond oils.)
.
Cosmetic Preparations