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10.1016/j.ahj.2017.11.014: American Heart Journal
10.1016/j.ahj.2017.11.014: American Heart Journal
10.1016/j.ahj.2017.11.014: American Heart Journal
Left Ventricular Ejection Fraction Reassessment Post-Myocardial Infarction:
Current Clinical Practice and Determinants of Adverse Remodeling
PII: S0002-8703(17)30381-2
DOI: doi: 10.1016/j.ahj.2017.11.014
Reference: YMHJ 5584
Please cite this article as: Chew Derek S., Wilton Stephen B., Kavanagh Katherine,
Southern Danielle A., Tan-Mesiatowsky Liong Eng, Exner Derek V., Left Ventricu-
lar Ejection Fraction Reassessment Post-Myocardial Infarction: Current Clinical Prac-
tice and Determinants of Adverse Remodeling, American Heart Journal (2017), doi:
10.1016/j.ahj.2017.11.014
This is a PDF file of an unedited manuscript that has been accepted for publication.
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Clinical Practice and Determinants of Adverse Remodeling
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Derek S. Chew, MD; Stephen B. Wilton, MD, MSc; Katherine Kavanagh, MD; Danielle A.
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Southern, MSc; Liong Eng Tan-Mesiatowsky, MD; Derek V. Exner, MD, MPH; on behalf of the
APPROACH Investigators
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Libin Cardiovascular Institute of Alberta
Corresponding Author:
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Email: exner@ucalgary.ca
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ABSTRACT
Background: Left ventricular (LV) dysfunction may be sustained or aggravated during the
convalescent months following an acute myocardial infarction (MI) and is difficult to predict. We
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sought to determine current practice patterns of LV ejection fraction (LVEF) reassessment
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during the months following MI, and evaluate the predictors and clinical significance of LVEF
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change in a prospective post-MI patient cohort.
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Methods: Patients with an acute MI between June 2010 to August 2014 were identified using
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the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease registry.
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Patients with initial LV dysfunction (LVEF <40% with first MI or <45% with multiple MI events)
Results: Of 5,964 MI patients, follow up LVEF assessments were attained for 442 of the 695
patients who had significant LV dysfunction. A sizable proportion (25%) had either no increase
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or a decline in LVEF. Adverse remodeling was associated with an anterior MI location, greater
peak serum troponin T, and a higher baseline LVEF at time of MI. Adverse LV remodeling
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conferred a 3-fold risk of death (HR 3.0, 95% CI 1.6 to 5.7, p=0.001), adjusted for baseline
Conclusions: Current practice of LVEF reassessment during the convalescent months post-MI
Targeting processes affecting low rates of LVEF reassessment may reduce missed care
opportunities and ensure that patients consistently receive appropriate evidence-based and
guideline-recommended care.
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KEYWORDS
Myocardial Infarction
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Left Ventricular Remodelling
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LV Ejection Fraction
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INTRODUCTION
Left ventricular (LV) dysfunction following an acute myocardial infarction (MI) identifies
patients at higher risk of sudden cardiac arrest and death,1-3 and remains an important predictor
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of morbidity and mortality, even in an era of primary percutaneous coronary intervention.4, 5 The
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change in LV function during the convalescent months following MI varies, and is difficult to
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predict. Improvement of LV function may occur early after MI due to recuperation of hibernating
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or stunned myocardium; however, the degree of long-term LV recovery is tempered by adverse
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Up to 50% of patients do not demonstrate improvement in LV ejection fraction (EF)
during the months following acute MI despite revascularization and optimal medical therapy.9, 10
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The absence of LVEF recovery has prognostic significance; and is associated with an increased
risk of sudden cardiac arrest and all-cause mortality, independent of baseline LVEF.11
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systolic dysfunction and the predictors of LVEF change. In addition to its prognostic
significance, predicting LVEF deterioration may have important therapeutic implications, such as
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qualifying patients for additional medical or device therapies. In the absence of reliable
the convalescent months post-MI.12 Unfortunately, few studies have assessed the prevalence
of LVEF reassessment, but current practice is thought to variable and suboptimal. Patient-
reported LVEF reassessment at 6 months follow up was less than 40% in one cohort study that
The current study sought to evaluate the existing practice of LVEF assessment in routine
clinical practice, and identify the factors associated with LV remodeling in a contemporary
longitudinal, observational post-MI cohort from the Acute Myocardial Quality Assurance
(AMIQA) Study.
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METHODS
Patient Population
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prospective, observational cohort aimed at evaluating the incidence of LV dysfunction post-MI,
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and assessing the prognostic utility of change in ejection fraction (EF) over the initial 12 months
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following MI. Patients were enrolled if they survived an acute MI (ST segment elevation
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myocardial infarction [STEMI] or non-ST elevation myocardial infarction [NSTEMI]) within
southern Alberta (approximate catchment population of 1.7 million people) and had evidence of
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a reduced LVEF at time of myocardial infarction (i.e. LVEF measured within two months of MI):
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defined as at least moderate LV dysfunction (LVEF < 0.40) with no prior history of MI, or mild-
moderate dysfunction (LVEF < 0.45) with prior MI events). This study was approved by the the
Conjoint Health Research Ethics Board of the University of Calgary, and conducted in
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Patients were identified through the Alberta Provincial Project for Outcome Assessment
in Coronary Heart Disease (APPROACH) database, which is a provincial registry with that
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angiography in Alberta since 1995, and all patients admitted to a cardiac service in Southern
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Alberta since 2004. Data collection includes demographics, cardiac risk factors, comorbidities,
procedures.14 The accuracy of comorbidities and cardiac risk factors is verified through a data
enhancement procedure to ensure completeness of the database.15 Follow-up mortality data for
all patients in the database is attained through quarterly patient-level linkage to the Alberta
This project was conducted in 2 phases. First, to assess the rate of LVEF reassessment
in routine clinical practice, patients with index MI between June 2010 and November 2011 were
included. This included both passive (collection of clinical LVEF reassessment data) and active
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(protocol-directed LVEF reassessment where clinical LVEF reassessment was not planned)
surveillance.
To determine factors associated with LVEF change, all patients meeting inclusion criteria
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between December 2011 and August 2014 underwent protocol-directed LVEF reassessment.
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Specifically, the patient’s family physician or primary cardiologist was reminded to arrange for
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reassessment of LVEF beyond during the convalescent months post-MI (i.e. within 2 to 12
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months after index myocardial infarction). The imaging modality used for EF reassessment was
left to the discretion of the ordering physician, although the majority of imaging was by
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echocardiography: 81% for initial LVEF assessment and 74% for follow up LVEF assessment
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(Supplemental Appendix 1). We prospectively collected all EF values during the initial 12
months of follow-up.
Funding
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Statistical Analysis
Continuous variables are presented as median and interquartile ranges (IQR). Categorical data
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are expressed as frequencies and percentages. The Kruskal-Wallis test was used to compare
continuous variables, while the Pearson’s Chi-squared test was used to compare categorical
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variables. Multivariate logistic regression analysis was used to examine the predictors of LVEF
recovery.
Patients were stratified according to the degree of LVEF recovery by the following pre-
specified LVEF categories: decline or no recovery (LVEF Δ ≤ 0%), modest improvement (LVEF
Δ 1% to 9%), or large improvement (LVEF Δ > 10%). The ability of these EF recovery groups to
predict all-cause mortality was assessed using Cox multivariate models from which hazard
ratios and 95% confidence intervals (CI) were obtained. Kaplan-Meier time to event curves and
the differences in survival were assessed using the log-rank test statistic. Statistical tests were
2-sided with a p value less than 0.05 considered significant. Analyses were performed using
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Stata/IC 13.1 (StataCorp, TX). The authors are solely responsible for the design and conduct of
this study, all study analyses, the drafting and editing of the paper and its final contents
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RESULTS
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LVEF Reassessment Rates in Routine Clinical Practice
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Between June 2010 and November 2011, 3,318 patients sustained a myocardial
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infarction. Of these patients, 321 (10%) had significant initial LV dysfunction using the study
definition and 152 (47%) underwent LVEF reassessment within 12 months per clinical practice.
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Of these 152 patients, 67 (44%) had persistent LV dysfunction (LVEF < 0.40) when reassessed
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(Figure 1). There were 169 patients in whom clinical LVEF reassessment was not planned and
LVEF < 0.40 remote to the index MI (p < 0.001 for clinical vs. protocol-identified LVEF < 0.40).
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Routine clinical practice was sub-optimal in identifying patients with sustained LV dysfunction
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(i.e. LVEF <0.40) with a sensitivity of 74% and specificity of 63%. All-cause mortality at 2 years
Between December 2011 and August 2014, there were 5,964 MIs (Figure 2). There
were 695 patients (12%) with evidence of impaired LV systolic function. There were 253
patients that were excluded from the final analysis: 68 died prior to repeat LVEF assessment,
108 were either lost to follow up or had an out-of-province residence, 68 declined participation
(i.e. patient or primary physician refusal), and 9 were not included on basis of limited life-span
due to active medical comorbidities (e.g. palliative care patients). For data analysis, there were
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The overall median baseline ejection fraction was 35% (IQR 31% to 40%) assessed
within 1 day [IQR 0 to 3 days] post-MI. The median follow up LVEF was 43% (IQR 34 to 51%)
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reassessed by 17 weeks (IQR 13 to 24 weeks) after MI. There were 128 patients (30%) who
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had an LVEF ≤ 35% upon follow up assessment.
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Of the 442 patients, 109 (25%) had no recovery (LVEF Δ ≤ 0%), 150 (34%) had a
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modest improvement (LVEF Δ 1% to 10%) and 183 (41%) had large improvement (LVEF Δ
>10%). Interestingly, regardless of the initial baseline LVEF, there was a similar proportion of
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patients that underwent adverse remodeling, defined as a LVEF Δ ≤ 0% (Figure 3). An inverse
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relationship between baseline LVEF and LVEF recovery group was observed. Patients with no
LVEF recovery tended to have higher median baseline EFs (38%, IQR 35 to 40%) compared to
those with modest LVEF recovery (36%, IQR 33 to 40%) and large LVEF recovery (35%, IQR
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29 to 40%; p<0.001).
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Baseline Characteristics
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Table 1. The frequency of medical comorbidities among the three LVEF recovery groups were
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similar, except for prior history of myocardial infarction or coronary artery bypass graft surgery
(CABG).
between the EF recovery groups. Of the 108 patients that were treated with medical
management alone, PCI was not possible in 23 patients, medical therapy was thought to be the
best option in 22 patients, 17 patients were deemed too high risk for either CABG or PCI, 7
patients declined revascularization, 25 patients did not have viable myocardium in the territory
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Of the 411 patients surviving beyond 1 year post-MI, the rates of cardiac medication
usage (assessed at an average of 14.7 months post-index MI) were as follows: 85% aspirin,
36% P2Y12 inhibitor, 82% ACE-inhibitor or ARB, 81% beta-blocker, 21% aldosterone
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antagonist, 19% oral anticoagulant, and 86% statin.
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Predictors of Adverse LV Remodeling
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The predictors of adverse LV remodeling (i.e. no LVEF recovery (Δ ≤ 0%) vs. modest or
large EF recovery) are listed in Table 2. By multivariate logistic regression analysis, an anterior
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location of myocardial infraction was an independent predictor for adverse LV remodeling with
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an odds ratio (OR) of 2.4 (95% CI, 1.3-4.5, p=0.007). Peak serum troponin T was also
was observed between baseline LVEF and adverse LV remodeling (OR 2.4 per 10% increase in
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LVEF; 95% CI 1.4–4.2; p=0.001) was observed. That is, a higher baseline LVEF at time of
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There were 43 deaths over a median follow up of 1.5 years (IQR 1.0 to 2.0 years).
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There was no significant difference in the median baseline LVEF between patients who died
(35%, IQR 32 to 40%) and those who did not (38%, IQR 29 to 40%; p=0.74). However,
mortality rates differed when stratified by degree of LVEF recovery. A linear trend in the all-
cause mortality was observed among patients with no recovery (18%), a moderate increase
(11%) and a large increase in LVEF (4%), respectively (p < 0.001) (Figure 4). Patients with no
LVEF recovery had a 3-fold higher risk of death (unadjusted HR 3.0, 95% CI 1.6 to 5.7,
p=0.001) compared to patients with a modest or large recovery in LVEF. Similar results were
observed after adjustment for important covariates (Table 3). Of note, the absence of EF
recovery was associated with an increase risk of all-cause mortality independent of baseline EF.
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DISCUSSION
Main Findings
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In a contemporary, prospective post-MI cohort of patients, we explored the role for
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repeat LVEF assessment in the convalescent months post-MI. In particular, we determined the
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existing practice of LVEF reassessment post-MI, assessed the prognostic significance of LVEF
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recovery, and evaluated clinical, laboratory and angiographic predictors of LVEF change.
The main findings from this study were as follows: 1) in patients with significant LV
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systolic dysfunction post-MI, the rate of routine LVEF reassessment was less than 50% during
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the convalescent post-MI months; 2) absence of LVEF recovery was associated with a 3-fold
anterior location of MI, greater peak serum troponin T, and a higher initial LVEF at time of MI.
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systolic dysfunction in the months and years following their MI, which puts them at risk of a
number of adverse outcomes including heart failure, and sudden cardiac death. In our
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contemporary cohort of post-MI patients, 25% underwent adverse ventricular remodeling with
sustained or aggravated LV dysfunction. These rates are similar to earlier studies, despite the
important to identify these high risk patients, as the detection of sustained or aggravated LV
systolic dysfunction may have important therapeutic implications. In our study, 30% of patients
had an LVEF ≤ 35% upon repeat LVEF assessment, who may be considered for additional
The frequency of LVEF reassessment has not been well studied in the literature, but is
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function at least 40 days post-MI is a class I indication as per the current ACC/AHA STEMI
Guidelines especially in patients with reduced LVEF who are potential candidates for
implantable cardioverter defibrillator (ICD).12 The NSTEMI guidelines are less clear regarding
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the need and frequency for LVEF reassessment post-MI.17 However, in patients who undergo
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LVEF reassessment, there is an increased likelihood of appropriate ICD implantation.18
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In our study, only 47% of patients with initial LV dysfunction had an LVEF reassessment
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within 12 months as per routine clinical practice. These low rates are consistent with the
available literature. In one cohort study, the patient-reported LVEF reassessment rate was 35%
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within 6 months post-discharge among those patients with an LVEF < 40% at index
hospitalization.13 Lower rates of LVEF reassessment were associated with lack of medical
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insurance or involvement of a cardiologist during the index hospitalization for MI, despite similar
scheduled outpatient cardiology follow up.13 Interestingly, although 31% the 258 patients who
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were excluded from the analysis were lost to follow up, an additional 30% patients did not
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undergo repeat LVEF assessment due to their physician declining participation in the registry
during the protocol-driven phase of our study. Further study is required to explore the patient
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and provider factors contributing to sub-optimal LVEF reassessment; however, our results
suggest that the current clinical practice in determining the need for LVEF reassessment has
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poor sensitivity (74%) and specificity (63%) in predicting the patients with sustained LV systolic
Baseline LVEF post-MI is a powerful predictor of cardiac morbidity and mortality.2, 19, 20 Few
studies have been performed to investigate the late recovery of LV function21, 22 and the existing
data supporting the use of LVEF change in the months post-MI to predict outcomes is even
more sparse.9, 10 Parodi et al. found that the 5-year cardiac mortality was over 2-fold higher
among post-MI patients without LVEF improvement (18%), compared to patients with a >10%
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increased in LVEF over 6 months (8%; p=0.02).23 However, the lack of adjustment for important
covariates, and exclusion of high risk patients represent important limitations. In three
independent post-MI cohorts from Europe and Canada,24-26 the absence of LVEF recovery over
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the initial 3 months was associated with a 6-fold increased risk of sudden cardiac arrest, and 4-
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fold increase in all-cause mortality.27 These findings are congruent with the results of the
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current study, which found a 3-fold risk of death in post-MI patients that failed to demonstrate an
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improvement in LVEF. This risk was independent of revascularization, medications, and
baseline LVEF.
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The results of the current study add to the existing literature by validating the association
The current study identified predictors of adverse LV remodeling, including peak serum
troponins, anterior location of infarction, and a higher baseline LVEF at time of myocardial
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infarction. Our data parallels work by Hallen et al. who found that a higher troponin I measured
within 24 to 48 hours post-MI was associated with attenuated LVEF improvement and increased
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prior studies,29, 30 findings were limited by retrospective post-hoc analyses, narrow inclusion
criteria, and brief follow up. The usefulness of drawing inferences from those observations to
real-life contemporary post-MI management may be limited. In the present study, we describe a
prospective post-MI cohort of patients with peak serum troponin T as a predictor of sustained or
attributed to their ability to estimate infarct size,31-33 which has been studied as a powerful
resonance imaging.34, 35
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to have greater irreversible ischemic LV damage, mainly due to the greater magnitude of
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myocardium at risk intrinsic to anterior infarcts.38 However, there has been some dispute
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whether the adverse post-MI LV remodeling is primarily due to a larger infarct size, or whether
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there is an independent contribution to remodeling and prognosis based on infarct location.38-40
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In our study, both anterior location and peak serum troponin were independent predictors of
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addition to infarct size, as estimated by peak serum troponin levels. Unfortunately, only limited
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conclusions can be drawn, as we did not collect systematic information on infarct size.
Interestingly, there was an inverse relationship between baseline LVEF and adverse LV
remodeling; that is, patients with a lower baseline LVEF at time of MI showed the greatest
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improvement in LV function. Reasons for this inverse relationship between baseline LVEF and
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LV function improvement are not entirely clear. However, it is possible that patients with a lower
initial LVEF have greater amounts of stunned myocardium, and subsequently a greater potential
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for functional recuperation.11 Christian et al. reported that 25% of their post-MI patients had a
lower than expected LVEF expected by scintigraphic estimates of their infarct size due to
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myocardial stunning.41 These patients had a late improvement in LVEF at 6 weeks post-MI.
Alternatively, our observation could simply represent regression toward the mean, as has been
reported previously.42
Limitations
The study results must be interpreted in the context of some inherent limitations. There were
several methods used for the LVEF assessment, which may cause some variation in the
accuracy of LVEF measurements. The majority of LVEF measurements were attained through
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endocardium visualization. An additional limitation was the failure to capture a precise LVEF in
all patients due to physician preference in reporting LVEF numerically or categorically. These
limitations must be interpreted in the context of attaining real-world registry based data, and the
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pragmatism of acquiring LVEF assessments that reflect clinical practice. Unfortunately, a
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significant number of patients were not included in the analysis due to failure to attain a repeat
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LVEF assessment. Finally, the EF recovery was treated categorically instead of as a
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continuum. However, the categories chosen allow for simplicity in clinical use, and as shown by
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CONCLUSIONS
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In this contemporary cohort study, less than half of patients with significant LV dysfunction post
MI had routine LVEF reassessment within 12 months. Using a prospective system of physician
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reminders and facilitation of testing, the proportion of these patients undergoing post-MI LVEF
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reassessment was increased. When reassessed, one quarter of patients had sustained or
fold increase in total mortality. Together, these findings support the importance of LVEF
processes affecting low rates of LVEF reassessment may reduce missed care opportunities and
recommended care.
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35. Nijveldt R, Beek AM, Hirsch A, Stoel MG, Hofman MB, Umans VA, Algra PR, Twisk JW
and van Rossum AC. Functional recovery after acute myocardial infarction: comparison
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37. Stone PH, Raabe DS, Jaffe AS, Gustafson N, Muller JE, Turi ZG, Rutherford JD, Poole
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WK, Passamani E, Willerson JT and et al. Prognostic significance of location and type of
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myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll
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Carbone I, Lombardi M, Agati L, Janssens S and Bogaert J. Relationship between location and
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size of myocardial infarction and their reciprocal influences on post-infarction left ventricular
39. Erlebacher JA, Weiss JL, Weisfeldt ML and Bulkley BH. Early dilation of the infarcted
segment in acute transmural myocardial infarction: role of infarct expansion in acute left
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40. Thanavaro S, Kleiger RE, Province MA, Hubert JW, Miller JP, Krone RJ and Oliver GC.
Effect of infarct location on the in-hospital prognosis of patients with first transmural myocardial
41. Christian TF, Behrenbeck T, Pellikka PA, Huber KC, Chesebro JH and Gibbons RJ.
Mismatch of left ventricular function and infarct size demonstrated by technetium-99m isonitrile
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42. Berger PB and Gersh BJ. Ventricular function after primary angioplasty for acute
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Figure 1. Current Practice of LVEF Reassessment for patients with index MI occurring between
June 2010 to November 2011
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Figure 2. Prospective project-directed LVEF reassessment for patients with index MI occurring
between December 2011 to August 2014
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Figure 3. Change in Left Ventricular Ejection Fraction Stratified by Degree of Initial LV Systolic
Dysfunction.
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LVEF Change
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(n = 109) (n = 150) (n = 183)
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Age (years) 67 [59, 75] 64 [56, 73] 63 [53, 74] 0.04
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Female (%) 19 15 28 0.01
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BMI (kg/m2) 28 [25, 30] 28 [25, 32] 27 [24, 31] 0.2
Median Baseline EF (%) 38 [35, 40] 36 [33, 40] 35 [29, 40] 0.0001
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Median Change in EF (%) -5 [-10, -2]
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Management
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Thrombolysis (%) 15 13 9 0.3
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Medical Management (%) 30 25 21 0.2
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Index MI Details
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STEMI (%) 63 60 55
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NSTEMI (%) 37 40 45
LVEDP (mmHg) 27 [19, 32] 24, [18, 30] 24 [17, 30] 0.2
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Laboratory Data
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Baseline LDL (mmol/L) 2.2 [1.6, 2.8] 2.1 [1.5, 3.0] 2.3 [1.7, 3.0] 0.08
Peak Troponin T (mcg/L) 2.7 [0.7, 10.2] 3.0 [0.6, 8.1] 1.9 [0.6, 5.6] 0.04
Discharge Medications
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Univariate Multivariate
OR 95% CI P OR 95% CI P
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Age (per decade) 1.3 1.1 – 1.5 0.01 -- -- --
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Female -- -- NS -- -- --
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Diabetes -- -- NS -- -- --
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History of Prior MI 1.8 1.2 – 2.9 0.007 -- -- --
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Anterior MI Location 2.2 1.4 – 3.5 0.001 2.4 1.3 – 4.5 0.007
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CAD Extent 1.5 1.1 – 2.0 0.005 -- -- --
Peak Troponin T (per 5.0 1.1 1.04 – 1.20 0.01 1.4 1.1 – 1.7 0.006
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mcg/L)
Baseline Creatinine -- -- NS -- -- --
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Baseline EF (per 10%) 1.9 1.3 – 2.8 0.001 2.4 1.4 – 4.2 0.001
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OR 95% CI P
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Model 2 (No EF Recovery, Anterior 3.0 1.5 – 5.9 0.001
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Location, baseline EF)
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Model 3 (No EF Recovery, Anterior 3.0 1.5 – 5.8 0.002
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Location, baseline EF, and Lack of
Beta-Blocker or ACE-I/ARB)
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