Is the Genesis Serenity®

prenatal test right for you?

What is the The Genesis Serenity® test is a non-invasive prenatal test (NIPT) that offers
the reassurance of knowing in the early stages of pregnancy, as early as
Genesis Serenity® 10 weeks, that your baby is at low risk of Down Syndrome (Trisomy 21),
prenatal test? Edwards Syndrome (Trisomy 18), and Patau Syndrome (Trisomy 13).

Other tests that are commonly requested are sex chromosome linked conditions
such as Klinefelter syndrome and Turner syndrome. (Please discuss with your
healthcare provider to suggest if these are right for you). The test does not
assess risk for mosaicism, partial trisomies or translocations.

The test will provide accurate answers when they matter most — simply,
safely, sooner.

How is it Your baby’s cell free DNA can be detected circulating in your blood and so
it requires a simple blood test, which is sent to Genesis Genetics’ labs in
carried out? London, analysed and the results returned within one week. You will also be
required to have an ultrasound scan prior to the blood test to check the
viability of your pregnancy.

It is recommended that expectant parents meet and discuss with their

healthcare professional both before and after the test. In the case of a positive
result, Genesis Genetics will be able to provide genetic counselling to support
your healthcare provider.

Who can have It can be carried out for most pregnancies including IVF, singleton and twins.
It can be performed on women who have conceived via assisted reproductive
the Genesis technology (ART) including use of a donor egg.
Serenity®
prenatal test? Studies began by only testing pregnancies in women aged 35 or over but as
scientific evidence is increasingly showing, it is a valuable test for pregnancies
at all maternal ages.

Is the Genesis Although it’s not 100% conclusive, Genesis Serenity® is highly accurate.
The test identifies, in singleton pregnancies: more than 99% of fetuses with
Serenity® test Trisomy 21; 98% of fetuses with Trisomy 18; 98% of fetuses with Trisomy 13;
conclusive? and 95% of fetuses with Turner Syndrome. X and Y analysis provides >99%
accuracy for fetal sex. Accuracy for detecting other sex chromosome
anomalies varies by condition.

The risk of requiring further testing such as CVS or Amniocentesis after a

Genesis Serenity® test is dramatically reduced.

Genesis Genetics UK
The London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH
T: +44 (020) 7691 2084 E: serenity@genesisgenetics.org www.genesis-serenity.com
 How does the The Genesis Serenity® test is able to deliver a much higher accuracy than NHS
tests giving you greater peace of mind. It’s totally non-invasive, posing minimal
Genesis Serenity® risk to mother or baby, can test for more than just Down Syndrome, and can be
test differ from carried out as early as 10 weeks’ pregnant.
NHS tests? NHS Down Syndrome screening tests are typically undertaken via a nuchal
translucency ultrasound between 11 and 14 weeks. This can only estimate the risk
of your baby having Down’s, it can’t tell you for sure either way. For example, if
your result is one in 1,000, this means that for every 1,000 babies with your level
of risk, one will have Down’s syndrome. A risk of one in 150 or less is considered
high. If for some reason the scan cannot be completed, expectant mothers
are offered a blood test between 14 and 20 weeks of pregnancy, which is less
accurate than the nuchal test.

Further testing such as CVS and amniocentesis are invasive and have risk factors
associated with them.

How does the Clinical evidence shows that the failure rate of this test is the lowest at 0.07%.
Additionally, the false positive and false negative rates are exceptionally low.
Genesis Serenity® More information is available on our website at www.genesis-serenity.com
test differ from
Our dedicated and experienced team work in CPA accredited labs in London,
other NIPTs on ensuring that your results are returned to you faster than many of our
the market? competitors who send samples to the United States or China for analysis.

Where can I There are number of private clinics that Genesis Genetics have already set
up contracts with to easily supply you with access to the test. We are happy
get the test? to put you in touch with a clinic near you. or get your healthcare professional
to contact Genesis Genetics to set up an account and get a collection kit
sent out. Call 020 7691 2084 or email serenity@genesisgenetics.org

How long Once you have seen your healthcare professional and had your scan then a
single maternal blood sample is taken and sent to Genesis Genetics labs for
does it take? processing. Results are returned to the healthcare professional in less than one
week from receipt of the sample.

About Genesis Genetics About verifi®

Genesis Genetics is the pioneer of pre-implantation testing of Genesis Serenity® uses the verifi®
embryos for inherited genetic abnormalities and was founded technology developed by Illumina and
by world-renowned scientists who are largely responsible for licensed to Genesis Genetics, called
implementing pre-implantation genetic diagnosis (PGD) as a “massively parallel DNA sequencing”
clinical practice. We at Genesis Genetics also have extensive to count the number of copies of fetal
experience with invasive cytogenetic prenatal testing across our chromosomes in maternal blood. It then
laboratory group. uses a calculation method to determine
if there are too many or too few copies
Our world class team of genetic counselors, molecular geneticists of chromosomes 13, 18 and 21 present
and physicians work closely with your doctors to fulfill our in your fetus. The verifi® test has been
mission: helping couples build healthy families. Throughout our scientifically shown to be the most
locations in the United States, and in Brazil, England, South sensitive and accurate non-invasive
Africa, Jordan and Taiwan, Genesis Genetics testing has helped prenatal screening test available.
thousands of families.