Pathophysiology of Nephrotic

Syndrome

Primary NS Secondary NS
(Idiopathic)

Damage to the glomerular

filtering membrane

Defect in permeability of membranes

(increased pore size and effacement)

Foamy urine Massive proteinuria (>3.5 per Loss of antithrombin III

24hr period) and protein S and C

Loss of
immunoglobulin G in Hypoalbuminemiaa
the urine Hypercoagulation
state

Increased risk
for infection Hepatic
Decreased oncotic lipoprotein
pressure synthesis Increased risk
for
cardiovascular
diseases
Salt and water retention; Hyperlipidemia
movement of fluids from
intravascular to interstitial

Weight gain Edema

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