Cobetter Catalog For Biopharma 2020

Filtration, Separation & Purification
Solutions for Biopharma Applications

Membrane
Manufacturing
Validation Filter
Center Manufacturing
Gamma
Irradiation
Endotoxins Housing
Manufacturing
Redundant Removal
Filters Filters
Filters
Ultrafiltration
Sterilizing-Grade Product
Filters
Validation
Mycoplasma Services
Removal
Filters
Depth Stainless Steel System Design
(Sterilizing Filtration
Filtration Filters /CIP System/
UFF System...)
Monoclonal Recombinant
Antibodies Protein
Vaccines Blood Product
Application
C1 Factory
Penicillin-streptomycin Probiotics Membrane Filter Manufacturing
9400 SQM
Gene-based Medicine
C2 Factory
Depth Filter Manufacturing
9000 SQM
Cobetter dedicates itself to providing Filtration, Separation, & Purification C3 Factory
1,200+ technical analysis reports annually C4

Semiconductor Products Manufacturring
13600 SQM, 2019
Solutions across all industries.Cobetter provides over
C5 C4 Factory
for customers in the pharmaceutical industry and over 1,300+ technical analysis reports annually
Sustainless Filter Manufacturing
C2 C1 & Fluoroplastics Resurtech Manufacturing

& Housing Manufacturing
for customers in chemical, microelectronics and life sciences industries

C3 C6
28000 SQM
C5 Lab
R&D, Lab Center
41000 SQM, 2020
C6 Factory
Life Center
25000 SQM
Filtration, Separation & Purification Filtration, Separation & Purification

Solutions for Biopharma Applications -1- -2- Solutions for Biopharma Applications
1 2
Taketomi Hidetoshi, Japanese

Previous Pall Lab Expert for
More Than 30 Years.
Advanced Japanese Quality Control Methods

Ensure that Every Product is Safe, Reliable, and Stable
3
Quality Assurance is based on the Quality Assurance System
- Focus on the Production Process
Implement 4M Quality Management Concept

- Process and System Simultaneous Completion
All Products are based on the QC Project Table

- Produced as per SOP for Stable Production
Validation Center
Accredited by China National Accreditation Service for Conformity (CNAS)
Established with an initial 10milllion USD investment
4
4M
Manufacture
ilac-MRA Man Material Machine Method
50+ Equipments ISO 17025
180+ SOP Manufacturing
80+ Engineers 3 Elements of

Product
Cover all the Validation Tests the Products
Life & Science Validation Center Quality Cost Delivery
1 6 Bacterial Challenge Test : Retention tests for Mycoplasma, B.diminuta, Serratia

marcescens, lactobacillus, saccharomycetes, colibacillus and other microorganisms
Chemical Analysis : Extractable & Leachables , Chemical Compatibility test
UV/PDA-HPLC : UV/PDA scanning to determine extractables and leachables
6 4 UPLC/MS : Determine the nonvolatile and semivolatile of extractable & leachables
quantitatively and qualitatively
5 GC-MS : Determine volatile/semi-volatile status of extractables and leachables
quantitatively and qualitatively
2 IC/ICP-MS : Analyze alkalis, halogen family, acid radicals, ammonia, and other ions
quantitatively
NVR : Analyze non-volatile extractable from water, IPA, Acetone and other volatile
solutions quantitatively
FTIR : Analyze polymers and oligiomers in non-volatile extractable & leachables
qualitatively
3 SEM/EDS : Analyze filter membrane defect, appearance, and impurities. SEM
analysis of chemical compatibility

Flow Diagram of Bioprocess 3 Buffer Filtration
3 Buffer Filtration 3 Buffer Filtration
1 Media Filtration 2 Sterile Vent
Affinity Virus Inactivation 5 Column

Centrifugation Chromatography Protection Purification
Chromatography
8 Virus Removal 7 Virus Removal

2 Gas Filtration 6 Concentration Filtration Pre-filtration 3 Buffer
Filtration
Fermentation/Bioreactor
4 Clarification
5 Column/TFF
Protection
3 Buffer Filtration Polishing
Chromatography
6 Concentration and
Diafiltration
Tangential Flow
Microfiltration 3 Buffer Filtration
Diafiltration
1 Media Filtration Buffer Filtration
Bioburden Reduction and Particle Control 3 Buffer Filtration

-Greclary® CHV -Glass Fiber 9 Sterile Filtration Filling
-Safetect® PME -PES -Purcise® PLE -Double Layer PES
-Purcise® PLE -Double Layer PES -Purcise® PAF -PES
-Safetect® PME -PES
Sterilizing-grade Filtration
-Purcise® SLE -Double Layer PES
-Corevital® SAF -Double Layer PES
-Purcise® SLE -Double Layer PES
5 Column / TFF Protection
-Purcise® SPS -PES -Purcise® SPS -PES
-Corevital® SND -Double Layer PVDF -Corevital® SND -Double Layer PVDF Clarification
-Corevital® SMD -PVDF -Corevital® SMD -PVDF -Greclary® CHV -Glass Fiber
Mycoplasma Removal -Excesal® CHE -PP
-Excesal® CHC -PP
-Purcise® MLE -Double Layer PES -Excesal® CHT -PP
4 Clarification Filtration
Bioburden Reduction and Particle Control
2 Vent and Gas Filtration -Roheap® CSD -Purcise® PLE -Double Layer PES 7 Viral Remove Prefiltration
-Safetect® PME -PES
-Corevital® PND -Double Layer PVDF
9 Sterile Filtration
-Aegivast® AFL -Hydrophobic PTFE -Purcise® SLE -Double Layer PES
-SafesureTM AFM -Hydrophobic PTFE 6 Concentration and Purification Sterilizing-grade Filtration -Purcise® SPS -PES 8 Virus Clearance -Purcise® SLE -Double Layer PES
-Aegivast® ACE -Hydrophobic PTFE -Purcise SLE -Double Layer PES
® -Corevital® SND -Double Layer PVDF -Purcise® SPS -PES
-Corevital® APB -Hydrophobic PVDF -Consieve® UET -PES -Corevital® SND -Double Layer PVDF -Purcise® MLE -Double Layer PES -Viruclear® -PES* -Corevital® SND -Double Layer PVDF
* Being Developed

Inlet /Outlet Connections
Bricap & Brisip Capsule Filter Series C Female Luer Lok™ Inlet
Bricap®/BriScale® Disc Capsule Filters

Item Diameter Max. Length Inlet/Outlet Vent
Bricap V50D 64mm 70mm N/A
P
®
Male Luer Lok™ Outlet
6-13 mm (1/4"-1/2") Stepped Hose Barb
Bricap V50A
®
73mm 74mm N/A
Bricap V42
®
56mm 47mm 6-9 mm (1/4"-3/8") Stepped Hose Barb N/A
BriScale A50
®
64mm 71mm 6-13mm(1/4''-1/2'') Stepped Hose Barb Luer lock
14 mm (9/16")
K Sanitary Flange
Bricap® C/D Series Capsule Filters 19 mm (3/4")
Item Diameter Max. Length Inlet/Outlet Vent/Drain T Sanitary Flange
14 mm (9/16") Sanitary Flange
Bricap® C01 106mm
19 mm (3/4") Sanitary flange
Bricap® C02 64mm 136mm 31 mm (1 1/4") Sanitary Flange 6mm Hose Barb
6-13 mm (1/4"-1/2") Stepped Hose Barb
Bricap C03
®
173mm 9.6mm (3/8") Hose Barb
F 31 mm (1 1/4")
Sanitary Flange
Brisip® Series Capsule Filters S 38 mm (1 1/2")

Sanitary Flange
Item Diameter Max. Length Inlet/Outlet Vent/Drain
6mm Hose Barb
Brisip SP3
® 81mm 159mm 38 mm (1 1/2") Sanitary Flange Stäubli
Y 9.6 mm (3/8")
Single Stepped Hose Barb
Bricap® L Series Capsule Filters
Item Diameter Max. Length Inlet/Outlet Vent/Drain
H 13 mm (1/2")
Cartridge Filters
Bricap® L03 190mm 14 mm (9/16") Sanitary Flange
19 mm (3/4") Sanitary flange V 14 mm (9/16")
Single Stepped Hose Barb Nominal Length Adaptor Seal Material
Bricap® L05 233mm 38 mm (1 1/2") Sanitary Flange
Bricap® L10 89mm 347mm
13 mm (1/2") Hose Barb
6mm Hose Barb X 16 mm (5/8")
5"
10"
226/Fin
226/Flat
Silicone
EPDM
Bricap® L20 16 mm (5/8") Hose Barb
585mm
Bricap® L30 838mm
25 mm (1") Hose Barb
M 19 mm (3/4")
20" 222/Fin Viton
30" 222/Flat TEV
D 25 mm (1")
40" Double Open End
Bricap® T Series Capsule Filters

Item Diameter Max. Length Inlet/Outlet Gauge Port Vent/Drain
Bricap T10
®
354mm 38 mm (1 1/2")
Bricap T20
®
89mm
/152mm
592mm
Sanitary Flange
19mm (3/4” )
14 mm (9/16") Sanitary Flange
38 mm (1 1/2") Sanitary Flange
6mm
Hose Barb
B 6-13 mm (1/4"-1/2")
Multiple Stepped Hose barb
(Inlet/Outlet) No top port
Bricap® T30
E
845mm Sanitary Flange 6-9 mm (1/4"-3/8")
Multiple Stepped Hose barb
Filtration, Separation & Purification 38 mm (1 1/2") Filtration, Separation & Purification

Solutions for Biopharma Applications -7- S-S Sanitary Flange -8- Solutions for Biopharma Applications
(Only for T -Type Capsule)
Catalog
Clarification Filter Series
Roheap® CSD Filter

High Dirt Holding Capacity
Features 1.2
Differential Pressure (bar)

Clarification Filter Series Sterile-Grade Filter Series Gas Filtration Filter Series · Filter media composed of lignocellulose and inorganic filter aids
1 0040
· Gradient filter structure provides high dirt holding capacity and
Roheap® CSD Filter P 10 Purcise SLE Filter P 21 Aegivast AFL Filter P 33 retention efficiency 0.8
High Dirt Holding Capacity Hydrophilic Sterile-Grade Filter with Hydrophobic Filter with High Retention Rates · Low initial pressure difference and long service life 0.6
Low Extractables · Positive Zeta charge results in removal efficiency for host DNA, HCP, etc. 0100
Greclary CHV Filter P 12 Aegivast ACE Filter P 34 0.4
High Dirt Holding Capacity Purcise SAF Filter P 23 Hydrophobic Filter with High Retention Rates
0.2
and Retention Efficiency Hydrophilic Sterile-Grade Filter 0500
with High Flow Rates Safesure AFM Filter P 35 Applications

0
Excesal® CHC P 14
10 20 30 40 50
Hydrophobic Filter with High Retention Rates Flow Rate ( L /min /m2 )
High Dirt Holding Capacity Purcise SPS Filter P 24 · Clarification of fermentation broth/cell cultures
Hydrophilic Sterile-Grade Steam · Filtration of blood and blood products
Excesal CHT P 16 -in-Place (SIP) Filter Corevital APB Filter P 37 · Filtration of enzyme preparation
High Dirt Holding Gamma-resistant Hydrophobic Filter · Filtration of colloids/viscous liquids
Corevital SND Filter P 27
Excesal® CHE P 17 Hydrophilic Sterile-Grade Filter
High Retention Efficiency with High Flow Rates Filter Material
Filter Media Cellulose diatomite filter aid and ionic
Corevital SMD Filter P 28 wet-strength resin
Other Products
High Flow Rate, Low Protein
Binding Hydrophilic Sterile Filter
Operating Conditions Chemical Compatibility
TFF P 39 @20°C @80°C
Apexision® SBC Filter P 31 Max. Temperature 80°C Chemicals Concentration
Cassettes /Stainless Holder /System
Hydrophilic Sterile-Grade Filters Max. Differential Pressure 0.24 MPa NaOH 2% G P
Pre-filtration and with Large EFA Rinse Flushing volume 50L/m², HCl 5% G P
Integrity Test Instrument P 41
Redundant Filter Series Flow Rate 10L/min/m² HNO3 5% G P
H2SO4 10% G P
Purcise PAF P 19 Clean Steam Bag P 41
Acetic acid 38% G G
Hydrophilic Sterile-Grade Filter
Citric acid 10% G G
with High Flow Rates Vacccum Filter P 41 Peracetic acid 0.1% G G
Butanol 80% G G
Purcise PLE Filter P 20 Mycoplasma Removal Filter Housing P 42
Ethanol 80% G G
Hydrophilic Filter with Low Extractables Filter Series
G = Recommended ; P = Not recommended
Corevital PND P 22 Purcise MLE Filter P 25
Hydrophilic Sterile-Grade Filter Hydrophilic Filter with
with Low Protein Binding Low Extractables Biological Safety Leachables
Endotoxins <0.25 EU/ml B Series Ion ppb Ion ppb DSeries Ion ppb Ion ppb
Corevital PMD P 29 Mg 0.73 Ni - Mg 0.755 Ni -
Bio-compatibility Meet the requirement of USP<87> In Vitro
Low Protein Binding and Cytotoxicity Test;
Al 5.33 Cu 0.162 Al 3.86 Cu -
Hydrophilic Filter Meet the criteria of the USP<88> Biological
Reactivity Test for Class VI-121°C plastics Ca 5.65 As 0.987 Ca 1.48 As -
Cr 0.071 Pb - Cr 0.082 Pb -
Fe 13.1 Fe 3.28
Explanation：- means < 0.05ppb

Solutions for Biopharma Applications - 9- - 10 - Solutions for Biopharma Applications
Clarification Filter Series
Greclary CHV Filter

and Retention Efficiency
CSD Lenticular Filter Series Features Water Flow Rate - Cobetter Greclary CHV 10″ Cartridge
· Composed of super-fine glass fiber media 10
Differential Pressure kPa

C S D D O E P · Rigid fiber material which is suitable for colloid filtration
Removal Ratings Control Grade Diameter Seal Material

· High dirt holding capacity and retention efficiency 8
Number of Layers End Cap Number of Lenses
0.2
· Low initial pressure, high flow rates and long service life
CSD Single-Layer 0004 0.04-0.2μm PB Pharma Grade DOE Double Open End 12 12 inch W 2 S Silicone P Pharmaceutical
6
0.45
0020 0.2-0.4μm PC 16 16 inch Y 3 E EPDM

0040 0.4-0.6μm PD G 4 V Viton 4
5 Soft PTFE
1.0
0060 0.6-0.8μm PE B T
0100 0.8-1.5μm SA Standard Grade N 9 F Hard PTFE Applications
2
0150 1.5-3.0μm X 10
11
Q
· Pre-filtration of cell culture medium
0300 3.0-6.0μm 0
12 · Clarification of fermentation broth/cell cultures 0 10 20 30 40 50

0400 4.0-9.0μm T
0500 5.0-12.0μm F 15 · Filtration blood products/serums Flow Rate @ 20°C (L/min)
0600 6.0-15.0μm D 16 · Filtration of colloids/viscous liquids

0700 7.0-18.0μm
0800 8.0-20.0μm
CSDD Double-Layer 0102 0.04-0.4μm

0106 0.04-0.8μm Operating Conditions Materials of Construction
0140 0.04-9.0μm
0180 0.04-20.0μm Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge
0280 0.2-20.0μm Max. Differential Pressure 0.55 MPa / 25°C Membrane Glass Microfiber (GF) Glass Microfiber (GF)
0680 0.6-20.0μm 0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP)
Polypropylene (PP) ⸺
1080 0.8-20.0μm
Capsule Shell
O-ring ⸺ Silicone/EPDM/Viton/PTFE
Biological Safety Capsule Vent O-ring Silicone ⸺
Removal Ratings 0.2/0.45/0.8/1.0/3.0/5.0μm
Endotoxins <0.25 EU/ml
C D F C C S D P Cytotoxicity Test;
Filter Name Number of Layers Filter Media Removal Ratings Control Grade Meet the criteria of the USP<88> Biological
Reactivity Test for Class VI-121°C plastics
S Single-Layer 0004 0.04-0.2μm PB Pharma Grade P Pharmaceutical
0020 0.2-0.4μm PC
0040 0.4-0.6μm PD
0060 0.6-0.8μm PE
0100 0.8-1.5μm SA Standard Grade
Effective Filtration Area
0150 1.5-3.0μm
0300 3.0-6.0μm Bricap C Bricap L Bricap T Cartridge
0400 4.0-9.0μm C01: 80cm 2
L03: 0.07m 2
T10: 0.24m 2
5" : 0.12m2
0500 5.0-12.0μm C02: 200cm2 L05: 0.12m2 T20: 0.48m2 10" : 0.24m2
0600 6.0-15.0μm C03: 300cm2 L10: 0.24m2 T30: 0.72m2 20" : 0.48m2
0700 7.0-18.0μm
0800 L20: 0.48m2 30" : 0.72m2
8.0-20.0μm
L30: 0.72m2 40": 0.96m2
D Double-Layer 0102 0.04-0.4μm
0106 0.04-0.8μm
0140 0.04-9.0μm
0180 0.04-20.0μm
0280 0.2-20.0μm
Sterilization Capability
0680 0.6-20.0μm · Bricap C、Bricap L、Bricap T Series and Filter Cartridges: Autoclave
1080 0.8-20.0μm

Solutions for Biopharma Applications - 11 - - 12 - Solutions for Biopharma Applications
Greclary Series Part Number Configuator (GF)
Capsule Filter Example : C01TTCHV02A1P Clarification Filter Series
Bricap C Small Capsule Filter Series
Inlet Outlet Membrane Type Sterilization Quantity/Package

P
Market
Excesal® CHC
Capsule Formats
C01 Bricap C01 T 3/4" (19 mm) Sanitary Flange CHV02 CHV 0.2μm A Autoclavable 1 1 / pkg P
C02 Bricap C02 A 1/4"-1/2" (6-13 mm) Multiple Stepped CHV04 CHV 0.45μm S Sterile
C03 Bricap C03 Hose Barb with Filling Bell (liquids only) CHV08 CHV 0.8μm
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped CHV10 CHV 1.0μm
Hose Barb
CHV30 CHV 3.0μm
Y 3/8" (9.6mm) Hose Barb
CHV50 CHV 5.0μm
K 9/16" (14mm) Sanitary Flange
Features
Bricap Inline Capsule Filters Series · Special Winding structure
P · Composed of multi-layer with increasing accuracy
· Long service life
Capsule Formats Inlet Outlet Sterilization Quantity/Package Market
· High flow rate
L03 Bricap L03 S 1 1/2" (38 mm) Sanitary Flange A Autoclavable 1 1 / pkg P
L05 Bricap L05 T 3/4" (19 mm) Sanitary Flange S Sterile
L10 Bricap L10 K 9/16" (14 mm) Sanitary Flange
Applications
L20 Bricap L20 D 1" (25 mm) Hose Barb
L30 Bricap L30 M 3/4" (19 mm) Hose Barb · Pre-filtration of cell culture medium
X 5/8" (16 mm) Hose Barb · Clarification of fermentation broth/cell culture
V 9/16" (14 mm) Hose Barb
H 1/2" (13 mm) Hose Barb · Pre-filtration of blood products/serums
· Pre-filtration of colloids/viscous liquids
Bricap T Capsule
P
T10 Bricap T10 S 1 1/2" (38 mm) Sanitary Flange A Autoclavable 1 1 / pkg P Operating Conditions Materials of Construction
T20 Bricap T20 N without Gauge Port S Sterile
T30 Bricap T30 Max. Temperature 80°C Filter Type Bricap® C/L/T Cartridge
Max. Differential Pressure 0.55 MPa / 25°C Membrane Polypropylene (PP) Polypropylene (PP)
0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP)
Capsule Shell Polypropylene (PP) ⸺
Capsule Vent O-ring Silicone ⸺
Biological Safety
Removal Ratings 0.5/0.6/0.8/1.5/5.0/10/20/40/70/90μm
Bio-compatibility Meet USP <87> In Vitro Cytotoxicity Test
Requirements
Meet USP <88> Biological Reactivity Test for
Class VI-121°C Plastics Requirements

Bricap® C Bricap® L Bricap® T Cartridge
C01: 70cm2 L02: 375cm2 T10: 0.18m2 5" : 0.09m2
Cartridge Filter Example : ACHV02050S1P C02: 160cm2 L03: 530cm2 T20: 0.36m2 10" : 0.18m2
Cartridge Filters C03: 260cm2 L05: 0.09m2 T30: 0.54m2 20" : 0.36m2
L10: 0.18m2 30" : 0.54m2
A P
L20: 0.36m2 40": 0.72m2
Cartridge Type Media Length Code O-ring Material Quantity/Package Market
L30: 0.54m2
A Standard Cartridge CHV02 CHV 0.2μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Pharmaceutical CHV04 CHV 0.45μm 10 10 inch 2 226 / Falt V Fluoroelastomer
CHV08 CHV 0.8μm 20 20 inch 7 226 / Fin S Silicone Sterilization Capability
CHV10 CHV 1.0μm 30 30 inch 3 222 / Falt P FEP/PFA encap-sulated
O-rings
· Bricap® L、Bricap® T Series and Filter Cartridges : Autoclave
CHV30 CHV 3.0μm 40 40 inch 8 222 / Fin
CHV50 CHV 5.0μm

Exceal Series Part Number Configuator (PP)
Capsule Filter Example : L03TTCHC05A1P Clarification Filter Series
Bricap Inline Capsule Filters Series
Excesal CHT
P
Capsule Formats Inlet Outlet Membrane Type Sterilization Quantity/Package Market
L03 Bricap L03 S
T
1 1/2" (38 mm) Sanitary Flange CHC05
CHC10
CHC
CHC
0.5μm
1.0μm
A Autoclavable 1 1 / pkg P High Dirt Holding
L05 Bricap L05 3/4" (19 mm) Sanitary Flange S Sterile
L10 Bricap L10 K 9/16" (14 mm) Sanitary Flange CHC30 CHC 3.0μm
L20 Bricap L20 D 1" (25 mm) Hose Barb CHC50 CHC 5.0μm
L30 Bricap L30 M 3/4" (19 mm) Hose Barb CHC1X CHC 10μm
X 5/8" (16 mm) Hose Barb
V 9/16" (14 mm) Hose Barb Features
H 1/2" (13 mm) Hose Barb
· Composed of multi-layer Polyproylene media
· High retention efficiency
· All raw materials meet NSF requirements* No adhesives or surfactants
Bricap T Capsule Filters
P
T10 Bricap T10 S 1 1/2" (38 mm) Sanitary Flange A Autoclavable 1 1 / pkg P
Bricap T20
Applications
T20 N without Gauge Port S Sterile
T30 Bricap T30 · Pre-filtration of cell culture medium
· Clarification of fermentation broth/cell cultures
· Filtration blood products/serums
· Filtration of colloids/viscous liquids
Operating Conditions Materials of Construction

Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge
Biological Safety
Removal Ratings 0.5/0.6/0.8/1.0/1.5/5.0/10/20/40/70/90μm
Cytotoxicity Test;
Meet the criteria of the USP<88> Biological

Bricap® C Bricap® L Bricap® T Cartridge
Cartridge Filter Example : ACHC03050S1P C01: 70cm2 L02: 375cm2 T10: 0.18m2 5" : 0.09m2
Cartridge Filters C02: 160cm2 L03: 530cm2 T20: 0.36m2 10" : 0.18m2
C03: 260cm2 L05: 0.09m2 T30: 0.54m2 20" : 0.36m2
A P L10: 0.18m2 30" : 0.54m2
Cartridge Type Media Length Code O-ring Material Quantity/Package Market L20: 0.36m2 40": 0.72m2
A Standard Cartridge CHC05 CHC 0.5μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P L30: 0.54m2
Pharmaceutical CHC 1.0μm 10 2 V Fluoroelastomer
CHC10 10 inch 226 / Falt
CHC30 CHC 3.0μm 20 20 inch 7 226 / Fin P FEP/PFA encap-sulated
CHC 5.0μm 30 30 inch 3 222 / Falt O-rings
CHC50
CHC 10μm 40 40 inch 8 222 / Fin Sterilization Capability
CHC1X
· BriScale Disc、Bricap C、Bricap L、Bricap T Series and Filter Cartridges: Autoclave

Exceal Series Part Number Configuator (PP)
Capsule Filter Example : C01TTCHE03A1P
Clarification Filter Series Bricap C Small Capsule Filter Series
P
Excesal CHE ®
High Retention Efficiency C01

C02
Bricap C01
Bricap C02
T
A
3/4" (19 mm) Sanitary Flange
1/4"-1/2" (6-13 mm) Multiple Stepped
CHE03
CHE06
CHE
CHE
0.3μm
0.65μm
A
S
Autoclavable
Sterile
1 1 / pkg P
C03 Bricap C03 Hose Barb with Filling Bell (liquids only) CHE10 CHE 1.0μm
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped CHE30 CHE 3.0μm
Hose Barb
CHE50 CHE 5.0μm
CHT05 CHT 0.5μm
Features CHT06 CHT 0.6μm
CHT08 CHT 0.8μm
· Composed of double-layer Polypropylene media Bricap Inline Capsule Filters Series CHT10 CHT 1.0μm
· Inner layer uses nanofibers to provide high retention efficiency CHT15 CHT 1.5μm
CHT50 CHT 5.0μm P
Capsule Formats Inlet Outlet CHT1X CHT 10μm Sterilization Quantity/Package Market
CHT2X CHT 20μm
CHT4X CHT 40μm
K 9/16" (14 mm) Sanitary Flange CHT7X CHT 70μm
Applications L10 Bricap L10
D 1" (25 mm) Hose Barb CHT9X CHT 90μm
L20 Bricap L20
· Pre-filtration of cell culture medium L30 Bricap L30 M 3/4" (19 mm) Hose Barb
· Clarification of fermentation broth/cell cultures X 5/8" (16 mm) Hose Barb
· Pre-filtration of blood products/serums
· Pre-filtration of colloids/viscous liquids
Bricap T Capsule Filters

P
Operating Conditions Materials of Construction T10 Bricap T10 S 1 1/2" (38 mm) Sanitary Flange A Autoclavable 1 1 / pkg P
T20 Bricap T20 N without Gauge Port S Sterile
Max. Temperature 80°C Filter Type Bricap® C/L/T Cartridge
T30 Bricap T30
BriScale® Disc Liquid Filter
O-ring ⸺ Silicone/EPDM/Viton/PTFE A 5 0 P
Capsule Vent O-ring Silicone ⸺ Sterilization Quantity/Package Market
Biological Safety Capsule Formats Inlet Outlet
Removal Ratings 0.3/0.65/1.0/3.0/5.0μm
A50 BriScale® A50 A 6-13 mm (1/4"-1/2") Multiple Stepped A Autoclavable 1 1 / pkg P
Endotoxins <0.25 EU/ml Hose Barb with Filling Bell (outlet only)
G Gamma Compatible 2 2 / pkg
Bio-compatibility Meet the requirement of USP<87> In Vitro B 6-13 mm (1/4"-1/2")
Multiple Stepped Hose Barb (no Filling Bell) S Sterile
Cytotoxicity Test;

BriScale® A25/A50 Bricap® C Bricap® L Bricap® T Cartridge
A25: 3.4cm2 C01: 140cm2 L03: 0.1m2 T10: 0.36m2 5" : 0.18m2 Cartridge Filter Example : ACHE03050S1P
A50: 20cm2 C02: 320cm2 L05: 0.18m2 T20: 0.72m2 10" : 0.36m2 Cartridge Filters
C03: 500cm2 L10: 0.36m2 T30: 1.08m2 20" : 0.72m2
L20: 0.72m2 30" : 1.08m2 A P
L30: 1.08m2 40": 1.44m2 Cartridge Type Media Length Code O-ring Material Quantity/Package Market
A Standard Cartridge CHE03 CHE 0.3μm CHT10 CHT 1.0μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Pharmaceutical CHE 0.65μm 10 2 V Fluoroelastomer
CHE06 CHT15 CHT 1.5μm 10 inch 226 / Falt
CHE10 CHE 1.0μm CHT50 CHT 5.0μm 20 20 inch 7 226 / Fin P FEP/PFA encap-sulated
Sterilization Capability O-rings
CHE30 CHE 3.0μm CHT1X CHT 10μm 30 30 inch 3 222 / Falt
· BriScale Disc、Bricap C、Bricap L、Bricap T Series and Filter Cartridges : Autoclave
® ® ® ®
CHE50 CHE 5.0μm CHT2X CHT 20μm 40 40 inch 8 222 / Fin
· BriScale Disc、Bricap C、Bricap L、Bricap T Series and Filter Cartridges: Autoclave CHT05 CHT 0.5μm CHT4X CHT 40μm
CHT06 CHT 0.6μm CHT7X CHT 70μm
CHT08 CHT 0.8μm CHT9X CHT 90μm
Pre-filtration and Redundant Filter Series
Purcise PAF
Hydrophilic Sterile-Grade Filter Purcise PLE Filter
with High Flow Rates Hydrophilic Filter with Low Extractables
Features
Features
· Efficient bacteria and particulate retention
· Extensive chemical compatibility (pH 1-14) · Composed of double-layer hydrophilic Polyestersulfone media Water Flow Rate- Cobetter Purcise PLE 0.8+0.45µm Bricap L10 Capsule
· High flow rates · Efficient bacteria and particulate retention 150

· Extensive chemical compatibility (pH 1-14) SV
125
· Low extractables
100
75 VV
Applications 50
SD
· Sterilize filtration of cell culture medium Applications 25 SS
· Buffer filtration · Pre-filtration of cell culture medium 0

0 10 20 30 40 50 60
· Buffer filtration Flow Rate @ 20°C (L/min)
Operating Conditions Materials of Construction Operating Conditions Material of Construction

Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge Max. Temperature 80°C Filter Type Bricap C/D/L/T Cartridge
Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES) Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES)
0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP) 0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP)
Capsule Shell Polypropylene (PP) ⸺ Capsule Shell Polypropylene (PP) ⸺
O-ring ⸺ Silicone/EPDM/Viton/PTFE O-ring ⸺ Silicone/EPDM/Viton/PTFE
Biological Safety Capsule Vent O-ring Silicone ⸺ Biological Safety Capsule Vent O-ring Silicone ⸺
Endotoxins <0.25 EU/ml Removal Ratings 0.45 μm / 1.0 μm Endotoxins <0.25 EU/ml Removal Ratings 0.8+0.45 μm / 1.0+0.65 μm / 1.5+0.8 μm
Bio-compatibility Meet the requirement of USP<87> In Vitro Bio-compatibility Meet the requirement of USP<87> In Vitro
Cytotoxicity Test; Cytotoxicity Test;
Meet the criteria of the USP<88> Biological Meet the criteria of the USP<88> Biological
Reactivity Test for Class VI-121°C plastics Reactivity Test for Class VI-121°C plastics
Effective Filtration Area Effective Filtration Area

BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge
A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2 A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2
A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2 A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2
C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20" : 1.1m2 C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20": 1.1m2
D01 : 350cm² L10: 0.55m2 30" : 1.65m2 D01 : 350cm² L10: 0.55m2 30": 1.65m2
L20: 1.1m2 40": 2.2m2 L20: 1.1m2 40": 2.2m2
L30: 1.65m2 L30: 1.65m2
Sterilization Capability Sterilization Capability

· BriScale Disc、Bricap C、Bricap L、Bricap T : Autoclave (126°C, 60min, 3 times), · BriScale Disc、Bricap C、Bricap L、Bricap T : Autoclave (126°C, 60min, 3 times),
Gamma irradiation or Pre-sterilization Gamma irradiation or Pre-sterilization
· Bricap D : Autoclave · Bricap D : Autoclave
· Filter Cartridges: SIP & Autoclave · Filter Cartridges: SIP & Autoclave

Sterile-Grade Filter Series Pre-filtration and Redundant Filter Series
Purcise SLE Filter Corevital PND

Hydrophilic Sterile-Grade Filter with Hydrophilic Sterile-Grade Filter
Low Extractables with Low Protein Binding
Features
Features
· Composed of double-layer Polyestersulfone media
Water Flow Rate- Cobetter Purcise SLE 0.2µm Bricap L10 Capsule · Efficient bacteria and particulate retention
· Extensive chemical compatibility (pH 1-14) 150 · Low extractables and protein binding

VV
· Low extractables SV
125
100
Applications 75
· Sterilize filtration of cell culture medium SD Applications

50 SS
· Buffer filtration · Sterilize filtration of cell culture medium
25
· Pre-column/ultra-filtration protection · Buffer filtration
· Filtration of intermediate products/stock solutions 0
0 10 20 30 40 50 60
· Filtration of blood products/serums Flow Rate @ 20°C (L/min)
· Sterile filtration of terminal products


Operating Conditions Materials of Construction Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge
Max. Temperature 80°C Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES)
Filter Type Bricap C/D/L/T Cartridge
Max. Differential Pressure 0.55 MPa / 25°C 0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP)
Membrane Hydrophilic Polyethersulfone (PES)
Polypropylene (PP) Polypropylene (PP)
0.1 MPa / 80°C Capsule Shell
Support
⸺
O-ring Silicone/EPDM/Viton/PTFE
Core/Cage/End Cap
⸺
Polypropylene (PP)
Capsule Vent O-ring Silicone
Capsule Shell ——
⸺
Biological Safety O-ring Silicone/EPDM/Viton/PTFE Biological Safety Removal Ratings 0.8+0.45 μm
Endotoxins <0.25 EU/ml Capsule Vent O-ring Silicone —— Endotoxins <0.25 EU/ml
Bio-compatibility Meet the requirement of USP<87> In Vitro Removal Ratings 0.2 μm / 0.45+0.2 μm / 0.65+0.2 μm Bio-compatibility Meet the requirement of USP<87> In Vitro
Cytotoxicity Test; 0.8+0.2 μm / 1.2+0.2 μm Cytotoxicity Test;

BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge
A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2 A25: 3.4cm2 C01 : 180cm² L02 : 0.12m² T10 : 0.55m² 5" : 0.28m2
A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2 A50: 20cm2 C02 : 420cm² L03 : 0.16m² T20 : 1.1m² 10" : 0.55m2
C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20" : 1.1m2 C03 : 660cm² L05 : 0.28m² T30 : 1.65m² 20" : 1.1m2
D01 : 350cm² L10: 0.55m2 30" : 1.65m2 D01 : 350cm² L10 : 0.55m² 30" : 1.65m2
L20: 1.1m2 40": 2.2m2 L20 : 1.1m² 40" : 2.2m2
L30: 1.65m2 L30 : 1.65m²

· Filter Cartridges: SIP & Autoclave · Filter Cartridges: SIP & Autoclave

Sterile-Grade Filter Series Sterile-Grade Filter Series
Purcise SAF Filter Purcise SPS Filter

Hydrophilic Sterile-Grade Filter Hydrophilic Sterile-Grade Steam
with High Flow Rates -in-Place (SIP) Filter
Features Features
· Efficient bacteria and particulate retention · Efficient bacteria and particulate retention
Water Flow Rate- Purcise SAF 0.2µm Bricap C02 Capsule Water Flow Rate - Cobetter Purcise SPS 0.2µm Brisip SP3 Capsule
· Extensive chemical compatibility (pH 1-14) 125
· Extensive chemical compatibility (pH 1-14) 150

· High flow rates · Low extractables
125
100
BB · SIP 0.2
KK
100
75
Applications 75
· Sterilize filtration of cell culture medium 50 Applications

50
· Buffer filtration · Sterilize filtration of cell culture medium
25
25
· Pre-column/ultra-filtration protection · Buffer filtration
· Filtration of intermediate products/stock solutions 0
0 1.0 2.0 3.0 4.0 5.0 6.0 7.0 8.0 9.0 · Pre-column/ultra-filtration protection 0
0 10 20 30 40 50 60
· Filtration of blood products/serums Flow Rate @ 20°C (L/min) · Filtration of intermediate products/stock solutions Flow Rate @ 20°C (L/min)
· Sterile filtration of terminal products · Filtration of blood products/serums

· Filtration of colloids/viscous liquids · Sterile filtration of terminal products

Max. Temperature 80°C Filter Type Bricap C/D/L/T Cartridge Operating Conditions Materials of Construction
Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES) Max. Temperature 80°C Filter Type Brisip SP3
0.1 MPa / 80°C Support Polyester (PET) Polypropylene (PP) Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES)
Polypropylene (PP)
Core/Cage/End Cap 0.1 MPa / 80°C Support
Polypropylene (PP)
Capsule Shell
Biological Safety Core/Cage/End Cap
O-ring —— Silicone/EPDM/Viton/PTFE
Capsule Shell Polyetherimide (PEI)
Endotoxins <0.25 EU/ml Capsule Vent O-ring Silicone —— Biological Safety Capsule Vent O-ring Silicone
Bio-compatibility Meet the requirement of USP<87> In Vitro Removal Ratings 0.45+0.2 μm
Cytotoxicity Test; Endotoxins <0.25 EU/ml Removal Ratings 0.2 μm
Meet the criteria of the USP<88> Biological Bio-compatibility Meet the requirement of USP<87> In Vitro Filtration Area 0.15 m²
Reactivity Test for Class VI-121°C plastics Cytotoxicity Test;

BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge
A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2
A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2
C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20": 1.1m2
D01 : 350cm² L10: 0.55m2 30": 1.65m2
L20: 1.1m2 40": 2.2m2
L30: 1.65m2
· BriScale Disc、Bricap C、Bricap L、Bricap T : Autoclave ,
Gamma irradiation or Pre-sterilization · Brisip SP3 : Autoclave is optional (131°C, 30min, 10 times) ,
· Bricap D : Autoclave SIP (135°C, 60 min, 8 times)
· Filter Cartridges : SIP & Autoclave

Mycoplasma Removal Filter Series
Purcise (Liquid) Series Part Number Configuator (PES)
Capsule Filter Example : C01TTPLESA1P
Purcise MLE Filter Bricap C Small Capsule Filter Series
Hydrophilic Filter with

P
Low Extractables C01 Bricap C01
C02 Bricap C02
T
A
PLES
PLEH
PLE 0.8+0.45μm
PLE 1.0+0.65μm
A
S
Autoclavable
Sterile
1 1 / pkg P
C03 Bricap C03 Hose Barb with Filling Bell (liquids only) PLEL PLE 1.5+0.8μm
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped PAFS PAF 0.45μm
Hose Barb
PAFP PAF 1.0μm
SLEN SLE 0.2μm
Features K 9/16" (14mm) Sanitary Flange
SLES SLE 0.45+0.2μm
· Composed of a double-layer hydrophilic Polyestersulfone (PES) media Bricap Inline Capsule Filters Series SLEH SLE 0.65+0.2μm
· Efficient mycoplasma, bacteria and particulate retention SLEL SLE 0.8+0.2μm
SLEC SLE 1.2+0.2μm P
· Extensive chemical compatibility (pH 1-14)
SAFS SAF 0.45+0.2μm
· Low extractables Capsule Formats Inlet Outlet Sterilization Quantity/Package Market
SAFH SAF 0.65+0.2μm
SPSN SPS 0.2μm
MLEB MLE 0.2+0.1μm
MLES MLE 0.45+0.1μm
Applications M 3/4" (19 mm) Hose Barb
L30 Bricap L30
· Sterilize filtration of cell culture medium X 5/8" (16 mm) Hose Barb
· Pre-column/ultra-filtration protection
· Filtration of intermediate products/stock solutions
· Filtration of blood products/serums Bricap T Capsule
· Sterile filtration of terminal products
P
T20 Bricap T20 T 3/4" (19 mm) Sanitary Flange S Sterile
Max. Temperature 80°C Filter Type Bricap C/D/L/T Cartridge
T30 Bricap T30 K 9/16" (14 mm) Sanitary Flange
Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophilic Polyethersulfone (PES) N without Gauge Port
Capsule Shell Polypropylene (PP) —— Brisip Steam-in-Place Capsule Filters
O-ring ⸺ Silicone/EPDM/Viton/PTFE S P 3 P
Biological Safety Capsule Vent O-ring Silicone ⸺ Capsule Formats Inlet Outlet Vent/ Drain Quantity/Package Market
Endotoxins <0.25 EU/ml Removal Ratings 0.2+0.1 μm / 0.45+ 0.1 μm S
SP3 Brisip SP3 1 1/2" (38 mm) Sanitary Flange P 6 mm Hose Barb 1 1 / pkg P
Bio-compatibility X Vent Stäubli Connector
Meet the requirement of USP<87> In Vitro Drain 6 mm Hose Barb
Cytotoxicity Test;
T Stäubli Connector
Reactivity Test for Class VI-121°C plastics BriScale® Disc Liquid Filter
A 5 0 P
Effective Filtration Area Sterilization Quantity/Package Market
Capsule Formats Inlet Outlet
BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge A50 BriScale® A50 A 6-13 mm (1/4"-1/2") Multiple Stepped A Autoclavable 1 1 / pkg P
Hose Barb with Filling Bell (outlet only)
A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2 G Gamma Compatible 2 2 / pkg
B 6-13 mm (1/4"-1/2")
A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2 Multiple Stepped Hose Barb (no Filling Bell) S Sterile
C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20" : 1.1m2

D01 : 350cm² L10: 0.55m2 30" : 1.65m2
L20: 1.1m2 40": 2.2m2 Cartridge Filter Example : APLES050S1P
L30: 1.65m2
Cartridge Filters
A P
· BriScale Disc / Bricap C / Bricap L / Bricap T : Autoclave, Gamma Irradiation and Pre-steriliziation optional A Standard Cartridge PLES PLE 0.8+0.45μm SLES SLE 0.45+0.2μm SPSN SPS 0.2μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
· Bricap D: Autoclave Pharmaceutical PLEH PLE 1.0+0.65μm SLEH SLE 0.65+0.2μm MLEB MLE 0.2+0.1μm 10 10 inch 2 226 / Falt V Fluoroelastomer
· Filter Cartridges : SIP & Autoclave PLEL PLE 1.5+0.8μm SLEL SLE 0.8+0.2μm MLES MLE 0.45+0.1μm 20 20 inch 7 226 / Fin S Silicone
PAFS PAF 0.45μm SLEC SLE 1.2+0.2μm 30 30 inch 3 222 / Falt P FEP/PFA encap-sulated
40 8 O-rings
PAFP PAF 1.0μm SAFS SAF 0.45+0.2μm 40 inch 222 / Fin
SLEN SLE 0.2μm SAFH SAF 0.65+0.2μm
Sterile-Grade Filter Series Sterile-Grade Filters
Corevital SND Filter Corevital SMD Filter

Hydrophilic Sterile-Grade Filter High Flow Rate, Low Protein
with High Flow Rates Binding Hydrophilic Sterile Filter
Features
Features
· High flow rates
· Composed of dobule-layer PVDF membrane · Low protein binding
· Low extractable and protein binding · Efficient bacteria and particulate retention
Applications Applications
· Sterilize filtration of cell culture medium · Sterilize filtration of cell culture medium · Sterile filtration of intermediate products
· Buffer filtration · Buffer filtration · Pre-column/ultra-filtration protection
· Pre-filtration of cell culture medium · filtration of cell culture medium · Sterile filtration of terminal products
· Buffer filtration · Buffer filtration · Filtration of colloids/Viscous liquids
· Pre-column/ultra-filtration protection · Filtration of blood products/serums
Operating Conditions Materials of Construction Operating Conditions Materials of Construction

Max. Temperature 80°C Filter Type Bricap C/D/L/T Cartridge Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge
Max. Differential Pressure 0.55 MPa / 25°C Membrane Double-Layers Polyvinylidene fluoride (PVDF) Max. Differential Pressure 0.55 MPa / 25°C Membrane Polyvinylidene fluoride (PVDF)
0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP) 0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP)
Capsule Shell Polypropylene (PP) —— Capsule Shell Polypropylene (PP) ——
O-ring —— Silicone/EPDM/Viton/PTFE O-ring ⸺ Silicone/EPDM/Viton/PTFE
Biological Safety Capsule Vent O-ring Silicone Biological Safety
—— Capsule Vent O-ring Silicone ——
Endotoxins <0.25 EU/ml Removal Ratings 0.2+0.2 μm Endotoxins <0.25 EU/ml Removal Ratings 0.2+0.2 μm/0.45+0.2 μm
Bio-compatibility Meet the requirement of USP<87> In Vitro Bio-compatibility Meet the requirement of USP<87> In Vitro
Cytotoxicity Test; Cytotoxicity Test;

BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge BriScale A25/A50 Bricap C/D Bricap L
A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 T10: 0.55m2 5" : 0.28m2 A25: 3.4cm2 C01 : 180cm² L02: 0.12m2 Bricap T Cartridge
A50: 20cm2 C02 : 420cm² L03: 0.16m2 T20: 1.1m2 10" : 0.55m2 A50: 20cm2 C02 : 420cm² L03: 0.16m2 T10: 0.55m2 5" : 0.28m2
C03 : 660cm² L05: 0.28m2 T30: 1.65m2 20" : 1.1m2 C03 : 660cm² L05: 0.28m2 T20: 1.1m2 10" : 0.55m2
D01 : 350cm² L10: 0.55m2 30" : 1.65m2 D01 : 350cm² L10: 0.55m2 T30: 1.65m2 20" : 1.1m2
L20: 1.1m2 40": 2.2m2 L20: 1.1m2 30" : 1.65m2
L30: 1.65m2 L30: 1.65m2 40": 2.2m2

· Filter Cartridges : SIP & Autoclave · Filter Cartridges : SIP & Autoclave

Corevital (Liquid) Series Part Number Configuator (PVDF)
Capsule Filter Example : C01TTSNDBA1P
Corevital PMD Bricap C Small Capsule Filter Series
Low Protein Binding and Capsule Formats Inlet Outlet Membrane Type Sterilization Quantity/Package
P
Market
Hydrophilic Filter C01 Bricap C01
C02 Bricap C02
T 3/4" (19 mm) Sanitary Flange PNDS PND 0.8+0.45μm A Autoclavable 1 1 / pkg P
A 1/4"-1/2" (6-13 mm) Multiple Stepped PMDS PMD 1.0+0.45μm S Sterile
C03 Bricap C03 Hose Barb with Filling Bell (liquids only) SNDB SND 0.2+0.2μm
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped SMDN SMD 0.2μm
Hose Barb
SMDS SMD 0.45+0.2μm
SMDH SMD 0.65+0.2μm
Features K 9/16" (14mm) Sanitary Flange
· Composed of dobule-layer PES membrane
· Extensive chemical compatibility Bricap Inline Capsule Filters Series
· High dirt holding capacity
P
Applications L10 Bricap L10 K 9/16" (14 mm) Sanitary Flange
· Pre-filtration of cell culture medium M 3/4" (19 mm) Hose Barb
L30 Bricap L30
· Buffer filtration X 5/8" (16 mm) Hose Barb
· Pre-filtration of terminal products V 9/16" (14 mm) Hose Barb
· Pre-column/ultra-filtration protection
Bricap T Capsule
P
Max. Temperature 80°C Filter Type Bricap C/L/T Cartridge T10 Bricap T10 S 1 1/2" (38 mm) Sanitary Flange A Autoclavable 1 1 / pkg P
Max. Differential Pressure 0.55 MPa / 25°C Membrane Polyvinylidene fluoride (PVDF) T20 Bricap T20 T 3/4" (19 mm) Sanitary Flange S Sterile
Polypropylene (PP) Polypropylene (PP) T30 Bricap T30 K 9/16" (14 mm) Sanitary Flange
0.1 MPa / 80°C Core/Cage/End Cap
N
without Gauge Port
Capsule Shell
BriScale® Disc Liquid Filter
Biological Safety Removal Ratings 0.8+0.45 μm A 5 0 P
<0.25 EU/ml Capsule Formats Inlet Outlet Sterilization Quantity/Package Market

Endotoxins
Bio-compatibility Meet the requirement of USP<87> In Vitro A50 BriScale® A50 A 6-13 mm (1/4"-1/2") Multiple Stepped A Autoclavable 1 1 / pkg P
Cytotoxicity Test; Hose Barb with Filling Bell (outlet only)
G Gamma Compatible 2 2 / pkg
Meet the criteria of the USP<88> Biological B 6-13 mm (1/4"-1/2")
S Sterile
Reactivity Test for Class VI-121°C plastics Multiple Stepped Hose Barb (no Filling Bell)

BriScale A25/A50 Bricap C/D Bricap L Bricap T Cartridge
A25: 3.4cm2 C01 : 180cm² L02 : 0.12m² T10 : 0.55m² 5" : 0.28m2
A50: 20cm2 C02 : 420cm² L03 : 0.16m² T20 : 1.1m² 10" : 0.55m2
C03 : 660cm² L05 : 0.28m² T30 : 1.65m² 20" : 1.1m2
D01 : 350cm² L10 : 0.55m² 30" : 1.65m2 Cartridge Filter Example : ASNDB050S1P
L20 : 1.1m² 40" : 2.2m2
Cartridge Filters
L30 : 1.65m²
A P
Sterilization Capability Cartridge Type Media Length Code O-ring Material Quantity/Package Market
· BriScale Disc、Bricap C、Bricap L、Bricap T : Autoclave (126°C, 60min, 3 times), A Standard Cartridge PNDS PND 0.8+0.45μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Pharmaceutical PMDS PMD 1.0+0.45μm 10 10 inch 2 226 / Falt V Fluoroelastomer
Gamma irradiation or Pre-sterilization
SNDB 20 7 S
· Bricap D : Autoclave
SND 0.2+0.2μm 20 inch 226 / Fin Silicone
SMDN SMD 0.2μm 30 30 inch 3 222 / Falt P FEP/PFA encap-sulated
· Filter Cartridges: SIP & Autoclave SMDS SMD 0.45+0.2μm 40 40 inch 8 222 / Fin O-rings
SMDH SMD 0.65+0.2μm
Sterile-Grade Filters
Apexision Series Part Number Configuator (Nylon 66)
Capsule Filter Example : C01TTSBCA1P
Apexision® SBC Filter Bricap C Small Capsule Filter Series
Hydrophilic Sterile-Grade Filters Capsule Formats Inlet Outlet Membrane Type Sterilization Quantity/Package
P
Market
with Large EFA C01 Bricap C01 T 3/4" (19 mm) Sanitary Flange SBC SBC 0.45+0.2μm A Autoclavable 1 1 / pkg P
C02 Bricap C02 A 1/4"-1/2" (6-13 mm) Multiple Stepped S Sterile
C03 Bricap C03 Hose Barb with Filling Bell (liquids only)
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped
Hose Barb
Features K 9/16" (14 mm) Sanitary Flange
· Composed of a unique double-layer Nylon 66 membrane
· Inherently hydrophilic Bricap Inline Capsule Filters Series
P
· Excellent chemical compatibility
Applications D 1" (25 mm) Hose Barb
L20 Bricap L20
· Buffer filtration L30 Bricap L30 M 3/4" (19 mm) Hose Barb
· Filtration of intermediate products/stock solutions
· Sterile filtration of terminal products H 1/2" (13 mm) Hose Barb
Bricap T Capsule
P
Operating Conditions Materials of Construction Capsule Formats Inlet Outlet Sterilization Quantity/Package Market
Max. Temperature 80°C Filter Type Bricap® C/L/T Cartridge
Max. Differential Pressure 0.55 MPa / 25°C Membrane Nylon66 Nylon66 T30 Bricap T30 K 9/16" (14 mm) Sanitary Flange
0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP) N without Gauge Port
Capsule Shell Polypropylene (PP) ——
Biological Safety BriScale® Disc Liquid Filter
Capsule Vent O-ring Silicone ——
Endotoxins <0.25 EU/ml Removal Ratings 0.2+0.2 μm/0.45+0.2 μm A 5 0 P
Bio-compatibility Meet the requirement of USP<87> In Vitro Capsule Formats Inlet Outlet Sterilization Quantity/Package Market
Cytotoxicity Test;
A50 BriScale® A50 A 6-13 mm (1/4"-1/2") Multiple Stepped A Autoclavable 1 1 / pkg P
Meet the criteria of the USP<88> Biological Hose Barb with Filling Bell (outlet only)
Reactivity Test for Class VI-121°C plastics G Gamma Compatible 2 2 / pkg
B 6-13 mm (1/4"-1/2")
Multiple Stepped Hose Barb (no Filling Bell) S Sterile

BriScale® A25/A50 Bricap® C Bricap® L Bricap® T Cartridge
A25: 3.4cm2 C01 L03 T10 5”
A50: 20cm2 C02 L05 T20 10”
C03 L10 T30 20”
L20 30”
L30 40”
Cartridge Filter Example : ASBC050S1P
Cartridge Filters
A P
· BriScale® Disc、Bricap® C、Bricap® L、Bricap® T : Autoclave, Gamma Irradiation and Pre-steriliziation optional
· Filter Cartridges : SIP & Autoclave A Standard Cartridge SBC SBC 0.45+0.2μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Pharmaceutical 10 10 inch 2 226 / Falt V Fluoroelastomer
20 20 inch 7 226 / Fin S Silicone
30 30 inch 3 222 / Falt P FEP/PFA encap-sulated
40 40 inch 8 222 / Fin O-rings

Gas Filtration Filter Series Gas Filtration Filter Series
Aegivast AFL Filter Aegivast ACE Filter

Hydrophobic Filter with Hydrophobic Filter with
High Retention Rates High Retention Rates
Features Air Flow Rate - Cobetter Aegivast ACE Bricap SFU Series Disc Filter
Features Air Flow Rate - Cobetter Aegivast AFL Bricap L03 Capsule 40
Differential Pressure (kPa)

· High retention rates SFU13
· Inherently hydrophobic membrane 8.0

VV · Low pressure differential 30 SFU25 SFU33
· High retention rates
6.0 · Efficient mycoplasma, bacteria and particulate retention
· Low pressure differential
20
· Efficient mycoplasma, bacteria and particulate retention 4.0
SS
10
2.0 Applications
· Vent Filters for fermentors, tanks, etc. 0
Applications 0
· Sterile-grade filtration for compressed air, oxygen, nitrogen, etc.
0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0
0 50 100 150 200 250 Air Flow Rate @ 20°C (L/min)

· Vent Filters for fermentors, tanks, etc. Air Flow Rate @ 20°C (L/min)
· Sterile-grade filtration for air, oxygen, nitrogen, etc. Air Flow Rate - Cobetter Aegivast ACE Bricap V Series Disc Filter
80
Operating Conditions

V42
Max Operating Temperature 50°C 60 V50A
Max Differential Pressure 0.24 MPa / 25°C V50D

Operating Conditions Biological Safety
0.42 MPa / 25°C (noly for V50D) 40
Max. Temperature 80°C Endotoxins <0.25 EU/ml

20
Max. Differential Pressure 0.55 MPa / 25°C Bio-compatibility Meet the requirement of USP<87> In Vitro
Cytotoxicity Test; Biological Safety
0.1 MPa / 80°C
Meet the criteria of the USP<88> Biological 0
Reactivity Test for Class VI-121°C plastics Endotoxins <0.25 EU/ml 0 5.0 10.0 15.0 20.0 25.0 30.0 35.0 40.0
Air Flow Rate @ 20°C (L/min)

Materials of Construction Cytotoxicity Test;
Filter Type Bricap L/T Brisip SP3 Cartridge Reactivity Test for Class VI-121°C plastics
Membrane Hydrophobic Polytetrafluoroethylene (PTFE)
Support Polypropylene (PP) Polypropylene (PP) Polypropylene (PP)
Core/Cage/End Cap Polypropylene (PP) Polypropylene (PP) Polypropylene (PP) Materials of Construction
Capsule Shell Polypropylene (PP) PEI polyetherimide (PEI) —— Type Bricap SFU13 / SFU25 / SFU33 Bricap V42 / V50A / V50D
O-ring —— Silicone Silicone Membrane Hydrophobic polytetrafluoroethylene(PTFE) Hydrophobic polytetrafluoroethylene(PTFE)
Capsule Vent O-ring Silicone Silicone —— Support layer Polyester (PET) Polyester or Polypropylene(PET/PP)
Removal Ratings 0.2 μm Core/Cage /End cap Polypropylene(PP) Polypropylene(PP)
Capsule shell 0.2 μm
Bricap L Bricap T Brisip SP3 Cartridge
L03 : 0.2m² T10 : 0.68m² 0.2m² 5”
L05 : 0.34m² T20 : 1.36m² 10” Bricap SFU Bricap V
L10 : 0.68m² T30 : 2.04m² 20” SFU13 : 0.72cm2 V42 : 13.8cm2
L20 : 1.36m² 30” SFU25 : 3.4cm2 V50A : 20cm2
L30 : 2.04m² 40” SFU33 : 4.5cm2 V50D : 20cm2

· Bricap L 、Bricap T : Autoclave · Bricap SFU13 / SFU25 / SFU33 Disc : Autoclave, Gamma Irradiation or Pre-sterilization optional
· Brisip SP3、Filter Cartridge : Autoclave & SIP · Bricap V42/V50A/V50D Disc: Autoclave (130°C, 30min, 20 times), Gamma irradiation or Pre-sterilization

Gas Filtration Filter Series
Aegivast (Gas) Series Part Number Configuator (PTFE)
Capsule Filter Example : L03TTACEBA1P
SafesureTM AFM Filter Bricap Inline Capsule Filters Series
Hydrophobic Filter with Capsule Formats Inlet Outlet Membrane Type Sterilization Quantity/Package
P
Market
High Retention Rates L03 Bricap L03 S 1 1/2" (38 mm) Sanitary Flange ACEB
AFMB
ACE 0.2μm
AFM 0.2μm
A Autoclavable 1 1 / pkg P
L10 Bricap L10 K 9/16" (14 mm) Sanitary Flange AFLK AFL 0.2μm
L30 Bricap L30 M 3/4" (19 mm) Hose Barb
Features Air Flow Rate - Cobetter Aegivast AFM Bricap L03 Capsule
· Inherently hydrophobic membrane 8.0

· High retention rates VV Bricap T Capsule
6.0
· Low pressure differential P
· Efficient mycoplasma, bacteria and particulate retention 4.0
SS Capsule Formats Inlet Outlet Sterilization Quantity/Package Market
2.0
T30 Bricap T30 K 9/16" (14 mm) Sanitary Flange
Applications 0 N without Gauge Port
0 50 100 150 200 250
· Vent Filters for fermentors, tanks, etc. Air Flow Rate @ 20°C (L/min)
· Sterile-grade filtration for air, oxygen, nitrogen, etc.
Brisip Steam-in-Place Capsule Filters
S P 3 P
Capsule Formats Inlet Outlet Vent/ Drain Quantity/Package Market
Operating Conditions Biological Safety SP3 Brisip SP3 S 1 1/2" (38 mm) Sanitary Flange P 6 mm Hose Barb 1 1 / pkg P
X Vent Stäubli Connector
Drain 6 mm Hose Barb
Max. Temperature 80°C Endotoxins <0.25 EU/ml
T Stäubli Connector
Max. Differential Pressure 0.55 MPa / 25°C Bio-compatibility Meet the requirement of USP<87> In Vitro
Cytotoxicity Test; Bricap SFU/V Disc Gas Filters
0.1 MPa / 80°C
Reactivity Test for Class VI-121°C plastics P
Materials of Construction U13 Bricap SFU13 CP Female Luer Lok™ Inlet and Male Luer Lok™ A Autoclavable 1 1 / pkg P
U25 Bricap SFU25 Outlet (Bricap SFU Series only) S Sterile
Filter Type Bricap L/T Brisip SP3 Cartridge
U33 Bricap SFU33 EE 1/4"-3/8" (6-9 mm) Stepped Hose Barb
Membrane Hydrophobic Polytetrafluoroethylene (PTFE) V42 Bricap V42 Inlet and Outlet (Bricap V42 only)
Support Polypropylene (PP) Polypropylene (PP) Polypropylene (PP) V5A Bricap V50A BB 1/4"-1/2" (6-13 mm) Stepped Hose Barb
Polypropylene (PP) Polypropylene (PP) V5D Bricap V50D Inlet and Outlet (Bricap V50A & V50D only)
Core/Cage/End Cap Polypropylene (PP)
Capsule Shell Polypropylene (PP) PEI polyetherimide (PEI) ——
O-ring —— Silicone Silicone
Capsule Vent O-ring Silicone Silicone ——
Removal Ratings 0.2 μm

Bricap C Bricap L Bricap T Brisip SP3 Cartridge
C01 : 200cm² L02 : 0.14m² T10 : 0.68m² 0.2m² 5" : 0.34m2
C02 : 480cm² L03 : 0.2m² T20 : 1.36m² 10" : 0.68m2 Cartridge Filter Example : AACEB050S1P
C03 : 750cm² L05 : 0.34m² T30 : 2.04m² 20" : 1.36m2
Cartridge Filters
L10 : 0.68m² 30" : 2.04m2
L20 : 1.36m² 40" : 2.72m2 A P
L30 : 2.04m² Cartridge Type Media Length Code O-ring Material Quantity/Package Market
A Standard Cartridge ACEB ACE 0.2μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Sterilization Capability Pharmaceutical AFMB AFM 0.2μm 10 2 V
· Bricap L 、Bricap T : Autoclave
10 inch 226 / Falt Fluoroelastomer
AFLB AFL 0.2μm 20 20 inch 7 226 / Fin S Silicone
· Brisip SP3、Filter Cartridge : Autoclave & SIP 30 30 inch 3 222 / Falt P FEP/PFA encap-sulated

Corevital (Gas) Series Part Number Configuator (PVDF)
Gas Filtration Filter Series
Capsule Filter Example :C01APBBSA1P | Cartridge Filter Example: AAPBB050S1P
Bricap C Small Capsule Filter Series
Corevital APB Filter Capsule Formats Inlet Outlet Membrane Type Sterilization Quantity/Package
P
Market
Gamma-resistant Hydrophobic Filter C01 Bricap C01
C02 Bricap C02
T
A
APBB APB 0.2μm A
S
Autoclavable
Sterile
1 1 / pkg P
C03 Bricap C03 Hose Barb with Filling Bell (liquids only)
D01 Bricap D01 B 1/4"-1/2" (6-13 mm) Multiple Stepped
Hose Barb
Air Flow Rate - Cobetter Corevital APB Bricap C02 Capsule
Features
120
Bricap Inline Capsule Filters Series

· High retention efficiency
100
· Low differential pressure BB
P
80
· Gamma irradiation 60
40
Applications 20 L10 Bricap L10 K 9/16" (14 mm) Sanitary Flange
· Vent Filters for fermentors, tanks, etc. 0
0 25.0 50.0 75.0 100.0 125.0 150.0 L30 Bricap L30 M 3/4" (19 mm) Hose Barb
· Sterile-grade filtration for compressed air, oxygen, nitrogen etc. Air Flow Rate @ 20°C (L/min)
Bricap T Capsule
P
Max. Temperature 80°C Filter Type Bricap C/D/L K 9/16" (14 mm) Sanitary Flange
T30 Bricap T30
Max. Differential Pressure 0.55 MPa / 25°C Membrane Hydrophobic Polyvinylidene Fluoride (PVDF) N without Gauge Port
0.1 MPa / 80°C Core/Cage/End Cap Polypropylene (PP)
Capsule Shell Polypropylene (PP) BriScale® Disc Liquid Filter
O-ring Polypropylene (PP)
Biological Safety A 5 0 P
Capsule Vent O-ring Silicone
Endotoxins <0.25 EU/ml Removal Ratings 0.2 μm
A50 BriScale® A50 A 6-13 mm (1/4"-1/2") Multiple Stepped A 1 P
Bio-compatibility Meet the requirement of USP<87> In Vitro Hose Barb with Filling Bell (outlet only)
Autoclavable 1 / pkg
Cytotoxicity Test; G Gamma Compatible 2 2 / pkg
B 6-13 mm (1/4"-1/2")
Meet the criteria of the USP<88> Biological S Sterile
Multiple Stepped Hose Barb (no Filling Bell)

Bricap SFU/V Bricap C/D Bricap L Bricap T Cartridge
SFU13 : 0.72cm² C01 : 290cm² L03 : 0.25m² T10 : 0.75m² 5" : 0.375m2
SFU25 : 3.4cm² C02 : 640cm² L05 : 0.375m² T20 : 1.5m² 10" : 0.75m2
SFU33 : 4.5cm² C03 : 1000cm² L10 : 0.75m² T30 : 2.25m² 20" : 1.5m2
V42 : 13.8cm² D01 : 450 cm² L20 : 1.5m² 30" : 2.25m2
V50A : 20cm² L30 : 2.25m² 40" : 3.0m2
V50D : 20cm² Cartridge Filter Example : ASNDB050S1P
Cartridge Filters
A P
Sterilization Capability Cartridge Type Media Length Code O-ring Material Quantity/Package Market
· BriScale Disc、Bricap C、Bricap L、Bricap T : Autoclave (126°C, 60min, 3 times), A Standard Cartridge APBB APB 0.2μm 05 5 inch 0 DOE E EPDM 1 1 / pkg P
Pharmaceutical
Gamma irradiation or Pre-sterilization 10 10 inch 2 226 / Falt V Fluoroelastomer
· Bricap D : Autoclave 20 20 inch 7 226 / Fin S Silicone
· Filter Cartridges : SIP & Autoclave

30 30 inch 3 222 / Falt P FEP/PFA encap-sulated

TFF Cassettes H-CFH TFF Stainless Steel Holder
Consieve UET Cassette membranes have a high retention efficiency and are easy to
clean/install. Available in a wide range of configurations.
Due to its design, it is easy to amplify/increase based on specific process requirements.

The inner gaskets make installation/cleaning/storage/replacement quick and easy. Low
working volume and high efficiency ensure product yields.
Applications Fields
· Biomacromolecules · Blood products
· Dialysis · Vaccines
· Desalting · Recombinant proteins
· Buffer replacement · Monoterpenes
0.1 m² Stainless Steel Holder 0.5 m² Stainless Steel Holder
· Analysis purification · Plasmids
Process development and small-volume parentals production with Accomodate an effective filter area of 0.5 m2 -2.5 m2 up to 5 m2
an EFA of 0.1m2.
· Endotoxin removal · Chemicals
Unique design is fully compliant with biopharmaceutical
· Macromolecular removal · Chinese medicine injections
applications and their requirements.
Information Ordering Information

Materials PES
Effective Filtration Area Filter Plate Material Inlet/Outlet/Rententate Seals Materials Surface Finish Design Pressure Industry
Material Features Low protein binding and high product yield superior flow rates
PH Range Broad chemical compatibility: pH 1-14 H-CFH 01 S T15 S A X P
NMWL 5/8/10/30/50/100KD 01 0.1 m² S 316L T15 DN15 S Silicone A Mirror Polish X 0.6Mpa P Pharmaceutical
Operating Temperature Range 4-50°C 05 0.5 m² T20 DN20
25 2.5 m² T38 DN38
Max. Operating Pressure 6.0 bar @ 25°C ...
Diffusion Flow (Air) 0.11 m² ≤12ml/min@1.0bar,
0.46 m² ≤50ml/min@1.0bar Pilot System
Pressure Drop 0.3~0.6 bar ( Circulation Flow Rate 6L/min/m² ) Throughput (50-100L)
Types Available Size Applications Throughput Notes

TFF System
Lab LA 100 cm² R&D 200-2000ml Membrane Cassette ;
0.11 m² R&D, Pilot Production 5-50L Cobetter is able to design TFF system based on customer specifications
Stainless Steel Holder required and requirements especially for Pilot Labs and Process Systems
Flow FL 0.46 m² Pilot Production, Large Scale Production ＞50L
2.33 m² Pilot Production, Large Scale Production ＞50L
SCU SC 0.11 m² R&D, Pilot Production 5-50L Plastic Housing , self-clamping
Ordering Information
Application Material of membrane Format NMWL Effective Filtration Area Industry
UF E LA 0005 010 P
UF Ultrafiltration E PES LA 0005 5 KD 001 100 cm² P Pharmaceutical
FL 0008 8 KD 010 0.11 m²
SC 0010 10 KD 050 0.46 m²
0030 30 KD 250 2.33 m²
0050 50 KD
0100 100 KD

Filter Housing Catalog
Integrity Test Instrument

CF 7.2
Specifications
Sanitary Liquid Filter Housing
Number of Filter Length Materials End Cap Housing Inlet/Outlet Sealing Surface Design Industry
Power Requirements 100-240V AC , 50/60Hz 120W Filter Connection Materials Finish Pressure
Display Screen 7-inch High-Definition Color Touchscreen H-SCF-A 01 05 F S T T25 S A X P
Dimensions 450mm×280mm×190mm
Test Range Bubble Point (BP) : 100-8000 mbar H-SCF-B 01 1 round 05 5 inch F 304 S 226 T Tri-clamp T25 Tri-clamp DN25 S Sillicone A Mirror polishing X 0.6MPa P Pharmaceutical
two drain valves 10 10 inch S 316L T 222 E EPDM B Internal Y 1.0MPa
Diffusion Flow (DF) : 1-600ml/min 20 20 inch D DOE V Viton Electrolytic-polishing
Water intrusion : 0.01-100ml/min 30 30 inch F PTFE
Test Method Manual Bubble Point Test
Basic Bubble Point Test
Enhanced Bubble Point Test
Pressure Holding/Pressure Decay Test
Diffusion Flow Test
Vent Housing
Water Intrusion Test
Max. Operating Pressure 10000 mbar (150 psi) at least 1000mbar higher than the highest tested bubble point
Minimum Input Pressure Temperature Range : 5°C to 40°C
Operating Conditions Relative Humidity : 10% to 80%
Number of Filter Length Materials End Cap Housing Inlet/Outlet Sealing Surface Design Industry
Test Time Range Net Volume Test Time : 4mins±2mins Filter Connection Materials Finish Pressure
Diffusion Flow Test : 8mins±2mins H-VCF 01 05 F S T T25 S A X P
Bubble Point Test : 10mins±2mins H-VCF II
Enhanced Bubble Point Test : 15mins±2mins 01 1 round 05 5 inch F 304 S 226 T Tri-clamp T25 Tri-clamp DN25 S Sillicone A Mirror Polish X 0.6MPa P Pharmaceutical
Water Intrusion Test : estasblished testing time ± 2minss 10 10 inch S 316L T 222 T38 Tri-clamp DN38 E EPDM B Internal
Electro-polish
T50 Tri-clamp DN50 V Viton
Print Function English / Chinese language, Output Test parameters and result, Auto/manual print options
History Record Function Unlimited test records storage with SD card; USB connection to output data
Language Options English / Chinese
Cleansteam Bag
Breathing Side Arjo60-70 Dialysis Paper Dupont Tyvek Gas Filter Housing
Holding Side Temperature resistant medical High Density Number of Housing Sealing Surface Design
Filter Length Materials End Cap Inlet/Outlet Industry
composite membrane(PET+CPP) Polyethylene (HDPE) Filter Connection materials Finish Pressure
Sterilization Indicators Autoclave sterilization indicator H-GCF 01 05 F S T T38 S A X P
Ethylene oxide sterilization indicator
01 1 round 05 5 inch F 304 S 226 T Tri-clamp T25 Tri-clamp DN25 S Sillicone A Mirror Polish X 0.6MPa P Pharmaceutical
Package Double-layer packaging: additional protection which 03 3 round 10 10 inch S 316L F Flange T38 Tri-clamp DN38 E EPDM B Internal Y 1.0MPa
protects the bags from scratching 20 20 inch T50 Tri-clamp DN50 V Viton Electro-polish
30 30 inch F25 Flange DN25
Steel Membrane Holder

Arjo60-70 Dialysis Paper Dupont Tyvek Number of Housing Sealing Design
Membrane O.D. Material Inlet/Outlet Surface Finish Industry
Membrane Connection Materials Pressure
H-DMF 01 47 F T T25 S A X P
Vacuum Filter 01 1 membrane 47 47mm F 304 T Tri-clamp T25 Tri-clamp DN25 S Sillicone A Mirror Polish X 0.6MPa P Pharmaceutical
90 90mm S 316L L Screwed Connection E EPDM B Internal
Electro-polish
142 142mm V Viton
Specification 150ml、250ml、500ml、1000ml 200 200mm
293 293mm
Membrane PES, CN, CA, NY
Removal Ratings 0.1 /0.2/0.45μm

Solutions for Biopharma Applications - 41 - -42 - Solutions for Biopharma Applications
CBPFSPSB95b97 E

Cobetter Catalog For Biopharma 2020

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Filtration, Separation & Purification

Solutions for Biopharma Applications

Vaccines Blood Product

Cobetter dedicates itself to providing Filtration, Separation, & Puriﬁcation C3 Factory

1,200+ technical analysis reports annually C4

C2 C1 & Fluoroplastics Resurtech Manufacturing

for customers in chemical, microelectronics and life sciences industries

Filtration, Separation & Purification Filtration, Separation & Purification

Taketomi Hidetoshi, Japanese

Advanced Japanese Quality Control Methods

Implement 4M Quality Management Concept

All Products are based on the QC Project Table

ilac-MRA Man Material Machine Method

50+ Equipments ISO 17025

180+ SOP Manufacturing

80+ Engineers 3 Elements of

Cover all the Validation Tests the Products

Life & Science Validation Center Quality Cost Delivery

1 6 Bacterial Challenge Test : Retention tests for Mycoplasma, B.diminuta, Serratia

Filtration, Separation & Purification Filtration, Separation & Purification

1 Media Filtration 2 Sterile Vent

Afﬁnity Virus Inactivation 5 Column

8 Virus Removal 7 Virus Removal

Bioburden Reduction and Particle Control 3 Buffer Filtration

Filtration, Separation & Purification Filtration, Separation & Purification

Bricap®/BriScale® Disc Capsule Filters

Brisip® Series Capsule Filters S 38 mm (1 1/2")

Bricap® T Series Capsule Filters

Filtration, Separation & Purification 38 mm (1 1/2") Filtration, Separation & Purification

Roheap® CSD Filter

Differential Pressure (bar)

with High Flow Rates Safesure AFM Filter P 35 Applications

Filtration, Separation & Purification Filtration, Separation & Purification

Greclary CHV Filter

· Composed of super-ﬁne glass ﬁber media 10

Differential Pressure kPa

Removal Ratings Control Grade Diameter Seal Material

0020 0.2-0.4μm PC 16 16 inch Y 3 E EPDM

12 · Clariﬁcation of fermentation broth/cell cultures 0 10 20 30 40 50

0600 6.0-15.0μm D 16 · Filtration of colloids/viscous liquids

CSDD Double-Layer 0102 0.04-0.4μm

Filtration, Separation & Purification Filtration, Separation & Purification

Inlet Outlet Membrane Type Sterilization Quantity/Package

Effective Filtration Area

Filtration, Separation & Purification Filtration, Separation & Purification

Operating Conditions Materials of Construction

Effective Filtration Area

Filtration, Separation & Purification Filtration, Separation & Purification

High Retention Efﬁciency C01

Bricap T Capsule Filters

Effective Filtration Area

· High ﬂow rates · Efﬁcient bacteria and particulate retention 150

Differential Pressure kPa

· Buffer ﬁltration · Pre-ﬁltration of cell culture medium 0

Operating Conditions Materials of Construction Operating Conditions Material of Construction

Effective Filtration Area Effective Filtration Area

Sterilization Capability Sterilization Capability

Filtration, Separation & Purification Filtration, Separation & Purification

Purcise SLE Filter Corevital PND

Differential Pressure kPa

· Sterilize ﬁltration of cell culture medium SD Applications

· Filtration of blood products/serums Flow Rate @ 20°C (L/min)

· Sterile ﬁltration of terminal products