Activity 2:

Timeline
Sleep Medicine throughout History

17th Century

Santorio Sanctorious

Design the thermometer, and currently use in medical guideline that associated with circadian rhythm.

-He is the one of the first to accumulate data on biological temperature cycle known to be the part of the
normal circadian changes.

1729

Jean Jacques d’Ortous de Mairan

She observed that the flower leaves opened during the day and close at night. To assumed that the
movement of the flower depend on the lights.

1711

Luigi Galvani

Use a dead frog to came up with the purpose of the nervous system in the body.

Camillio Golgi

The first person to see nerve cell in the microscope.

Jean Baptist Edouard

He named the Narcolepsy as disorder of uncontrolled sleepiness.

Wilhelm Griesinger

Reported that the movement of the eye during dreaming state.

Sigmund Freud

He wrote the skeletal muscle paralysis during sleep

 1907

Rene Legendre and Henri Pieron

Removed the blood serum from sleep drive dogs and injected it to other dogs
that were not sleep deprived. This experiment demonstrated that there is a
presence of chemical factors that associated with sleep.

1929

Constantin von Economo

Argue in the study of “center for regulation of sleep” that was according to him there is a substance that circulated
in the blood and influence it to cerebral cortex to stimulate sleep.

Walter Rodult Hess

He believe in the study of Von Ecomo’s finding by the thalamus in the brain is responsible to induce sleep.

1949

Guiseppe Moruzzi and Horace Magoun

Published groundbreaking work that stated the stimulation of

Ascending Activating System (ARAS) that is located in the thalamus.

1875

Richard Caton

Recorded the brain rhythm in the rabbits and monkey.

1929

Johannes Hans Berger

Recorded first electrical activity of the human brain and

differentiated activity between wakefulness and sleep.
 The Evolution of polysomnography

1935
Alfred Loomis
Describe a non-rapid eye movement (NREM) in sleep.

1937
Alfred Loomis E, Newton Harvey, and Garret A. Hobart III
Classified the EEG sleep pattern has Five (5) stages

1939
Nathaniel Kleitman
“Father of Sleep research”
Invented a sensor together with Eugene Aserinsky founf a “Turturous” observing
sleeping people’s eye movement all night.

1957
Kleitman and William Dement
Peforemed all night slepp studies and discovered district stages pattern
in sleep that were consistent among all adults and discovered the
cyclical human sleep cycles of REM and NREM sleep.

1975
Researches interested in the diagnosis and treatment of
sleep disorder organized the Association of Sleep
Disorder Center (ASDC)

1978
ASDC creates medical journal about Sleep.
 1999
From Association of sleep disorder center changed it to American Academy
of Sleep Medicine (AASM), a professional society
Narcolepsy
dedicated
Research
exclusively to
the medical subspecialty of sleep medicine

1964
William Dement
Interested in the study of Narcolepsy and led to him soliciting
the narcoleptic in the area to participate in the study.

Narcolepsy
Believe to be a psychiatric disorder associated with the patient
sleeping excessively due to the repression of feeling.

1970
The development of Multiple Sleep Latency test (MSLT) an
objective measurement of daytime sleepiness used for
diagnosis of narcolepsy.

Obstructive Sleep Apnea

-characterized by cessation of breathing caused by a partial or complete obstruction of the
airway.
Charles Dicken
Discovered the obstruction sleep apnea in his work Posthumous Papers of the Pickwick
club, but he is not a scientist.

1877
Henry Broadbent
-describe the clinical feature of OSA as snoring, interspersed
between periodic breathing stop.

1956
Albert G. Bickelmann and C. Sidney Burwell
-Dubbed the clinical characteristic of the Picwickian syndrome
 1972
Christian Guilleminant
Moved to United States to study and introduced the use to respiratory and
cardiac monitoring to provide additional monitoring parameters
demonstrated the disorder breathing associated with OSA.

1975
-OSA was known as Pickwickian
syndrome

1981
Colin Sullivan
-He developed an air-blowing device with attached snout-like mask for
treating OSA in dogs.

1979
ASDC published the first widely used classification manual
“Diagnostic Classification of Sleep and Arousal Disorder

Mid 1970s and the mid 1990s

Sleep study data were collected via analog
polysomnographs