PHARMA EXAM

1. When administering a systematic antifungal agent, the nurse incorporate understanding that all systemic
antifungal drugs function to
- Alter cell permeability of the fungus, leading to cell death
2. The saying “One rotten apple can spoil the whole barrel”, can be used to refer to the cell-degrading properties of
- Lysosomes
3. Neurons communicate through neurotransmitters at the synapse
- True
4. Combination therapy is often used in treating infections. An important considerations for using combination
therapy would be that
- The combination of drugs can delay the emergence of resistant strains
5. A patient with a fungal infection asks the nurse why she cannot take antibiotics. The nurse explains that the
reason for this is that a fungus is resistant to antibiotics because
- Antibiotics are developed to affect only bacterial cell walls.
6. Selective toxicity is
- The ability of a drug to attack only those systems found in foreign or abnormal cells.
7. Spinal nerve consist of motor nerve only
- False
8. A client is experiencing a reaction to the penicillin injection that the nurse administered approximately ½ hour
ago. The nurse is concerned that it might be an anaphylactic reaction. What signs and symptoms would validate
her suspicion?
- Dyspnea
9. Digoxin 0.125 mg is ordered for a patient who is having trouble swallowing. The bottle of digoxin elixir reads 0.5
mg/2 mL. How much would you give?
- 0.5 ml
10. When describing the development of malaria caused by the Plasmodium protozoan. The instructor would
explain that the organism depends on
- A mosquito and a red blood cell for maturation
11. Active immunity develops when a vaccine containing antibody is injected into a person
- True/False
12. A bacteriostatic substances is one that
- Prevents the growth of any bacteria
13. When reviewing a drug to be given, the nurse notes that the drug is excreted in the urine. Important points
should be included in the nurse’s assessment of the patient, except
- The patient’s renal function test
14. The cell membrane is composed of
- A phospholipid structure
15. D5LR 1 liter to run for 12 hours is given to client a client who will have abdominal surgery. Compute for the
numbe of drops per minute using dropfactor of 15
- 21 gtss/min
16. Autoimmune disease attacks a person’s own healthy cells
- True
17. Amebiasis or amebic dysentery
- Is caused by a protozoan that can enter the body in the cyst stage in water or food
18. Much of the biotransformation that occurs when a drug is taken occurs as part of
- The first-pass effects through the liver
19. Receptor sites
- Are protein areas of cell membranes that react with specific chemicals
20. Anxiolytic is given to induce sleep
- false
21. The storing, prescribing and distributing of controlled substances- drugs that are more apt to be addictive- are
monitored by
- the DEA
22. When trying to determine why the desired therapeutic eeffects is not being seen with an oral drug, the nurse
should consider
 - Food altering the makeup of gastric juices
23. The sodium-potassium pump maintain a negative change on the cell membrane by
- Active transport
24. Antibiotics that are used together to increase their effectiveness and limit the associated adverse effects are said
to be
- Synergistic
25. A heparin 800 unit is ordered for a patient. The heparin is supplied in a multidose vial that is labelled 10,00
units/mL. How many millilitres of heparin would be needed to treat this patient?
- 0.08

26. Matching Type (14/15)

Interfere with cell wall building ability of bacteria and inhibits Antibiotic
Protein synthesis

Affects mycolic acid coating of bacterium INH

Prevents HIV from replicating by blocking reverse transcription Reverse Transcription

of RNA to DNA

Binds or impair synthesis of ergosterol allowing increase cell Antifungal

permeability and leakage of cell component

Interrupts plasmodial reproduction of protein synthesis in RBC Antiprotozoal

stage, as well as heapatic and gametocyte stage

Inhibits reproduction of abnormally growing cells by affecting Antineoplastic

DNA synthesis

Inhibits prostaglandin, blocks the effects of pyrogens at salicylates

hypothalamus, and decreases platelet adhesiveness

Prevent anxiety by potentiating the effects of GABA in the Anxiolytics

limbic system and RAS

Inhibit the reuptake of norepinephrine and serotonin, tricyclic antidepressant

increasing their levels in the synapse

Inhibit Monoamine oxidase to break down norepinephrine MAOIs

and serotonin

Blocks dopamine and serotonin receptors; depress the RAS Antipsychotic Drugs

The altered state of reaction wherein the body forms hypersensitivity reaction
antibodies to a drug

“Lock and Key” Receptor site

Substance that catalyze Enzymes

Produce antibody antifungal

27. Biogenic amine theory of depression states that depression results from deficiency of neurotransmitters
acetylcholine, dopamine, and serotonin
 - False
28. Patients receiving antineoplastic drugs that disrupt cell function often have adverse effects involving cell that
turn over rapidly in the body. These cells include
- Bone marrow cells
29. A patient needs to take 0.75 g of tetracycline PO. The drug comes in 250-mg tablets. How many tablets should
the patient take?
- 3 tablets
30. A patient with a severe case of athlete’s foot is seen with lesions between the toes, which are oozing blood and
serum. After teaching the patient, the nurse determines that the instruction was effective if the patient states
which of the following?
- “Ishould wear white socks and keep my feet clean and dry. I shouldn’t use the antifungal cream in areas
where I have open lesion.”
31. A woman has had repeated bouts of bronchitis throughout the fall and has been taking antibiotics. She calls the
clinic with complaints of vaginal pain and itching. When she is seen, it is discovered that she has developed a
yeast infection. You could explain to her that
- She has developed a superinfection because antibiotics kill bacteria that normally provide protection.
32. An order is written for 700 mg of ampicillin PO. The drug is supplied in liquid form as 1 g/3.5 mL. How much of
the liquid should be given? Do not round off your answer.
- 2.45 ml
33. Nursing interventions for the patient receiving antiviral drugs for the treatment of HIV probably would include
- Monitoring renal and hepatic function periodically during therapy.

PHARMA MIDTERMS

34. Anaphylaxis can cause bronchospasm

True

35.Prevents peripheral conversion of levodopa to dopamine by dopa carboxylase

Carbidopa

36. Gamma aminobutyric acid Communicates between nerves and muscles

True

37. In assessing a patient, a viral cause might be suspected if the patient was diagnosed with

the common cold

38. Neurotransmitter for arousal and sleep, promoting motivation is dopamine

False

39. The generic name of a drug is

The original name assigned to the drug at the beginning of the evaluation process

40. Generic name of a drug is designated by the drug company selling it

True

41. B cells of immune system directly destroy antigens

true

42. HIV selectively enters which of the following cells:

Helper t cell

43. When anti-infective agents destroy the normal flora of the body, a secondary infection develops. This is
called:

superinfection

44. Chemotherapeutic agents are drugs that

Interfere with foreign cell body functioning, such as…

45. Naturally occurring substances that are released in the body in response to viral invasion are called:

Interferons

46. Compute for a drug order if the ordered is: 0.35 mg. Available: 1.2 mg/2 mL. Proper dose is: _ mL.

Note: Write the number only. Round your final answer to the nearest tenths.

0.6

47. The ribosomes are important sites for

Production of proteins

48. Compute for a drug order if the ordered is: 150, 000 units. Available: 400,000 units/5 mL. Proper dose is:
_mL.

Note: Write the number only. Do not round off your answer

1.875

49. A human cell placed a salty seawater will

shrivel and die from water leaving the cell

50. Sensitivity testing of culture shows

Drugs that are capable of controlling that particular microorganism

51. The goal of antibiotic therapy is

To reduce the number of invading bacteria so that the immune system…

52. An example of an anti-infective used as a means of prophylaxis would be

no answer

53. A broad-spectrum antibiotic would be the drug of choice when

One is waiting for a culture and sensitivity results

54. Clinical pharmacology is the study of

Drugs used to treat, prevent or diagnose disease

55. Aminophylline is spoiled in a 500mg/2.5 mL solution. How much would be given if an order were written
for 100 mg of aminophylline IV?

0.5 ml

56. Gram-negative bacteria

Are mostly found in the GI and GU tracts

57. Virus infected cells release interferons protecting other cells

True

58. A patient who is receiving a combination drug to treat malaria asks the nurse why. The nurse responds to the
patient based on the understanding that combination drugs are

Effective at various stages in the life cycle of the protozoan

59. An example of a drug allergy is

Breathing difficulty after an injection of penicillin

60. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibits cyclooxygenase (COX) 2 enzyme.

false

61. Compute for a drug order if the ordered is 6.5 mg. Available: 10 mg/mL. Proper dose is: _ mL.

Note: Write the number only. Do not round off your answer

0.65

62. (7/10) Dili sure sa uban

Membrane transport does not require energy Passive transport

to carry out the process

A process by which drugs are changed into Biotransformation

new, less active chemicals.

Percentage of active substance in a drug that Bioavailability

becomes available to target tissues

Is the time it takes for the amount of drug in Half life

the body to decrease to one-half of the peak
level it is previously achieved

Sites of drug’s binding for accumulation to Receptor Sites

sustain pharmacologic effect

Free drug enters plasma to bind with protein Plasma CHON binding

Lipid soluble drug have increased affinity for Fat tissue binding
adipose tissue

The result of a drug other therapy in addition Side effect

to or in extension of the therapeutic effect

Process whereby drugs are eliminated from Excretion

the body

Portion of drug that gets through the first pass Distribution

effect is delivered to the to the circulatory
system for transport

63. Antitoxin provides passive immunity to specific antigens

True

64. Alkylating agent and interferon are antineoplastic

False

65. Virus interferons have proved difficult to treat because they

Inject themselves into human cells to survive and to reproduce

66. (10/10)

It is where oral drugs are absorbed and Liver

detoxified

Competes with agonist Antagonist

A protein on human cell membrane Human leukocyte antigen

recognized by the body as self-cells

Neoplasm Cancer

Drugs affecting development of fetus Teratogenic

Found in bacterial cell wall only Peptidoglycan layer

Enzyme produced by organisms that destroy Beta lactamase

antimicrobial drugs

Medications given to prevent infections Prophylaxis

before they occur

Antibiotics that interfere with a biochemical Broad-spectrum

reaction common to many Organisms

Enzyme use by HIV to produce DNA from Reverse transcriptase

RNA

67. The nurse is describing fungi that cause infections of the skin and mucous membranes, appropriately calling
these which of the following?

dermatophytes

68. The penicillin

are bactericidal, interfering with bacteria cell walls