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  • Rizky Ariska Ningsih - 1801072 - Tekfar Steril Tugas 2

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    The document describes two formulations: 1. A 0.28% tetrahydrozoline HCl and 0.16% benzalkonium Cl ophthalmic solution. Using the freezing point depression method, the concentrations were adjusted to make it isotonic. 2. An ascorbic acid injection at three different concentrations - 100 mg/mL, 50 mg/mL, and 25 mg/mL. For each, the freezing point depression method was used to calculate the concentration adjustment needed to make the solution isotonic. In all cases, the ascorbic acid concentration needed to be decreased.

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    The document describes two formulations: 1. A 0.28% tetrahydrozoline HCl and 0.16% benzalkonium Cl ophthalmic solution. Using the freezing point depression method, the concentrations were adjusted to make it isotonic. 2. An ascorbic acid injection at three different concentrations - 100 mg/mL, 50 mg/mL, and 25 mg/mL. For each, the freezing point depression method was used to calculate the concentration adjustment needed to make the solution isotonic. In all cases, the ascorbic acid concentration needed to be decreased.

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    15 views1 page

    Rizky Ariska Ningsih - 1801072 - Tekfar Steril Tugas 2

    Uploaded by

    Rizky
    The document describes two formulations: 1. A 0.28% tetrahydrozoline HCl and 0.16% benzalkonium Cl ophthalmic solution. Using the freezing point depression method, the concentrations were adjusted to make it isotonic. 2. An ascorbic acid injection at three different concentrations - 100 mg/mL, 50 mg/mL, and 25 mg/mL. For each, the freezing point depression method was used to calculate the concentration adjustment needed to make the solution isotonic. In all cases, the ascorbic acid concentration needed to be decreased.

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    © All Rights Reserved
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    of 1

    SOAL

    1. R/Tetrahydrozoline HCl 2% (0,28)


    Benzalkonium Cl qs (0,16)
    NaCl qs
    WFI ad 10 ml
    m.f. guttae ophtalmic
    2. Ascorbic acid 25 mg/ml E = 0,18
    Aqua PI 1 ml
    Mf. Inj. 1 ml no. XV

    JAWABAN

    1. Metode penurunan titik beku (ΔTf)


    Tetrahydrozoline HCl 2% = 2 x 0,28 = 0,56 g/10 ml
    Benzalkonium Cl 0,02% = 0,02 x 0,048 = 0,00096 g/10 ml
    W = 0,52 – (0,56 + 0,00096)
    0,576
    = 0,52 – 0,56096
    0,576
    = -0,0711 g/10 ml (Hipertonis, konsentrasi zat aktif diturunkan)

    2. a. Ascorbic acid = 100 mg/ ml = 10 g/100 ml = 10%


    PTB5% = -0,51o
    W = [0,52 – (10 x 0,51)] / 0,576
    = (0,52 – 5,1) / 0,576 = -7,95138 g/100 ml
    = -0,0795138 g/ml (Hipertonis, konsentrasi ascorbic acid diturunkan)

    b. Ascorbic acid = 50 mg/ ml = 5 g/100 ml = 10%


    PTB5% = -0,51o
    W = [0,52 – (5 x 0,51)] / 0,576
    = (0,52 – 2,55) / 0,576 = -3,5243 g/100 ml
    = -0,035243 g/ml (Hipertonis, konsentrasi ascorbic acid diturunkan)

    c. Ascorbic acid = 25 mg/ ml = 2,5 g/100 ml = 10%


    PTB3% = -0,31o
    W = [0,52 – (2,5 x 0,31)] / 0,576
    = (0,52 – 0,775) / 0,576 = -0,4427 g/100 ml
    = -0,004427 g/ml (Hipertonis, konsentrasi ascorbic acid diturunkan)

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