Moi520 High Definition Plus Colonoscopy Combined With I-Scan Tone Enhancement is Superior in the Detection of Colorectal Neoplasias Compared to High Definition Colonoscopy - A Prospective Randomized Back to Back Trial Arthur Hoffman*, Linn G. Loth, Fareed Rahman, Martin Goetz, Peter R. Galle, Ralf Kiesslich Forty patients underwent tandem colonoscopies. The first exam was always a HD WLE exam followed by a randomly assigned second HD WLE or HD WLE plus Tone Enhancement. Histology prediction was also performed and compared with histopathology results. There was no difference in adenoma detection rate in the first HD WLE exam among groups. The second colonoscopy detected significantly more adenomas in the HD WLE plus TE group (n=60) compared to the HD WLE (n=18). Additional adenomas detected with HD WLE plus TE were small (mean size 2.6640.97mm) and were more often flat. The authors concluded that HD WLE plus TE allowed for significantly better detection of flat lesions and to predict histopathology of the identified lesions with a high sensitivity and specificity.