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(Healthbio) Business Plan & Valuation Guidanceq54e
(Healthbio) Business Plan & Valuation Guidanceq54e
This presentation has been prepared by Ernst & Young as instructed by and agreed with Turku
Science Park Oy (HealthBIO cluster). The information and opinions contained in this document are
derived from public and private sources which we, without further investigation, cannot be warranted
as to their accuracy, completeness or correctness. This information is supplied on the condition that
Ernst & Young, and any partner or employee of Ernst & Young, are not liable for any error or
inaccuracy contained herein, whether negligently caused or otherwise, or for loss or damage suffered
by any person due to such error, omission or inaccuracy as a result of such supply. In particular any
numbers, initial valuations and opinions contained in this document are preliminary and are for
discussion purposes only.
This presentation was prepared by Ernst & Young exclusively for the benefit of Turku Science Park Oy
(HealthBIO cluster). The presentation is proprietary to Ernst & Young but Turku Science Park Oy
(HealthBIO cluster) may disclose it together with this disclaimer to third parties for general
discussion purposes. Such third parties should not use the presentation for any other purposes and
they should, if in need of more specific information, seek professional advise and other sources of
information. Disclosure of this presentation by Turku Science Park Oy (HealthBIO cluster) to any
third party does not create any liability for Ernst & Young to such a third party.
Page
Section 1 Business plan guidance 4
Section 2 Valuation guidance 10
Section 3 Contacts 17
Note: please see e.g. European Private Equity & Venture Capital Association (www.evca.eu) for useful information
• How the business has evolved and its past performance? Where the company is now and what it has already achieved?
History • In the case of a start-up company, history section summarizes the stages leading to the creation of the company.
• Summary of who the owners/directors are and the degree of their control over the company.
• Evidence that the assembled team has the track record, experience and expertise to achieve its goals (put detailed CVs in an
Management appendix). Highly important to show that the team will be able to deliver the business plan.
• Confirmation that the interests and competence of the team members are complementary.
• Analysis of expected future staffing needs?
• A precise description of what the product or service is and what it will be used for. Do patents adequately protect the firm’s products?
• Stage of production: design, prototype, pre-production? How to manage the smooth transition from producing a prototype to producing
in volume?
• Status of pre-clinical/clinical/other required studies? Costs of required studies and probability to pass the tests?
Products and services • A realistic assessment of product's unique or distinctive competitive advantages and the way in which these advantages will translate
into benefits for customers.
• A simple, but not simplistic, analysis of the technology you are using and an appraisal of the risks associated with it. Confine technical
details to an appendix.
• Weaknesses?
• Estimated size and composition of the market, including geographical spread and major customer types.
• Recent history and likely future developments: growing, static etc.
• The ways in which the market operates and the principal axes of competition: price, quality, service, reputation.
• Regulatory constraints and how these are likely to develop?
• Who are the potential competitors, how large are they and how are they organized?
Market and competitors • On what basis do rivals compete: price, sales volume, reputation, product design, quality, reliability, service?
• How does the product compare with those already available in terms of price, performance, reliability and so forth?
• What makes the product superior or different and how is it possible to protect its unique features from imitation?
• What barriers does a new entrant face and how is the competition likely to react to the entrance into the market?
• In what areas are the competitors demonstrably competent? How do the potential customers see the competition?
Exit possibilities • When and how the investor will be able to exit from the investment?
The analysis of a biotechnology firm includes a thorough study of both business strategy and financial health. In
contrast to companies in more mature industries, many biotech firms do not have commercial track records. Thus,
analysts sometimes have to rely more heavily on qualitative rather than quantitative methods of valuation.
• What are the company’s key products and features of the company’s technology platform?
• How is the research pipeline? Do patents adequately protect the products? Past research success?
Products, pipeline, patents, R&D, • Status of pre-clinical/clinical/other required studies? Study costs and probability to pass the tests?
alliances • Has the firm entered into any promising collaborations or partnerships?
• What are the key milestones that must be achieved on the company’s path to success?
Valuation guidance
► Estimated future cash flows of the ► Theoretically the “right” valuation method and
Discounted Cash Flow company are discounted to present value purely forward looking. Highly dependent on the
DCF with Weighted Average Cost of Capital quality of future estimates
(WACC)
► Valuation multiples of listed peer ► Suitable peer group for biotechnology SMEs is not
Peer Group Valuation companies are used to calculate enterprise easily available. The multiples used must be selected
values carefully
Transaction Multiples ► Valuation multiples from executed ► Not always possible due to lack of comparable
transactions are used to calculate transactions. Supports and complements the
Valuation enterprise values findings of peer group valuation
Venture Capital ► Discounting optimistic future earnings to ► Appropriate for investments in a company with
present value at a subjective required rate initial negative cash flows at the time of investment
Method (VCM) of return specified by investors
► Valuation of biotechnology venture companies poses a range of challenges as there is limited operating history and many early stage
companies have never generated profit or revenues.
► Young companies bear significant risk that can not be easily quantified and thus appraisal of intangibles, such as the founders’
entrepreneurial skills, know-how, experience and patents form a significant role in the valuation.
Note: please see The International Private Equity and Venture Capital Valuation Guidelines (www.privateequityvaluation.com) for useful information
Note: Please see e.g. Valuation; Measuring and Managing the Value of Companies (Koller, Goedhart, Wessels) for useful information
Note: Please see e.g. Valuation in Life Sciences (Bogdan, Villiger) for useful information
Median 87 13,4x 13,5x 3,9x 3,3x 22,8x 16,7x 10,6x 9,2x 35,6x 25,4x 13,6x 11,5x
Date Acquiror nam e Com pany Country Business description Sales EBITDA EBIT EV/ Sales EV/ EBITDA EV/ EBIT
18.2.2010 Albany Molecular Research Inc. Excelsyn Ltd United Kingdom Pharmaceutical chemical development 13,5 2,2 1,7 1,3x 7,8x 9,9x
18.12.2009 Launchchange Ltd Genetix Group plc United Kingdom Robotic gene research equipment supplier 29,9 3,1 1,3 1,8x 17,3x 40,7x
5.11.2009 Biovitrum AB Sw edish Orphan International AB Sw eden Pharmaceuticals research and development services 46,4 6,9 6,8 7,4x 49,3x 50,6x
12.10.2009 BH Holding SpA Sorin SpA Italy Medical equipment manufacturing 668,6 90,6 53,4 0,9x 6,8x 11,5x
25.9.2009 Omega Diagnostics Group plc Co-Tek (South West) Ltd United Kingdom Bacterial diseases diagnosing tests production services 0,2 0,1 0,1 2,1x 4,1x 4,4x
24.9.2009 Consort Medical plc Medical House plc, The United Kingdom Medical equipment designer 3,3 1,1 0,9 5,6x 16,7x 21,6x
14.7.2009 Laboratorio Reig Jof ré SA Bioglan AB Sw eden Pharmaceuticals research and development services 7,3 0,9 0,8 1,0x 8,4x 9,7x
30.1.2009 Gen-Probe Inc. Tepnel Life Sciences plc United Kingdom Biotechnology based on DNA analysis 27,1 4,2 3,1 3,6x 23,4x 31,2x
26.1.2009 Magnum Capital Partners Generis Farmacêutica SA Portugal Pharmaceuticals manuf acturer 39,8 6,7 4,2 6,7x 39,8x 63,7x
22.12.2008 RPS Spain SL Inf ociencia SL Spain Clinical research services 9,7 0,9 0,9 0,1x 0,7x 0,7x
9.12.2008 MBO Team - Portugal Farma APS-Produtos Farmacêuticos SA Portugal Pharmaceuticals manuf acturer 63,4 16,9 11,9 3,9x 14,5x 20,7x
2.12.2008 Intertek Group plc EKO-LAB Sp zoo Poland Microbiological and chemical analysis provider 1,4 0,4 0,3 2,8x 10,8x 13,3x
10.10.2008 Henry Schein España SA Prolavi SL Spain Animal medicine manufacturer 6,7 0,2 0,2 0,2x 8,1x 8,1x
4.7.2008 LinkMed AB Olerup SSP AB Sw eden Transplantation and biotechnical products developer 7,3 3,9 3,8 3,1x 5,8x 5,9x
17.6.2008 NeutraHealth plc Perrigo UK Ltd United Kingdom Pharamceutical and drug manufacturer 22,8 1,5 0,6 0,3x 5,0x 12,4x
20.3.2008 Pegasus Bidco Ltd Premier Research Group plc United Kingdom Pharmaceutical and biotechnological research 52,4 8,8 5,9 1,7x 10,3x 15,5x
29.2.2008 Optopol Technology SA Optotek doo Slovenia Ophthalmic and medical equipment manuf acturer 3,8 0,6 0,5 2,2x 14,0x 16,2x
22.2.2008 Castlerise Investments Ltd Alltracel Pharmaceuticals plc Ireland Biopharmaceutical research and development 19,9 1,2 0,3 1,3x 22,3x 85,2x
Median 16,7 1,9 1,1 2,0x 10,6x 14,4x
Source: Zephyr
Contacts