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3-Aplastic anemia (AA) Lesson 5-2

Developed by-Dr.Abdulrazzaq Othman Alagbare

M.D M.S.c C.P - Lecturer of Hematology and Immunohematology
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Aplastic anemia (AA)

Terms must be known

Pancytopenia
Aplasia Hypoplasia. Hypoplastic
anemia: low count of all
no production low production
type of cells in
in all types of in all types of low production
peripheral
cells cells in RBC only
blood
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Aplastic anemia

Definition Aplastic anemia is one of a group of hypo proliferative disorders has

Bone marrow failure to produce any type of cells

Reduced production of blood cells of myeloid group,

Lymphocyte production is not affected

Pancytopenia in the peripheral blood with anemia , infection and

bleeding
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Aplastic anemia

Characterized by

Peripheral pancytopenia

and marrow hypoplasia

or absent hematopoietic precursors. Up to fibrosis
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1-CBC Tests to Establish the Diagnosis of Aplastic Anaemia

RBC WBC PLT
A-Hb, PCV  < 7g/dl Low count Low count

B-RBC count  Low Neutropenia

C-MCV Normal Normal Lymphocytes absolute count
D-MCH  Normal
E-Recticulocytes Low
or absent
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PBS -Aplastic Anaemia

Normocytic/normochromic
anemia
Tear drops
Target cell
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Diagnostic test :
• Bone marrow biopsy, shows
• Hypoplasia, or fibrotic
marrow
• Notes: A plastic anemia is
not malignant case
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Modern diagnosis

Flow cytometry phenotyping shows virtual absence of CD34 hematopoietic

stem cells in blood and marrow.

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‫الحمد هلل رب‬

‫العالمين‪ ....‬هذا‬
‫ابتغاء مرضات هللا‬