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16 Tooth Development English
16 Tooth Development English
• Tooth development
Osteon
Havers lamella
Periosteum
Osteocyte
longitudinal
section
the enamel
covers the dentin
Tooth development
A: enamel organ
B: dental papilla
C: dental follicle
Tooth bud
formation
Histologic slide of tooth in cap stage
Histologic slide of tooth in early bell stage.
Note cell organization
Histologic slide of tooth in late bell stage.
Note disintegration of dental lamina at top
Histologic slide of developing hard tissues.
Ameloblasts form enamel,
while odontoblasts form dentin.
Histologic slide of tooth erupting into the
mouth.
A: tooth
B: gingiva
C: bone
D: periodontal ligaments
Histologic slide of tooth.
Note the tubular appearance of dentin.
A: enamel
B: dentin
Cross-section of tooth at root.
Note clear, acellular appearance of cementum.
A: dentin
B: cementum
Sections of tooth undergoing development.
Neuronal development:
a link to tooth development
Mesenchyme
The Runx2 gene is necessary for tooth
development -
In Runx2 knockout mice tooth developments stops at
very early stage
Oligodontia in a human patient with
hypohydrotic ectodermal dysplasia (HED) -
The ectodysplasin gene is crucial for tooth development
Ectodysplasin stimulates tooth formation
Effect of knock-out
(KO) and
Normal overexpression of
ectodysplasin gene in
mouse
Decreased number of
Ectodysplasin molars
KO -/-
Increased number of
Ectodysplasin molars
overexpression
Tooth development (summary)
• Tooth development