No Generic Name Mechanism Indication

Typical Antipsychotic
1 Chlorpromazine Psychotic disorder, nausea &
vomiting, preoperative
sedation, acute intermitten
prophyria, tetanus, bipolar
disorder, intractable hiccups,
ADHD
 Dosage & Administration Special Population

Geriatric Patients: No specific

dosage recommendations for
geriatric patients, but generally
select dosage at the lower end of
recommended range; increase
dosage more gradually and
monitor closely.

Pediatic Patient: Distuptive Behaviour Disorder &

ADHD > Outpatient: PO/IM 1-12 years initialy
0,55mg/kg every 4-6 hours or IM every 6-8 hours
as necessary, increase dosage gradually as
required. > Hospitalized patient: PO/IM initiate
with low dosage as with outpatients and increase
dosage gradually. For severe behaviour disorder,
higher dosages (50-100 mg/ daily, and in older
children: ≥ 200 mg daily) may be necessary. There
is little evidence that behavior improvement in
severely distrubed, mentally retarded patients is
further enhanced at dosages .500 mg daily. IM
max 40 mg daily for children < 5 years (or 22,7kg).
Max ≤ 75 mg daily for children 5-12 years of age
(or 22,7-45,5 kg); dosage may be further increased
in unmanageable patients.

Adults: Psychotic Disorder >Hospitalized patients :

little therapeutic gai achieved by dosages > 1 g
daily administered for extended periods. Less
acutely agitated patients: usually do not exceed
400 mg daily. IM max IM dosage of 400 mg every
4-6 hours.
 Contra Indication
Comatose states or in the
presence of large amounts of
CNS depressants (eg; alcohol,
barbiturates, opiates). Knownd
hypersensitivity to
phenotiazines.
Warnings/ Precautions
Warnings: EPS, tardives dyskinesia,
neuroleptic malignant syndrome, CNS
depression, fetal/neonatal morbidity.
Precautions: sensitivity reactions
(hypersensitivity and cross sensitivity),
photosensitivity, sulfite sensitivity.
General precautions: nervous system
effects (supress cough reflex and
aspiration gastric content) , prolactin
secretion (elevated prolactin
concentration reported; elevation
persists during chronic administration).
Common Adverse Effects Interactions