PHA 6130 Laboratory

Prescriptions with
Incompatibilities
Prof. Mary Jho-Anne T. Corpuz, PhD
Asst. Prof. Gina C. Castro, PhD
Asst. Prof. Marie Cicelie C. Ng, PhD
Asst. Prof. Renz Kenneth G. Cadiang, MSc
 The University of Santo Tomas

Prescription 11
UNIVERSITY OF SANTO TOMAS HOSPITAL
España, Manila
Name: Divina Nuesa Date: March 10, 2021
Address: 21 N. Domingo, San Juan Age: 25 y/o
Wt./Ht.: 118lbs. / 64”

Quinine sulfate …..…………. ... 2 g

Dil. Sulfuric acid ………………. 2 mL
Sodium Acetate ………………... 4 g
Syrup…………………………. 30 mL
Dist. water, q.s. ad ....................... 120 mL
M. S. A.
Sig. one tsp. t.i.d.
Cecil Santos, M.D.
Lic. No. 201234
PTR No. 721406
S2 No._______________
 The University of Santo Tomas

Prescription 11
Remarks:
• If quinine sulfate is dissolved with sulfuric
acid And mixed with the solution of
sodium acetate, a bulky precipitate of
quinine acetate will form.
• Sodium acetate is also partly converted to
sodium sulfate and acetic acid.
 The University of Santo Tomas

Prescription 11
Remarks:
• Qn SO4 + H2SO4 → Qn bisulfate
• Qn HSO4 + NaAc → Qn acetate
• NaAc + H2SO4 → Na2SO4 + HAc
 The University of Santo Tomas

Prescription 11
Remedy:
• If the acid is omitted, a fine suspension of
quinine sulfate is produced.
• Add a suspending agent.
• Place a shake-well label.
 The University of Santo Tomas

Prescription 11
Compounding Procedure:
1. Dissolve the quinine sulfate with water.
2. In separate container, dissolve sodium acetate
with 4 mL of water.
3. Mix the two solutions.
4. Add 2% suspending agent (e.g. acacia mucilage)
5. Add Syrup.
6. Add enough water to make 120 mL
 The University of Santo Tomas

Prescription 12
UNIVERSITY OF SANTO TOMAS HOSPITAL
España, Manila
Name: Angelina Alonzo Date: March 10, 2021
Address: 74 Tagumpay Rd. Caloocan Age: 50 y/o
Wt./Ht.: 120lbs. / 62”

Ferric chloride tincture ….……. ... 15 mL

Glycerin ……….………………. 45 mL
Ammonia water …………….…... 12 mL
Dist. water, q.s. ad ....................... 120 mL
M. Ft. Soln.
Sig. as directed
Delia Cabrera, M.D.
Lic. No. 201233
PTR No. 721415
S2 No._______________
 The University of Santo Tomas

Prescription 12
Remarks:
• Chemical reaction takes place between
the acid of the tincture and the ammonia
water forming ammonium chloride and
ferric hydroxide.
 The University of Santo Tomas

Prescription 12
Remedy:
• The precipitation of ferric hydroxide may be
prevented by mixing the glycerin with the
tincture before adding the ammonia.
• If the ammonia is added to the tincture followed
by the glycerin, the precipitated ferric hydroxide
dissolves but slowly in the glycerin.
• Honey, sugar, or acacia may also prevent such
precipitation of the metals by alkali hydroxides.
 The University of Santo Tomas

Prescription 12
Compounding Procedure:
1. Mix ferric chloride tincture with the
glycerin.
2. Add the ammonia water.
3. Add enough water to make 120 mL.