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  • Calculo de Practica Diluc

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    Diosairis G
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    1) This document contains data from an experiment measuring the absorption of a drug over time in two patients (A and B). It includes measurements of the drug concentration in each patient's blood at regular time intervals. 2) The area under the curve (AUC) was calculated for each patient using the trapezoidal rule to summarize the total absorption. The AUC for patient A was 922.75 mg*min and for patient B was 610 mg*min. 3) The percentage of drug absorbed (%EF) was calculated for each patient based on their AUC. Patient A absorbed 76.89% of the drug and patient B absorbed 50.83% of the drug.

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    1) This document contains data from an experiment measuring the absorption of a drug over time in two patients (A and B). It includes measurements of the drug concentration in each patient's blood at regular time intervals. 2) The area under the curve (AUC) was calculated for each patient using the trapezoidal rule to summarize the total absorption. The AUC for patient A was 922.75 mg*min and for patient B was 610 mg*min. 3) The percentage of drug absorbed (%EF) was calculated for each patient based on their AUC. Patient A absorbed 76.89% of the drug and patient B absorbed 50.83% of the drug.

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    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
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    Download as xlsx, pdf, or txt
    33 views8 pages

    Calculo de Practica Diluc

    Uploaded by

    Diosairis G
    1) This document contains data from an experiment measuring the absorption of a drug over time in two patients (A and B). It includes measurements of the drug concentration in each patient's blood at regular time intervals. 2) The area under the curve (AUC) was calculated for each patient using the trapezoidal rule to summarize the total absorption. The AUC for patient A was 922.75 mg*min and for patient B was 610 mg*min. 3) The percentage of drug absorbed (%EF) was calculated for each patient based on their AUC. Patient A absorbed 76.89% of the drug and patient B absorbed 50.83% of the drug.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
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    Download as xlsx, pdf, or txt
    of 8

    Dosis = 20mg

    Patron Problema ti= (ti + tf)/2 ΔQ A (Qf-Qi)


    Tiempo )M A (Q) (mg) B (Q) (mg) ti (min) A ΔQ (mg)
    0 0 0 0 + 5 / 2 = 2.5 1-0=1
    5 1 0.8 2.5 1
    Gilsy 10 8.4 5.6 7.5 7.4
    Angel 15 13.3 8.9 12.5 4.9
    Xiomara 20 16.3 12.1 17.5 3
    Diosairi 25 18.2 14.1 22.5 1.7
    Mari 30 19 15.8 27.5 0.8
    julia 35 19.3 16.7 32.5 0.3
    Diosairi 40 19.5 18.3 37.5 0.2
    Angel 50 19.9 19.7 45 0.4
    Gilsy 60 20 20 55 0.1
    Σ ((ti ) * ∆Q)

    MDT= Σ ((ti ) * ∆Q) = 272.75 mg * min= 13.79 min


    Q∞ 20mg

    MDT= Σ ((ti ) * ∆Q) = 395.75 mg * min= 19.79 min


    Q∞ 20mg

    Dosis = 20mg %EF

    Patron Problema
    AUC A (mg * AUC B (mg *
    Tiempo (mini) A (Q) (mg) B (Q) (mg) min) min)
    0 0 0
    5 1 0.8 2.5 2
    Gilsy 10 8.4 5.6 23.5 16

    Angel 15 13.3 8.9 54.25 36.25 1)


    Xiomara 20 16.3 12.1 74 52.5
    Diosairi 25 18.2 14.1 86.25 65.5
    Mari 30 19 15.8 93 74.75
    Julia 35 19.3 16.7 95.75 81.25
    Diosairi 40 19.5 18.3 97 87.5
    Angel 50 19.9 19.7 197 95
    Meleni 60 20 20 198.5 99.25
    AUC = 922.75 610
    1) bxh .= 0.8mg x 5min .=2 mg * min
    2 2

    2) B+b xh .= 5.6mg + 0.8mg x 5min .= 16 mg *min


    2 2

    3) B+b xh .= 8.9mg + 5.6mg x 5min .= 36.25mg *min


    2 2

    4) B+b xh .= 12.1mg + 8.9mg x 5min .= 52.5mg *min


    2 2

    5) B+b xh .=14.1mg + 12.1mgx 5min .= 65.5mg *min


    2 2

    6) B+b xh .= 15.8mg + 14.1mgx 5min .= 74.75mg *min


    2 2

    7) B+b xh .= 16.7mg + 15.8mgx 5min .= 81.25mg *min


    2 2

    8) B+b xh .= 18.3mg + 16.7mgx 5min .= 87.5mg *min


    2 2

    9) B+b xh .= 19.7mg + 18.3mgx 5min .= 95mg *min


    2 2

    10) B+b xh .= 20mg + 19.7mg x 5min .= 99.25mg *min


    2 2

    B (Q) (mg) Problema


    25
    19.7 20
    20 18.3
    16.7
    15.8
    14.1
    15
    B (Q) mg

    12.1

    10 8.9
    5.6
    5
    0 0.8
    0
    0 10 20 30 40 50 60 70
    Tiempo min
    5
    0 0.8
    0
    0 10 20 30 40 50 60 70
    Tiempo min

    Problema

    Tiempo (mini) B (Q) (mg)


    0 0
    5 0.8
    10 5.6
    15 8.9
    20 12.1
    25 14.1
    30 15.8
    35 16.7
    40 18.3
    50 19.7
    60 20
    ti * ΔQ ti = (ti + tf)/2 ΔQ B (Qf-Qi) ti * ΔQ
    ti(min)* ΔQ(mg) ti (min) B ΔQ (mg) ti(min)* ΔQ(mg)
    2.5 x 1 0 + 5 / 2 = 2.5 0.8 - 0 = 0.8 2.5 x 0.8
    2.5 2.5 0.8 2
    55.5 7.5 4.8 36
    61.25 12.5 3.3 41.25
    52.5 17.5 3.2 56
    38.25 22.5 2 45
    22 27.5 1.7 46.75
    9.75 32.5 0.9 29.25
    7.5 37.5 1.6 60
    18 45 1.4 63
    5.5 55 0.3 16.5
    272.75 Σ ((ti ) * ∆Q) = 395.75

    Triangualo = bxh= Trapezpode = ( B+ b) xh


    2 2

    bxh .= 1mg x 5min .=2.5mg * min 2) B+b xh .= 8.4mg + 1mg


    2 2 2 2

    3) B+b xh .= 13.3mg +8.4mg


    %EF A = AUC X100 2 2
    Q100 * t
    4) B+b xh .= 16.3mg +13.3mg
    %EF A = 922.75 mg*min X100 2 2
    20mg * 60min
    5) B+b xh .= 18.2mg +16.3mg
    %EF A = 76.89% 2 2
    6) B+b xh .= 19mg +18.2mg
    2 2

    %EF B = AUC X100 7) B+b xh .= 19.3mg +19mg


    Q100 * t 2 2

    %EF B = 610 mg*min X100 8) B+b xh .= 19.5mg +19.3mg


    20mg * 60min 2 2

    %EF B = 50.83% 9) B+b xh .= 19.9mg +19.5mg


    2 2

    10) B+b xh .= 20mg +19.9mg


    2 2

    A (Q) (mg) patron

    19.3 19.5 19.9 20


    18.2 19
    16.3
    A (Q) mg

    13.3

    8.4

    1
    0
    0 5 10 15 20 25 30 35 40 50 60
    Tiempo (min)
    1
    0
    0 5 10 15 20 25 30 35 40 50 60
    Tiempo (min)
    x 5min .= 23.5mg *min

    x 5min .= 54.25mg *min

    x 5min .= 74 mg *min

    x 5min .= 86.25mg *min


    x 5min .= 93mg *min

    x 5min .= 95.75 mg *min

    x 5min .= 97mg *min

    x 10min .= 197 mg *min

    x 10min .= 199.5 mg *min

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