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Catat Hidro
Catat Hidro
Catat Hidro
rapidly by the kidney. When plasma levels have been need to be considered if the intraocular pressure potentiation.
followed for at least 24 hours, the plasma half-life remains uncontrolled. Risk factors for developing Cholestyramine and Colestipol Resins:
has been observed to vary between 5.6 and 14.8 acute angle-closure glaucoma may include a history Absorption of hydrochlorothiazide is impaired in the
hours. At least 61% of the oral dose is eliminated of sulfonamide or penicillin allergy. presence of anionic exchange resins. Single doses
unchanged within 24 hours. Hydrochlorothiazide of either cholestyramine or colestipol resins bind the
crosses the placental but not the blood-brain barrier PRECAUTIONS: General: All patients receiving hydrochlorothiazide and reduce its absorption from
and is excreted in breast milk. diuretic therapy should be observed for evidence of the gastrointestinal tract by up to 85% and 43%,
fluid or electrolyte imbalance: namely, hyponatrem respectively.
INDICATIONS AND USAGE: Hydrochlorothiazide ia, hypochloremic alkalosis, and hypokalemia.
tablets are indicated as adjunctive therapy in edema Corticosteroids, ACTH: Intensified electrolyte
Serum and urine electrolyte determinations are par
associated with congestive heart failure, hepatic cir depletion, particularly hypokalemia.
ticularly impor tant when the patient is vomiting
rhosis, and corticosteroid and estrogen therapy. excessively or receiving parenteral fluids. Warning Pressor Amines (e.g., Norepinephrine): Possible
Hydrochlorothiazide tablets have also been found signs or symptoms of fluid and electrolyte imbal decreased response to pressor amines but not suffi
useful in edema due to various forms of renal dys ance, irrespective of cause, include dryness of cient to preclude their use.
function such as nephrotic syndrome, acute mouth, thirst, weakness, lethargy, drowsiness, rest Skeletal Muscle Relaxants, Nondepolarizing
glomerulonephritis, and chronic renal failure. lessness, confusion, seizures, muscle pains or (e.g., Tubocurarine): Possible increased respon
Hydrochlorothiazide tablets are indicated in the cramps, muscular fatigue, hypotension, oliguria, siveness to the muscle relaxant.
management of hypertension either as the sole ther tachycardia, and gastrointestinal disturbances such Lithium: Generally should not be given with diuret
apeutic agent or to enhance the effectiveness of as nausea and vomiting. ics. Diuretic agents reduce the renal clearance of
other antihyper tensive drugs in the more severe Hypokalemia may develop, especially with brisk lithium and add a high risk of lithium toxicity. Refer to
forms of hypertension. diuresis, when severe cirrhosis is present or after the package insert for lithium preparations before
Use in Pregnancy: Routine use of diuretics during prolonged therapy. use of such preparations with hydrochlorothiazide.
normal pregnancy is inappropriate and exposes Interference with adequate oral electrolyte intake Non-Steroidal Anti-Inflammatory Drugs: In
mother and fetus to unnecessary hazard. Diuretics will also contribute to hypokalemia. Hypokalemia some patients, the administration of a non-steroidal
do not prevent development of toxemia of pregnancy may cause cardiac arrhythmia and may also sensi anti-inflammatory agent can reduce the diuretic,
and there is no satisfactory evidence that they are tize or exaggerate the response of the heart to the natriuretic, and antihyper tensive effects of loop,
useful in the treatment of toxemia. toxic effects of digitalis (e.g., increased ventricular potassium-sparing and thiazide diuretics. Therefore,
NDC 0378-3601-01
doses of up to approximately 100 mg/kg/day). The Renal: Renal failure, renal dysfunction, interstitial bottles of 100 tablets
NTP, however, found equivocal evidence for hepa nephritis (see WARNINGS).