Mutation of - Genetics/Family

tumor Hx

Cannot suppressor - Demographics

genes -Prolonged Alcohol High Smoking Previous

repair (high risk= breast cancer
(BRCA1/ estrogen exposure
BMI
damaged 2-5 drinks/ or carcinoma
DNA or BRCA2) - Medical Hx

-Lifestyle day) in situ (CIS),

destroy radiation
affected
cells
Family hx Adipocy
of breast or other Old age, Nulliparity, tes Moderately
cancers, rare females early produce increased if
genetic syndromes (99%) menarche estroge high pack
(<12), late High n from years, early
menopause serum androge initiation,
(>55), older estrogen ns longer duration
Increased age at first
protoonco delivery
genes like (>30), etc.
HER2

Increased
tissue
growth, no
regulation

Breast
Cancer

Non-
Invasive invasive

Lobular Ductal
Rarer Paget’s Inflammatory Invasive Invasive carcinoma in carcinoma in
types: male disease carcinoma lobular ductal situ (LCIS) situ (DCIS)
breast (1-3%) (1-4%) carcinoma carcinoma
cancer, (8-15%) (80%)
lymphoma,
sarcoma

Ductal Infiltrates
Ductal carcinoma Infiltrates surrounding Malignant Malignant
carcinoma invading surrounding breast cells cells
Male breast invading dermal breast tissue, contained contained
cancer nipple
lymphatics tissue, 20% palpable if within breast within breast
usually , bilateral, large or lobule, ducts,
invasive Scaling, aggressive
diagnosed detected on detected on detected on
ductal eczema- microscopic mammogra biopsy done mammogram
carcinoma, like Tender, ally m for other
diagnosed at lesions on red, warm, indication
advanced nipple swollen
stage breast;
peas d’
orange=ad
vanced