CNS CARDIOVASCULAR RESPIRATORY OTHER ORGAN

SYSTEM (pls. specify)

BENZODIAZEPINES Decreased CBF Display minimal left-ventricular Depress the ventilatory

depressant effects. response to CO2.
Decreased ICP
Decrease arterial blood
Little effect on pressure, cardiac output, and
CPP peripheral vascular resistance.

Decreased Increase heart rate

CMRO2

BARBITURATES Decreased CBF Decrease in blood pressure. Depress the medullary RENAL – reduce renal
ventilatory center, decreased blood flow and
Decreased ICP Increase in heart rate. response to hypercapnia and glomerular filtration rae
hypoxia.
Increased CPP Vasodilation of peripheral HEPATIC – hepatic
capacitance vessels. Decreased tidal volume and blood flow is
Decreased respiratory rate decreased.
CMRO2 Increased peripheral pooling of
blood. Depress the airway reflex IMMUNOLOGICAL –
response to laryngoscopy and Mast cell histamine
intubation. release in vitro (sulfur-
containing
thiobarbiturates.
PROPOFOL Decreased CBF Decreased in arterial blood Apnea
pressure and drop in SVR,
Decreased ICP preload and cardiac Decreased tidal volume
contractility.
Decreased Increased respiratory rate
CPP Decreased cardiac output,
cardiac index, and stroke Bronchodilation (Patients with
Decreased index. COPD)
CMRO2

KETAMINE Increased CBF Increased arterial blood Apnea (if with combination with
pressure, heart rate and opioids)
Increased ICP cardiac output.
Bronchodilation
Increased Increased pulmonary artery
CMRO2 pressure and myocardial work. Increased salivation

DEXMEDETOMIDINE Locus Bradycardia Maintained respiration

Coeruleus
activates sleep Hypotension
pattern in the
brain.
ETOMIDATE Decreased CBF Decreased peripheral vascular Minimal respiratory depression. ENDOCRINE –
resistance and arterial blood adrenocortical
Decreased ICP pressure. suppression

Unchanged or Unchanged myocardial

Increased CPP contractility and cardiac output.

Decreased
CMRO2