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  • Hepatoblastoma Pathophysiology

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    jennachristy03
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    Hepatoblastoma is a type of liver cancer that usually affects male infants and children under 5 years old. Risk factors include genetic conditions like Beckwith-Weidemann syndrome and familial adenomatosis polyposis. Early detection and treatment through surgery to remove the tumor and chemotherapy can lead to a good prognosis, while untreated hepatoblastoma may metastasize to the lungs and other nearby organs, resulting in death or a poor prognosis.

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    hepatoblastoma pathophysiology

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    Hepatoblastoma is a type of liver cancer that usually affects male infants and children under 5 years old. Risk factors include genetic conditions like Beckwith-Weidemann syndrome and familial adenomatosis polyposis. Early detection and treatment through surgery to remove the tumor and chemotherapy can lead to a good prognosis, while untreated hepatoblastoma may metastasize to the lungs and other nearby organs, resulting in death or a poor prognosis.

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    1K views2 pages

    Hepatoblastoma Pathophysiology

    Uploaded by

    jennachristy03
    Hepatoblastoma is a type of liver cancer that usually affects male infants and children under 5 years old. Risk factors include genetic conditions like Beckwith-Weidemann syndrome and familial adenomatosis polyposis. Early detection and treatment through surgery to remove the tumor and chemotherapy can lead to a good prognosis, while untreated hepatoblastoma may metastasize to the lungs and other nearby organs, resulting in death or a poor prognosis.

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    of 2

    Predisposing Factors: Precipitating Factors:

    infancy- 5 years old (/) exposed to hepatitis B infection at an


    Male (/) early age (X)
    Beckwith-Weidemann syndrome (X)
    familial adenomatosis polyposis (X)
    low birth weight (X)
    hemihypertrophy (X) If not treated:
    If treated: Metastasize to lungs, and
    nearby organs
    surgery (to remove tumor and
    part or all of the liver)
    Unkown
    chemotherapy
    DEATH/ POOR
    liver transplant PROGNOSIS
    Beta-catenin (CTTNNB1)
    accumulation

    GOOD PROGNOSIS
    Beta-catenin (CTTNNB1)
    gene mutation

    oncogene activation of
    embryonic fetal hepatocytes

    Biallelic APC tumor


    suppressor inactivation

    cancer cells lose cell contact


    inhibition

    uncontrolled proliferation of
    Cancer cells

    enlarged abdominal mass


    abdominal pain
    jaundice encapsulated tumor
    severe anemia formation in the liver
    anorexia
    weight loss

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