Sorbitol, Oral Sweetener, Laxative: Uses, Side Effects, Dosage 2/7/21, 10:48 PM

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What is oral sorbitol? What are the uses for oral sorbitol?

Sorbitol is a sugar alcohol naturally found in fruits. Its chemical properties allow it to have

multiple actions within the body. Its sweetening properties allow it to be used as a low-

calorie sweetener in medicinal solutions. Its hyperosmotic properties allow it to work as a

laxative, drawing water into the colon from surrounding body tissues to allow softening of

stool and relieve constipation. This ability to draw in water also allows it to be used in

saliva substitutes to relieve dry mouth and during transurethral prostatectomy as a

urinary bladder wash. The FDA approved sorbitol in February 1978.

Is oral sorbitol available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for oral sorbitol?

Laxative Syrup No

IrrigationYes

What are the side e!ects of oral sorbitol?

Common side e!ects of sorbitol are:

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Sorbitol, Oral Sweetener, Laxative: Uses, Side Effects, Dosage 2/7/21, 10:48 PM

abdominal discomfort,

diarrhea,

dry mouth,

nausea, and

vomiting.

fluid retention in tissues (edema),

dehydration,

loss of electrolytes,

increased blood sugar, and

acidification of blood due to lactate production.

"

QUESTION

You are constipated if

you don't have a bowel
movement every day.

See Answer

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Sorbitol, Oral Sweetener, Laxative: Uses, Side Effects, Dosage 2/7/21, 10:48 PM

What is the dosage for oral sorbitol?

The initial dose for use as a laxative in adults is 30-150 mL of an oral 70% solution, or 120

mL of a 25% to 30% rectal enema solution. For transurethral surgical procedures, a

continuous wash of 3% to 3.3% solution is used.

Which drugs or supplements interact with oral sorbitol?

Combining sorbitol with calcium/sodium polystyrene sulfonate should be avoided due

to the significant risk of causing death of gut tissue (intestinal necrosis).

Is oral sorbitol safe to take during pregnancy or while

breastfeeding?

There are no adequate studies of sorbitol in pregnant women.

Sorbitol should be used cautiously by nursing mothers.

What else should I know about oral sorbitol?

What preparations of oral sorbitol are available?

Irrigation Solution 3%, 3.3%; Oral Solution 70%, Oral Suspension, Oral Syrup, Lozenge

How should I store oral sorbitol?

Sorbitol should be stored at room temperature, 25 C (77 F). Heating above 66 C (150 F) or

freezing should be avoided.

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Sorbitol, Oral Sweetener, Laxative: Uses, Side Effects, Dosage 2/7/21, 10:48 PM

Summary

Oral sorbitol (Ora-Sweet SF, PCCA Sweet-SF, PCCA Syrup Vehicle, PCCA-Plus, Numoisyn)

is a sweet solution that is hyperosmotic, which enables it to relieve constipation. Review

side e!ects, drug interactions, dosage, and pregnancy safety information prior to taking

this product.

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Medically Reviewed on 7/5/2019

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