Abstracts / Osteoarthritis and Cartilage 25 (2017) S76eS444
other joints. The purpose of this study was to investigate the extent of
multi-joint involvement in a representative sample of the population
with OA.
Methods: Analysis of data from the Survey on Living with Chronic
Diseases in Canada, Arthritis Component. This was based on a nationally
representative sample of people aged 20 or older reporting arthritis as a
long term health problem, diagnosed by a health professional, in the
parent Canadian Community Health Survey, 2008. Respondents were
asked about their type of arthritis, extent of pain on a 0-10 scale, and the
extent to which arthritis affected their life (not at all; a little; moder-
ately; quite a bit; extremely). Participants were also asked to indicate
which joints were painful. The joints asked about were the right and left
hands, wrists, elbows, shoulders, hips, knees, ankles, feet, back and
neck. Data on other reported chronic health conditions (heart disease,
respiratory, high blood pressure, migraines, mood disorders, bowel
disorder/ulcers, stroke, cancer, and diabetes) and body mass index
(BMI) were obtained from the parent survey. Analysis was restricted to
people reporting OA (n ¼ 1749).
Results: The mean age of the sample was 65 years, with 44% aged less
than 65; 74% were women. Ninety-three percent reported joint pain in
the previous month. The mean ‘average’ pain score was 5.2/10 with very
little variation by age and gender. Overall, 92% reported that their
arthritis affected their life at least a little, with 24% reporting quite a bit
or worse, similarly with little variation by age and gender. The most
frequently reported joint sites (e.g. one or both knees) were the knee
(58%), hands (49%), back (47%), and hips (42%). Overall the sample was
characterized by multi-joint involvement: only 10% reported only one
troublesome joint, and 17% only one site. The mean number of painful
joints was 5.6 (ranging from 1 to 18: median 5), and the mean number
of joint sites was 3.9 (median 3). Women reported more joints than men
(mean 5.9 vs 4.8) but there was no significant trend by age. There was
no significant trend in number of joints by BMI, although the number of
co-occurring conditions was higher in people with more painful joints;
25% of those with only 1-2 joints had a 2 or more co-occurring con-
ditions, compared to 43% of those with 5 or more joints.
Conclusions: Although the most frequently reported painful joints
were the knee, hip or hand, few people reporting OA in this repre-
sentative population-based sample had joint symptoms in that joint
alone, suggesting that studies that focus only on a primary joint may be
missing the point. The lack of association of mean number of joints with
obesity was surprising given a postulated metabolic contribution to OA.
The association with co-occurring conditions needs further inves-
tigation. A reappraisal of our understanding of OA appears to be war-
ranted given that multi-joint involvement appeared to be the rule not
the exception.
313
THE ALBERTA YOUTH PREVENTION OF EARLY OSTEOARTHRITIS
COHORT; EXAMINING 1-YEAR CHANGES IN KOOS AND OTHER
BEHAVIORAL, FUNCTIONAL AND PHYSIOLOGICAL OUTCOMES
C.A. Emery y, z, J.L. Whittaker x, k, C. Toomey y, L. Palacios-Derflingher y.
y Sport Injury Prevention Res. Ctr., Faculty of Kinesiology, Univ. of
Calgary, Calgary, AB, Canada; z The Alberta Children's Hosp. Res. Inst.,
Faculty of Med., Univ. of Calgary, Calgary, AB, Canada; x Dept. of Physical
Therapy, Faculty of Rehabilitation Med., Univ. of Alberta, Edmonton, AB,
Canada; k Glen Sather Sports Med. Clinic, Univ. of Alberta, Edmonton,
AB, Canada
Purpose: Osteoarthritis (OA) is a leading cause of pain and disability
worldwide. OA most commonly affects the knee joint and is associated
with chronic pain, disability and a reduced quality of life. Prospective
studies report a 10-fold increased risk of post-traumatic osteoarthritis
(PTOA) 12-20 years post knee injury however, there is a paucity of
research examining outcomes associated with OA early in the period
(<10 years post-injury) between joint injury and OA onset. The Knee
Osteoarthritis and Injury Outcome Score (KOOS) has been used to
examine self-reported outcomes across the timespan from time of knee
injury to OA onset through to joint arthroplasty. The KOOS assesses
perceived pain, other symptoms, difficulty with function during daily
life and sport and recreational activities, and knee-related quality of life.
Our previous research has shown that young adults 3-10 years post
intra-articular knee injury report more symptoms, have greater
adiposity, lower levels of physical activity and more functional deficits
compared to uninjured controls. This investigation aimed to examine
the association between sport-related knee joint injury history and
S199
one-year change in KOOS and other functional and physiological out-
comes from 3-10 years to 4-11 years following injury using a matched
historical cohort study design.
Methods: Participants in this historical cohort study included a sub-
sample (n ¼ 80) of the Alberta Youth Prevention of Early OA (PrE-OA)
cohort (n ¼ 200) who completed one-year follow-up (FU) testing.
Individuals with a youth sport-related intra-articular knee injury sus-
tained 3-10 years previously (n ¼ 40) were compared to 40 age, sex and
sport matched controls. Intra-articular knee injury was defined as a
clinical diagnosis of bone, cartilage, ligament or meniscal injury
requiring medical attention and time loss from sport. Outcome meas-
ures included the one-year [FU1 (4-11 years post-injury) - baseline (3-
10 years post-injury)] change in: Knee Injury and OA Outcome Score
weighted average (KOOS5), weekly minutes of moderate-vigorous
physical activity (PA; Godin Leisure Time Questionnaire); fat mass index
(FMI; DXA); aerobic fitness (20m Shuttle run estimated VO2max); triple
single leg hop (TSLH) and side-to-side quadriceps strength differential
(dynamometry). Paired t-tests or Wilcoxon signed rank test were used
to compare study groups on change in all outcomes over one-year. A
multivariable linear mixed effects model with a random effect for
participant and matched pair was used to assess the relationship
between the one-year change in the KOOS5 and injury history including
time since injury (cases), age at injury (cases), sex and interaction
between time since injury and injury group, and age at injury and injury
group.
Results: The median age of participants was 23.5 years (range 14-27)
and 50% were female. Of those with a previous injury, median age of
injury was 16 years (range 9-19). There was no difference in one-year
change in KOOS5 score between previously injured and uninjured study
groups [mean pair difference (95%CI); 0.28 (-0.38,0.93), p ¼ 0.40].
However, the multivariable analyses revealed that for every one-year
increase in time since injury, there was a significant increase in KOOS5
for the previously injured participants [0.41, 95%CI (0.14,0.68)], whereas
for the controls the effect was not significant [-0.002, 95%CI
(-0.239,0.236)]. There were no one-year changes seen in either study
group based on mean pair differences across all other outcomes (all p-
values >0.05).
Conclusions: The findings of this study suggest that there is no dif-
ference in the one-year change in KOOS5 score, adiposity, physical
activity, FMI, aerobic fitness, TSLH and side-to-side quadriceps strength
differential between youth and young adults with a knee injury sus-
tained 3-10 years previously and uninjured healthy controls. However,
it does appear that the mean one-year change in KOOS5 score is affected
by time since injury. Continued longitudinal follow-up of the PrE-OA
cohort is expected to elucidate the progression of the KOOS sub-scale
scores as well as change in adiposity, physical activity, FMI, aerobic
fitness, TSLH and side-to-side quadriceps strength differential over
time. These findings will inform the early identification of individuals at
risk of PTOA and development of secondary prevention strategies.
314
INCIDENCE AND RISK FACTORS OF PHYSICAL INACTIVITY OVER 2
YEARS AMONG ELDERLY CHINESE: RESULTS FROM A POPULATION-
BASED LONGITUDINAL SURVEY
Q. Liu, X. Li, Z. Li, D. Xing, B. Wang, J. Lin. Peking Univ., Beijing, China
Purpose: To describe incidence of physical inactivity (PI) and to
examine the risk factors for physical inactivity over 2 years in a pop-
ulation-based longitudinal study.
Methods: China Health and Retirement Longitudinal Study (CHARLS) is
a nationally population-based longitudinal survey. Multistage proba-
bility sampling strategy and probability-proportional-to-size sampling
technique were applied. Residents, aged 45 years or older and their
spouses, were interviewed at baseline visit in 2011. Participants were
followed until August 2013. At baseline and follow-up visits, data on the
demographic factors (i.e., age, gender, living area), socioeconomic status
(i.e., education levels, living alone, accessibility of physical activity (PA)
facilities, income and work status) and medical history (i.e., doctor-
diagnosed arthritis and comorbidities) were collected. Subjects had a
clinical examination including height and weight. A random subsample
was queried with the amount of time spend on different types of
physical activities (i.e., vigorous physical activities, moderate physical
activities, and walking) in a usual week. Only activities last for 10
minutes or more at one time were involved. We defined PI as not
meeting any of the following 3 criteria: 30min of moderate-intensity PA