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Diuretics: PHRM 306: Drugs Affecting CVS
Diuretics: PHRM 306: Drugs Affecting CVS
Diuretics: PHRM 306: Drugs Affecting CVS
LOOP DIURETICS
Loop diuretics
• Loop diuretics are diuretics that act on the
ascending loop of Henle in the nephron.
• Loop diuretics act on the Na+-K+-2Cl-
symporter (cotransporter) in the thick
ascending limb of the loop of Henle to inhibit
sodium and chloride reabsorption.
• Example: Furosemide (most common),
Bumetanide, Ethacrynic acid, Torsemide.
• https://www.youtube.com/watch?v=22DTm-J
VdWo
Diuretics
POTASSIUM-SPARING DIURETICS
Potassium-Sparing Diuretics
• Potassium-sparing diuretics act in the
collecting tubule to inhibit Na+ reabsorption
and K+ excretion.
Aldosterone antagonists
• Spironolactone:
• Spironolactone is a synthetic steroid that
antagonizes aldosterone at intracellular
cytoplasmic receptor sites.
• The spironolactone-receptor complex is
inactive.
Spironolactone
• It is a weak diuretic, because only 2% of the
total Na+ reabsorption is under aldosterone
control.
Heart failure