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Investigation of unilateral pleural effusion

Algorithm adapted by permission from BMJ Publishing


Group Limited. Thorax, Hooper C, Lee YCG, Maskell N
on behalf of the BTS Pleural Disease Guideline Group,
65 (Suppl 2): ii14-ii7, 2010). *Record initial appearance of fluid
(e.g. straw coloured, turbid, blood
History, clinical examination and CXR stained).

Does the clinical picture suggest a transudate? E.g. LVF, YES


hypoalbuminaemia, dialysis

NO Treat the cause

Refer to chest physician Resolved?

* Pleural aspiration (with ultrasound guidance). NO YES


Send for cytology, protein, LDH, pH, Gram stain, culture
and sensitivity.
STOP

Is it a transudate? YES

NO Treat the cause

Has the fluid analysis and clinical features given a


YES
diagnosis?

NO Treat appropriately

Request contrast enhanced CT thorax

Consider LA thorascopy or surgical Consider radiological guided pleural biopsy +/-


VATS chest tube drainage if symptomatic

Cause found? YES

NO

Re-consider treatable conditions such as PE, TB, Treat appropriately


chronic heart failure and lymphoma. Watchful waiting
often appropriate.

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