SNP Function class allele global AFR EUR EAS SAS AMR

1.
rs233574 T=0.1576 T=0.0847 T=0.330 T=0.004 T=0.184 T=0.233
Intron T>C
2.
rs233575 Intron G>A G=0.1367 G=0.0120 G=0.336 G=0.004 G=0.184 G=0.214
3.
rs714205 C=0.6917 C=0.8993 C=0.795 C=0.465 C=0.529 C=0.529
Intron C>G
4.
rs757066 C=0.1436 C=0.0120 C=0.351 C=0.007 C=0.198 C=0.218
5. Intron C>T
rs879922 C=0.3176 C=0.5464 C=0.354 C=0.037 C=0.286 C=0.281
6. Intron C>G
rs971249 T=0.1968 T=0.1934 T=0.352 T=0.352 T=0.198 T=0.252
7. Intron T>C
rs1132186 A=0.3118 A=0.5244 A=0.351 A=0.037 A=0.286 A=0.284
Intron A>C
South Asian; AMR: American.

8.
rs1514279 G=0.1968 G=0.1934 G=0.354 G=0.007 G=0.198 G=0.250
9. Intron G>A
rs1514280 A=0.1979 A=0.2084 A=0.345 A=0.004 A=0.198 A=0.246
10. Intron A>G
rs1514281 T=0.8906 T=0.6899 T=0.997 T=0.967 T=0.915 T=0.973
11. Intron T>C
rs1514282 T=0.8882 T=0.6839 T=0.997 T=0.967 T=0.915 T=0.968
12. Intron T>C
rs1514283 T=0.8906 T=0.6899 T=0.997 T=0.967 T=0.967 T=0.973
13. Intron T>C
rs1978124
14. Intron T>C T=0.2053 T=0.0997 T=0.471 T=0.007 T=0.219 T=0.290
rs2023802
15. Intron G>A G=0.1958 G=0.1944 G=0.349 G=0.007 G=0.198 G=0.248
rs2048683
16. Intron T>G T=0.1966 T=0.1934 T=0.352 T=0.007 T=0.198 T=0.198
rs2048684
17. Intron A>C A=0.1677 A=0.0907 A=0.349 A=0.007 A=0.198 A=0.244
rs2074192
18. Intron C>T C=0.6368 C=0.6540 C=0.574 C=0.572 C=0.774 C=0.601
rs2106809 A=0.6837 A=0.9113 A=0.753 A=0.478 A=0.517 A=0.676
19. Intron A>G
rs2158083 C=0.1918 C=0.1765 C=0.352 C=0.007 C=0.198 C=0.248
20. Intron C>T
Table S2. ACE2 SNPs showing different frequencies between different populations
according to 1000 genome project. AFR: African; EAS: Asian; EUR: European; SAS:

rs2285666 C=0.6498 C=0.6498 C=0.765 C=0.463 C=0.521 C=0.664

21. Intron C>T
rs2316903 G=0.1722 G=0.1077 G=0.349 G=0.007 G=0.198 G=0.244
22. Intron G>T
rs2316904 C=0.1725 C=0.1077 C=0.350 C=0.007 C=0.198 C=0.244
23. Intron C>T
rs4240157 C=0.3179 C=0.5434 C=0.359 C=0.037 C=0.286 C=0.281
Intron C>T
Function class allele global AFR EUR EAS SAS AMR
G=0.2646 G=0.3111 G=0.473 G=0.007 G=0.219 G=0.311
Intron  G>A
A=0.9505 A=0.8215 A=0.999 A=1.000 A=1.000 A=0.987
Intron A>G
C>T C=0.9693 C=0.8893 C=1.000 C=1.000 C=1.000 C=0.990
Intron
T>C T=0.1963 T=0.1964 T=0.349 T=0.007 T=0.198 T=0.248
Intron
A>G A=0.1907 A=0.1765 A=0.349 A=0.007 A=0.198 A=0.246
Intron
delA (A)8=0.1966 (A)8=0.1954 (A)8=0.351 (A)8=0.007 (A)8=0.198 (A)8=0.248
Intron
T>C T=0.9714 T=0.8963 T=0.999 T=1.000 T=1.000 T=0.994
Intron
G>C G=0.6413 G=0.7597 G=0.762 G=0.462 G=0.521 G=0.664
Intron
T>C T=0.1725 T=0.1077 T=0.350 T=0.007 T=0.198 T=0.244
Intron
T>A T=0.1719 T=0.1077 T=0.349 T=0.007 T=0.196 T=0.244
Intron
insATTA
Intron insATTA=0.8283 insATTA=0.8923 insATTA=0.653 insATTA=0.993 insATTA=0.802 insATTA=0.758
A>G A=0.1677 A=0.0907 A=0.349 A=0.007 A=0.198 A=0.244
Intron
C>T C=0.1682 C=0.0907 C=0.351 C=0.007 C=0.198 C=0.244
Intron
C>T C=0.9385 C=0.8654 C=0.999 C=0.967 C=0.915 C=0.981
Intron
A>T A=0.1974 A=0.1964 A=0.349 A=0.007 A=0.203 A=0.248
Intron
insGATAA
Intron insGATAA=0.8342 insGATAA=0.9153 insGATAA=0.653 insGATAA=0.993 insGATAA=0.797 insGATAA=0.763
C>G C=0.9682 C=0.8853 C=0.999 C=1.000 C=1.000 C=0.992
Intron
A>C A=0.9730 A=0.9023 A=0.999 A=1.000 A=1.000 A=0.994
Intron
T>C T=0.9298 T=0.8325 T=0.999 T=0.967 T=0.915 T=0.981
Intron
T>C T=0.9838 T=0.9422 T=1.000 T=1.000 T=1.000 T=0.994
Intron
C>G C=0.9306 C=0.8355 C=0.999 C=0.967 C=0.915 C=0.981
Intron

Intron A>G A=0.9563 A=0.9980 A=0.869 A=1.000 A=0.937 A=0.966

C>T C=0.3158 C=0.5424 C=0.351 C=0.037 C=0.284 C=0.281

Intron
C>G C=0.5197 C=0.1974 C=0.614 C=0.580 C=0.786 C=0.548
Intron
dupA 
Intron dupA=0.7886 dupA=0.7787 dupA=0.634 dupA=0.983 dupA=0.794 dupA=0.742
dupA
Intron dupA=0.8238 dupA=0.8893 dupA=0.649 dupA=0.986 dupA=0.801 dupA=0.750
 SNP
24.
rs4646120
25.
rs4646122
26.
rs4646123
27.
rs4646124
Allele Global AFR EUR EAS SAS AMR 28.
rs4646127
C=0.9619 C=0.8714 C=1.000 C=1.000 C=1.000 C=0.971 29.
C>T
rs4646131
dupA dupA=0.8090 dupA=0.8225 dupA=0.651 dupA=0.993 dupA=0.802 dupA=0.754 30.
rs4646135
31.
delT (T)8=0.3085 (T)8=0.516 (T)8=0.041 (T)8=0.351 (T)8=0.286 (T)8=0.281 rs4646142
32.
dup(GGAA)2 dup(GGAA)2=0.8204 dup(GGAA)2=0.8674 dup(GGAA)2=0.651
0.992 dup(GGAA)2=2 dup(GGAA)2=0.802 dup(GGAA)2=0.75 rs4646143
33.
T=0.9099 T=0.7647 T=0.999 T=0.966 T=0.914 T=0.971 rs4646147
T>G 34.
rs4646148
C>T C=0.3179 C=0.2552 C=0.406 C=0.171 C=0.444 C=0.349 35.
rs4646152
36.
C>T C=0.9118 C=0.7418 C=0.997 C=1.000 C=0.918 C=0.975
rs4646153
37.
A>G A=0.9619 A=0.8714 A=1.000 A=1.000 A=1.000 A=0.971 rs4646155
38.
rs4646156
dupA dupA=0.6405 dupA=0.5394 dupA=0.594 dupA=0.834 dupA=0.624 dupA=0.643 39.
rs4646158
dupA dupA=0.0201 dupA=0.0628 dupA=0.004 dupA=0.004 dupA=0.006 dupA=0.006 40.
rs4646168
41.
dupT dupT=0.8358 dupT=0.9163 dupT=0.653 dupT=0.993 dupT=0.802 dupT=0.765 rs4646170
42.
T=0.9979 T=0.9980 T=0.995 T=1.000 T=0.997 T=1.000 rs4646171
T>C
43.
T=0.9955 T=1.0000 T=0.982 T=1.000 T=0.999 T=0.996 rs4646175
T>C
44.
G=0.9952 G=0.9831 G=1.000 G=1.000 G=1.000 G=0.998 rs4646176
G>A
45.
A=0.9987 A=0.9950 A=1.000 A=1.000 A=1.000 A=1.000 rs4646188
A>G
46.
rs4830542
47.
rs4830964
48.
rs11374008
49.
rs11394305
 SNP Function class
50.
rs16997059
51. Intron
rs34481900
Intron
52.
rs35482260
Intron
53.
rs57823828
Intron
54.
rs58967744
Intron
55.
rs72614593
Intron
56.
rs73635099
Intron
57.
rs113506453
Intron
58.
rs141554379
Intron
59.
rs200217737
Intron
60.
rs397822493
Intron
61.
rs4646116
Missense 

62.
63. Missense 
rs147311723
64. Missense 
rs149039346
Missense