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PubMed Central, Table 1 - BMC Biol. 2017 15 - 53. Published Online 2017 Jun 29. Doi - 10.1186 - s12915-017-0392-4
PubMed Central, Table 1 - BMC Biol. 2017 15 - 53. Published Online 2017 Jun 29. Doi - 10.1186 - s12915-017-0392-4
Foetal monocytes
Bone Monocytes Monocytosis Release controlled by CD169
marrow Stromal mϕ Haemopoietic islands, phagocytosis of erythroid nuclei Sialoadhesin (CD169) and integrin
mediate selective adhesion
Haemopoiesis: erythroid (Fe recycling), myeloid (PMN,
monocytes, eosinophils); plasma cells
Osteoclasts Bone remodelling Mutinucleated giant cells
CSF1, RANK ligand, vacuolar ATPase,
− +
polarised adhesion; F4/80 , CD68
Osteoblast interactions
+ +
Spleen Red pulp Clearance of senescent erythrocytes, PMN F4/80 , CD206
Haem catabolism, Fe recycling Induction Spi-C transcription factor
+,
Marginal zone, metallophils Sinusoidal—clearance of polysaccharides, antigens, CD169 CSF-1 dependent
microbes; stimulate migration
+ +
Outer marginal zone Phagocytic MARCO , SIGNR-1 , type I interferon
induction
++
White pulp Clearance of apoptotic T and B lymphocytes F4/80 negative, CD68
Migrating metallophils transfer antigen to DC, which migrate
to white pulp to activate T and B cells
Lymph Subcapsular macrophages Analogous to marginal zone
nodes Afferent lymph delivers DC and antigens and viruses to Subcapsular sinus macrophages capture
lymph node antigens for delivery to DC, for
activation of B and T lymphocytes
Medulla Activation of T and B cells Filter for mϕ which do not enter efferent
lymph
Gut Lamina propria mϕ Interaction microbiome, epithelium, innate (ILC2/3) and Active migration beneath epithelium of
acquired lymphocytes villi, sample the lumen
Modulation of inflammation and immune activation TGFbeta (F4/80, oral tolerance)
Submucosal mϕ Interactions with smooth muscle cells, myenteric and Peristalsis
autonomic nervous system
Peritoneal Large and small resident mϕ; elicited and Interactions B1 lymphocytes. Inflammation stimulates Prototypic in vivo inflammation model
+
cavity activated migration to draining lymph nodes and abdominal organs, Reservoir of mature GATA-6
such as liver, upon injury macrophages for repair
+
Liver Kupffer cells Sinusoidal, clearance, phagocytosis and receptor-mediated F4/80 , CR3 dim, Kupffer cell-specific
endocytosis, interactions with hepatocytes, acute phase CRIG and other lectins. Clearance
synthesis through contact and cytokines. Metabolism: iron, through CD206, SR-A, also by