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C019589-Unique Pathology
Shop No.26 Band Master Chouraha Sultaniya Road Nashema Apartment
Bhopal, 462001
MADHYA PRADESH, India
Tel : 9329432104; 7000058488
Email : alfishapathology@gmail.com
BIOCHEMISTRY
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C000000087-LIFELINE DIAGNOSTICS (Bhopal)
BIOCHEMISTRY
Specimen:
SERUM
INTERPRETATION:
Male 1.3-11.8
⦁ Circulating levels of follicle stimulating hormone vary throughout the menstrual cycle in response to estradiol and progesterone. A small but
significant increase in FSH accompanies the mid-cycle LH surge, while FSH declines in the luteal phase in response to estradiol and
progesterone production by the developing corpus luteum.
⦁ At menopause FSH and LH increase sufficiently in response to diminished feedback inhibition of gonadotropin release.
⦁ In males, FSH, LH and testosterone regulate spermatogenesis by sertoli cells in seminiferous tubules of the testis.
⦁ FSH may also be elevated in Klinefelter’s syndrome or as a consequence of sertoli cell failure
⦁ In females, situations in which FSH is elevated and gonadal steroids are depressed include - menopause, premature ovarian failure and
oophorectomy, in polycystic ovarian syndrome the LH/FSH ratio may be increased. Abnormal FSH concentrations may indicate dysfunction
of the hypothalamic-pituitary axis. In sexually mature adults, FSH deficiency together with low concentrations of LH and sex steroids may
indicate panhypopituitarism.
LIMITATIONS:
-Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may show either false positive
or depressed values.
LUTEINIZING HORMONE, SERUM
LUTEINIZING HORMONE 15.91 NORMALLY MENSTRUATING mIU/mL
FEMALES:
1.90 - 12.50 FOLLICULAR PHASE
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Specimen:
SERUM
Comment :
Human Luteinizing Hormone (LH) is a glycoprotein hormone secreted by the anterior pituitary gland. LH, FSH and other
steroid hormones play important role in regulating the ovulation and ovarian functions during the menstrual cycle.
Maturation of an ovarian follicle and its oocyte begins during the end of the preceding menstrual cycle. When FSH is
released by the pituitary gland, the ovarian follicle undergoes rapid increases. This rapid increase is generally believed to
trigger the rapid rise and peak of LH activity at mid-cycle, the LH surge. Ovulation begins twelve to twenty-four hours after
the LH surge. The wall of the enlarged follicle ruptures and the mature ovum is extruded. Within two days the LH
concentration returns to its baseline level. A concomitant rise in progesterone level initiates the luteal phase, which lasts
approximately fourteen days. During this time, if the mature ovum is not fertilized, a new follicle enters the maturation
route marking the beginning of the next menstrual cycle. In light of the characteristic fluctuation of LH levels during the
menstrual cycle, rapid and sensitive detection of LH is useful in the diagnosis and treatment of infertility and in the
detection of the LH surge to predict the time of ovulation. As the onset of the LH surge precedes ovulation by
approximately thirty hours, its determination has been used successfully to time oocyte retrieval for in vitro fertilization
and to assist in the timing of artificial insemination. INCREASED LEVELS are seen in Luteal phase of menstrual cycle,
Primary hypogonadism, Gonadotropin secreting pituitary tumours, Menopause. DECREASED LEVELS are seen in
Hypothalamic gonadotropin releasing hormone deficiency, Pituitary LH deficiency, Ectopic steroid hormone production,
Gonadotropin releasing hormone analog treatment.
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