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    Logcpvst: 0.8 1 F (X) 0.07 X + 0.93 R 1 Log CP Linear (Log CP)

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    Anonymous xh1gDv3PA9
    This document contains information about the pharmacokinetics of a drug with a dose of 300 mg administered to a 50 kg patient. It includes: 1) Calculations of the drug's volume of distribution (Vd = 34.9 L), elimination rate constant (k = 0.1704/hr), and half-life (t1/2 = 4.066 hrs). 2) Determination that it will take 8.555 hrs for the drug concentration to reach 2 mg/ml. 3) Calculation that it will take 40.53 hrs for the drug concentration to reach 0.1% of the initial concentration. 4) Prediction that if the dose is doubled to

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    Logcpvst: 0.8 1 F (X) 0.07 X + 0.93 R 1 Log CP Linear (Log CP)

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    Anonymous xh1gDv3PA9
    9 views2 pages
    This document contains information about the pharmacokinetics of a drug with a dose of 300 mg administered to a 50 kg patient. It includes: 1) Calculations of the drug's volume of distribution (Vd = 34.9 L), elimination rate constant (k = 0.1704/hr), and half-life (t1/2 = 4.066 hrs). 2) Determination that it will take 8.555 hrs for the drug concentration to reach 2 mg/ml. 3) Calculation that it will take 40.53 hrs for the drug concentration to reach 0.1% of the initial concentration. 4) Prediction that if the dose is doubled to

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    5. NofritaMarli-1801028.xlsx

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    This document contains information about the pharmacokinetics of a drug with a dose of 300 mg administered to a 50 kg patient. It includes: 1) Calculations of the drug's volume of distribution (Vd = 34.9 L), elimination rate constant (k = 0.1704/hr), and half-life (t1/2 = 4.066 hrs). 2) Determination that it will take 8.555 hrs for the drug concentration to reach 2 mg/ml. 3) Calculation that it will take 40.53 hrs for the drug concentration to reach 0.1% of the initial concentration. 4) Prediction that if the dose is doubled to

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    9 views2 pages

    Logcpvst: 0.8 1 F (X) 0.07 X + 0.93 R 1 Log CP Linear (Log CP)

    Uploaded by

    Anonymous xh1gDv3PA9
    This document contains information about the pharmacokinetics of a drug with a dose of 300 mg administered to a 50 kg patient. It includes: 1) Calculations of the drug's volume of distribution (Vd = 34.9 L), elimination rate constant (k = 0.1704/hr), and half-life (t1/2 = 4.066 hrs). 2) Determination that it will take 8.555 hrs for the drug concentration to reach 2 mg/ml. 3) Calculation that it will take 40.53 hrs for the drug concentration to reach 0.1% of the initial concentration. 4) Prediction that if the dose is doubled to

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    of 2

    5.

    t (jam) Cp t (jam) Log cp


    0,25 8,21 0,25 0,914343
    0,5 7,87 0,5 0,895975
    1 7,23 1 0,859138
    3 5,15 3 0,711807
    6 3,09 6 0,489958
    12 1,11 12 0,045323
    18 0,4 18 -0,39794

    Log cp vs t
    1
    0.8 f(x) = − 0.07 x + 0.93
    R² = 1
    0.6
    Log cp
    0.4 Linear (Log cp)
    0.2
    0
    -0.2 0 2 4 6 8 10 12 14 16 18 20
    -0.4
    -0.6

    Pers Regresi y = -0,074x + 0,9332, R² = 1

    Diketahui:

    BB = 50 kg

    Dosis tunggal =6 mg/kg

    Dosis = 6 mg/kg x 50 kg = 300 mg

    Cp0 = antilog 0,9332 = 8,574 mg/L

    a. Nilai Vd,K, dan t1/2


    - Vd = Dosis/Cp = 300 mg/ 8,574 mg/L = 34,9 liter
    - Slop = -k/2,303
    K = 0,074 x 2,303 = 0,1704/jam
    - T1/2 = 0,693 / 0,1704 = 4,066 jam

    b. Berapa lama kerja obat? Cp = 2 mg/ml


    Log Cp = -kt/2,303 + log Cp0
    Log 2 = -0,1704t /2,303 + log 8,574
    0,3 = -0,1704t /2,303 + 0,933
    0,1704t/2,303 = 0,633
    t =8,555 jam

    c. Berapa lama untuk sampai 99,9%?


    Sisa = 100-99,9 = 0,1 %
    Cp = 1/100 x 8,574 = 0,008574 mcg/ml
    Log Cp = -kt/2,303 + log Cp0
    Log 0,008574 = -0,1704t/2,303 + log 8,574
    -2,0668 = -0,1704t/2,303 + 0,933
    2,999 = 0,1704t/2,303
    t = 40,53 jam

    d. Jika dosis di 2x
    Dosis = 2 x 8,574 = 17,148 mcg/ml
    Log Cp = -kt/2,303 + log Cp0
    Log 2 = -0,1704t /2,303 + log17,148
    0,3 = -0,1704t /2,303 + 1,234
    0,934 = 0,1704t /2,303
    t = 12,623 jam

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