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Biopharmaceutics
Biopharmaceutics
B 163. These are compounds whose pharmacological action results primarily from their chemical reaction:
a. structural nonspecific drugs b. structural specific drugs c. both a & b d. none of the above
B 164. The following are the common drug metabolism reactions, except:
a. oxidation b. carboxylation c. reduction d. conjugation
A 165. A drug which possesses affinity and intrinsic activity:
a. agonist b. toxins c. antagonist d. none of the above
C 166. The application of pharmacokinetic principles in the safe and effective treatment of individual patients, and in the optimization of
drug therapy:
a. clinical pharmacy c. clinical pharmacokinetics
b. clinical pharmacology d. clinical biopharmaceutics
C 167. A term defined as the combination of a drug molecule with a receptor:
a. antagonism b. intrinsic activity c. affinity d. none of the above
B 168. Dose dumping is defined as:
a. an intended sudden release of large amounts of drugs into systemic circulation
b. an unintended sudden release of large amounts of drugs into systemic circulation
c. slow release of the drug into the systemic circulation
d. slow absorption of the drug into the systemic circulation
A 169. Which of the following properties of surfactants tend to increase the rate of dissolution:
a. surface tension lowering effect
b. production of micelles with the parent drug
c. absence of peptizing action
d. all of the above
C 170. Cholekinesis is a process which involves the:
a. formation of bile in the liver
b. formation of bile in the gall bladder
c. emptying of bile from the gall bladder
d. emptying of bile from the liver
A 171. It deals with physical and chemical properties of the drug substance, the dosage form and drug product upon administration:
a. biopharmaceutics b. pharmacokinetics c. both a & b d. none of the above
A 172. A transport of absorption that does not proceed against a concentration gradient:
a. facilitated transport b. active transport c. ion-pair transportd. none of the above
B 173. Antagonist has high affinity but low intrinsic activity;
a. chemical antagonism c. competitive antagonism
b. partial antagonism d. all of the above
D 174. The pharmacologic action of structurally nonspecific drugs depend directly on:
a. chemical structure c. presence of a functional group
b. physical properties of the drug d. a & c
D 175. A theory which advances the idea that maximum pharmacologic effect can be obtained if all the receptors are occupied:
a. hypothesis of Paton c. lock & key hypothesis
b. hypothesis of Ariens & Stephenson d. hypothesis of Clark
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D 176. The following mechanisms of absorption require the presence of drug in aqueous solution except:
a. passive diffusion b. convective transport c. facilitated transport d. pinocytosis
D 177. Gastric emptying is slowed by all of the following except,
a. vigorous exercise b. fatty foods c. hot meals d. hunger
D 178. A relative bioavailability study is necessary when there is:
a. change in the ionic form of the drug b. change in the method of manufacture
c. change in the means of preservation d. all of them
D 179. Absorption is not involved when a drug is administered by which of the following routes:
a. intravenous b. intra-arterial c. intraspinal d. all of the above
B 180. In organs and tissues that are well perfused:
a. distribution is slower b. distribution is faster c. distribution rate is negligible
A 181. If drug A is more lipophilic than drug B, then:
a. drug A will be better distributed than drug B
b. drug B will be better distributed than drug A
c. distribution of drug B is equal to that of drug A
d. b & c
A 182. A phenomenon that occurs when drugs filtered through the glomeruli are reabsorbed from the tubuli into the systemic circulation:
a. urinary recycling b. biliary recycling c. reabsorption d. a & b
A 183. Drugs that are absorbed in the GIT are generally:
a. absorbed into the portal circulation
b. filtered from the blood by the kidney, then reabsorbed into the general circulation
c. not affected by the liver enzymes
d. stored in the liver
A 184. The volume of distribution of a drug is:
a. a mathematical relationship between the total amount of drug in the body and the concentration of drug in the blood
b. a measure of an individual’s blood volume
c. an expression of total body volume
d. a measure of the individual’s fluid volume
D 185. In ophthalmic administration, the permeability of the drug onto the cornea depends on:
a. aqueous solubility of the drug b. Lipid solubility c. rate of permeability d. a and b
A 186. C max is the peak drug concentration in the:
a. plasma b. urine c. muscle d. bile
D 187. Compartments of body water include:
a. vascular fluid b. extracellular fluid c. salivary fluid d. a and b
D 188. Types of carrier mediated transport
a. active mechanism b. facilitated diffusion c. passive mechanism d. a and b
D 189. Characteristic of aerosol particles to absorbed is:
a. impact on the alveolar sac c. dissolves in the stomach fluid
b. dissolve sin the lung fields d. a and b
A 190. Which body muscle causes more rapid absorption when given as intramuscular injection?
a. adeltoid b. gluteal c. intravenous d. a and b
A 191. In percutaneous administration, absorption of the drug is delayed due to:
a. presence of horny layer in the skin c. presence of oil in the skin
b. thickness of the skin d. a and b
B 192. In general, the form of the dryg that can be absorbed faster is
a. ionized b., unionized c. bound form d. a and c
D 193. When can absorption of a drug be slower than its elimination?
a. when drugs are rapidly metabolized and excreted b. when drugs are poorly soluble in water
c. when drugs are soluble in fats and oils d. a and b
A 195. The peak of the serum concentration vs time curve approximates the :
a. point when the maximum pharmacologic effect occurs b. point when absorption and elimination of the drug equalize
c. maximum concentration of the drug in the urine d. point when the drug begins to be metabolized
A 196. The primary proof of the drugs’ availability is the:
a. production of its pharmacologic effect b. production of high levels in the blood
c. production of high urine levels d. appearance of metabolite in the blood
C 197. Drug products can also be evaluated by comparing curves of serum concentration vs time (blood level curve). The most important
parameters for comparing that can be obtained from such curves are:
a. peak concentration, biologic concn, t1/2, elimination rate constant
b. biologic half time, peak concentration, total AUC
c. peak concn, peak time, total AUC
d. average serum concn, AUC, absorption rate constant
B 198. Two diff oral formulations of the same drug having equal areas under their respective serum concn time curve:
a. deliver the same total amount of drug to the body and are therefore bioequivalent
b. deliver the same total amount of drug to the body but are not necessarily bioequivalent
c. are bioequivalent by definition
d. are bioequivalent if they meet USP standards
D 199. The area under the serum concentration time curve represents:
a. biologic half life of the drug b. amt of drug that is cleared by the kidney
c. amt of drug in the orig form d. amt of drug absorbed
B 200. The intensity of the pharmacologic action of the drug is most dependent upon the:
a. concentration of the drug at the receptor area
b. onset time of the drug at the receptor area
c. minimum toxic drug concentration (MTC) in the plasma
B 201. Drug concentration in systemic circulation rises to a peak followed by a steep fall:
a. open one compartment IV b. open one compartment EV
c. open two compartment IV d. open two compartment EV
D 202. Which of the ff refers to the intensity of pharmacologic response?
a. C max b. T max c. AUC d. MEC
D 203. A disadvantage of inert diluents for powders as a s dosage form is:
a. adsorbs onto the active drug substance b. high cost
c. drugs may not be released immediately d. a and c
D 204. A test to evaluate dosage forms:
a. chemical content b. content uniformity c. moisture content d. a and b
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Drug A
Drug B
Drug C