Perinatal Infections

Antenatal Care

With Veronica Gillispie, MD, FACOG

Eniii Enii, ritusing20062000@gmail.com

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 Perinatal Infections – TORCHeS

Toxoplasmosis

Others

Rubella

CMV

Herpes, HIV

Syphilis

Eniii Enii, ritusing20062000@gmail.com

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 Toxoplasmosis

Transmission Diagnosis Affect on fetus Treatment High-yield

• Cat feces • Serologic • Chorioretinitis, • Pyrimethamine

hydrocephalus (Daraprim) and
sulfadiazine

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 Others – Varicella

brownpau, Shingles Lesions (Varicella Zoster, Trigeminal/Mandibular), cropped, CC BY 2.0, flickr

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 Others – Varicella

Transmission Diagnosis Affect on fetus Treatment High-yield

• Respiratory • Serologic • Chorioretinitis, • None

encephalitis,
muscle atrophy

Eniii Enii, ritusing20062000@gmail.com

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 Hepatitis B

Transmission Diagnosis Effect on fetus Treatment High-yield

• Parenteral • HBsAg • Increased risk • Hepatitis B

for progressing immunoglobulin
• Sexual to chronic hepa- and vaccination
titis (80 %) of neonate after
delivery

Eniii Enii, ritusing20062000@gmail.com

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 Hepatitis B

Transmission Diagnosis Effect on fetus Treatment High-yield

• Parenteral • HBsAg • Increased risk • Cesarean

for progressing delivery ONLY
• Sexual to chronic hepa- for obstetric
titis (80 %) complications

• Breastfeeding
allowed

Eniii Enii, ritusing20062000@gmail.com

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 Hepatitis C

Transmission Diagnosis Effect on fetus Treatment

High-yield
• Parenteral • Screening not • Increased risk • Cesarean
routinely for progressing delivery ONLY
• Sexual recommended to chronic for obstetric
hepatitis complications
• When suspected:
HCV antibody, • Breastfeeding
followed by HCV allowed
nucleic acid testing

Eniii Enii, ritusing20062000@gmail.com

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 Group B β Hemolytic Streptococcus

Transmission Diagnosis Effect on fetus Treatment High-yield

• During delivery • Vaginal and rectal • Pneumonia, • Intrapartum

after passing cultures routinely sepsis, antibiotic
through obtained at 35–37 meningitis prophylaxis with
colonized weeks gestation iv penicillin G
genital tract

Eniii Enii, ritusing20062000@gmail.com

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 Rubella

CDC, ID#: 712, PD

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 Rubella

The Armed Forces Institute of Pathology, PD

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 Rubella

Transmission Diagnosis Affect on fetus Treatment High-yield

• Cough or • Serologic • Congenital • No treatment

sneeze hearing loss, available during
cataracts, pregnancy
“blueberry
muffin” rash

Eniii Enii, ritusing20062000@gmail.com

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 CMV

Transmission Diagnosis Affect on fetus Treatment High-yield

• Body fluids, • PCR of amniotic • Congenital • No treatment

such as urine, fluid hearing loss, available during
saliva, blood, vision loss, pregnancy
tears, semen, seizures
and breast milk

Eniii Enii, ritusing20062000@gmail.com

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 Herpes Simplex Virus

CDC/ Donated by Dr. N.J. Fiumara; New Zealand, Genital herpes, https://phil.cdc.gov/phil/details.asp, #15138
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 Herpes Simplex Virus

Transmission Diagnosis Affect on fetus Treatment High-yield

• Sexual • Serologic • Life-threatening • Antivirals

transmission via CNS or death
body fluids

Eniii Enii, ritusing20062000@gmail.com

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 HIV

Transmission Diagnosis Affect on fetus Treatment High-yield

• Via contact • ELISA, Western • None • HAART

through body blot
fluids

Eniii Enii, ritusing20062000@gmail.com

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 Syphilis

Herbert L. Fred, MD, and Hendrik A. van Dijk, https://commons.wikimedia.org/wiki/File:2ndsyphil2.jpg, CC BY 2.0

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 Syphilis

Transmission Diagnosis Affect on fetus Treatment High-yield

• Sexual contact • Screening: • Hepatomegaly, • Penicillin

RPR/VDRL CNS
abnormalities,
• Confirmation: saddle nose,
FT-Abs or dark- Hutchinson's
field microscopy and FTA-ABS

Eniii Enii, ritusing20062000@gmail.com

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 List of References

• Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment
Guidelines, 2015. MMWR Recomm Rep 2015;64(No. RR-3): 1-137.

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