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Adrenergic Drugs: S. Parasuraman, M.Pharm., PH.D.
Adrenergic Drugs: S. Parasuraman, M.Pharm., PH.D.
Adrenergic Drugs: S. Parasuraman, M.Pharm., PH.D.
• Heart:
– Adrenaline (Adr) increases heart rate by increasing the
slope of slow diastolic depolarization of cells in the SA
node.
– Adr also increase the force of contraction and reduce
refractory period (RP) of all types of cardiac cells
acting through β1 receptor.
– In higher dose Adr produce arrhythmias and increases
blood pressure (BP).
• Blood vessels:
– Adrenergic drug produces both vasoconstriction
(mediated through α) and, vasodilatation
(mediated through β2) and these effect depends
on drug and its dose.
– The direct effect of Adr/ NA on cerebral vessels is
not prominent.
Overall actions of Adrenaline and
Noradrenaline
• Blood pressure:
– The effect is depends on the amine, its dose and
rate of administration.
– NA causes rise in systolic, diastolic and mean
blood pressure and it dose not cause vasodilation.
• NA: more specific to alpha ARs than beta ARs
• Adr: alpha ARs and beta ARs equal action
• Isoprenaline: More specific to beta ARs than
alpha ARs
Norepinephrine • Heart Rate - Decreases due to reflex increase in
vagal tone on SA and AV nodes.
• Contractile Force - Increases due to effects on beta1-ARs
on myocardial cells.
• Total Peripheral Vascular Resistance - Increases due to
activation of alpha1-ARs on vascular smooth muscle cells.
• Blood Pressure - Increases due to effects on total
peripheral vascular resistance
Isoproterenol • Heart rate - increases due to activation of beta1 receptors
in SA and AV nodes.
• Contractile force - increases due to activation of beta 1
receptors on myocardial cells.
• Total peripheral vascular resistance - decreases due to
activation of beta 2 receptors.
• Blood pressure = cardiac output x total peripheral vascular
resistance
Low dose of • Heart Rate - Increases due to beta1-ARs on SA and AV
Epinephrine nodal tissues
• Contractile Force - Increases due to activation of beta1-
ARs on myocardial cells
• Total Peripheral Vascular Resistance - Decreases due to
preferential activation of beta2-ARs, at these doses there
would be little activation of alpha1-ARs
• Blood Pressure - Similar to isoproterenol
High dose of • Heart Rate - Similar to the effects of norepinepherine
Epinephrine • Contractile Force - Increases due to beta1-ARs on
myocardial cells
• Total Peripheral Vascular Resistance - Increases due to
activation of alpha1-ARs on vascular smooth muscle cells.
• Blood Pressure - Increases due to activation of alpha1-
ARs on vascular smooth muscle cells
Overall actions of Adrenaline and
Noradrenaline
• Respiration:
– Adr and isoprenaline are potent bronchodilators
(β2) but not NA.
– In therapeutic dose Adr can directly stimulate
respiratory centre (RC) and in toxic dose it causes
pulmonary edema by shifting blood from systemic
to pulmonary circuit.
• Eye:
– Mydriasis occurs due to contraction of radial
muscles of iris (α1). Adr has complex effects on
aqueous humor dynamics.