ER/PR+ HER2-

BREAST CANCER
Carissa Trapp
ER+ Defined
•Stands for Estrogen Receptor Positive
•Binds to the hormone estrogen.
•This cancer type needs estrogen to grow
•Treated with drugs that down regulate estrogen receptors.
PR+ Defined
•Stands for Progesterone Receptor Positive
•Binds to hormone progesterone.
•Cancer cells need progesterone to grow.
•Treated with hormones that block progesterone from binding.
HER2- Defined

•Stands for Human Epidermal Growth Factor Receptor 2

•Helps to control cell growth in normal cells.
•Cancer cells without the receptor are slow growing.
•Less likely to recur or metastasize.
Additional Facts of ER/PR+ HER2- Breast Cancer

• Cancer biologists theorize that breast cancer cells progress through

stages as they develop into tumor cells.
• ER/PR+ HER2- is the majority subtype of breast cancer for all
race/ethnicities except for African Americans.
• 3-year survival rate is 93.3% for patients with stage 1 and 2 ER/PR+
HER2- breast cancer.
• Higher percent of patients are tumor grades 1 and 2.
• Both men and women can develop breast cancer.
• Death rates for breast cancer patients have been decreasing since
the 1990s.
• The 5-year survival rate for patients with metastatic breast cancer is
27%.
Disease Development
•Develops when a mutation in the cell growth factors causes the cell to
reproduce uncontrollably.
•Contact Inhibition
•Glycoproteins of the normal cell determine the breast cancer subtype
of the mutated cells.
Affected Organs
•Breasts are the primary organs affected.
•Ductal Carcinoma
•Lobular Carcinoma
•Sarcoma

•90% occur in the epithelial cells that line the inside of the ducts.
Metastases
•Lymph Nodes
•Skeleton
•Lung
•Brain
Symptoms
•Mass in breast
•Bloody discharge from nipple
•Changes in shape of nipple and/or breast
•Redness or swollen lymph nodes
Early Detection
•Mammogram
•Self exams
•Know what is normal
•Medical exams
Causes and Risk Factors
•Mutated BRCA gene
•Gender
•Age
•Exposure to estrogen/progesterone
•Previous radiation to the chest
•Smoking
•Diet
•Alcohol consumption
•Activity Level
•Contraceptive use
Treatment Options
•Surgical Removal
•Margins
•Chemotherapy
•Radiation
•Natural Cures
ER/PR+, HER2- Breast Cancer
References
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Khalid, A. B., Krum, S. A. (2016). Estrogen Receptors Alpha and Beta in Bone. Bone, volume 87, pages
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Life Number Two. (n.d.). Retrieved October 21, 2019, from

https://www.promega.com/resources/pubhub/inspiration/life-number-two/

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Onitilo, A. A., Engel, J. M., Greenlee, R. T., Mukesh, B. N. (2009). Breast Cancer Subtypes Based on ER/PR
and HER2 Expression. Comparison of Clinicopathologic Features and Survival. Clinical Medicine and
Research, volume 7(1-2), pages 4-13. https://ncbi.nlm.nih.gov/pmc/articles/PMC2705275/
References Continued
Parise, C. A., Caggiano, V. (2014). Breast Cancer Survival Defined by the ER/PR/HER2 Subtypes and a
Surrogate Classification according to Tumor Grade and Immunohistochemical Biomarkers. Journal of
Cancer Epidemiology. 2014(469251), 1-11. https://doi.org/10.1155/2014/469251/

Torre, L. A., Siegel, R. L., Ward, E. M., & Jemal, A. (2016). Global Cancer Incidence and Mortality Rates
and Trends. Cancer Epidemiology, Biomarkers, & Prevention, volume 25(1), pages 16-27.

Shareef, M., Ashraf, M. A., & Sarfraz, M. (2016). Natural Cures for Breast Cancer Treatment. Saudi
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What Your Breast Cancer Type Means. (2019, July 9). Retrieved October 21, 2019, from
https://www.mayoclinic.org/diseases-conditions/breast-cancer/in-depth/breast-cancer/art-20045654/