Ineos 1-Ethoxy-2-Propanol

SAFETY DATA SHEET
Based on Regulation (EC) No. 453/2010
1-ethoxy-2-propanol
1. Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier:
Product name : 1-ethoxy-2-propanol
Synonyms : 1-ethoxypropan-2-ol
2-propanol, 1-ethoxy-
1-ethoxy-2-propanol
alpha-propylene glycol 1-ethyl ether
EP
PGEE
REACH Registration number : 01-2119462792-32-0000
Product type REACH : Substance/mono-constituent (Organic)
CAS number : 1569-02-4
EC index number : 603-177-00-8
EC number : 216-374-5
RTECS number : UB5250000
Molecular mass : 104.15 g/mol
Formula : C5H12O2
1.2 Relevant identified uses of the substance or mixture and uses advised against:
1.2.1 Relevant identified uses
Exposure scenario title Exposure Sector of Use descriptors (PROC or PC) Use
scenario use descriptors
group (ERC)
: Consumer use in coatings (water-based) Consumer PC 9a ERC 8a
Consumer PC 9a ERC 8d
: Industrial use in coatings (solvent-based) Industrial PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 4
5, PROC 8a, PROC 9, PROC 15
ES1: Manufacture of substance Industrial SU 8 PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 1
8a, PROC 8b, PROC 15
Industrial SU 9 PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 1
ES2: Use as an intermediate Industrial SU 8 PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 6a
Industrial SU 9 PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 6a
ES3: Formulation & (re)packing of substances and mixtures Industrial SU 10 PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 2
5, PROC 8a, PROC 8b, PROC 9, PROC 15
ES5: Industrial use in coatings (water-based) Industrial PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 4
5, PROC 7, PROC 8a, PROC 8b, PROC 9,
PROC 10, PROC 13, PROC 14, PROC 15
ES6: Professional use in coatings (solvent-based) Industrial PROC 8a, PROC 8b, PROC 10, PROC 11, ERC 8a
PROC 13, PROC 15, PROC 19
Industrial PROC 1, PROC 2, PROC 2, PROC 4, PROC ERC 8b
5, PROC 8a, PROC 8b, PROC 10, PROC
11, PROC 13, PROC 15, PROC 19
Professional PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 8a
5
ES7: Professional use in coatings (water-based) Industrial PROC 9, PROC 11, PROC 13, PROC 15 ERC 8b
Professional PROC 1, PROC 15, PROC 3, PROC 4, ERC 8a
PROC 5, PROC 8a, PROC 8b, PROC 9,
PROC 11, PROC 13, PROC 15, PROC 19
Professional PROC 1, PROC 2, PROC 3, PROC 4, PROC ERC 8b
5, PROC 8a, PROC 8b, PROC 19
ES9: Consumer use in coatings (solvent-based) Consumer PC 9a, PC 18 ERC 8a
Consumer PC 9a, PC 18 ERC 8d
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Revision number: 0105 Project number:

Date of revision: 2010-11-29 Publication date: 2006-02-16
Reason for revision: REACH/CLP Product number: 50439
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1-ethoxy-2-propanol
Exposure scenario title Exposure Sector of Use descriptors (PROC or PC) Article (AC)
scenario use
group
1.2.2 Uses advised against
Group Uses advised against Use descriptors Use

descriptors
(ERC)
Consumer No uses advised against
Industrial No uses advised against
Professional No uses advised against
Group Uses advised against Use descriptors Article (AC)

Consumer No uses advised against
Industrial No uses advised against
Professional No uses advised against
1.3 Details of the supplier of the safety data sheet:

Supplier of the SDS
INEOS N.V.
Haven 1053 - Nieuwe Weg 1
B-2070 Zwijndrecht
Tel: +32 3 250 91 11
Fax: +32 3 252 84 33
info@ineos.com
Producer of the product

INEOS N.V.
Haven 1053 - Nieuwe Weg 1
B-2070 Zwijndrecht
Tel: +32 3 250 91 11
Fax: +32 3 252 84 33
info@ineos.com
1.4 Emergency telephone number:
24h/24h: +32 14 58 45 45 (BIG)
2. Hazards identification
2.1 Classification of the substance or mixture:
2.1.1 Classification according to Regulation EC No 1272/2008
Class Category Hazard statement code(s)
Flam. Liq. category 3 H226: Flammable liquid and vapour.
STOT SE category 3 H336: May cause drowsiness or dizziness.
Eye Irrit. category 2 H319: Causes serious eye irritation.
2.1.2 Classification according to Directive 67/548/EEC-1999/45/EC

R10 - Flammable.
R67 - Vapours may cause drowsiness and dizziness.
2.2 Label elements:

CLP
Classification and labelling according to Regulation (EC) No 1272/2008 – Annex VI and after adaptation according to 1.2
Hazard pictograms
Signal word Warning

H-statements
H226 Flammable liquid and vapour.
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1-ethoxy-2-propanol
H336 May cause drowsiness or dizziness.
H319 Causes serious eye irritation.
P-statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves and eye protection/face protection.
P261 Avoid breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P306 + P360 IF ON CLOTHING: rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
DSD/DPD
Labelling in accordance with 29th adaptation of EC directive 67/548/EEC
R-phrases
10 Flammable
67 Vapours may cause drowsiness and dizziness
S-phrases
(02) (Keep out of the reach of children)
24 Avoid contact with skin
2.3 Other hazards:
3. Composition/information on ingredients
3.1 Substances:
Classification
CAS No Classification according
Name ( REACH Registration No ) Conc. according to DSD/ Note Remark
EC-No to CLP
DPD
1-ethoxypropan-2-ol ( 01-2119462792-32 ) 1569-02-4 100 % R10 Flam. Liq. 3; H226 (1)(2) Mono-constituent
216-374-5 R67 STOT SE 3; H336
Eye Irrit. 2; H319
(1) For R-phrases and H-statements in full: see heading 16
(2) Substance with a Community workplace exposure limit
3.2 Mixtures:
4. First aid measures
4.1 Description of first aid measures:
General:
Check the vital functions. Unconscious: maintain adequate airway and respiration. Respiratory arrest: artificial respiration or oxygen. Cardiac
arrest: perform resuscitation. Victim conscious with laboured breathing: half-seated. Victim in shock: on his back with legs slightly raised.
Vomiting: prevent asphyxia/aspiration pneumonia. Prevent cooling by covering the victim (no warming up). Keep watching the victim. Give
psychological aid. Keep the victim calm, avoid physical strain. Depending on the victim's condition: doctor/hospital.
After inhalation:
Remove the victim into fresh air. Respiratory problems: consult a doctor/medical service.
After skin contact:
Rinse with water. Soap may be used. Take victim to a doctor if irritation persists.
After eye contact:
Rinse immediately with plenty of water. Do not apply neutralizing agents. Take victim to an ophthalmologist if irritation persists.
After ingestion:
Rinse mouth with water. Do not induce vomiting. Consult a doctor/medical service if you feel unwell.
4.2 Most important symptoms and effects, both acute and delayed:
4.2.1 Acute symptoms
If applicable and available it will be listed below.
After inhalation:
EXPOSURE TO HIGH CONCENTRATIONS:. Irritation of the respiratory tract. Irritation of the nasal mucous membranes. Central nervous system
depression. Dizziness. Headache. Narcosis. Coordination disorders. Disturbances of consciousness.
After skin contact:
Slight irritation.
After eye contact:
Irritation of the eye tissue.
After ingestion:
Nausea.
4.2.2 Delayed symptoms
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.
4.3 Indication of any immediate medical attention and special treatment needed:
.
5. Firefighting measures
5.1 Extinguishing media:
5.1.1 Suitable extinguishing media:
Carbon dioxide. Sand/earth. Water spray. Alcohol-resistant foam. BC powder.
5.1.2 Unsuitable extinguishing media:
Solid water jet ineffective as extinguishing medium.
5.2 Special hazards arising from the substance or mixture:

Upon combustion CO and CO2 are formed.
5.3 Advice for firefighters:

5.3.1 Instructions:
Cool tanks/drums with water spray/remove them into safety. Do not move the load if exposed to heat.
5.3.2 Special protective equipment for fire-fighters:
Heat/fire exposure: compressed air/oxygen apparatus. Gloves. Protective goggles. Protective clothing. Large spills/in enclosed spaces:
compressed air apparatus.
6. Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures:
6.1.1 For non-emergency personnel
See heading 8.2
6.1.2 For emergency responders
General
Gloves
Protective goggles
Protective clothing
Large spills/in enclosed spaces: compressed air apparatus
Suitable protective clothing
butyl rubber
Unsuitable protective clothing
nitrile rubber
6.2 Environmental precautions:

Contain released substance, pump into suitable containers. Plug the leak, cut off the supply. Dam up the liquid spill. Try to reduce evaporation.
Prevent spreading in sewers.
6.3 Methods and material for containment and cleaning up:

Take up liquid spill into inert absorbent material, e.g.: dry sand/earth. Scoop absorbed substance into closing containers. Spill must not return in its
original container. Carefully collect the spill/leftovers. Damaged/cooled tanks must be emptied. Do not use compressed air for pumping over spills.
Take collected spill to manufacturer/competent authority. Clean contaminated surfaces with an excess of water. Wash clothing and equipment after
handling.
6.4 Reference to other sections:

See heading 13.
7. Handling and storage
The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the relevant
exposure scenarios that correspond to your identified use.
7.1 Precautions for safe handling:

Use spark-/explosionproof appliances and lighting system. Take precautions against electrostatic charges. Keep away from naked flames/heat. Keep
away from ignition sources/sparks. Observe normal hygiene standards. Keep container tightly closed. Do not discharge the waste into the drain.
7.2 Conditions for safe storage, including any incompatibilities:

7.2.1 Safe storage requirements:
35 °C. Store in a dry area. Ventilation at floor level. Fireproof storeroom. Provide for a tub to collect spills. Provide the tank with earthing.
Aboveground. Store at ambient temperature. Keep out of direct sunlight. Meet the legal requirements.
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7.2.2 Keep away from:
Combustible materials, oxidizing agents, (strong) acids, (strong) bases, water/moisture.
7.2.3 Suitable packaging material:
Steel, stainless steel, glass.
7.2.4 Non suitable packaging material:
Aluminium, copper, synthetic material.
7.3 Specific end use(s):

If applicable and available, exposure scenarios are attached in annex. See information supplied by the manufacturer .
8. Exposure controls/personal protection
8.1 Control parameters:
8.1.1 Occupational exposure
If limit values are applicable and available these will be listed below.
a) Occupational exposure limit values
TRGS 900 (Germany)

1-Ethoxypropan-2-ol Time-weighted average 220 mg/m³
exposure limit 50 ppm
b) National biological limit values
8.1.2 Sampling methods
Product name Test Number Remarks Sampling method
No data available
8.1.3 Applicable limit values when using the substance or mixture as intended
8.1.4 DNEL/PNEC values
Acute: systemic/local effects workers
Effect level (DNEL/DMEL) Type Value Remark
DNEL Acute systemic effects inhalation 317 mg/m³
Long-term systemic effects dermal 74 mg/kg bw/day
Long-term systemic effects inhalation 211 mg/m³
Acute: systemic/local effects general population
Effect level (DNEL/DMEL) Type Value Remark
DNEL Acute systemic effects inhalation 190 mg/m³
Long-term systemic effects dermal 44.3 mg/kg bw/day
Long-term systemic effects inhalation 127 mg/m³
Long term -systemic effects oral 14 mg/kg bw/day
PNEC
Compartments Value Remark
FRESH WATER 10 mg/l
MARINE WATER 1 mg/l
Fresh water sediment 37.6 mg/kg sediment dw
Marine water sediment 3.76 mg/kg sediment dw
SOIL 2.4 mg/kg soil dw
STP 1250 mg/l
8.1.5 Control banding
8.2 Exposure controls:

The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the
relevant exposure scenarios that correspond to your identified use.
8.2.1 Appropriate engineering controls
Observe normal hygiene standards
Keep container tightly closed
Do not eat, drink or smoke during work
Use spark-/explosionproof appliances and lighting system
Take precautions against electrostatic charges
Keep away from naked flames/heat
Keep away from ignition sources/sparks
8.2.2 Individual protection measures, such as personal protective equipment
a) Respiratory protection:
High gas/vapour concentration: gas mask with filter type A
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1-ethoxy-2-propanol
b) Hand protection:
Gloves
- materials for protective clothing (excellent resistance)
No data available
- materials for protective clothing (good resistance)
butyl rubber
- materials for protective clothing (less resistance)
natural rubber
PVC
- materials for protective clothing (poor resistance)
nitrile rubber
c) Eye protection:
Protective goggles
d) Skin protection:
Protective clothing
8.2.3 Environmental exposure controls:
See headings 6.2, 6.3 and 13
9. Physical and chemical properties
9.1 Information on basic physical and chemical properties:
Physical form Liquid
Odour Mild odour
Sweet odour
Odour threshold No data available
Colour Colourless
Particle size No data available
Flammability Combustible
Log Pow 0 Calculated
Dynamic viscosity 0.0022 Pa.s 20 °C
Melting point -70 °C
Boiling point 132 °C
Flash point CC 40 °C
Relative evaporation rate to ether No data available
Vapour pressure 10 hPa 25 °C
Relative vapour density 3.6
Solubility water Complete
Relative density 0.897 20 °C
Decomposition temperature No data available
Auto-ignition temperature 255 °C
Explosive properties no chemical group
associated with
explosive properties
Oxidising properties no chemical group
associated with
oxidising properties
pH No data available
Physical hazards
Flammable liquid
9.2 Other information:

Minimum ignition energy Not applicable
Surface tension 0.0057 N/m
10. Stability and reactivity
10.1 Reactivity:
May be ignited by sparks.
10.2 Chemical stability:

Unstable on exposure to air. Hygroscopic.
10.3 Possibility of hazardous reactions:

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1-ethoxy-2-propanol
Oxidizes slowly on exposure to air. Reacts with (strong) oxidizers: (increased) risk of fire/explosion. Decomposes on exposure to (strong) acids.
Prolonged storage: on exposure to air: peroxidation resulting in increased fire or explosion risk.
10.4 Conditions to avoid:

Use spark-/explosionproof appliances and lighting system. Take precautions against electrostatic charges. Keep away from naked flames/heat.
Keep away from ignition sources/sparks.
10.5 Incompatible materials:

Combustible materials, oxidizing agents, (strong) acids, (strong) bases, water/moisture.
10.6 Hazardous decomposition products:

Upon combustion CO and CO2 are formed.
11. Toxicological information
11.1 Information on toxicological effects:
11.1.1 Test results
- Toxicokinetics: summary
Basic toxicokinetics: General considerations related to the metabolism of glycol ethers are well documented (Casarett & Doull’s Toxicology, 2001;
ECETOC Technical Report). Glycol ethers follow two main oxidative pathways of metabolism, either via alcohol dehydrogenase (ADH) or the
microsomal CYP mixed function oxidase (MFO) (O-demethylation or O-dealkylation). The first pathway gives rise to the formation and excretion of
alkoxyacetic acids. The second mainly leads to the production and exhalation of carbon dioxide (CO2) via ethylene glycol (MEG) or propylene
glycol, which enter intermediary metabolism via the tricarboxylic acid (TCA) cycle. Glycol ethers may also be conjugated with glucuronide or
sulfate, but this is thought to occur mainly after saturation of the other metabolic pathways.
According to their pathways of metabolism, the glycol ethers may be divided into three groups:
- ethylene glycol mono- and di-alkyl ethers and their acetates;
- diethylene glycol mono- and di-alkyl ethers and their acetates;
- propylene glycol ethers.
Monoethylene glycol ethers bearing a primary OH-group (alkoxyethanols) are primary alcohols that are oxidised via ADH and aldehyde
dehydrogenase (ALDH) to their corresponding alkoxyacetic acids.
Monopropylene glycol mono-alkyl ethers with a primary OH function (n-alkoxypropanols) follow similar
pathways yielding alkoxypropionic acid. In addition to ADH-mediated oxidation of glycol ethers bearing a primary alcohol function, microsomal
oxidation (catalysed by CYP MFO: O-demethylation or O-dealkylation) may also occur, but this pathway has relatively lower capacity.
Monopropylene glycol mono-alkyl ethers etherified at the primary carbon (sec-alkoxypropanols) are secondary alcohols that cannot be
metabolised to alkoxypropionic acids. These compounds are either renally excreted after conjugation or, to some extent may form ketones that
may enter the intermediary metabolism via the TCA cycle and eventually expired as CO2. Monopropylene glycol mono-alkyl ethers etherified at
the
Glycol ether acetates are rapidly hydrolysed in vivo to the parent glycol ethers by plasma esterases; and are thus likely to exhibit the same
systemic toxicity profile as the parent glycol ether. The toxicity of the propylene glycol ethers with the alkoxy group at the primary position is
quite different from that of the ethylene glycol ethers, presumably because these propylene glycol ethers are not metabolised to their
corresponding alkoxypropionic acids. Miller et al (1984) reported remarkable differences in the toxicological properties of ethylene glycol
monomethyl ether (EGME, 2-methoxyethanol, a primary alcohol), and propylene glycol monomethyl ether (PGME, 1-methoxy-2-propanol, a
secondary alcohol). The differences in toxicity were attributed to differences in metabolism, characterized by EGME being primarily oxidized to
methoxyacetic acid, and PGME undergoing O-demethylation to form propylene glycol. In the case of propylene glycol methyl ether, developmental
effects have been reported when the primary position is occupied by a hydroxyl group.
There is no information available on the metabolism of ethoxypropoxypropanol (DPGEE) but the closely related substance
methoxypropoxypropanol (dipropylene glycol methyl ether – DPGME) has been studied and results from this can be extrapolated. In this case, the
metabolic routes for the main isomer (secondary/secondary) were followed (equivalent to 85% of the DPGEE composition). Three main metabolic
routes were identified for DPGME. Microsomal O-dealkylation is a significant route of biotransformation since dipropylene glycol (DPG) is observed
in the urine. This in turn is believed to enter into intermediate metabolism, as does PG. The second major route of biotransformation is hydrolysis
of the ether linkage to form s-PGME secondary propylene glycol methyl ether) and propylene glycol (PG). The metabolites seen are consistent with
the s-PGME formed metabolising as indicated by the study with s-PGME itself, that is primarily to PG. Rates of elimination of metabolites
Dermal absorption: Dermal Absorption is an important exposure route for glycol ethers. Dugard et al (1984) studied the absorption of eight glycol
ethers through human skin in vitro. 2-methoxyethanol was most readily absorbed (mean steady rate of 2.82 mg/cm2/hr), followed by 1-
methoxypropan-2-ol (1.17 mg/cm2/hr). There was a trend of reducing absorption rate with increasing molecular weight for monoethylene glycol
ethers (2-methoxyethanol, 2.82 mg/cm2/hr; 2-ethoxyethanol, 0.796 mg/cm2/hr; 2-butoxyethanol, 0.198 mg/cm2/hr). The rate of absorption of 2-
ethoxyethanol was similar to that of the parent acetate.
Sumner (1999) studied the blood pharmacokinetics of 1-methoxypropan-2-ol in male rats following a single 6- hour dermal exposure and
compared results to those obtained in a similar experiment of the parent acetate. The efficiency of dermal absorption for the parent acetate was
found to be approximately 30% of that for 1- methoxypropan-2-ol.
Dermal uptake studies of 1-methoxypropan-2-ol have also been conducted in human volunteers. Brooke et al (1998) exposed subjects at rest to
100 ppm 1-methoxypropan-2-ol vapour with and without fresh-air fed half masks to compare skin-only and whole-body exposure, respectively,
and measured uptake in blood, breath and urine samples. Dermal uptake was calculated to be 9.6 ± 6.5% based on breath samples, 8.0 ± 5.7%
based on blood samples, and 4.2 ± 1.7% based on urine samples. In a similar study, Devanthéry et al, 2002 measured total and conjugated 1-
methoxypropan-2-ol levels in urine, exhaled air, and blood of human volunteers exposed to 1-methoxypropan-2-ol vapour, with and without
respiratory protection, at levels up to 95 ppm for 6 hours. These investigators reported that 1-methoxypropan-2-ol was not detected in breath,
blood or urine following dermal-only exposure.
The following information is taken into account for any hazard / risk assessment: Based on relative molecular weight and physicochemical
properties the dermal uptake of ethoxypropanol would be less than that
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Acute toxicity
1-ethoxypropan-2-ol
Route of Parameter Method Value Exposure time Species Gender Value
exposure determination
Oral LD50 Equivalent or >2 ml/kg bw - Rat Male/female Experimental
similar to OECD value
401
Dermal LD50 Equivalent or >2000 mg/kg bw 24 h Rat Male/female Read-across
similar to OECD
402
Inhalation LC50 Equivalent or >9.59 mg/l/4h 4 h Rat Male/female Experimental
similar to OECD value
403
Corrosion/irritation
1-ethoxypropan-2-ol
Route of exposure Result Method Exposure time Time point Species Value determination
Eye Not irritating Equivalent or similar 24 h 24; 48; 72 hours Rabbit Experimental value
to OECD 405
Dermal Not irritating Equivalent or similar 4 h 24; 48 hours Rabbit Experimental value
to OECD 404
Respiratory or skin sensitisation
1-ethoxypropan-2-ol
Route of Result Method Exposure time Observation time Species Gender Value
Dermal Not sensitizing Equivalent or - 24; 48; 72 hours Guinea pig Male/female Read-across
similar to OECD
406
Specific target organ toxicity
1-ethoxypropan-2-ol
Route of Parameter Method Value Organ Effect Exposure time Species Gender Value
Oral NOAEL OECD 408 1000 mg/kg No effect 90 days Rat Male/ Read-across
bw/day female
Dermal NOAEL Equivalent 1838 mg/kg 90 days Rabbit Male Read-across
or similar bw/day
to OECD
411
Dermal LOAEL Equivalent 3676 mg/kg 90 days Rabbit Male Read-across
or similar bw/day
to OECD
411
Inhalation NOAEC Equivalent 1.266 mg/l Rat Male/ Experimental
or similar female value
to OECD
413
Mutagenicity (in vitro)
1-ethoxypropan-2-ol
Result Method Test substrate Effect Value determination
Negative OECD 471 Bacteria (S.typhimurium) Experimental value
Negative Equivalent or similar to OECD 476 Chinese hamster lung Experimental value
fibroblasts
Negative OECD 473 Human lymphocytes Experimental value
Mutagenicity (in vivo)
1-ethoxypropan-2-ol
Result Method Exposure time Testsubstrate Gender Organ Value determination
No data available
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Carcinogenicity
1-ethoxypropan-2-ol
No data available
Reproductive toxicity
1-ethoxypropan-2-ol
Parameter Method Value Exposure Species Gender Effect Organ Value
time determination
Effects on fertility NOAEL (P) OECD 471 300 ppm gestation Rat Male/ Read-across
weeks female
weeks
(daily, 5
days/week)
NOAEL (F1) OECD 471 1000 ppm gestation Rat Male/ Read-across
weeks female
(daily, 5
days/week)
NOAEL (F2) OECD 471 1000 ppm gestation Rat Male/ Read-across
weeks female
(daily, 5
days/week)
Developmental toxicity NOAEC OECD 414 >2000 day 6-15 Rat Male/ Experimental
ppm gestation female value
(6h)
Toxicity other effects
1-ethoxypropan-2-ol
No data available
Conclusion
Low acute toxicity by the oral route
Low acute toxicity by the dermal route
Low acute toxicity by the inhalation route
Not classified as irritating to the skin
Not classified as irritating to the eye
Not sensitizing for skin
No respiratory sensitization data available
Low sub-chronic toxicity by the oral route
Low sub-chronic toxicity by the dermal route
Low sub-chronic toxicity by inhalation route
No carcinogenicity data available
Not classified for mutagenic or genotoxic toxicity (negative result)
Not classified for reprotoxic or developmental toxicity
11.1.2 Other information
1-ethoxypropan-2-ol
No data available
12. Ecological information
12.1 Toxicity:
1-ethoxypropan-2-ol
Parameter Method Value Duration Species Test design Fresh/salt Value
water determination
Acute toxicity fish LC0 OECD 203 >200 mg/l 96 h BRACHYDANIO FLOW- FRESH WATER Read-across
RERIO THROUGH
SYSTEM
Acute toxicity fish LC50 DIN 38412-15 6812 mg/l 96 h LEUCISCUS STATIC SYSTEM FRESH WATER Experimental
IDUS value
Acute toxicity invertebrates EC50 OECD 202 180 mg/l 48 h DAPHNIA STATIC SYSTEM Read-across
MAGNA
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1-ethoxy-2-propanol
Acute toxicity invertebrates LC50 ESR-ES-15 21100 mg/l 48 h DAPHNIA STATIC SYSTEM FRESH WATER Experimental
(Environment MAGNA value
al Sciences
Research
test)
Acute toxicity invertebrates LC50 1929 mg/l 48 h DAPHNIA QSAR
MAGNA
Threshold limit algae EC50 OECD 201 >100 mg/l 72 h DESMODESMU STATIC SYSTEM FRESH WATER Experimental
S value
SUBSPICATUS
Threshold limit algae EC50 384 mg/l 96 h QSAR
Threshold limit algae NOEC OECD 201 384 mg/l 72 h DESMODESMU STATIC SYSTEM FRESH WATER Experimental
S value
SUBSPICATUS
Threshold limit algae NOEC 105 mg/l 96 h QSAR
Long-term toxicity fish NOEC Equivalent or >200 21 days ONCORHYNCH FLOW- FRESH WATER Read-across
similar to US MYKISS THROUGH
OECD 204 SYSTEM
Long-term toxicity aquatic NOEC Equivalent or >180 mg/l 21 days DAPHNIA Semi-static FRESH WATER Read-across
invertebrates similar to MAGNA
OECD 202
Toxicity aquatic micro- EC10 ISO 10712 4600 mg/l 16 h PSEUDOMONA Experimental
organisms Water quality S PUTIDA value
-
Pseudomona
s putida
growth
Conclusion
Not harmful to fishes (LC50(96h) >1000 mg/l)
Not harmful to invertebrates (Daphnia) (EC50 (48h) > 1000 mg/l)
Not harmful to algae
Not harmful to bacteria (EC50 >1000 mg/l)
12.2 Persistence and degradability:

Biodegradation water
Method Value Duration Value determination
OECD 301D: Closed Bottle Test 68 % 28 days Experimental value
OECD 301F: Manometric Respirometry Test 78 % 28 days Experimental value
Conclusion
Readily biodegradable in water
12.3 Bioaccumulative potential:

BCF fishes
No data available
BCF other aquatic organisms
No data available
Log Pow
Method Value Temperature Value
determination
0 20 °C Calculated
Conclusion
Low potential for bioaccumulation (Log Kow <=3)
12.4 Mobility in soil:

Log Pow
Method Value Temperature Value
determination
0 20 °C Calculated
Mobility soil (log Poc)
No data available
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Volatility (Henry's Law constant H)
No data available
Percent distribution
Method Fraction air Fraction biota Fraction sediment Fraction soil Fraction water Value
determination
Mackay Level III 1.23 % 0 % 0.49 % 34.9 % 63.4 % QSAR
Mackay level I 33.7 % 0 % 0 % 2.4 % 63.8 % QSAR
Volatile organic compounds (VOC) 100 %
Surface tension 0.0057 N/m
Conclusion
Volatile
Soluble in water
Low potential for absorption in soil
12.5 Results of PBT and vPvB assessment:

Substance does not meet the screening criteria for persistency nor bioaccumulation so is neither PBT nor vPvB.
12.6 Other adverse effects:

Global Warming Potential (GWP)
No data available
Ozone-depleting potential (ODP)
No data available
Ozone layer Not dangerous for the ozone layer (Council Regulation (EC) no 1005/2009)
Surface water Mild water pollutant (surface water)
Ground water Ground water pollutant
13. Disposal considerations
The information in this section is a general description. If applicable and available, exposure scenarios are attached in annex. Always use the relevant
exposure scenarios that correspond to your identified use.
13.1 Waste treatment methods:

13.1.1 Provisions relating to waste
Waste material code (Directive 2008/98/EC, decision 2001/118/EC).
07 01 04* (other organic solvents, washing liquids and mother liquors). Depending on branch of industry and production process, also other
EURAL codes may be applicable. Hazardous waste according to Directive 2008/98/EC.
13.1.2 Disposal methods
Recycle by distillation. Incinerate under surveillance. Do not discharge into surface water.
13.1.3 Packaging/Container
Waste material code packaging (Directive 2008/98/EC).
15 01 10* (packaging containing residues of or contaminated by dangerous substances).
14. Transport information
ADR
14.1 UN number:
UN number 1987
14.2 UN proper shipping name:
Proper shipping name Alcohols, n.o.s.
Techn./chem. name ADR 1-ethoxypropan-2-ol
14.3 Transport hazard class(es):
Hazard identification number 30
Class 3
Classification code F1
14.4 Packing group:
Packing group III
Labels 3
14.5 Environmental hazards:
Environmentally hazardous substance mark no
14.6 Special precautions for user:
Special provisions 274
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1-ethoxy-2-propanol
Limited quantities Combination packagings: not more than 5 liters per inner
packaging for liquids. A package shall not weigh more than 30 kg.
(gross mass)
RID
14.1 UN number:
UN number 1987
Techn./chem. name RID 1-ethoxypropan-2-ol
Hazard identification number 30
Class 3
14.4 Packing group:
Packing group III
Labels 3
Limited quantities LQ7
ADN
UN number 1987
Techn./chem. name ADNR 1-ethoxypropan-2-ol
Class 3
14.4 Packing group:
Packing group III
Labels 3
Special provisions 274, 601
Limited quantities not more than 5 liters per inner packaging for liquids. A package
shall not weigh more than 30 kg. (gross mass)
IMDG
14.1 UN number:
UN number 1987
Proper shipping name alcohols n.o.s.
Techn./chem. name IMO 1-ethoxypropan-2-ol
Class 3
14.4 Packing group:
Packing group III
Labels 3
Marine pollutant
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code:
Not applicable, based on available data
ICAO-TI/IATA-DGR
14.1 UN number:
UN number 1987
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1-ethoxy-2-propanol
Techn./chem. name ICAO 1-ethoxypropan-2-ol
Class 3
14.4 Packing group:
Packing group III
Labels 3
Special provisions A3
15. Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture:
European legislation:
REACH registration This safety data sheet contains an ES in an integrated form. Contents of the exposure scenario
consist with sections 1.2, 8, 9, 12, 15 and 16 of this safety data sheet.
REACH Annex XVII - Restriction Enumerated in Annex XVII of Regulation (EC) No. 1907/2006: restrictions on the manufacture,
placing on the market and use of certain dangerous substances, mixtures and articles
National legislation
- The Netherlands
Waterbezwaarlijkheid (for NL) 11
Waste identification other lists of waste materials
- Germany
WGK 1 Classification water polluting according to external
literature source
TA-Luft 1-ethoxypropan-2-ol
15.2 Chemical safety assessment:

A chemical safety assesment has been performed.
16. Other information
CLP
Classification and labelling according to Regulation (EC) No 1272/2008 – Annex VI and after adaptation according to 1.2
Hazard pictograms
Signal word Warning

H-statements
P-statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves and eye protection/face protection.
P261 Avoid breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P306 + P360 IF ON CLOTHING: rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
DSD/DPD
Labelling in accordance with 29th adaptation of EC directive 67/548/EEC
R-phrases
10 Flammable
67 Vapours may cause drowsiness and dizziness
S-phrases
(02) (Keep out of the reach of children)
24 Avoid contact with skin
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1-ethoxy-2-propanol
Full text of any R-phrases referred to under headings 2 and 3:
R10 Flammable
R67 Vapours may cause drowsiness and dizziness
Full text of any H-statements referred to under headings 2 and 3:
Full text of any classes referred to under headings 2 and 3:
Flam. Liq.: Flammable liquid
STOT SE: Specific target organ toxicity - single exposure
Eye Irrit.: Eye irritation
(*) = INTERNAL CLASSIFICATION BY BIG
PBT-substances = persistent, bioaccumulative and toxic substances
DSD Dangerous Substance Directive
DPD Dangerous Preparation Directive
CLP (EU-GHS) Classification, labelling and packaging (Globally Harmonised System in Europe)
The information in this safety data sheet is based on data and samples provided to BIG. The sheet was written to the best of our ability and
according to the state of knowledge at that time. The safety data sheet only constitutes a guideline for the safe handling, use, consumption,
storage, transport and disposal of the substances/preparations/mixtures mentioned under point 1. New safety data sheets are written from time
to time. Only the most recent versions may be used. Old versions must be destroyed. Unless indicated otherwise word for word on the safety data
sheet, the information does not apply to substances/preparations/mixtures in purer form, mixed with other substances or in processes. The
safety data sheet offers no quality specification for the substances/preparations/mixtures in question.
Compliance with the instructions in this safety data sheet does not release the user from the obligation to take all measures dictated by common
sense, regulations and recommendations or which are necessary and/or useful based on the real applicable circumstances. BIG does not
guarantee the accuracy or exhaustiveness of the information provided. Use of this safety data sheet is subject to the licence and liability limiting
conditions as stated in your BIG licence agreement. All intellectual property rights to this sheet are the property of BIG and its distribution and
reproduction are limited. Consult your BIG licence agreement for details.
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1-ethoxy-2-propanol
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SAFETY DATA SHEET

Revision number: 0105 Project number:

1.2.2 Uses advised against

Group Uses advised against Use descriptors Use

Group Uses advised against Use descriptors Article (AC)

1.3 Details of the supplier of the safety data sheet:

Producer of the product

1.4 Emergency telephone number:

2.1.2 Classification according to Directive 67/548/EEC-1999/45/EC

2.2 Label elements:

Signal word Warning

Revision number: 0105 Project number:

2.3 Other hazards:

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5.2 Special hazards arising from the substance or mixture:

5.3 Advice for firefighters:

6.2 Environmental precautions:

6.3 Methods and material for containment and cleaning up:

6.4 Reference to other sections:

7.1 Precautions for safe handling:

7.2 Conditions for safe storage, including any incompatibilities:

Revision number: 0105 Project number:

7.3 Specific end use(s):

TRGS 900 (Germany)

8.2 Exposure controls:

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9.2 Other information:

10.2 Chemical stability:

10.3 Possibility of hazardous reactions:

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10.4 Conditions to avoid:

10.5 Incompatible materials:

10.6 Hazardous decomposition products:

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Respiratory or skin sensitisation

Specific target organ toxicity

Mutagenicity (in vitro)

Mutagenicity (in vivo)

Revision number: 0105 Project number:

Toxicity other effects

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12.2 Persistence and degradability:

12.3 Bioaccumulative potential:

12.4 Mobility in soil:

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12.5 Results of PBT and vPvB assessment:

12.6 Other adverse effects:

13.1 Waste treatment methods:

Revision number: 0105 Project number:

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15.2 Chemical safety assessment:

Signal word Warning

Revision number: 0105 Project number:

Revision number: 0105 Project number:

Revision number: 0105 Project number:

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