University of San Agustin

COLLEGE OF HEALTH AND ALLIED MEDICAL

PROFESSIONS DEPARTMENT OF PHARMACY
PharChem3: Quality Control 1: Drug Testing and Assay
(Laboratory)

NAME: DATE:___________________________
YR AND SECTION:

MODULE 3

Percent API Content per Tablet

3.1. PREPARATION AND STANDARDIZATION OF 0.1 N SULFURIC ACID

Discuss the preparation and standardization 0.1 N Sulfuric acid (Identify the primary standard, indicator,
titrant and indicator used)

3.2. CONTENT UNIFORMITY TEST OF SODIUM BICARBONATE TABLETS

Discuss the preparation and standardization 0.1 N Sulfuric acid (Identify the primary standard, indicator,
titrant and indicator used)
3.3. GUIDE QUESTIONS

1. What are the other ways of standardizing sulfuric acid?

2. Chemical reaction involved in Exercise 3.1.

3. If 25 mL sulphuric acid solution were required in the titration of 0.3592 g pure sodium carbonate,
what is the normality of the solution? (Show your solution)

4. A 500 mg sodium bicarbonate tablet weighs 499.54 mg and was used in an assay. The titration of the
sample used up 30 mL of 0.1 N sulfuric acid. Compute for the NaHCO3 contained in the tablet and its %
label claim. Each mL of 0.1 N H2SO4 is equivalent to 8.401 mg of NaHCO3. (Show your solution)

5. A 500 mg sodium bicarbonate tablet weighs 499.54 mg and was used in an assay. The titration of the
sample used up 30 mL of 0.1214 N sulfuric acid. Compute for the NaHCO3 contained in the tablet and its
label claim. Each mL of 0.1N H2SO4 is equivalent to 8.401 mg of NaHCO3. (Show your solution)