Overview

Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow —
the spongy tissue inside bones where blood cells are made.

The word "acute" in acute lymphocytic leukemia comes from the fact that the disease
progresses rapidly and creates immature blood cells, rather than mature ones. The
word "lymphocytic" in acute lymphocytic leukemia refers to the white blood cells called
lymphocytes, which ALL affects. Acute lymphocytic leukemia is also known as acute
lymphoblastic leukemia.

Acute lymphocytic leukemia is the most common type of cancer in children, and
treatments result in a good chance for a cure. Acute lymphocytic leukemia can also
occur in adults, though the chance of a cure is greatly reduced.

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Symptoms

Signs and symptoms of acute lymphocytic leukemia may include:

 Bleeding from the gums

 Bone pain

 Fever

 Frequent infections

 Frequent or severe nosebleeds

 Lumps caused by swollen lymph nodes in and around the neck, armpits,
abdomen or groin

 Pale skin

 Shortness of breath
  Weakness, fatigue or a general decrease in energy

When to see a doctor

Make an appointment with your doctor or your child's doctor if you notice any persistent
signs and symptoms that concern you.

Many signs and symptoms of acute lymphocytic leukemia mimic those of the flu.
However, flu signs and symptoms eventually improve. If signs and symptoms don't
improve as expected, make an appointment with your doctor.

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Causes

Acute lymphocytic leukemia occurs when a bone marrow cell develops changes
(mutations) in its genetic material or DNA. A cell's DNA contains the instructions that tell
a cell what to do. Normally, the DNA tells the cell to grow at a set rate and to die at a set
time. In acute lymphocytic leukemia, the mutations tell the bone marrow cell to continue
growing and dividing.

When this happens, blood cell production becomes out of control. The bone marrow
produces immature cells that develop into leukemic white blood cells called
lymphoblasts. These abnormal cells are unable to function properly, and they can build
up and crowd out healthy cells.

It's not clear what causes the DNA mutations that can lead to acute lymphocytic
leukemia.

Risk factors

Factors that may increase the risk of acute lymphocytic leukemia include:

 Previous cancer treatment. Children and adults who've had certain types of

chemotherapy and radiation therapy for other kinds of cancer may have an
increased risk of developing acute lymphocytic leukemia.
 Exposure to radiation. People exposed to very high levels of radiation, such as
survivors of a nuclear reactor accident, have an increased risk of developing acute
lymphocytic leukemia.

 Genetic disorders. Certain genetic disorders, such as Down syndrome, are

associated with an increased risk of acute lymphocytic leukemia.