Download as pdf or txt
Download as pdf or txt
You are on page 1of 3

182 D. Kumar et al.

2. Thatte UM, Dahanukar SA. Rasayana Concept: Clues from 26. Sinha K, Mishra NP, Singh J, Kanjua SPS. Tinospora cordifolia,
immunomodulatory therapy. In: Upadhyay SN, editor. Immu- a reservoir plant for therapeutic applications: A review. IJTK
nomodulation. New Dehli: Narosa Publishing House; 1997. p. 2004;3(3):257e70.
41e148. 27. Deshpande JR, Choudhary AA, Mirsha MR, Meghre VS,
3. Bhattacharya SK, Bhattacharya A, Chakrabarti A. Adaptogenic Wadokar SG, Dorle AK. Benefical effects of Lagenaria siceraria
activity of Siotone, a polyherbal formulation of Ayurvedic Mol. Fruit epicarp in animal models. Indian J Exp Biol 2008;
rasayanas. Indian J Experimental Biol 2000;38:119e28. 46:234e42.
4. Davis L, Kuttan G. Immunomodulatory activity of Withania 28. Halder S, Bharal N, Mediratta PK, Kaur I, Sharma KK. Anti-
somnifera. J Ethnopharmacol 2000;71:193e200. inflammatory, Immunomodulatory and anti-nociceptic
5. Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of Terminalia arjuna Roxb. Bark powder in mice
activity of alcoholic extract of Mangifera indica L. in mice. J and rats. Indian J Exp Biol 2009;47:577e83.
Ethnopharmacol 2001;78:133e7. 29. Ghaisas MM, Saikh SA, Deshpande AD. Evaluation of immuno-
6. Ford MS, Roach SS. Introductory clinical pharmacology. 27th modulatory activity of ethanolic extract of stem bark of
ed. USA: Lippincott Williams and Wilkins; 2009. 567e568. Bauhinia variegata Linn. IJGP 2009;3(1):70e4.
7. Hofmeyr SA. An interpretative introduction to the immune 30. Rinku M, Prasanth VV, Parthasarathy G. Immunomodulatory
system. In: Cohen I, Segel L, editors. Design principles for the activity of the methanolic extract of Urena lobata Linn. Int J
immune system and other distributed autonomous systems. Pharmacol:7, http://www.ispub.com/journal/the_internet_
NY, USA: Oxford University Press, Inc; 2001. p. 3e24. journal_of_pharmacology/volume_7_number_1_27/article/
8. Alfons B, Patrick M. Modes of action of Freund’s adjuvants in immunomodulatory-activity-of-the-methanolic-extract-of-
experimental models of autoimmune diseases. J Leukoc Biol urena-lobata-linn.html, 2009;1 [accessed 2009].
2001;70:849e60. 31. Malik JK, Manvi FV, Nanjwade BK, Alagawadi KR, Sinsh S.
9. Juyal PD, Singla LD. Herbal immunomodulatory and thera- Immunomodulatory activity of Gymnema sylvestre R.Br..
peutic approaches to control parasitic infection in livestock. leaves on in vitro human neutrophils. J Pharm Res 2009;2(8):
http://hillagric.ernet.in/edu/covas/vpharma/winter%20school/ 1284e6.
lectures/24%20Herbal%20immunomodulatory%20approaches% 32. Costa JFO, David JPL, David JM, Giulietti AM, Queiroz LP,
20parasitic.pdf [accessed] Santos RR, Soares MBP. Immunomodulatory activity of
10. El-Sheikh ALK. Renal transport and drug interactions of extracts from Cordia superba Cham. and Cordia rufescens A.
immunosuppressants [thesis]. Nijmegen, Netherlands: Rad- DC. (Boraginaceae), plant species native from Brazilian semi-
bound University; 2008:62. arid. Rev Bras Farmaacogn 2008;18(1):11e5.
11. Chulet R, Pradhan P. A review on rasayana. Phcog Rev 2010; 33. Smit HF. Picrorhiza scrophularii flora from traditional use to
3(6):229e34. immunomodulatory activity [doctoral thesis]. Utrecht,
12. Vaghasiya J, Datani M, Nandkumar K, Malaviya S, Jivani N. Netherlands: University of Utrecht; 2000.
Comparative evaluation of alcoholic and aqueous extracts of 34. Sharififar F, Pournourmohammadi S, Arabnejad M,
Ocimum sanctum for immunomodulatory activity. Int J Pharm Rastegarianzadeh R, Ranjbaran O, Purhemmaty A. Immuno-
Biol Res 2010;1(1):25e9. modulatory activity of aqueous extract of Heracleum persi-
13. Singh S, Taneja M, Majumdar DK. Biological activities of Oci- cum Desf. in mice. IJPR 2009;8(4):287e92.
mum sanctum Linn. fixed oil e an overview. Indian J Exp Biol 35. Bafna A, Mishra S. Antioxidant and immunomodulatory
2007;45:403e12. activity of the alkaloidal fraction of Cissampelos pareira Linn.
14. Khare CP. Indian Medicinal Plants. An illustrated dictionary. ÖPhG. 2009;78:21e31.
New York: Springer Publications; 2007. 36. Dashputre NL, Naikwade NS. Immunomodulatory activity of
15. Nadkarni KM, Nadkarni AK. Indian Materia medica. 3rd ed. Abutilon indicum Linn. on albino mice. IJPSR 2010;1(3):
Mumbai: Popular Prakashan; 2005. 178e84.
16. Bharani SER, Asad M, Dhamanigi SS, Chandrakala GK. Immu- 37. Thakur M, Bhargava S, Dixit VK. Immunomodulatory activity of
nomodulatory activity of methanolic extract of Morus alba Chlorophytum borivilianum Sant. F. Evid Based Complement
linn. (mulberry) leaves. Pak J Pharm Sci 2010;23(1):63e8. Alternat Med 2006;4(4):419e23.
17. Panax ginseng. Monograph. Altern Med Rev 2009;14:172e6. 38. Guerra RNM, Pereira HAW, Silveria LMS, Olea RSG. Evaluation
18. Sharififar F, Pournournohammadi S, Arabnejad M. Immuno- of immunomodulatory and anti-inflammatory effects and
modulatory activity of aqueous extract of Achiella wilhelmsii phytochemical screening of Alternanthera tenella Colla
C. Koch in mice. Indian J Exp Biol 2009;47:668e71. (Amaranthaceae) aqueous extract. Braz J Med Biol Res 2003;
19. Sikarwar Mukesh S, Patil MB, Shalini Sharma, Vishnu Bhat. 36:1215e9.
Aloe vera: plant of immortality. IJPSR 2010;1:7e10. 39. Habijanic J, Berovic M, Wraber B, Hodzar D, Boh B. Immu-
20. Hamman JH. Composition and applications of Aloe vera leaf nostimulatory effects of fungal polysaccharides from Gano-
gel. Molecules 2008;13:1599e616. derma lucidum submerged biomass cultivation. Food Technol
21. Cooper JC, Turcasso N. Immunostimulatory effects of b-1,3 Biotechnol 2001;39(9):327e31.
glucan and acemannan. JANA 1999;2:5e11. 40. Kannan M, AJA Ranjit Singh, Ajith Kumar TT, Jegatheswari P,
22. Varma A, Padh H, Shrivastava N. Andrographolide: A new Subburayalu S. Studies on immuno-bioactivities of Nyctanthes
plant-derived antineoplastic entity on horizon. Evid Based arbortristis (Oleaceae). Afr J Microbiol Res 2007;1(6):88e91.
Complement Alternat Med 2011;2011:815390. 41. Lu Y, Fan J, Zhao Y, Chen S, Zheng X, Yin Y, Fu C. Immuno-
23. Bopana N, Saxena S. Asparagus racemosusdethnophar- modulatory activity of aqueous extract of Actinidia macro-
macological evaluation and conservation needs. J Ethno- sperma. Asia Pac J Clin Nutr 2007;16(1):261e5.
pharmacol 2007;110:1e15. 42. Syed I, Mohammed A. Immunomodulatory activity of Acacia
24. Shah SA, Wakade AS, Juvekr AR. Immunomodulatory activity catechu. Indian J Physicol Pharmacol 2009;53(1):25e33.
methanolic extract of Murraya koenigii (L) Spreng. leaves. 43. Mikhaeil BR, Maatooq G, Badria T, Farid AA, Mohamed MA.
Indian J Exp Biol 2007;46:505e9. Chemistry and immunomodulatory activity of frankincense
25. Pradhan D, Panda PK, Tripathy G. Evaluation of immuno- oil. J Chem Sci 2002;58:230e8.
modulatory activity of methanolic extract of Couroupita 44. Gaur K, Kori ML, Nema RK. Comparative screening of immu-
guianensis Aubl flowers in rat. NPR 2009;8(1):37e42. nomodulatory activity of hydro-alcoholic extract of Hibiscus
Immunomodulators in traditional Indian health care 183

rosa sinensis Linn. and ethanolic extract of Cleome gynandra in vitro effect: cytotoxic anti-tumor activity and lymphocyte
Linn. GJP 2009;3(2):85e9. activation. BMC Complement Altern Med 2006;6(119):1e14.
45. Jain V, Bhagwat D, Jat RC, Bhardwaj S. The immunomodula- 63. Bhatt RP, Pandya BK, Sheth RN. Camellia sinensis L: the
tion potential of Hyptis suaveolens. IJPRD 2005;1(11):1e6. medicinal beverage: a review. IJPSRR 2010;3(2):6e9.
46. Satpute KL, Jadhav MM, Karodi RS, Katare YS, Patil MJ, 64. Killestein J, Hoogervorst ELJ, Reif M, Blauw B, Smits M,
Rukhsana Rub, Bafna AR. Immunomodulatory activity of fruits Uitdehaag BMJ, Nagelkerken L, Polman CH. Immunomodula-
of Randia dumetorum Lamk. JPP 2009;1(3):36e40. tory effects of orally administered cannabinoids in multiple
47. Jafarian A, Ghannadi A, Elyasi A. The effects of Allium hir- sclerosis. J Neuroimmunol 2003;137(1-2):140e3.
tifolium Boiss. on cell-mediated immune response in mice. 65. Ordway D, Hohmann J, Viveiros M, Viveiros A, Molnar J,
IJPR 2003;2:51e5. Leandro C, Arroz MJ, Gracio MA, Amaral L. Carpobrotus edulis
48. Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, methanol extract inhibits the MDR efflux pumps, enhances
Koshimizu K, Ohigashi H. Immunomodulatory action of Citrus killing of phagocytosed S aureus and promotes immune
auraptene on macrophage functions and cytokine production modulation. Phytother Res 2003;17(5):512e9.
of lumphocytes in female BALB/c mice. Carcinogenesis 1999; 66. Mali RJ, Hatapakki BC. An in vitro study of effect of Centella
20(8):1471e6. asiatica on phagocytosis by human neutrophils. IJPSN 2008;
49. Jeong SC, Jeong YT, Yang BK, Song CH. Chemical character- 1(3):297e302.
istics and immuno-stimulating properties of biopolymers 67. Ebringerova A, Hromadkova Z, Hribalova V, Hirsch J. An
extracted from Acanthopanax sessiliflorus. J Biochem Mol immunomodulating pectic arabinogalactan from roots Cis-
Biol 2005;39(1):84e90. tanche deserticola. Chem Pap 2002;56(5):320e5.
50. Hung LC, Lin CC, Hung SK, Wu BC, Jan MD, Liou SH. A synthetic 68. Sugumaran M, Robinson WE. Bioactive dehydrotyrosyl and
analog of a-galactosylceramide induces macrophage activa- dehydrodopyl compounds of marine origin. Mar Drugs 2010;8:
tion via the TLR4-signaling pathways. Biochem pharmacol 2906e35.
2007;73(12):1957e70. 69. Hsu CH, Sun HL, Sheu JN, Ku MS, Hu CM, Chan Y, Lue KH.
51. Zheng W, Chen C, Cheng Q, Wang Y, Chu C. Oral administra- Effects of the immunomodulatory agent Cordyceps militaris
tion of exopolysaccharide from Aphanothece halophytica on airway inflammation in a mouse asthma model. Pediatr
Chroococcales significantly inhibits influenza virus H1N1- Neonatol 2008;495(5):171e8.
induced pneumonia in mice. Int Immunopharmacol 2006; 70. Zvetkova E, Wirleitner B, Tram NT, Schennach H, Fuchs D.
6(7):1093e9. Aqueous extracts of Crinum latifolium L and Camellia
52. Cherng JM, Chiang W, Chiang LC. Immunomodulatory activi- sinensis show immunomodulatory properties in human
ties of common vegetables and spices of Umbelliferae and its peripheral blood mononuclear cells. Int Immunopharmacol
related coumarins and flavonoids. Food Chem 2007;106(3): 2001;1(12):2143e50.
944e50. 71. Amirghofran Z, Azadbakht M, Karimi MH. Evaluation of the
53. Kobayashi H, Mejia ED. The genus Ardisia: a novel source of immunomodulatory effects of five herbal plants. J Ethno-
health-promoting compounds and phytopharmaceuticals. J pharmacol 2000;72(1-2):167e72.
Ethnopharmacol 2005;96:347e54. 72. Senchina DS, McCann DA, Asp JM, Johnson JA, Cunnick JE,
54. Wang C, Tao W, Wang Y, Bikow J, Lu B, Keating A, Verma S, Kaiser MS, Kohut ML. Changes in immunomodulatory proper-
Parker TG, Han R, Wen XY. Rosuvastatin, identified from ties of Echinacea spp root infusions and tinctures stored at 4
a zebrafish chemical genetic screen for antiangiogenic degrees C for four days. Clinica Chimica Acta 2005;355(1(2)):
compounds, suppresses the growth of prostate cancer. Eur 67e82.
Urol 2010;58:418e26. 73. Jayathirtha MG, Mishra SH. Preliminary immunomodulatory
55. Noori S, Naderi GA, Hassan ZM, Habibi Z, Bathaie SZ, activities of methanol extracts of Eclipta alba and Centella
Mahmoud S. Immunosuppressive activity of a molecule iso- asiatica. Phytomedicine 2004;11:361e5.
lated from Artemisia annua on DTH responses compared with 74. Patil SB, Naikwade NS, Magdum CS. Review on phytochemistry
cyclosporin A. Int Immunopharmacol 2004;4(10-11):1301e6. and pharmacological aspects of Euphorbia hirta Linn. JPRHC
56. Steinbach WJ, Stevens DA. Review of newer antifungal and 2009;1(1):113e33.
immunomodulatory strategies for invasive Aspergillosis. Clin 75. Ganju L, Karan D, Chanda S, Srivastava KK, Sawhney RC,
Infect Dis 2003;37(3):157e87. Selvamurthy W. Immunomodulatory effects of agents of plant
57. Ballarin L. Immunobiology of compound ascidians, with origin. Biomed Pharmacother 2003;57(7):296e300.
particular reference to Botryllus schlosseri: state of art. ISJ 76. Amirghofran Z, Azadmeh A, Javidnia K. Haussknechtia Ely-
2008;5:54e74. matica: A plant with immunomodulatory effects. Iran J
58. Chang SL, Chiang YM, Chang CLT, Yeh HH, Shyur LF, Kuo YH, Immunol 2007;4(1):26e31.
Wu TK, Yang WC. Flavonoids, centaurein and centaureidin, 77. Chen C, Zheng W, Gao X, Xiang X, Sun D, Wei J, Chu C.
from Bidens pilosa, stimulate IFN expression. J Ethno- Aqueous extract of Inonotus obliquus (Fr.) Pilat (Hyme-
pharmacol 2007;112:232e6. nochaetaceae) significantly inhibits the growth of sarcoma
59. Mungantiwar AA, Nair AM, Shinde UA, Dikshit VJ, Saraf MN, 180 by inducing apoptosis. Am J Pharmacol Toxicol 2007;2(1):
Thakur VS, Sainis KB. Studies on the immunomodulatory 10e7.
effects of Boerhaavia diffusa alkaloidal fraction. J Ethno- 78. Davicino R, Mattar A, Casali Y, Porporatto C, Correa SG,
pharmacol 1999;65(2):125e31. Micalizzi B. In vivo immunomodulatory effects of aqueous
60. Sredni B, Kalechman Y, Albeck M, Gross O, Aurbach D, extracts of Larrea divaricata Cav. Immunopharmacol Immu-
Sharon P, Sehgal SN. Cytokine secretion effected by synergism notoxicol 2007;29(3(4)):351e66.
of the immunomodulator AS101 and the protein kinase C 79. Gan L, Zhang SH, Liu Q, Xu HB. A polysaccharide-protein
inducer bryostatin. Immunology 1990;70:473e7. complex from Lycium barbarum upregulates cytokine
61. Bonacorsi C, Raddi MSG, Carlos IZ, Sannomiya M, Vilegas W. expression in human peripheral blood mononuclear cells. Eur
Anti-Helicobacter pylori activity and immunostimulatory J Pharmacol 2003;471:217e22.
effect of extracts from Byrsonima crassa Nied. (Malpighia- 80. Reis LSLS, Frazatti-Gallina NM, Paoli RL, Giuffrida AA, Oba E,
ceae). BMC Complement Altern Med 2009;9(2):1e7. Pardo PE. Efficiency of Matricaria chamomilla CH12 and
62. Medina EJ, Lora AG, Paco L, Algarra I, Collado A, Garrido F. A number of doses of rabies vaccine on the humoral immune
new extract of the plant Calendula officinalis produces a dual response in cattle. J Vet Sci 2008;9(4):433e5.
184 D. Kumar et al.

81. Ferreira AP, Soares GLG, Salgado CA, Goncalves LS, 91. Leung K, Leung P, Kong L, Leung P. Immunomodulatory effects
Teixeira FM, Teixeira HC, Kaplan MAC. Immunomodulatory of esculetin (6, 7-dihydroxycoumarin) on murine lymphocytes
activity of Mollugo verticillata L. Phytomedicine 2003;10: and peritoneal macrophages. Cell Mol Immunol 2005;2(3):
154e8. 181e7.
82. Gupta A, Gautam MK, Singh RK, Kumar MV, Rao CV, Goel RK, 92. Thanh PN, Wen YJ, Gyu YS, Ki HB, Sam SK. Cytotoxic
Anupurba S. Immunomodulatory effect of Moringa oleifera coumarins from the root of Angelica dahurica. Arch Pharm
extract on cyclophosphamide induced toxicity in mice. Ind J Res 2004;27(12):1211e5.
Exp Biol 2010;48:1150e67. 93. Alamgir M, Uddin SJ. Recent advances on the ethnomedicinal
83. Kumar DS, Lau CS, Wan JM, Yang D, Hyde KD. Immunomodu- plants as immunomodulatory agents. In: Ethnomedicine:
latory compounds from Pestalotiopsis leucothes, an endo- a source of complementary therapeutics. Kerala, India:
phytic fungus from Tripterygium wilfordii. Life Sci 2005;78: Research Signpost, http://www.trnres.com/ebookcontents.
147e56. php?idZ83; 2010. pp. 217e224.
84. Sunila ES, Kuttan G. Immunomodulatory and antitumor 94. Rios J. Effects of triterpenes on the immune system. J Eth-
activity of Piper longum Linn and piperine. J Ethnopharmacol nopharmacol 2010;128:1e14.
2004;90(2,3):339e46. 95. Wagner H In: Hikino H, Farnsworth NR, editors. Economic and
85. Mishra KP, Padwad YS, Dutta A, Ganju L, Sairam M, medicinal plant research, vol. 1. London: Academic Press;
Banerjee PK, Sawhney RC. Aqueous extract of Rhodiola 1984. p. 113e53.
imbricata rhizome inhibits proliferation of an eryth- 96. Bafna AR, Mishra SH. Immunostimulatory effect of methanol
roleukemic cell line K-562 by inducing apoptosis and cell extract of Curculigo orchioides on immunosuppressed mice. J
cycle arrest at G2/M phase. Immunobiology 2008;213(2): Ethnopharmacol 2006;104:1e4.
125e31. 97. Xiu-feng Z, Yan C, Jia-jun H, Ya-zhou Z, Zhou N, Lan-fen W,
86. Meeran SM, Katiyar S, Elmets CA, Katiyar SK. Silymarin inhibits Bao-zhen Y, Ya-lin T, Yang L. Immuno-stimulating properties
UV radiation-induced immunosuppression through augmenta- of diosgenyl saponins isolated from Paris polyphylla. Bioorg
tion of interleukin-12 in mice. Mol Cancer Ther 2006;5(7): Med Chem Lett 2007;17(9):2408e13.
1161e8. 98. Calis I, Yuruker A, Tasdemir D, Wright AD, Sticher O,
87. Im SA, Kim K, Lee CK. Immunomodulatory activity of poly- Pezzuto JM. Cycloartan triterpine glycosides from the root of
saccharides isolated from Salicornia herbacea. Int Immuno- Astragalus melanophrurius. Planta Med 1997;63:183e6.
pharmacol 2006;6(9):1451e8. 99. Erdem Y, Erdal B, Ihsan C, Yoshihisa T, Yasukazu O. Effects of
88. Elluru S, Huyen JPD, Wootla B, Delignat S, Prost F, Negi VS, triterpene saponins from Astragalus species on in vitro cyto-
Kaveri SV. Tumor regressive effects of viscum album prepa- kine release. J Ethnopharmacol 2005;96:71e7.
rations exploration of immunomodulatory mechanisms. 100. Raphael T, Kuttan JG. Effect of naturally occurring triterpe-
Medicina 2007;67(2):85e9. noids glycyrrhizic acid, ursolic acid, oleanolic acid and
89. Gohla SH, Zeman RA, Bogel M, Jurkiewicz E, Schrum S, nomilin on the immune system. Phytomed 2003;10:483e9.
Haubeck HD, Schmitz H, Hunsmann G, Neth RD. Modification 101. Kumar D, Bhat ZA, Singh P, Shah MY, Bhujbal SS. Ailanthus
of the in vitro replication of the human immunodeficiency excelsa Roxb. is really a plant of heaven. Int J Pharmacol
virus HIV-1 by TPSg, a polysaccharide fraction isolated from 2010;6(5):535e50.
the Cupressaceae Thuja occidentalis L Arborvitae. Haematol 102. Blasdell KS, Sharma HM, Tomlinson Jr PF, Wallace RK.
Blood Transfus 1992;35:140e9. Subjective survey, blood chemistry and complete blood
90. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 29th ed. profile of subjects taking Maharishi Amrit Kalash (MAK). FASEB
Mumbai: Nirali Prakashan; 2004. 167,231,235,311,446. J 1991;5:A1317.

You might also like