Generic/Brand Name Dosage and Usage Side and Adverse Effects Contraindication Nursing Consideration

Generic Name: Methimazole Stock dose: 5mg/10mg  Stomach upset
Brand Name: Tapazole Forms: Oral/tablet  Nausea
 Vomiting
 Mild skin rash/ itching
 Headache
 Drowsiness
 Dizziness
 Muscle/ joint/ nerve pain
 Swelling
 Hair loss
Tell your doctor if you experience
rare but serious side effects
 Yellowing eyes/ skin (jaundice)
 Dark urine
 Severe stomach or abdominal
pain
 Persistent nausea or vomiting
 Changes in the amount of urine
 A condition with low thyroid
hormone levels
 A type of blood disorder with a
decrease in all types of blood
cells called pancytopenia
 Anemia
 A decrease in the blood clotting
protein prothrombin
 Decreased blood platelets
 Very low levels of granulocytes
 A type of white blood cells
 Low levels of white blood cells
 Low levels of a type of white
blood cell called neutrophils
 Damage to the liver and
inflammation
 Abnormal liver function tests
 Pregnancy
 An autoimmune disease
affecting small blood vessels in
the body called ANCA-
positivenvasculitis
 Instruct patient to take medication
as directed, around the clock. Take
missed doses as soon as remembered;
take both doses together if almost time
for next dose; check with health care
professional if more than 1 dose is
missed. Consult health care professional
prior to discontinuing medication.
 Instruct patient to monitor weight
2–3 times weekly. Notify health care
professional of significant changes.
 May cause drowsiness. Caution
patient to avoid driving or other
activities requiring alertness until
response to medication is known.
 Advice patient to consult health care
professional regarding dietary sources of
iodine (iodized salt, shellfish).
 Advise patient to report sore throat,
fever, chills, headache, malaise,
weakness, yellowing of eyes or skin,
unusual bleeding or bruising, rash, or
symptoms of hyperthyroidism or
hypothyroidism promptly.
 Instruct patient to notify health care
professional of all Rx or OTC
 medications, vitamins, or herbal products
being taken and to consult with health
care professional before taking other
medications.
 Advise patient to carry
identification describing medication
regimen at all times.
 Advise patient to notify health care
professional of medication regimen prior
to treatment or surgery.
 Rep:  Advice female patients of
reproductive potential to notify health
care professional if pregnancy is planned
or suspected or if breast feeding. May
cause fetal harm, especially during 1st
trimester. If breast feeding, monitor
infant thyroid levels weekly or biweekly.
 Emphasize the importance of
routine exams to monitor progress and to
check for side effects.