GROUP I

IMMUNOSUPPERENTS MCQ
The drugs that lower the body ability to reject the transplanted organ are called
a. immunosupperents
b. sulphonamides
c. Antibiotics
d. none
Crohn disease is due to?
a. overactivity of immune system
b. reduce activity of immune system
c. both
d. none
There are ……types of immunosuppernts
a. 2
b. 3
c. 4
d. 5
Cyclosporine affects
a. cell mediated response
b. cell mediated immunity
c. none
d. C4 receptors

Cyclosporine bound to lymphocytes

a. more than 1 tenth
b. less than 1 eight
c. less than 1 tenth
d. none

For tacrolimus ….. route is more preferable

a. IV
b. Oral
c. IM
d. otic
Tacrolimus is excreated in….
a. urine
b. Feaces
c. Both
d. none of these
Cyclosporine function is preventing rejection of
a. liver
b. Kidney
c. Heart
d. a and b both
Azathiophrene is deactivated by
a. xanthine
b. xanthine oxidase
c. immunosupperents
d. angiotensinogen
The alternative of methotrexate is
 a. azathiophrene
b. Cyclosporine
c. Tacrolimus
d. Mycophenol
Which drugs specifically inhibits calcineurin in the activated T lymphocytes?
a. Basiliximab
b. Belatacept
c. Tacrolimus
d. None
Which immunosuppressant medication avoids the need of therapeutic drug
monitoring?
a. Cyclosporine
b. Tacrolimus
c. Mycophenolate mofetil
d. Sirolimus
Which drugs used to prevent allograft rejection can cause hyperlipidemia?
a. Basilimab
b. Sirolimus
c. Betacepts
d. All of the above
One of the drugs in Mr Hart's maintenance drug regimen increases the likelihood for
renal toxicity, and should not be combined with other immunosuppressants that also
have a high incidence of renal toxicity. Which drug is this?
a. Azathioprine
b. Cyclosporine
c. Enalapril
d. None
A patient on immunosuppresive therapy is given tacrolimus as part of their drug
regimen. Which side effect is most likely to occur with this drug?
a.  Hypokalemia
b. Hypotension
c. Renal toxicity
d. Hypoglycemia
One of the drugs Mr Short was taking to suppress organ rejection was azathioprine.
Which of the following describes its mechanism of action?
a. conversion to 6 mercaptopurine, a purine antimetabolite toxic to
stimulated lymphocytes
b.  inhibition of TNF-alpha
c. decreased prostaglandin production due to inhibition of phospholipase A2
d. all of the above