Pharmacology

Anti-seizure Drugs
Q1
• A 33 years old woman had a history of Abnormal electrical
discharges at times. On examination, she was diagnosed with a
Genetic defect of Neural adhesion molecule leading to seizures.
• Possible defect?
• A:PCDHI9
• B:PCD19
• C:P140
• D:Cadherins
Q2
• A Patient was admitted to a hospital with a History of Seizures.On
interrogation One of his relatives told that He marks certain
symptoms during seizures . He Falls, Stiffens, Jerks and Loses
consciousness.
• Most Likely diagnosis:
• A:Absence seizures
• B:Tonic Clonic Seizures
• C:Atonic seizures
• D:Clonic seizures
Q3
• A drug was administered to a patient who was on sustained
Excitability Discharges in brain. On examination The drug mainly
Targeted GABA receptors and GABA levels were elevated.
• Most Likely Drug:
• A:Tiagabine
• B:Oxcarbazepines
• C:Lacosamide
• D:None
Q4
• A 33 years old man with a history of Partial Seizures was Prescribed a
drug.Afters few days patient had complaints of Drowsiness, dizziness,
tinnitus and Vertigo. Patient was diagnosed with over-dosage of
drug.
• Main metabolism :Glucuronidation And Acetylation
• Half-life:8-11 hrs (No induction of cytochrome p450)
• Likely drug:
• A:Eslicarbamazepine. B:Retigabine
• C:Primidone
• D:Phenytoin
5
• A sodium channel blocker was administered to a Patient who was
experiencing strong episodes of Pain on Cheecks, Jaws, Teeth of Face
region. On examination Drug exhibited Use Dependence and Voltage
dependence inhibitory actions in the patient’s body while given oraly.
• Most likely drug:
• A:Carbamazepine
• B:Lacosamide
• C:Eslicarbazepine acetate
• D:Phenytoin
6
• A 42 years old woman was diagnosed with Trigeminal neuralgia.She was
Prescribed a certain Drug by Physician.But she was mistaken with
overdosage of drugs. She had complaints of GI discomfort and blurred
vision.
• Her neutrophills profile was taken.
• Neutrophill count: LESS than 1000 /mm(3)
• Likely Drug:
• A:Pregablin
• B:Gabapentin
• C:Phenytoin
• D:Carbamazepine
7
• Certain Contra-indications were noted when A Sodium Channel
blocker was administered to a 51 years old man to treat Seizural
activities.Drug had no interactions with Cytochrome p450 on
examination.Patient disease profile also showed Phenylketunuria.
• Most likely drug of choice:
• A:Oxcarbazepine
• B:Phenytoin
• C:Lacosamide
• D:Carbazepine
8
• A 50 years old man with a history of Jaundice was administered a
drug mainly for Treatment of Focal onset seizures. After few days
Patient had complaints of Nystagmus and Absent Smooth
extraocular Pursuit movements.
• Likely drug of choice:
• A:Phenytoin
• B:Pregablin
• C:Carbazepine
• D:Lacosamide
9
• A Patient's ECG during Heart surgery of Patient exhibited Noticeable
Variations. On examination His Profile Showed Diabetic Neuropathy.
• Patient was diagnosed with a history of certain drug for past 1 year
whose elevated concenterations altered ECG.
• Likely Drug of Choice:
• A:Lacosamide
• B:Phenytoin
• C:Pregabln
• D:Valproic Acid
10
• A patient was Administered drug Phenytoin for treatment of Focal
onset seizures.On examination Patient’s Drug profile exhibited
another drug which can displace Phenytoin from protein Albumin.
• Likely Drug:
• A:Lacosamide
• B:Carbazepine
• C:Gabapentinoids
• D:Valproic Acid
11
• Drug which binds effectively To an Auxiliary Subunit of Calcium
channel during action.
• A:Gabapentine
• B:Tiagabine
• C:Retigabine
• D:Carbazepine
12
• Most Immediate Reason for the Fact that Bioavailability of
GABAPENTIN decreases with increasing dose due to saturation of:
• A:Cytochrome P450
• B:Hepatic Microsomal enzymes
• C:L amino acid Transport system
• D:GAT 1 transporter
13
• A 15 years old boy was diagnosed with Generalized Onset eepilepsy.A
certain drug was perscribed. After a week Boy had complaints of some
adverse effects Due to drug.
• Drug Pharmacokinetic profile:
• 90-100 percent bioavailability
• Highly Protein bound
• Oxidized by CYP3A
• Most Likely Drug:
• A:Lacosamide B:Pregablin
• C:Tiagabine. D:Retigabine
14
• A Sodium channel blocker was administered to treat Tonic clonic
seizures. On examination it was found that Drug is mainly
metabolized by CYP2C9 AND CYP2C19.
• Drug of choice :
• A:Retigabine
• B:Tiagabine
• C:Oxcarbazepine
• D:Phenytoin
15
• Drug named Retigabine was discontinued by the patient as the
Patient started exhibiting certain demarcations due to the Drug:
• Likely effects:
• A:Enhanced induction of Microsomal Hepatic enzymes
• B:Selective activation of GAT-1 transporter
• C:Pigment discoloration of Retina and Skin
• D:Atrophic gastric mucosa
ALCOHOL ABUSE
1
• Drug administered which mainly Targets Alcohol Dehydrogenase
enzyme:
• A:Fomipizol
• B:Benzodiazepines
• C:Disulfirum
• D:NONE
2
• A 35 years old man with Ethanol intoxication was admitted to
hospital.He was administered Certain Drug which mainly altered
activity profile of Aldehyde Dehydrogenase:
• Likely drug:
• A:Benzodiazepines
• B:Fomipizol
• C:Disulfirum
• D:Carbazepine
3
• More likely Concentration of Ethanol which causes
• Lack of consciousness and Leads to Comatose Condition:

A:60-80mg/dl
B:120-160 mg/dl
C:More than 300 mg/dl
D:Less than 50 mg/dl
4
• A 50 years old man with History of Ethanol intoxication was admitted
to Hospital.His Symptoms Profile exhibited :Confusion, Ataxia and
Paralysis Occular Muscles disorder.
• Most likely condition :
• A:Wernickel Korasekoff Syndrome
• B:Gynecomastia
• C:Hypertention
• D:Cardiomegaly
5
• Foetal Alcohlic Syndrome main marked Characteristics are:
• A:Mentaly Retarded and Microcephaly
• B:Loss of Vision
• C:Anemia
• D:Diplopia
6
• A 31 years old man was Prescribed certain drug for treatment of
Acute Ethanol Withdrawal Syndrome. He had also history of Liver
Cirrhosis.
• Likely Drug Prescription ?
• A:Diazepam
• B:Lorazepam
• C:Fomipizol
• D:NONE
7
• A 21 years old boy Had complaints of Loss of Cognitive Function,
Memory and Learning. His History Profile also exhibited Ethanol
exposure for Past 1 month.
• Likely Reason for the condition :
• A:Decreased GABA transmission
• B:Decreased Glutamate Transmission
• C:Oxidative stress
• D:Glutathione Depletion
8
• Most Immediate Drug Which inhibits movement of GABA from
Extracellular Space to Intracellular Space:
• A:Retigabine
• B:Tiagabine
• C:Fomipizol
• D:Disulfirum
9
• Most Likely Drug as 1st line Treatment for Fibromyoglia:
• A:Pregablin
• B:Carbazepine
• C:Disulfirum
• D:Oxcarbazepine
10
• Tissue damage experienced after Ethanol intoxication is mainly Due
to:

• A:Induction of Cytochrome P450

• B:Hepatic enzymes modification
• C:Oxidative Stress Due to Glutathione Depletion
• D:Prolonged GABA mediated transmission