Name :shady abo hamad

Group m1653

Aspirin; rs2519093; Medication use (HMG CoA

reductase inhibitors)
Chemical structure Drug common Drug name synonyms
name
aspirin 2-
Acetoxybenzenecarboxylic
acid, 2-Acetoxybenzoic
acid, 2-Carboxyphenyl
acetate, A.S.A., ASA,
Acetilsalicilico, Acetilum
acidulatum, Acetosalic
acid, Acetoxybenzoic acid,
Acetylsalicylate,
Acetylsalicylic acid,
Acetylsalicylsaure
(GERMAN), Acetysalicylic
acid, Acide
acetylsalicylique (FRENCH),
Acido O-acetil-benzoico,
Acido acetilsalicilico,
Acidum acetylsalicylicum,
Kyselina 2-
acetoxybenzoova, Kyselina
acetylsalicylova, O-
Acetylsalicylic acid, O-
accetylsalicylic acid,
Salicylic acid acetate,
Salicylic acid, acetate, o-
Acetoxybenzoic acid, o-
Carboxyphenyl acetate, 8-
hour Bayer, A.S.A. Empirin,
Acenterine, Acesal, Acetal,
Aceticyl, Acetisal, Acetol,
Acetonyl, Acetophen,
Acetosal, Acetosalin,
Acetylin, Acetylsal,
Acimetten, Acisal,
Acylpyrin, Adiro, Asagran,
Asatard, Ascoden-30,
Aspalon, Aspec, Aspergum,
Aspirdrops, Aspirin,
Aspirine, Aspro, Asteric,
Bayer Extra Strength
Aspirin For Migraine Pain,
Benaspir, Bi-prin,
Bialpirina, Bialpirinia,
Bufferin, Caprin, Cemirit,
Claradin, Clariprin, Colfarit,
Contrheuma retard,
Coricidin, Crystar, Decaten,
Delgesic, Dolean pH 8,
Duramax, ECM, Easprin,
Ecolen, Ecotrin, Empirin,
Endydol, Entericin,
Enterophen, Enterosarein,
Enterosarine, Entrophen,
Extren, Globentyl, Globoid,
Helicon, Idragin, Levius,
Measurin, Micristin,
Neuronika, Novid, Nu-
seals, Nu-seals aspirin,
Persistin, Pharmacin,
Pirseal, Polopiryna,
Premaspin,
Rheumintabletten,
Rhodine, Rhonal, Salacetin,
Salcetogen, Saletin, Solfrin,
Solprin, Solprin acid,
Solpyron, Spira-Dine, St.
Joseph, St. Joseph Aspirin
for Adults, Supac, Tasprin,
Temperal, Triaminicin,
Triple-sal, Vanquish, Xaxa,
Yasta, Aspirin Plus
Stomach Guard
(Acetylsalicylic Acid +
Calcium Carbonate +
Magnesium Carbonate +
Magnesium Oxide), Aspirin
Plus Stomach Guard
Ext.Stgth.Caplet
(Acetylsalicylic Acid +
 Calcium Carbonate +
Magnesium Carbonate +
Magnesium Oxide), Aspirin
Plus Stomach Guard Extra
Strength (Acetylsalicylic
Acid + Calcium Carbonate
+ Magnesium Carbonate +
Magnesium Oxide), Aspirin
Plus Stomach Guard Tab
(Acetylsalicylic Acid +
Calcium Carbonate +
Magnesium Carbonate +
Magnesium Oxide), Aspirin
with Stomach Guard
(Acetylsalicylic Acid +
Calcium Carbonate +
Magnesium Carbonate +
Magnesium Oxide), Aspirin
with Stomach Guard Extra
Strength - Tab
(Acetylsalicylic Acid +
Calcium Carbonate +
Magnesium Carbonate +
Magnesium Oxide), Extra
Strength Aspirin Backache
(Acetylsalicylic Acid +
Methocarbamol)
Metabolite(-s) PharmGKB ID

 Glucuronate PA448497
 Hippurates
 Salicylates
 Salicylic Aci
 Aspirin
 Glycine
Guideline Source Guideline Summary
PharmGK
B ID
PA166222201 This annotation is based on There are currently no
the CPIC® guideline for recommendations for dosing
Nonsteroidal Anti- of aceclofenac, aspirin,
inflammatory Drugs and diclofenac, indomethacin,
CYP2C9. The CPIC authors lumiracoxib, metamizole,
have evaluated therapeutic nabumetone and naproxen
dose recommendations for based on CYP2C9 genotypes.
dosing of aceclofenac,
aspirin, diclofenac,
indomethacin, lumiracoxib,
metamizole, nabumetone
and naproxen based on
CYP2C9 genotypes. They
conclude that there is
insufficient evidence to
provide a recommendation
to guide clinical practice at
this time.

Variant Gene Type Phenotype

rs67376798 DPYD Toxicity/ADR Neoplasms

rs3918290 DPYD Toxicity/ADR Neoplasms

rs55886062 DPYD Toxicity/ADR Neoplasms

 CACNA1S Malignant
rs1800559 Toxicity/ADR Hyperthermia

Variant Gene Signif P Value Stud Biogeog Paper PMID Associat

ic y raphical discusse ion
ant size group s
rs5918 ITGB3 no - 101 Unknow  efficacy 1649348 Allele C
n 6 is not
associat
ed with
increase
d risk of
non-
respons
e to
aspirin
when
treated
with
aspirin
in
people
with
Coronar
y Artery
Disease
as
compar
ed to
genotyp
e TT.
rs1896832 - no = 0.16 europi 2700581 Allele T
674 efficacy 7 is not
an associat
ed with
platelet
reactivit
y when
treated
with
aspirin
and
clopido
grel in
people
with
Coronar
y Artery
 Disease
and
Diabetes
Mellitus,
Type 2
as
compar
ed to
allele C.

rs1801278 IRS1 no = 0.59 674 eur Allele G

efficacy 2700581 is not
7 associat
ed with
platelet
reactivit
y when
treated
with
aspirin
and
clopido
grel in
people
with
Coronar
y Artery
Disease
and
Diabetes
Mellitus,
Type 2
as
compar
ed to
allele A.
rs28360521 CYP2 yes < 0.01 437 euro  toxicity 2436764 Genotyp
D6 6 e CC is
associat
ed with
increase
 d risk of
Gastroin
testinal
Hemorr
hage
when
treated
with
aspirin
as
compar
ed to
genotyp
es CT +
TT.
rs5050 yes < 0.05 425 eur  toxicity 2082450 Genotyp
AGT 5 e GG is
associat
ed with
increase
d risk of
Peptic
Ulcer
Hemorr
hage
when
treated
with
aspirin
as
compar
ed to
genotyp
es GT +
TT.
rs2427827 no = 0.287 303 eur  toxicity Allele T
FCER1 1859568 is not
A 2 associat
ed with
increase
d risk of
aspirin-
intolera
nt
asthma
when
exposed
to
aspirin
in
people
with
Asthma
as
compar
ed to
allele C.
.

Database Database Database Number of

category name description records

Literature Pubmed central Associations 106903

between aspirin use and
the risk of cancers: a
meta-analysis of
observational studies

Clinical clinical 2128

TIME ASPIRIN:
Chronotherapy
With Aspirin for
Reduction of
Cardiovascular Disease

Genomes nucletide KR 1020100012986-A/43:

Biomarker for diagnosis 1296
of aspirin hypersensitivity,
method for manufacturing
the same, and method for
diagnosis
of aspirin hypersensitivity
using the same
Total number of article 106903

Number of article last year 9410

Associations between aspirin use and the risk of cancers: a meta-analysis of
observational studies
Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu
BMC Cancer. 2018; 18: 288. Published online 2018 Mar 13. doi: 10.1186/s12885-018-4156-5

PMCID: 
PMC5851082
A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome
Michael H. Tatham, Christian Cole, Paul Scullion, Ross Wilkie, Nicholas J. Westwood, Lesley A.
Stark, Ronald T. Hay
Mol Cell Proteomics. 2017 Feb; 16(2): 310–326. Published online 2016 Dec 5. doi: 10.1074/mcp.O116.065219

PMCID: 
PMC5294217
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose:
analysis of individual patient data from randomised trials
Peter M Rothwell, Nancy R Cook, J Michael Gaziano, Jacqueline F Price, Jill F F Belch, Maria
Carla Roncaglioni, Takeshi Morimoto, Ziyah Mehta
Lancet. 2018 Aug 4; 392(10145): 387–399. doi: 10.1016/S0140-6736(18)31133-4

PMCID: 
PMC6083400
ArticlePubReaderPDF–806KCitation

Select item 4383813 4.

A Systematic Review of Aspirin in Primary Prevention: Is It Time for a New Approach?
Carlos Brotons, Robert Benamouzig, Krzysztof J. Filipiak, Volker Limmroth, Claudio Borghi
Am J Cardiovasc Drugs. 2015; 15(2): 113–133. Published online 2014 Dec 12. doi: 10.1007/s40256-014-0100-5

PMCID: 
PMC4383813
ArticlePubReaderPDF–418KCitation

Select item 6741347 5.

Aspirin and colorectal cancer: the promise of precision chemoprevention
David A. Drew, Yin Cao, Andrew T. Chan
Nat Rev Cancer. Author manuscript; available in PMC 2019 Sep 12.
Published in final edited form as: Nat Rev Cancer. 2016 Mar; 16(3): 173–186. Published online 2016 Feb
12. doi: 10.1038/nrc.2016.4

PMCID: 
PMC6741347
ArticlePubReaderPDF–1.0MCitation

Select item 6134920 6.

Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated
apoptosis of cancer stem-like cells in colorectal cancer
Zhigang Chen, Wenlu Li, Fuming Qiu, Qi Huang, Zhou Jiang, Jun Ye, Pu Cheng, Cho Low,
Yikun Guo, Xinchi Yi, Wenteng Chen, Yongpin Yu, YueHua Han, Jun Wu, Shenghang Jin, Dong
Kong, Jian Huang
Theranostics. 2018; 8(16): 4447–4461. Published online 2018 Aug 7. doi: 10.7150/thno.24284

PMCID: 
PMC6134920
ArticlePubReaderPDF–2.5MCitation

Select item 4973997 7.

Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational
Studies
Luis A. García Rodríguez, Mar Martín-Pérez, Charles H. Hennekens, Peter M. Rothwell, Angel
Lanas
PLoS One. 2016; 11(8): e0160046. Published online 2016 Aug 4. doi: 10.1371/journal.pone.0160046

PMCID: 
PMC4973997
ArticlePubReaderPDF–1.7MCitation

Select item 6077698 8.

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory
Dhruv Patel, Avik Roy, Madhuchhanda Kundu, Malabendu Jana, Chi-Hao Luan, Frank J.
Gonzalez, Kalipada Pahan
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): E7408–E7417. Published online 2018 Jul
16. doi: 10.1073/pnas.1802021115

PMCID: 
PMC6077698
ArticlePubReaderPDF–2.7MCitation

Select item 5557878 9.

Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of
chemoprevention
Argentina Ornelas, Niki Zacharias-Millward, David G. Menter, Jennifer S. Davis, Lenard
Lichtenberger, David Hawke, Ernest Hawk, Eduardo Vilar, Pratip Bhattacharya, Steven Millward
Cancer Metastasis Rev. 2017; 36(2): 289–303. Published online 2017 Jul 31. doi: 10.1007/s10555-017-9675-z

PMCID: 
PMC5557878
ArticlePubReaderPDF–910KCitation

Select item 6067079 10.

Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse
Model of Alzheimer's Disease via PPARα
Sujyoti Chandra, Malabendu Jana, Kalipada Pahan
J Neurosci. 2018 Jul 25; 38(30): 6682–6699. doi: 10.1523/JNEUROSCI.0054-18.2018
PMCID: 
PMC6067079
ArticlePubReaderPDF–6.6MCitation

Select item 4838306 11.

Aspirin in the Treatment of Cancer: Reductions in Metastatic Spread and in Mortality: A
Systematic Review and Meta-Analyses of Published Studies
Peter C. Elwood, Gareth Morgan, Janet E. Pickering, Julieta Galante, Alison L. Weightman,
Delyth Morris, Mark Kelson, Sunil Dolwani
PLoS One. 2016; 11(4): e0152402. Published online 2016 Apr 20. doi: 10.1371/journal.pone.0152402

PMCID: 
PMC4838306
ArticlePubReaderPDF–879KCitation

Select item 5778440 12.

Contemporary Reflections on the Safety of Long-Term Aspirin Treatment for the Secondary
Prevention of Cardiovascular Disease
Alexander C. Fanaroff, Matthew T. Roe
Drug Saf. Author manuscript; available in PMC 2018 Jan 23.
Published in final edited form as: Drug Saf. 2016 Aug; 39(8): 715–727. doi: 10.1007/s40264-016-0421-1

PMCID: 
PMC5778440
ArticlePubReaderPDF–268KCitation

Select item 6486024 13.

Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo
Donadini, Cochrane Heart Group
Cochrane Database Syst Rev. 2017 Dec; 2017(12): CD005158. Published online 2017 Dec
14. doi: 10.1002/14651858.CD005158.pub4

PMCID: 
PMC6486024
ArticlePubReaderPDF–799KCitation

Select item 4941319 14.

AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer
effects of aspirin
Mei Gao, Qingbin Kong, Hui Hua, Yancun Yin, Jiao Wang, Ting Luo, Yangfu Jiang
Oncotarget. 2016 Mar 29; 7(13): 16349–16361. Published online 2016 Feb 23. doi: 10.18632/oncotarget.7648

PMCID: 
PMC4941319
ArticlePubReaderPDF–4.7MCitation

Select item 6769718 15.

Molecular Targets of Aspirin and Prevention of Preeclampsia and Their Potential Association
with Circulating Extracellular Vesicles during Pregnancy
Suchismita Dutta, Sathish Kumar, Jon Hyett, Carlos Salomon
Int J Mol Sci. 2019 Sep; 20(18): 4370. Published online 2019 Sep 5. doi: 10.3390/ijms20184370

PMCID: 
PMC6769718
ArticlePubReaderPDF–1.6MCitation

Select item 6464254 16.

Aspirin (single dose) for perineal pain in the early postpartum period
Sujana Molakatalla, Emily Shepherd, Rosalie M Grivell
Cochrane Database Syst Rev. 2017 Feb; 2017(2): CD012129. Published online 2017 Feb
9. doi: 10.1002/14651858.CD012129.pub2
Update in: 
Cochrane Database Syst Rev. 2020 Jul; 2020(7): CD012129.

PMCID: 
PMC6464254
ArticlePubReaderPDF–834KCitation

Select item 6442621 17.

Aspirin-triggered proresolving mediators stimulate resolution in cancer
Molly M. Gilligan, Allison Gartung, Megan L. Sulciner, Paul C. Norris, Vikas P. Sukhatme, Diane
R. Bielenberg, Sui Huang, Mark W. Kieran, Charles N. Serhan, Dipak Panigrahy
Proc Natl Acad Sci U S A. 2019 Mar 26; 116(13): 6292–6297. Published online 2019 Mar
12. doi: 10.1073/pnas.1804000116

PMCID: 
PMC6442621
ArticlePubReaderPDF–1.2MCitation

Select item 5681618 18.

Aspirin for Prevention of Preeclampsia
A. Atallah, E. Lecarpentier, F. Goffinet, M. Doret-Dion, P. Gaucherand, V. Tsatsaris
Drugs. 2017; 77(17): 1819–1831. Published online 2017 Oct 16. doi: 10.1007/s40265-017-0823-0

PMCID: 
PMC5681618
ArticlePubReaderPDF–1.0MCitation

Select item 4673260 19.

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in
vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
Wen Yue, Xi Zheng, Yong Lin, Chung S. Yang, Qing Xu, Darren Carpizo, Huarong Huang,
Robert S. DiPaola, Xiang-Lin Tan
Oncotarget. 2015 Aug 28; 6(25): 21208–21224. Published online 2015 May 12. doi: 10.18632/oncotarget.4126

PMCID: 
PMC4673260
ArticlePubReaderPDF–1.7MCitation

Select item 6232753 20.

Diabetes and Platelet Response to Low-Dose Aspirin
Mohammed E Al-Sofiani, Lisa R Yanek, Nauder Faraday, Brian G Kral, Rasika Mathias, Lewis
C Becker, Diane M Becker, Dhananjay Vaidya, Rita R Kalyani
J Clin Endocrinol Metab. 2018 Dec; 103(12): 4599–4608. Published online 2018 Sep 27. doi: 10.1210/jc.2018-01254

PMCID: 
PMC6232753