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Report On Cyclization
Report On Cyclization
What is cyclization?
Radical cyclization:
1. Organic chemical transformations that yield cyclic products through radical intermediates.
2. There are 3 basic steps.
A. Selective radical generation:
- This can be achieved at the carbons bound to variety of the functional groups & there
are numerous reagents for radical generation.
B. Radical cyclisation:
- This step involves the attack of the radical on the multiple bonds.
C. Conversion of the cyclized radical to product:
- cyclized radicals are quenched through the action of a radical scavenger, a
fragmentation process, or an electron-transfer reaction.
Three conditions must be met for an efficient radical cyclization to take place: