Relapsing Polychondritis

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Dermatoses Morphology Etiology Pathogenesis Treatment/Management

RELAPSING -Characterized by -F=M; 40-50 years old -Dapsone


intermittent episodes of -Cholchicine
POLYCHONDRITIS inflammation of the -A rare multisystem autoimmune disease with both -Leflunomide
articular and non-articular autoantibodies and cellular immune reactions to different -Hydroxychloroquine
cartilage leading to cartilage proteins -Azathioprine
progressive destruction of -Methotrexate
cartilaginous structures -The course of the disease is chronic and variable with episodic -Mycophenolate mofetil
flares -Cyclophosphamide
-IVIG
-Saddle-nose deformity:
destruction of the nasal septal -Associated with: -Systemic corticosteroids
cartilage  Conductive deafness should be used to treat acute
 Conjunctivitis flares
 Scleritis rhinitis
 Saddle nose deformity
 Hoarseness
 Coughing
 Dyspnea
-Bright red swollen tender -Migratory arthralgia and atypical chest pain
cartilaginous portion of the
ear, sparing the earlobe -MAGIC SYNDROME: is a combination of Becet’s diasease
and Relapsing polychondritis (mouth and genital ulcers with
inflamed cartilage)

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