Published by/ D.

T Mahmoud sultan

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 Drug food
interactions

Prepared By
Pharmacist Zaki Al Nahab
Drug Information
Pharmaceutical Care Dept
January 2019
Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interactions

Drug Food Interaction
AcetaZOLAMIDE No interaction
Aciclovir (Acyclovir) No interaction
Acitretin No interaction
Adefovir No interaction
May result in increased risk of
Adenosine Caffeine seizures; decreased therapeutic
effect of adenosine.
May result in increased risk of
Albendazole Grapefruit juice
albendazole adverse effects
May result in reduced
Dairy foods
alendronate exposure.
May result in decreased
Alendronate Orange juice
alendronate bioavailability.
May result in decreased
Food
alendronate bioavailability.
May result in increased alfuzosin
alfuzosin Grapefruit juice
plasma concentrations.
Allopurinol No interaction
May result in increased
Grapefruit juice
alprazolam exposure
ALPRAZolam May result in reduced sedative
Caffeine and anxiolytic effects of
alprazolam
Aluminium Hydroxide and
No interaction
Magnesium Hydroxide
May result in increased risk of
Alteplase Celery
bleeding.
May result in increased
Caffeine theophylline plasma
Aminophylline concentrations.
May result in altered
Food
theophylline concentrations
Amantadine No interaction
Amitriptyline No interaction
AmLODIPine No interaction

1 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Amoxicillin No interaction
Amoxicillin and Clavulanate No interaction
May result in increased bleeding
Apixaban Grapefruit juice
risk
May result in increased
ARIPiprazole Grapefruit juice
aripiprazole exposure.
May result in increased risk of
Aspirin Celery
bleeding
May result in enhanced
bioavailability of atazanavir and
Atazanavir Food
reduced pharmacokinetic
variability
Atenolol No interaction
May result in increased
bioavailability of atorvastatin
AtorvaSTATin Grapefruit juice
resulting in an increased risk of
myopathy or rhabdomyolysis.
AzaTHIOprine No interaction
Azithromycin No interaction
May result in decreased
Carbidopa/Levodopa High protein food
levodopa concentrations.
Benztropine No interaction
Benzylpenicillin [Penicillin G]
No interaction
Benzathine
Betahistine No interaction
May result in gastric or duodenal
Bisacodyl Milk
irritation.
Bisoprolol No interaction
Bosentan No interaction
May result in increased
Bromocriptine Grapefruit juice
bromocriptine concentrations.
Cabergoline No interaction
May result in decreased calcium
Oxalic acid foods
exposure.
Calcium Carbonate
May result in decreased calcium
Phytic acid foods
effectiveness.
Calcium Folinate No interaction

2 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in decreased calcium
Oxalic acid foods
exposure.
Calcium Gluconate
May result in decreased calcium
Phytic acid foods
effectiveness.
Candesartan No interaction
May result in decreased
Captopril Food
captopril concentration
Carbachol No interaction
May result in increased
CarBAMazepine Grapefruit juice
carbamazepine bioavailability.
May result in decreased
Carbidopa/LEVODOPA High protein food
levodopa concentrations.
Carvedilol No interaction
Castor Oil No interaction
Cefixime No interaction
Cefuroxime No interaction
Celecoxib No interaction
Cetirizine No interaction
Charcoal, Activated No interaction
Chloral Hydrate No interaction
Chloroquine No interaction
Chlorpheniramine No interaction
ChlorproMAZINE No interaction
May result in an increased risk
Pomelo juice
of cycloSPORINE toxicity.
May result in an increased risk
CycloSPORINE
of cycloSPORINE toxicity (renal
Grapefruit juice
dysfunction, cholestasis,
paresthesias).
May result in increased
Cinacalcet Food
bioavailability of cinacalcet.
Cinnarizine No interaction
May result in increased caffeine
Caffeine concentrations and enhanced
Ciprofloxacin CNS stimulation.
May result in decreased
Dairy foods
ciprofloxacin concentrations.

3 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Citalopram No interaction
Clarithromycin No interaction
Clindamycin No interaction
May result in reduced sedative
CloBAZam Caffeine and anxiolytic effects of
clobazam.
May result in reduced
Clofazimine Orange juice clofazimine plasma
concentrations.
Clomifene No interaction
May result in an increased risk
ClomiPRAMINE Grapefruit juice
of clomiPRAMINE toxicity.
may result in reduced sedative
ClonazePAM Caffeine and anxiolytic effects of
clonazepam.
CloNIDine No interaction
May result in reduced exposure
Grapefruit juice of the active clopidogrel
Clopidogrel metabolite.
May result in increased risk of
Celery
bleeding.
Cloxacillin No interaction
May result in increased clozapine
Grapefruit juice
plasma levels.
CloZAPine may result in an increased risk
Caffeine of clozapine toxicity (sedation,
seizures, hypotension).
May result in increased
colchicine concentrations and
Colchicine Grapefruit juice
increased risk for colchicine
toxicity.
May result in decreased systemic
Cholecalciferol Olestra cholecalciferol (vitamin D)
concentrations.
Cholestyramine No interaction
Colistimethate No interaction
Cotrimoxazole No interaction
Cyanocobalamin No interaction

4 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Cyclopentolate No interaction
CycloSERINE No interaction
Cyproterone No interaction
Dabigatran No interaction
May result in increased
Daclatasvir Grapefruit juice
daclatasvir exposure.
May result in increased risk of
Dalteparin Celery
bleeding.
Danazol No interaction
Dantrolene No interaction
Dapsone No interaction
Darunavir and Cobicistat No interaction
Dasabuvir No interaction
May result in increased dasatinib
Dasatinib Grapefruit juice
plasma concentrations.
May result in variably increased
Deferasirox Food
deferasirox bioavailability.
Deferiprone No interaction
Denosumab No interaction
Desmopressin No interaction
Dexamethasone No interaction
May result in increased
absorption, bioavailability, and
Dextromethorphan Grapefruit juice
excretion of dextromethorphan
by grapefruit juice.
May result in increased plasma
Grapefruit juice
concentrations of diazepam.
May result in reduced sedative
DiazePAM Caffeine and anxiolytic effects of
diazepam.
May result in increased
High fat food
diazepam concentrations.

Diazoxide No interaction

Diclofenac No interaction
May result in decreased digoxin
Digoxin Food high in bran
concentrations.

5 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in increased plasma
Food
concentrations.
DilTIAZem
May result in increased serum
Grapefruit juice
diltiazem concentrations.
Dimethyl Fumarate No interaction
DiphenhydrAMINE No interaction
Dolutegravir No interaction
May result in increased
Domperidone Grapefruit juice domperidone plasma
concentrations.
Doxazosin No interaction
Doxycycline No interaction
DULoxetine No interaction
Edetate CALCIUM Disodium No interaction
May result in increased
Efavirenz Food
efavirenz absorption.
Elbasvir and Grazoprevir No interaction
Elvitegravir, Cobicistat,
Emtricitabine, and No interaction
Tenofovir Alafenamide
Emtricitabine and
No interaction
Tenofovir Alafenamide
Enalapril No interaction
May result in increased risk of
Enoxaparin Celery
bleeding.
May result in decreased
Entecavir Food
entecavir exposure.
May result in hypertensive crisis
EPHEDrine Bitter orange (headache, hyperpyrexia,
hypertension).
May result in altered
Food
erythromycin concentrations.
Erythromycin
May result in increased
Grapefruit juice
erythromycin bioavailability.
Escitalopram No interaction
May result in reduced
Esomeprazole Cranberry effectiveness of proton pump
inhibitors.

6 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Ethambutol No interaction
Ethionamide No interaction
Ethosuximide No interaction
Etravirine No interaction
Ezetimibe No interaction
May result in an increased risk
of fentanyl toxicity (CNS
FentaNYL Grapefruit juice
depression, respiratory
depression).
May result in reduced iron
Phytic acid foods
absorption.
Ferrous Fumarate May result in decreased iron
Dairy foods
Ferrous Sulfate bioavailability.
May result in reduced iron
Soy
absorption.
Finasteride No interaction
Fingolimod No interaction
FlavoxATE No interaction
Fluconazole No interaction
Fluconazole No interaction
Fludrocortisone No interaction
Flumazenil No interaction
FLUoxetine No interaction
FluPHENAZine No interaction
May result in increased
Fluticasone Grapefruit juice
fluticasone exposure.
Fluvastatin No interaction
May result in increased
FluvoxaMINE Grapefruit juice
fluvoxamine exposure.
Folic Acid No interaction

Follitropin Alfa No interaction

Follitropin Beta No interaction

May result in reduced
Avocado
anticoagulant effectiveness.
Fondaparinux
May result in increased risk of
Celery
bleeding.

7 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in decreased
Furosemide Food furosemide exposure and
efficacy.
Gabapentin No interaction
Gemfibrozil No interaction
Gentamicin No interaction
Glibenclamide No interaction
Gliclazide No interaction
Glimepiride No interaction
May result in increased
Griseofulvin Food
griseofulvin exposure.
GuaiFENesin No interaction
Haloperidol No interaction
May result in reduced
Avocado
anticoagulant effectiveness.
Heparin
May result in increased risk of
Celery
bleeding.
May result in decreased
Enteral nutrition
hydrALAZINE concentrations.
HydrALAZINE May result in decreased
Food hydrALAZINE exposure and
efficacy.
HydroCHLOROthiazide No interaction
Hydrocortisone No interaction
HYDROmorphone No interaction
Hydroquinone No interaction
Hydroxyurea No interaction
Hydroxychloroquine No interaction
HydrOXYzine No interaction
Hyoscine Butylbromide
No interaction
[Scopolamine]
Ibuprofen No interaction
May result in increased risk of
Iloprost Celery
bleeding.
May result in increased imatinib
Imatinib Grapefruit juice
plasma concentrations.
Imipramine No interaction

8 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Indapamide No interaction
Indomethacin No interaction
Irbesartan No interaction
May result in reduced iron
Iron Sucrose Phytic acid foods
absorption.
May result in decreased
Food
isoniazid exposure.
May result in increased blood
Tyramine foods
pressure.
Isoniazid
May result in exaggerated
Histamine response to foods containing
containing food histamines (eg, skipjack, tuna,
other tropical fish).
Isosorbide Dinitrate No interaction
ISOtretinoin No interaction
Ispaghula [Psyllium] No interaction
May result in decreased oral
bioavailability of itraconazole
Grapefruit juice
resulting in an increased risk of
clinical antifungal failure.
Itraconazole
May result in increased or
decreased bioavailability of
Food
itraconazole, depending on the
dosage form of itraconazole.
May result in increased
Ivabradine Grapefruit juice
ivabradine exposure.
May result in increased labetalol
Labetalol Food
exposure.
Lactulose No interaction
Lamivudine\Zidovudine No interaction
LamoTRIgine No interaction
Ledipasvir\Sofosbuvir No interaction
May result in increased
Lercanidipine Grapefruit juice lercanidipine exposure and
increased hypotension.
Letrozole No interaction
LevETIRAcetam No interaction
LevoFLOXacin No interaction

9 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Enteral nutrition May result in hypothyroidism.
Levothyroxine May result in decreased
Soy
effectiveness of levothyroxine
Lidocaine No interaction
Linagliptin No interaction
May result in hypertensive crisis
Avocado (headache, palpitation, neck
stiffness).
May result in hypertensive crisis
Linezolid
Bitter orange (headache, hyperpyrexia,
hypertension).
May result in a significant
Tyramine foods
pressor response.
Liraglutide No interaction
Lisinopril No interaction
Loperamide No interaction
Lopinavir\Ritonavir No interaction
Loratadine No interaction
May result in reduced sedative
LORazepam Caffeine and anxiolytic effects of
lorazepam.
May result in increased half-life
(t1/2) and decreased area under
Losartan Grapefruit juice the concentration time curve
(AUC) of losartan's active
metabolite (E3174).
Magnesium Sulfate No interaction
Mebendazole No interaction
Mebeverine No interaction
May result in enhanced CNS
MedroxyPROGESTERone Caffeine
stimulation.
Mefloquine No interaction
Meloxicam No interaction
Memantine No interaction
Meropenem No interaction
Mesalamine No interaction
Mesna No interaction

10 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

MetFORMIN No interaction
May result in increased
methadone exposure, decreased
Methadone Grapefruit juice
clearance of all enantiomers
(R-, S-, R,S-methadone).
May result in increased
Methotrexate Cola methotrexate serum levels and
increased risk of toxicity.
Methoxy Polyethylene
No interaction
Glycol-Epoetin Beta
Methyldopa No interaction
Methylphenidate No interaction
May result in increased
MethylPREDNISolone Grapefruit juice
methylPREDNISolone exposure.
Metoclopramide No interaction
MetOLazone No interaction
May result in increased
Metoprolol Food
metoprolol concentrations.
MetroNIDAZOLE No interaction
May result in an increased risk
Mexiletine Caffeine
of caffeine adverse effects
Miconazole No interaction
May result in increased
bioavailability and
Grapefruit juice
pharmacodynamic effects of
midazolam.
Midazolam May result in increased CNS
Bitter orange
depression.
May result in reduced sedative
Caffeine and anxiolytic effects of
midazolam.
May result in increased
Mirtazapine Grapefruit juice
mirtazapine exposure.
Modafinil No interaction
Mometasone No interaction
May result in increased
Montelukast Grapefruit juice
montelukast exposure.
Morphine No interaction

11 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Moxifloxacin No interaction
Mycophenolate No interaction
Naproxen No interaction
Neostigmine No interaction
May result in severe
hypotension, myocardial
NIFEdipine Grapefruit juice
ischemia, increased vasodilator
side effects.
May result in increased nilotinib
Grapefruit juice
plasma concentrations.
Nilotinib
May result in increased nilotinib
Food
exposure.
May result in increased
Grapefruit juice
nimodipine bioavailability.
NiMODipine
May result in reduced nimodipine
Food
efficacy.
Nitrofurantoin No interaction
May result in enhanced CNS
Norethindrone Caffeine
stimulation.
Nystatin No interaction
Ofloxacin No interaction
OLANZapine No interaction
Olmesartan No interaction
Ombitasvir, Paritaprevir, May result in increased
Grapefruit juice
and Ritonavir (Viekirax®) paritaprevir exposure.
May result in reduced
Omeprazole Cranberry effectiveness of proton pump
inhibitors.
Ondansetron No interaction

Oral Rehydration Therapy No interaction

Oseltamivir No interaction

Paliperidone No interaction

May result in reduced

Pantoprazole Cranberry effectiveness of proton pump
inhibitors.

12 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in decreased
Cabbage
acetaminophen effectiveness.
Paracetamol
May result in decreased peak
Food
acetaminophen concentrations.
Paricalcitol No interaction
PARoxetine No interaction
May result in decreased
PenicillAMINE Food
penicillamine concentrations.
Pentamidine No interaction
Pentoxifylline No interaction
Perindopril No interaction
May result in increased
Pethidine plasma concentrations
Pethidine Grapefruit juice
and increased risk of respiratory
depression.
PHENobarbital No interaction
Phenoxymethylpenicillin No interaction
Phentolamine No interaction
May result in hypertensive crisis
Phenylephrine Bitter orange (headache, hyperpyrexia,
hypertension).
May result in decreased serum
phenytoin levels and
Enteral nutrition subsequently reduced
Phenytoin therapeutic response to
phenytoin.
May result in altered phenytoin
Food
concentrations.
Physostigmine No interaction
May result in decreased vitamin K
Phytonadione Olestra
levels.
Pioglitazone No interaction
Polyethylene Glycol-
No interaction
Electrolyte Solution
Pramipexole No interaction
Praziquantel No interaction
Prazosin No interaction
PrednisoLONE No interaction

13 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Pregabalin No interaction
May result in increased
Primaquine Grapefruit juice
primaquine plasma concentration.
Procyclidine No interaction

Promethazine No interaction
May result in increased
Propafenone Grapefruit juice
propafenone exposure.
May result in increased
Propranolol Food
propranolol concentrations.
May result in altered drug
Propylthiouracil Food
concentrations.

Pyrazinamide No interaction

May result in decreased

Pyridoxine Food
pyridoxine exposure
Pyrimethamine No interaction
May result in increased
QUEtiapine Grapefruit juice
quetiapine exposure
May result in decreased
Grapefruit juice metabolic conversion of quinidine
to 3-hydroxyquinidine.
QuiNIDine May result in increased quinidine
Food
concentrations.
May result in increased quinidine
Alkaline foods
concentrations.

QuiNINE No interaction

Raltegravir No interaction
May result in reduced
RaNITIdine Cranberry effectiveness of histamine-2
blockers.
May result in increased risk of
Reteplase Celery
bleeding.
Ribavirin No interaction

14 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in decreased rifampin
Rifampicin Food
concentrations.
May result in decreased
isoniazid exposure.
Food
May result in decreased rifampin
concentrations.
Concurrent use of isoniazid and
Tyramine foods tyramine foods may result in
Rifampicin/Isoniazide increased blood pressure.
Concurrent use of isoniazid and
histamine containing food may
Histamine result in exaggerated response
containing food to foods containing histamines
(eg, skipjack, tuna, other
tropical fish).
Riluzole No interaction

RisperiDONE No interaction

Ritonavir No interaction

Rivaroxaban No interaction
Rosuvastatin No interaction
Salbutamol No interaction
SAXagliptin No interaction
Senna No interaction
May result in elevated sertraline
serum concentrations and an
Sertraline Grapefruit juice
increased risk of adverse side
effects.
Sevelamer No interaction
May result in increased sildenafil
Rapefruit juice bioavailability and delayed
sildenafil absorption.
Sildenafil
May result in reduced plasma
Pomelo juice concentrations and efficacy of
sildenafil.

15 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in increased
Simeprevir Grapefruit juice
simeprevir exposure.
Simeticone No interaction
May result in increased
bioavailability of simvastatin
Grapefruit juice
resulting in an increased risk of
Simvastatin myopathy or rhabdomyolysis.
May result in increased risk of
Cranberry juice hepatitis and
myopathy/rhabdomyolysis.
May result in an increased risk
of sirolimus toxicity (anemia,
Sirolimus Grapefruit juice
leukopenia, thrombocytopenia,
hypokalemia, diarrhea).
SITagliptin No interaction

Sofosbuvir No interaction

Sofosbuvir and Velpatasvir No interaction

Somatropin No interaction
SORAfenib No interaction
Sotalol No interaction

Spironolactone No interaction
May result in increased risk of
Streptokinase Celery
bleeding.
Streptomycin No interaction

Sucralfate No interaction

SulfaSALAzine No interaction

Sulpiride No interaction

SUMAtriptan No interaction
May result in increased
Tacrolimus Grapefruit
tacrolimus concentration.

16 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in increased
Pomegranate
tacrolimus exposure.
May result in an increase in
Grapefruit juice
tamsulosin plasma exposure.
Tamsulosin
May result in decreased
Food
tamsulosin bioavailability.
Telaprevir No interaction
Telmisartan No interaction
Telmisartan and
No interaction
Hydrochlorothiazide
Tenofovir Alafenamide No interaction

Terbinafine No interaction

Teriflunomide No interaction
May result in decreased
Tetracycline Dairy foods
tetracycline concentrations.
May result in increased
Caffeine theophylline plasma
Theophylline concentrations.
May result in altered
Food
theophylline concentrations.
Thiamine No interaction
May result in increased
Ticagrelor Grapefruit juice ticagrelor exposure and
antiplatelet activity.
May result in increased risk of
Tinzaparin Celery
bleeding.
May result in increased risk of
Tirofiban Celery
bleeding.
Tolterodine No interaction

Topiramate No interaction
May result in increased tramadol
plasma concentrations and
TraMADol Grapefruit juice
increased risk of respiratory
depression.

17 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

Tranexamic Acid No interaction

Trihexyphenidyl No interaction

Trimetazidine No interaction
May result in hypertensive crisis
Triprolidine and
Bitter orange (headache, hyperpyrexia,
Pseudoephedrine
hypertension).
Ursodeoxycholic Acid No interaction
ValACIclovir No interaction
May result in increased
ValGANciclovir High fat food
ganciclovir exposure.
Valproic Acid No interaction
Valsartan No interaction
Valsartan and
No interaction
Hydrochlorothiazide
Venlafaxine No interaction
May result in an increased risk of
verapamil adverse effects
Grapefruit juice
(flushing, edema, hypotension,
Verapamil myocardial ischemia).
May result in increased caffeine
Caffeine serum concentrations and enhanced
CNS stimulation.
Vildagliptin No interaction
Vitamin A No interaction
Vitamin B 1 (Thiamin) No interaction
Vitamin B 12 (Cyanocobalamin) No interaction
Vitamin B2 No interaction
may result in decreased
Vitamin B 6 Food
pyridoxine exposure.
Vitamin B Complex No interaction

May result in decreased systemic

Vitamin D3 Olestra cholecalciferol (vitamin D)
concentrations.

Vitamin E No interaction

18 DRUG FOOD INTERACTIONS

Prepared By : Pharmacist Zaki Ali Al Nahab

Drug Food Interaction

May result in decreased vitamin K
Vitamin K Olestra
levels.
May result in decreased
Voriconazole Food
voriconazole exposure.
Cranberry juice May result in an increased risk
of bleeding
May result in increased warfarin
Pomegranate plasma concentrations and
increased risk of bleeding.

Vitamin k foods May result in altered

anticoagulant effectiveness.
May result in reduced
Green tea
anticoagulant effectiveness.
May result in decreased
Black tea
warfarin effectiveness.
May result in reduced warfarin
High-protein diet
anticoagulant effectiveness.
Warfarin
May result in decreased PT/INR
Enteral nutrition response to warfarin and
development of warfarin resistance.

Avocado May result in reduced

anticoagulant effectiveness.
May result in risk of acquiring
Noni juice
warfarin resistance.

Soy May result in reduced warfarin

effectiveness.
May result in increased risk of
Celery
bleeding.
May result in increased
Parsley
anticoagulant effectiveness.

Pharmaceutical Care Dept Reference

Drug Information IBM Micromedex Solution Online
Pharmacist Zaki Ali Al Nahab Lexicomp Online
Prepared on January 2019

19 DRUG FOOD INTERACTIONS

 Published by/ D.T Mahmoud sultan

For more books and articles join to the channel in Telegram

https://t.me/Mss01098772552

WhatsApp: 00201098772552