DRUG THERAPEUTIC RECORD

MECHANISM CONTRAINDICA SIDE EFFECTS/

DRUG NAME DRUG CLASS INDICATIONS NURSING CONSIDERATION
OF ACTION TIONS ADVERSE EFFECTS
Generic: Therapeutic: Depresses the Sedation for the relief - Hypersensitivi CNS: Before:
Mephobarbital Sedative- sensory cortex, of anxiety, tension, ty to any Somnolence(common) 1. Assess B/P, pulse, respirations
hypnotic, decrease motor and apprehension, barbiturate. ; Agitation, confusion, before administration.
anticonvulsant activity, alter and as an hyperkinesia, ataxia, 2. Observe patient closely; maintain
cerebellar anticonvulsant for the - Manifest or CNS depression, airway. Have equipment for
Brand: function, and treatment of grand latent nightmares, artificial respiration immediately
Mebaral produce mal and petit mal porphyria. nervousness, available.
drowsiness, epilepsy. psychiatric 3. Assess hypersensitivity to any
sedation, and Adults: 32 mg to 100 disturbance, barbiturate or history of porphyria
Pharmacologic: hypnosis. mg (1/2 grain to 1 1/2 Pregnancy hallucinations, 4. Review if the patient is taking
Barbiturates grains)–optimum Category: D insomnia, anxiety, anticoagulants, corticosteroids
anticonvulsants dose, 50 mg (3/4 dizziness, thinking and other medications that may
grain)–three to four abnormality. cause drug interaction
times daily. GI: constipation, 5. Caution should be exercised
nausea and vomiting when a barbiturate is
Epilepsy: Average Respi: Apnea, administered to a nursing woman
dose for adults: 400 hypoventilation since small amounts of
mg to 600 mg (6 Cardio: Bradycardia, barbiturates are excreted in the
grains to 9 grains) Hypotension, milk
daily; children under 5 syncope. 6. Review the dosage of the
years: 16 mg to 32 mg Others: Headache, medication and the patients
(1/4 grain to ½ grain) hypersensitivity indications.
three or four times reactions
daily; children over 5 (angioedema, skin During:
years: 32 mg to 64 mg rashes, exfoliative 1. Closely monitor blood pressure
(½ grain to 1 grain) dermatitis), fever, liver and heart and respiratory
three or four times damage, rates.Watch for evidence of
daily.  megaloblastic anemia respiratory depression.
following chronic 2. Monitor CNS status before and
Combination with phenobarbital use. during therapy. And secure
Other Drugs: Drug Abuse And patient’s safety from injury from
 MEBARAL Dependence fall
(mephobarbital) may 3. Monitor for symptoms of acute
be used in intoxication with barbiturates
combination with include unsteady gait, slurred
phenobarbital, either speech, and sustained
in the form of nystagmus. Mental signs of
alternating courses or chronic intoxication include
concurrently. confusion, poor judgment,
irritability, insomnia, and somatic
complaints.
4. Monitor for hypersensitivity
reactions
After:
1. Advise patient to avoid other
CNS depressants such as
alcohol
2. Caution patient to avoid driving
and other hazardous activities.
3. As appropriate,review all other
significant and life-threatening
adverse reactions and
interactions, especially those
related to the drugs,tests and
behaviors mentioned above.
4. Monitor for signs of patient’s
dependence to the drug such as
a strong desire or need to
continue taking the drug; (b) a
tendency to increase the dose;
(c) a psychic dependence on the
effects of the drug related to
subjective and individual
appreciation of those effects, etc.

Reference: Mebaral - FDA prescribing information, side effects and uses (drugs.com)