Calculation and Visualization of synergy scores for Drug Combinations

Drug combinations:

Drug combination Synergy score Most synergistic area score Method

kopi - Tehh 3.08 9.68 Loewe

Chosen parameters:

Readout: viability ; Baseline correction: Yes ;

 kopi & Tehh

Dose−response matrix (inhibition)

Dose−response curve for drug: Tehh

100
320 33.41 22.04 7.13 23.02 51.67 48 47.37
80

60
160 19.37 4.91 16.71 28.24 29.8 33.02 24.96
40
●
20
● ● ●
● ●
0
80 17.18 9.02 22.9 27.06 29.96 13.89 27.95
inhibition (%)
100
10 20 50 100 200

Tehh (nM)
75
Concentration (nM)
40 15.45 19.92 22.2 23.69 11.6 25.68 28.59
50

Dose−response curve for drug: kopi 25

20 10.51 16.78 7.22 6.21 14.52 26.58 22.48

100

80

60 10 8.55 3.76 2.48 8.4 12 16.72 25.97

40

20 ● ● ●
●
● 0 100 2.57 9.42 15.63 20.28 21.1 23.29
0 ●

10 20 50 100 200 0 10 20 40 80 160 320

kopi (nM)
Concentration (nM)
 Loewe synergy score: 3.08
−30 −20 −10 0 10 20 30

320
Loewe synergy score: 3.08
−30 −20 −10 0 10 20 30

160

30
80
20
Tehh (nM)

10

δ − score
40 0

−10

−20
20
−30
320
160
80
10 320
Te

40 160
hh

20 80
(n

40
M

)
i (nM
20
)

10
0
10 kop
0 10 20 40 80 160 320
kopi (nM)