 PHA6444

 Assignments
 Module 4 Assignment

Question 1: Module 4 covered the interactions of epinephrine with β-adrenergic receptors as a

full agonist. The task at hand now is to model the interaction between epinephrine and the human
β2-adrenergic receptor using AutoDock. You need to document which receptor you selected from
the Protein data bank (http://www.rcsb.org/pdb/home/home.do (Links to an external site.)) and
which file you used for epinephrine from the same database. Document your steps in creating the
grid, especially which amino acid residue you chose as the covalent grid parameter, and what the
top 3 docking results are in regards to the amino acid residue interactions. You may want to go
back to assignment 1 and listen to the YouTube tutorial by John Cahill
(https://youtu.be/ZiuqSzqcD7M (Links to an external site.)). Your submission needs to include
the documentation as well as the grid and docking files.

https://www.youtube.com/watch?v=ZiuqSzqcD7M

You can once again use Discovery Studio Visualizer (https://discover.3ds.com/discovery-studio-

visualizer-download (Links to an external site.)) to display the amino acid-ligand interactions.

Always provide references with your assignment submissions.