Expected results: At the Human Vaccines Project, we are taking an entirely new approach to fighting disease. Harnessing the enormous potential of artificial intelligence, we are conquering one of the greatest remaining frontiers of human health—the immune system. Actual results: Vaccines that harness the human immune system already have added decades to our lives. They have helped people conquer and control a wide range of diseases, but humanity is increasingly held back by the limits of scientific knowledge. Today, the diseases that people have to battle are much more biologically complex than those conquered in the past. Despite decades of work and billions in investment, vaccines for HIV, tuberculosis, and cancers have evaded scientists’ best efforts and humanity remains unprepared against the next pandemic. Conclusion: At the Human Vaccines Project, we are taking an entirely new approach to fighting disease. We are harnessing the power of the human immune system with the enormous potential of machine learning and artificial intelligence, to decipher the key principles guiding human immunity across diseases.