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Endoscopic Management in The Bariatric Surgical Patient: Benjamin E. Levitzky and Wahid Y. Wassef
Endoscopic Management in The Bariatric Surgical Patient: Benjamin E. Levitzky and Wahid Y. Wassef
Keywords
bariatric surgery, laparoscopic adjustable gastric band, Roux-en-Y gastric bypass,
surgical complications, therapeutic endoscopy
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Bariatric endoscopy Levitzky and Wassef 633
controversial as data in this population remain limited Figure 1 Roux-en-Y gastric bypass anatomy
[6,7]. In light of this, radiographic studies and evaluation
for Helicobacter pylori by serology should be considered
since they provide an alternative means for preoperative
risk stratification. These recommendations are further
elaborated in a position statement by the American Society
for Gastrointestinal Endoscopy [9].
Intraoperative endoscopy
Gastroenterologists may be asked by their surgical col-
leagues to perform intraoperative endoscopy during
RYGB. EGD in this setting helps the surgeon immedi-
ately assess staple lines for hemorrhage, evaluate pouch
size, measure stomal diameter, and test for integrity of
the gastrojejunal anastomosis and pouch to help prevent
early postoperative leaks [7]. During leak testing, the
surgeon clamps the Roux limb and submerges the
gastrojejunal anastomosis and pouch in saline while
the endoscopist pneumatically insufflates the lumen.
Leaks may be identified as bubbles emanating from a
staple line and promptly repaired by the surgeon.
Pooled data from 1930 patients undergoing intraopera-
tive pneumatic testing successfully identified leaks in
7.3% of patients, with a subsequent postoperative leak
rate of 0.7% [7]. This postoperative leak rate is notably
lower than the estimated leak rate of 1.4% to 2% for
(Courtesy of Ethicon Endo-Surgery, Inc; with permission).
all RYGB procedures that were not evaluated intra-
operatively [10].
LAGB consists of an adjustable gastric band, a subcu-
taneous port, and tubing connecting the band and port
Postoperative management (Fig. 2). The band is secured laparoscopically around the
Bariatric surgical complications may occur early or late in proximal stomach just distal to the gastroesophageal junc-
the postoperative course in up to 40% of patients [11,12]. tion. The anterior aspect of the band is sutured in the
Early complications such as bleeding, infection, and region of the cardia to reduce band slippage [8]. When
anastomotic leaks are traditionally managed surgically saline is infused into the port, it passes through the tubing
[13]. Some late complications such as anastomotic stric- and expands the band’s reservoir, thereby increasing
tures and marginal ulcers can be managed endoscopically. gastric restriction.
This section will review the postsurgical anatomy of the Symptoms
gastrointestinal tract following LAGB and RYGB, outline Common postoperative symptoms include inadequate
common symptoms which may herald a postoperative weight loss, nausea and vomiting, and abdominal or
complication, and then discuss the recommended endo- retrosternal pain [8,14].
scopic approach to these complications.
Inadequate weight loss
Postsurgical anatomy Up to 25% of patients undergoing bariatric surgery experi-
It is essential for the gastroenterologist to fully under- ence inadequate weight loss, thus extensive preoperative
stand postoperative gastrointestinal tract anatomy in counseling is mandatory to help establish realistic weight
order to recognize potential symptoms and complications loss goals. It can be a diagnostic challenge to determine if
that may arise. The RYGB is formed by partitioning the inadequate weight loss is due to operative failure or dietary
stomach into a proximal gastric pouch and distal gastric noncompliance. Endoscopy remains the best way to assess
remnant by means of a laparoscopic stapling device the integrity of the postoperative anatomy and is indicated
(Fig. 1). The jejunum is incised 10–30 cm distal to when weight loss is less than anticipated despite appro-
the ligament of Treitz and the distal jejunal ‘Roux’ priate dietary habits [8]. Anatomic disturbances that may
limb is anastomosed to the gastric pouch. The proximal cause inadequate weight loss include pouch dilation,
‘biliopancreatic’ limb is attached downstream, creating a dilation of the gastrojejunal anastomotic aperture, and
separate jejunojejunal anastomosis. gastrogastric fistula formation.
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634 Stomach and duodenum
Figure 2 Laparoscopic adjustable gastric band anatomy ranted for moderate-to-severe pain or when dietary
changes fail to alleviate pain in order to evaluate for
stomal stenosis, marginal ulceration, and other structural
abnormalities. If abscess or seroma formation is of con-
cern, prompt abdominal CT scan is indicated [15].
Stenosis
The gastrojejunal anastomosis is the most common site of
stenosis following bariatric surgery. Stenosis may also
occur at the region of a gastric band, at sites of adhesions,
or at the jejunojejunal anastomosis.
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Bariatric endoscopy Levitzky and Wassef 635
this scenario include band replacement or conversion moderate weight loss observed over a 1-year follow-up
to RYGB. period [22]. Other promising techniques using clips,
endoscopic suturing devices, fibrin glue, and argon
Gastrointestinal bleeding plasma coagulation are evolving and may provide inno-
Significant upper gastrointestinal bleeding occurs in vative strategies for reduction of anastomotic aperture.
approximately 1–4% of patients after RYGB and may More confirmatory data are needed before these tech-
be acute or chronic [7]. It commonly occurs at the staple niques can be routinely recommended.
line of the gastrojejunal anastomosis and may be associated
with marginal ulceration. Hemorrhage may also occur at Staple-line disruption, fistulas, and leaks
staple lines of the gastric remnant, pouch, or jejunojejunal Staple-line disruption may result in extraluminal leaks or
anastomosis. Thorough examination of the Roux and gastrogastric fistulas. Extraluminal leaks are particularly
biliopancreatic limbs is technically challenging and may dreaded complications that occur in up to 5.6% of patients
require the use of an enteroscope, colonoscope, balloon after RYGB and may result in peritonitis, abscess for-
enteroscope, or shape-locking overtube [15]. The endo- mation, sepsis, and death [8]. One series of 63 patients
scopic management of early postoperative bleeding after with leaks after RYGB reported a mortality rate of 10%
RYGB is complicated by the risk of perforation at imma- [23]. The management of early postoperative leaks
ture surgical anastomotic sites. Some experts advocate remains primarily surgical and there is little role for
early operative intervention with or without laparoscopi- endoscopy in this setting [7]. Endoscopic evaluation
cally assisted endoscopy in this setting [7]. If early post- of suspected leaks should only be considered in a stable
operative endoscopy is considered, it must be conducted in patient whose diagnosis remains uncertain or in the rare
the operating room setting under general anesthesia to case in which an endoscopic intervention is planned.
permit immediate operative intervention should perfor- Endoscopic management of leaks has been described
ation occur or endoscopic intervention fail [7,19]. in small series using partially covered self-expanding
metal stents, Polyflex stents, argon plasma coagulation,
Early postoperative gastrointestinal bleeding is less com- endoscopic clips, and fibrin glue [24,25]. Such methods
mon following LAGB, and standard upper endoscopy is remain investigational at this time and are solely to be
usually sufficient for management of hemorrhage in considered as an adjunct to surgical therapy.
this situation.
Techniques for the endoscopic management of chronic
gastrogastric fistulas are being actively investigated [26].
Endoscopic management of complications In one series of 95 patients with small, symptomatic
following Roux-en-Y gastric bypass gastrogastric fistulas, endoscopic repair was attempted
Gastrojejunal anastomotic dilation, staple-line disrup- with the EndoCinch suturing system or endoscopic clips
tion, and marginal ulceration may all complicate RYGB. using a mean of 2.2 sutures or 3 clips [27]. Whereas
fistula closure was achieved in 95% of patients, reopening
Dilation of the gastrojejunal anastomosis occurred 65% of the time at a mean of 177 days. Fistula
Widening of the gastrojejunal anastomosis may present as size predicted long-term outcomes, with the best results
weight regain due to failure of the anastomosis to restrict observed in fistulas 10 mm or less in diameter. Other
food intake. Multiple endoscopic techniques to address investigators used the technique of endoscopic peristo-
this complication have been described. Endoscopic scler- mal mucosectomy followed by the use of an endoscopic
otherapy with circumferential injection of sodium morrh- tissue opposition device to achieve temporary gastrogas-
uate at the anastomosis has been used successfully for tric fistula closure [28]. Whereas temporary fistula repair
stomal contraction and offers a nonsurgical treatment may be feasible endoscopically, long-term durability
modality [20]. Endoscopic suturing provides an alterna- remains an ongoing challenge. Additional long-term data
tive means for stomal reduction. The EndoCinch system will be needed before these methods can be routinely
(C.R. Bard Inc., New Jersey, USA) has been used to recommended [7].
position sutures at the rim of dilated gastrojejunal ana-
stomoses [21]. When tightened, the sutures form tissue Marginal ulceration
plications that effectively reduce aperture diameter and Marginal ulcers develop in 0.6–16% of patients following
result in variable but significant weight loss. The Inci- RYGB [15]. They occur most commonly in the first
sionless Operating Platform (USGI Medical, Inc., Cali- several months following surgery with a progressively
fornia, USA) is a modality that allows for endoluminal decreased incidence thereafter. In one series, marginal
cutting, sewing, tissue manipulation, and creation of ulcers were found endoscopically at 1 month following
tissue plications. Multicenter experience with this plat- surgery in 4.1% of patients after open RYGB and 12.3%
form for gastrojejunal stomal dilation demonstrated a after laparoscopic RYGB, with 28% of all ulcers occurring
50% mean reduction in stomal diameter with mild-to- in the absence of symptoms [29]. Contributing factors to
Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
636 Stomach and duodenum
ulcer formation include local tissue ischemia, use of Figure 3 Slippage of a laparoscopic adjustable gastric band
nonsteroidal anti-inflammatory drugs, foreign body reac-
tions to staples or sutures, gastrogastric fistula, H. pylori
infection, and surgical factors including pouch orientation
and size.
Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
Bariatric endoscopy Levitzky and Wassef 637
in RYGB anatomy [31]. Another well described approach Figure 5 Vertical banded gastroplasty
is laparoscopic-assisted ERCP. In this technique, trans-
gastric ERCP is performed through a trocar placed surgic-
ally into the excluded portion of the stomach. Once the
trocar is in place, the endoscopist is able to advance a
duodenoscope to the papilla for biliary access [31]. Other
researchers have described the use of percutaneous gastro-
enterostomy tubes placed into the excluded stomach as
conduits for successful ERCP. All of these approaches are
reasonable means to address the difficult quandary of
ERCP after RYGB. Selection of an individual technique
is dependent on the resources available to the endoscopist
and the skill set of the operator.
Endoscopic gastroplasty
Endoscopic gastroplasty has been performed using both
(Reprinted with permission of the American Society for Gastrointestinal
endoscopic stapling and suturing devices. Initial studies Endoscopy) [35].
on a system for transoral gastroplasty (TOGa; Satiety Inc.,
California, USA) reported encouraging results for the
endoscopic creation of a stapled-restrictive pouch along of the gastric lumen (Fig. 5) [35]. In a trial of 64 patients,
the lesser curvature of the stomach [34]. Figure 4 demon- endoluminal vertical gastroplasty resulted in a decrease
strates the steps used by TOGa for pouch creation. A in the mean body mass index from 39.9 to 30.6 without
randomized, sham-controlled trial to assess the safety and serious adverse events reported [35]. Similar short-term
efficacy of TOGa is currently underway. efficacy of endoluminal vertical gastroplasty was reported
in 16 patients within the US and a randomized, multi-
Endoluminal vertical gastroplasty using the EndoCinch center trial is ongoing at this time [36]. Well designed
system utilizes endoscopic suturing to restrict the volume trials with long-term follow-up will be necessary to
Figure 4 Transoral gastroplasty (TOGa)
(a) Diagram depicting deployment of the TOGa over-the-scope, with the endoscope retroflexed for viewing the procedure. (b) Diagram illustrating
retroflexed endoscopic view of the TOGa device gathering anterior and posterior gastric mucosa into the suction chamber prior to stapling. (c) Diagram
depicting formation of a stapled restrictive pouch along the lesser curvature with overlapping staple lines using the TOGa system (Courtesy of Satiety
Inc; with permission).
Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
638 Stomach and duodenum
determine the durability of weight loss, particularly since Figure 7 The GI Dynamics duodenojejunal bypass sleeve
long-term stability of the gastric plications remains
unproven [37].
Intragastric balloon
The BioEnterics Intragastric Balloon (Allergan Inc., Cali-
fornia, USA) (Fig. 6) is an endoscopically placed balloon
that occupies the gastric lumen, thereby limiting func-
tional intragastric volume [38]. Studies on the use of this
balloon over 3-month and 1-year intervals have resulted
in significant weight loss, although concern for potential
gastrointestinal obstruction has been raised [8,37]. It
may have value in specific patients by providing a bridge
to surgery in high-risk, severely obese individuals who
may otherwise be nonoperative candidates [8,39]. Firm (Courtesy of GI Dynamics, with permission).
evidence of the long-term safety and efficacy of the
intragastric balloon is lacking, and it remains unapproved
by the Food and Drug Administration for use in the US. Duodenojejunal bypass sleeve
Endoluminal appliances used to induce gastrointestinal
Figure 6 The BioEnterics intragastric balloon malabsorption remain in an early stage of development
but may offer great potential for long-term weight loss
[37]. The EndoBarrier duodenojejunal bypass sleeve
(GI Dynamics, Massachusetts, USA) is an endoscopically
deployed prosthesis comprised of a self-expanding
implant which lodges in the duodenum and is attached
to a 60-cm plastic sleeve that extends to the proximal
jejunum (Fig. 7). In a trial of 25 patients, the sleeve
stayed in place over a 3-month period in 80% of patients
and achieved noninvasive duodenal exclusion and short-
term weight loss [40]. However, major adverse events
occurred in 20% of patients and included anchor
migration, stent obstruction, and upper gastrointestinal
bleeding. Further studies will be needed to clarify the
safety and efficacy of this device and it remains unap-
proved for use within the US.
Conclusion
As the prevalence of morbid obesity continues to rise,
gastroenterologists will care for bariatric surgical patients
with increasing frequency. It is imperative that gastro-
enterologists be knowledgeable about their role in the
management of bariatric patients preoperatively, intrao-
peratively, and postoperatively in the early recognition of
complications and their endoscopic management. As
technology continues to evolve, we can anticipate new
endoscopic platforms which will broaden the application
of endoscopy for the morbidly obese patient leading to
bariatric endoscopy. This is a term we are using here to
refer to primary endoluminal weight loss procedures that
provide a well tolerated and effective alternative to
surgery. These techniques are on the horizon and offer
the promise of less invasive weight loss strategies for the
morbidly obese patient. However, to date the use of such
(Reprinted with permission of the American Society for Gastrointestinal techniques cannot be routinely recommended outside the
Endoscopy) [38].
realm of a clinical trial. Until then, the role of endoscopy in
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Bariatric endoscopy Levitzky and Wassef 639
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