Patents

Production of 5-hydroxymethylfurfural from fructose using a single-phase mixed aqueous-organic solvent system

Abstract
WO2013053816A1
The present invention relates to a process for producing 5-hydroxymethylfurfural (HMF) from
WIPO (PCT)
fructose in a single-phase aqueous solution comprising an organic solvent.

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Other languages: French

C07D307/50
Preparation from natural products
Inventor: Jacob Skibsted JENSEN, Thomas Grotkjaer, Sven
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Pedersen, Rolf RINGBORG

Worldwide applications

2012

US
BR
WO
CN
EP
IN

Application PCT/EP2012/070151 events

2011-10-12 Priority to EP11184895.8

2011-10-12 Priority to EP11184895

2011-10-19 Priority to US201161548831P

2011-10-19 Priority to US61/548,831

2012-05-01 Priority to US61/640,958

2012-05-01 Priority to US201261640958P

2012-10-11 Application filed by Novozymes A/S

2013-04-18 Publication of WO2013053816A1

Info: Patent citations (14), Non-patent citations (13), Cited by (9)

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Applications

External links: Espacenet, Global Dossier, PatentScope, Discuss

Claims Hide Dependent

1 . A process for producing 5-hydroxymethylfurfural, said process comprising:

a) providing an aqueous solution comprising fructose and, optionally, glucose and/or mannose;

b) optionally contacting the solution with glucose isomerase enzyme (E.C. 5.3.1.5) which converts glucose to fructose and/or mannose isomerase enzyme (E.C. 5.3.1 .7) which
converts mannose to fructose;

c) combining the solution with at least one organic solvent as well as an acid catalyst and/or a salt to provide a reaction mixture, wherein the mixture forms a single-phase
system at standard conditions of 20°C and 1 atm. absolute pressure; and

d) heating said reaction mixture for a time sufficient to allow dehydration of fructose to provide 5-hydroxymethylfurfural in a resulting product mixture.

2. The process of claim 1 , wherein the aqueous solution in step (a) comprises glucose and/or mannose and step (b) is performed.

3. The process of claim 2, wherein the aqueous solution in step (a) contains at least 20w/w% glucose and fructose, such as, a total of 30-90w/w% fructose and glucose, e.g. 40-
90w/w% fructose and glucose, or a total of 50-90w/w% fructose and glucose, or a total of 60- 90w/w% fructose and glucose, or a total of 70-90w/w% fructose and glucose, or a
total of 80- 90w/w% fructose and glucose.

4. The process of claim 2, wherein the aqueous solution in step (a) contains least 20w/w% mannose and fructose, such as, a total of 30-90w/w% fructose and mannose, e.g. 40-
90w/w% fructose and mannose, or a total of 50-90w/w% fructose and mannose, or a total of 60-90w/w% fructose and mannose, or a total of 70-90w/w% fructose and mannose,
or a total of 80-90w/w% fructose and mannose.

5. The process of any of the preceding claims, wherein the glucose isomerase enzyme and/or the mannose isomerase enzyme is/are immobilized.

6. The process of any of the preceding claims, wherein the solution in step (c) comprises a concentration of carbohydrates above the solubilization limit.

The process of any of the preceding claims, wherein the salt is a metal halide, such NaCI, MgCI2, LiCI, KCI, CaCI2, CsCI, LiBr, NaBr, KBr or Kl; preferably the salt is NaCI.

8. The process of any of the preceding claims, wherein the concentration of the salt is in the range of 0.001 - 30 %(w/w), preferably in the range of 0.01 - 20 %(w/w), more
preferably in the range of 0.1 - 10 %(w/w), even more preferably in the range of 1 - 9 %(w) and most preferably in the range of 2 - 8 %(w/w).
 9. The process of any of the preceding claims, wherein the organic solvent is acetone, acetonitrile, dioxan, ethanol, methanol, n-propanol, isopropanol or tetrahydrofuran;
preferably the organic solvent is acetone.

10. The process of any of the preceding claims, wherein the acid catalyst is a strong acid, such as HCI, HN03, H2S04, H3P04, or a weak acid, such as boric acid; preferably the
acid catalyst is HCI.

1 1 . The process of any of the preceding claims, wherein the reaction mixture has a pH in the range of 1 .0 to 10.

12. The process of any of the preceding claims, wherein one or more of the steps are performed continuously.

13. The process of any of the preceding claims, wherein one or more steps is carried out in a continuous flow reactor.

14. The process of any of the preceding claims, wherein one or more steps is carried out in a reactor or vessel the inside of which is at least partially lined or coated with a non-
stick material, such as, polytetrafluoroethylene (PTFE), perfluoroalkoxy or fluorinated ethylene propylene.

15. The process of any of the preceding claims, wherein the solution, reaction mixture or product mixture is transported between one or more vessels or process steps in tubes
or pipes the inside of which is at least partially lined or coated with a non-stick material, such as, polytetrafluoroethylene (PTFE), perfluoroalkoxy or fluorinated ethylene
propylene.

16. The process of any of the preceding claims, wherein the at least one organic solvent is recovered from the product mixture and recycled to step (c) of the process; preferably
the at least one organic solvent is recovered by distillation from the product mixture and recycled to step (c) of the process.

17. The process of any of the preceding claims, wherein the 5-hydroxymethylfurfural is recovered from the product mixture, and wherein any remaining reaction mixture still
comprising unreacted fructose and/or glucose and/or mannose is then combined with glucose isomerase enzyme (E.C. 5.3.1.5) which converts glucose to fructose and/or
mannose isomerase enzyme (E.C. 5.3.1 .7) which converts mannose to fructose, and the resulting medium is then recycled to step (c) of the process.

18. The process of claim 17, wherein humins, if any, is partially or fully removed from the remaining reaction mixture prior to being combined with glucose isomerase enzyme
and/or mannose isomerase enzyme.

19. The process of any of the preceding claims, wherein the aqueous solution and at least one organic solvent are preheated prior to combining in step (c).

20. The process of any of the preceding claims, wherein the acid catalyst is combined with the organic solvent prior to combining the aqueous solution and the at least one
organic solvent in step (c).

Description

TITLE:

PRODUCTION OF 5 - HYDROXYMETHYLFURFURAL FROM FRUCTOSE USING A SINGLE- PHASE MIXED AQUEOUS -ORGANIC SOLVENT SYSTEM

FIELD OF THE INVENTION

The present invention relates to a process for producing 5-hydroxymethylfurfural (HMF) from fructose in a single-phase aqueous solution comprising an organic solvent.

BACKGROUND OF THE INVENTION

Many chemical compounds needed for various industries have for many years been derived from the petrochemical industry. However, due to increases in the price of
crude oil and a general awareness of replacing petrochemicals with renewable resources there has been and still is a wish to base the production of chemical
compounds on renewable resources.

5-hydroxymethylfurfural is an example of such a compound because it is derived from dehydration of sugars making it derivable from renewable biomass resources.
HMF can for example be converted to 2,5-dimethylfuran by hydrogenolysis of C-0 bonds over a copper-ruthenium (CuRu) catalyst (Roman-Leshkov Y et al., Nature, 2007,
447 (7147), 982- U5), which is a liquid biofuel or to 2,5-furandicarboxylic acid by oxidation (Boisen A et al., Chemical Engineering Research and Design, 2009, 87(9), 1318-
1327). The latter compound, 2,5-furandicarboxylic acid , can be used as a replacement of terephthalic acid in the production of polyesters such a s pol yethyl e n ete re p
hth a l ate ( P ET) a n d polybutyleneterephthalate (PBT).

US 2008/0033188 discloses a catalytic process for converting sugars to furan derivatives, e.g. 5-hydroxymethylfurfural, using a biphasic reactor containing a reactive
aqueous phase and an organic extracting phase.

US 2009/0030215 discloses a method of producing HMF by mixing or agitating an aqueous solution of fructose and inorganic acid catalyst with a water immiscible
organic solvent to form an emulsion of the aqueous and organic phases.

US 7,317,1 16 discloses a method for utilizing an industrially convenient fructose source in a dehydration reaction, converting a carbohydrate to a furan derivative.

Huang R et al., 2010, Chem. Comm., 46, 1 1 15-1 1 17 discloses the integration of enzymatic and acid catalysis for the selective conversion of glucose into HMF, where
borate- assisted isomerase was used to convert glucose into fructose and the resulting sugar mixtures were then dehydrated in water-butanol media to produce HMF.

Bicker M et al., 2003, Green Chem, 2003, 5, 280-284, studied the dehydration of D- fructose (10 g L"1) in an acetone-water mixture (90:10) with sulfuric acid as catalyst by
varying the parameters of temperature, pressure, catalyst concentration, solvent composition and residence time, as well as the influence of water content in a mixture
varied from 10 Vol.-% water in acetone to pure water where the sulfuric acid concentration, the temperature and the pressure were kept constant.

In the industrial manufacture of high-fructose corn syrup, glucose is often converted into fructose by a process catalyzed by the enzyme xylose isomerase (E.C. 5.3.1 .5)
which for these reasons is usually called a "glucose isomerase".

Glucose can be isomerized to fructose in a reversible reaction. Under industrial conditions, the equilibrium is close to 50% fructose. To avoid excessive reaction times, the
conversion is normally stopped at a yield of about 45% fructose.

Glucose isomerase (Gl) is one of the relatively few enzymes that are used industrially in an immobilized form. One reason for immobilization is to minimize the reaction
time in order to prevent degradation of fructose to organic acids and carbonyl compounds that inactivate the enzyme. The substrate to the Gl-columns is highly purified
to avoid clogging of the bed and destabilization of the enzyme. The recommended conductivity is < 50 μ8 cm.

The most commonly used commercially available immobilized glucose isomerases are SWEETZYME™ IT (Novozymes A/S, Denmark), an enzyme from S.murinus
crosslinked with glutaraldehyde; GENSWEET™ (Genencor Int. Inc, US), an enzyme from S.rubigonosus crosslinked with or without cellular debris using polyethylene imine
and glutaraldehyde; and AGI-S-600™ (Godo Shusei, Japan), an enzyme from S.griseofuseus treated with chitosan and glutaraldehyde. Other ways of producing fructose is
by hydrolysis of sucrose to obtain a composition comprising glucose and fructose in a 50:50 ratio or by catalytic conversion of mannose with mannose isomerase to
fructose.

SUMMARY OF THE INVENTION

In a first aspect, the invention provides a process for producing 5- hydroxymethylfurfural, said process comprising:

a) providing an aqueous solution comprising fructose and, optionally, glucose and/or mannose;

b) optionally contacting the solution with glucose isomerase enzyme (E.C. 5.3.1.5) which converts glucose to fructose and/or mannose isomerase enzyme (E.C. 5.3.1 .7)
which converts mannose to fructose;

c) combining the solution with at least one organic solvent as well as an acid catalyst and/or a salt to provide a reaction mixture, wherein the mixture forms a single-
phase system at standard conditions of 20°C and 1 atm. absolute pressure; and

d) heating said reaction mixture for a time sufficient to allow dehydration of fructose to provide 5-hydroxymethylfurfural in a resulting product mixture.

BRIEF DESCRIPTION OF DRAWINGS Fig. 1 shows a process diagram of a HMF-production process according to the invention.

Fig. 2 shows a process diagram comprising a preheater unit. DEFINITIONS AND ABBREVIATIONS

The terms "5-hydroxymethylfurfural", "hydroxymethylfurfural" and "HMF" may be used interchangeably in the context of the present invention. The l U PAC term of H MF is
5- (hydroxymethyl)-2-furaldehyde and it may also be used in the present context.

The term "enzymatic reaction" refers in the context of the present invention to a chemical reaction catalyzed by an enzyme, where "chemical reaction" refers to the general
understanding of this term as a process of transforming one or more chemical substances into one or more other chemical substances.

The term "glucose isomerase" refers in the context of the present invention to an enzyme of E.C. 5.3.1 .5 which is capable of catalysing the transformation of D-xylose to
D- xylulose. Such enzymes are generally used in the high corn syrup industry to convert glucose into fructose. In the context of the present invention glucose isomerase
may be abbreviated to "G l " wh ich is i ntended to encom pass any glucose isomerase, e.g. independent of wh ether it is i m mobi l ized or n ot. As the currently available
glucose isomerases are typically immobilized the term "IGI" may also be used which in the context of the present invention is intended to mean "immobilized glucose
isomerase".

The term "mannose isomerase" refers in the context of the present invention to an enzyme of E.C. 5.3.1 .7 which is capable of catalysing the transformation of D-
mannose to D- fructose,

The term "saccharide" refers in the context of the present invention to its well known meaning as an organic compound with the general formula Cm(H20)n also known as
a carbohydrate. Thus the term "saccharide" includes monosaccharides, disaccharides, oligosaccharides and polysaccharides.

The term "HFCS" refers in the context of the present invention to High Fructose Corn

Syrup.

DETAILED DESCRIPTION OF THE INVENTION

Methods of the present invention

The first aspect of the invention relates to methods of producing 5- hydroxymethylfurfural (HMF) by dehydration of fructose and/or glucose, or alternatively fructose
and/or mannose, comprising: a) providing an aqueous solution comprising fructose and, optionally, glucose and/or mannose;

b) optionally contacting the solution with glucose isomerase enzyme (E.C. 5.3.1.5) which converts glucose to fructose and/or mannose isomerase enzyme (E.C. 5.3.1 .7)
which converts mannose to fructose;

c) combining the solution with at least one organic solvent as well as an acid catalyst and/or a salt to provide a reaction mixture, wherein the mixture forms a single-
phase system at standard conditions of 20°C and 1 atm. absolute pressure; and

d) heating said reaction mixture for a time sufficient to allow dehydration of fructose to provide 5-hydroxymethylfurfural in a resulting product mixture.

In a preferred embodiment, the aqueous solution in step (a) comprises glucose and/or mannose and step (b) is performed; preferably, the aqueous solution in step (a)
contains at least 20w/w% glucose and fructose, such as, a total of 30-90w/w% fructose and glucose, e.g. 40-90w/w% fructose and glucose, or a total of 50-90w/w%
fructose and glucose, or a total of 60-90w/w% fructose and glucose; or preferably, the aqueous solution in step (a) contains least 20w/w% mannose and fructose, such
as, a total of 30-90w/w% fructose and mannose, e.g. 40-90w/w% fructose and mannose, or a total of 50-90w/w% fructose and mannose, or a total of 60-90w/w%
fructose and mannose.

In another preferred embodiment of the first aspect, the glucose isomerase enzyme and/or the mannose isomerase enzyme is/are immobilized. Several immobilized
isomerase enzymes are commercially available.

It is preferred, that the solution in step (c) comprises a concentration of carbohydrates above the solubilization limit.

In another preferred embodiment, the salt is a metal halide, such as NaCI, MgCI2, LiCI, KCI, CaCI2, CsCI, LiBr, NaBr, KBr or Kl ; preferably the salt is NaCI, as exemplified
herein.

It is also preferred, that the concentration of the salt is in the range of 0.001 - 30 %(w/w), preferably in the range of 0.01 - 20 %(w/w), more preferably in the range of 0.1 -
10 %(w/w), even more preferably in the range of 1 - 9 %(w) and most preferably in the range of 2 - 8 %(w/w).

In a preferred embodiment of the first aspect, the organic solvent is acetone, acetonitrile, dioxan, ethanol, methanol, n-propanol, isopropanol or tetrahydrofuran; preferably
the organic solvent is acetone, as exemplified herein.
It may be advantageous to supply an acid catalyst to the reaction mixture and it is preferably a strong acid, such as HCI, HN03, H2S04, H3P04, or a weak acid, such as
boric acid; preferably the acid catalyst is HCI, as exemplified herein. In some embodiments, the acid catalyst is combined with the organic solvent prior to combining the
aqueous solution and the at least one organic solvent in step (c).

Another preferred embodiment relates to the pH value of the reaction mixture, which is preferably in the range of 1 .0 to 10, such as in the range of pH 1 .5-10, or in the
range of pH 1 .6-10, or in the range of pH 1 .7-10, or in the range of pH 1.8-10, or in the range of pH 1 .9-10, or in the range of pH 2.0-10, or in the range of 2.1 -10, or in the
range of pH 2.2-10, or in the range of pH 2.3-10, or in the range of pH 2.4-10, or in the range of pH 2.5-10, or in the range of pH 2.6-10, or in the range of pH 2.7-10, or in the
range of pH 2.8-10, or in the range of pH 2.9-10, or in the range of pH 3 to 10, or in the range of pH 3 to 9, or in the range of pH 3.5 to 9, or in the range of pH 3 to 8, or in
the range of pH 3.5 to 8, or in the range of 4 to 9, or in the range of pH 4 to 8.5, or in the range of pH 4 to 8, or in the range of pH 4.5 to 10, or in the range of pH 4.5 to 9, or
in the range of pH 4.5 to 8.5, or in the range of pH 4.5 to 8, or in the range of pH 5 to 10, or in the range of pH 5 to 9, or in the range of pH 5 to 8.5, or in the range of pH 5 to
8, or in the range of pH 5.5 to 10, or in the range of pH 5.5 to 9, or in the range of pH 5.5 to 8.5, or in the range of pH 5.5 to 8, or in the range of pH 6 to 10, or in the range
of pH 6 to 9, or in the range of pH 6 to 8.5, or in the range of pH 6 to 8.

The aqueous solution and organic solvent may optionally be individually preheated prior to combining in step (c) (see Figure 2). The preheated solutions may be
combined to provide the reaction mixture of step (c) which is then heated in step (d) for a time sufficient to allow dehydration of fructose to provide 5-
hydroxymethylfurfural. If preheating is used, the acid catalyst is preferably combined with the organic solvent prior to combining the aqueous solution and the at least
one organic solvent in step (c).

Naturally, a process such as the HMF-production process of the first aspect may advantageously carried out continuously; accordingly, in a preferred embodiment of the
first aspect, one or more of the steps are performed continuously.

Preferably, one or more steps in the process of the first aspect is carried out in a continuous flow reactor.

It is well-known that dehydration of fructose to HMF can lead to formation of polymers (e.g. humins), that may easily clog the pipes and vessels, which leads to
difficulties, in particular where continuous processes are concerned. However, the present inventors have found that the use of an organic solvent in a single-phase

aqueous reaction mixture keeps this at a manageable level. When combining this insight with the use of reactor vessels and tubes or pipes, where the insides have been
at least partially lined with a non-stick material with similar properties to TEFLON® (DuPont).

Accordingly, in a preferred embodiment of the first aspect, one or more steps is carried out in a reactor or vessel the inside of which is at least partially lined or coated
with a non-stick material, such as, polytetrafluoroethylene (PTFE), perfluoroalkoxy or fluorinated ethylene propylene. Further, it is preferred that the solution, reaction
mixture or product mixture is transported between one or more vessels or process steps in tubes or pipes the inside of which is at least partially lined or coated with a
non-stick material, such as, polytetrafluoroethylene (PTFE), perfluoroalkoxy or fluorinated ethylene propylene.

Preferably, in the method of the first aspect, the at least one organic solvent is recovered from the product mixture and recycled to step (c) of the process; preferably the
at least one organic solvent is recovered by distillation from the product mixture and recycled to step (c) of the process.

It is also preferable in a method of the first aspect, that the 5-hydroxymethylfurfural is recovered from the product mixture, and wherein any remaining reaction mixture
still comprising unreacted fructose and/or glucose and/or mannose is then combined with glucose isomerase enzyme (E.C. 5.3.1.5) which converts glucose to fructose
and/or mannose isomerase enzyme (E.C. 5.3.1 .7) which converts mannose to fructose, and the resulting medium is then recycled to step (c) of the process. In some
embodiments, reaction byproducts, such as humins, are partially or fully removed before recycling unreacted fructose, glucose and/or mannose.

Use of HMF

The HMF produced by any of the above mentioned first and second methods may be further processed to obtain another product. Examples of such products include but
are not limited to 2,5-furandicarboxylic acid (FDCA), diformylfuran (DFF), formylfuran carboxylic acid (FFCA), 2,5-dimethylfuran (DMF), and p-xylene.

The HMF produced by any of the above mentioned processes may in particular be oxidized to produce 2,5-furandicarboxylic acid, diformylfuran (DFF) or formylfuran
carboxylic acid (FFCA). Hence any of the above mentioned methods may comprise a further step of oxidizing the obtained HMF to 2,5-furandicarboxylic acid.

Examples of methods suitable for oxidizing HMF to 2,5-furandicarboxylic acid include but are not limited to those described in US patents US 4,977,283 and US 7,41 1
,078, and US patent application US 2008/0103318.

US 4,977,283 describes a process for the oxidation of 5-hydroxymethylfurfural which comprises oxidizing 5-hydroxymethylfurfural in an aqueous medium with oxygen in
the presence of a catalyst which contains at least one metal of the platinum group.

US 7,41 1 ,078 describes oxidizing e.g. 5-hydroxymethylfurfural with a metal permanganate in an alkaline environment to produce 2,5-furandicarboxylic acid.
Advantageously, the alkaline environment contains at least one of alkali metal hydroxides and alkali earth metal hydroxides, and the oxidation is performed at a
temperature of from 1 to 50°C. US 2008/01003318 describes a method of oxidizing hydroxymethylfurfural (HMF) includes providing a starting material which includes
HMF in a solvent comprising water into a reactor. At least one of air and 02 is provided into the reactor. The starting material is contacted with a catalyst comprising Pt
on a support material where the contacting is conducted at a reactor temperature of from about 50°C to about 200°C.

Hence any of the methods of the present invention may comprise as a further step a process of oxidizing HMF to 2,5-furandicarboxylic as described above.

Furthermore, the present invention also relates to the products obtained by any method according to the present invention.

Compositions

The present invention relates to the production of hydroxymethylfurfural by dehydration of fructose and/or glucose.

The methods of the present invention may use different starting materials, i.e. a composition comprising fructose, a composition comprising glucose, a composition
comprising mannose, a composition comprising glucose and fructose, a composition comprising glucose and mannose, a composition comprising fructose and
mannose or a composition comprising fructose, glucose and mannose. As these compositions may have certain features in common the term "starting material" used in
the following refers to all the listed compositions. Often such industrially produced compositions comprise different saccharides, such as both glucose and fructose, or
both fructose and mannose or even all three of fructose, glucose and mannose, however the present invention is not limited to such composition as compositions which
have been purified with respect to either glucose, mannose or fructose can also be used.

The term "composition" is in the context of the present invention to be understood in its broadest context; however it may typically be an aqueous solution.

The compositions used in the present invention as starting materials may typically contain a total of at least 20 % (w/w) glucose and/or mannose and/or fructose.
The starting material preferably contains at least 20w/w% glucose and fructose, such as, a total of 30-90w/w% fructose and glucose, e.g. 40-90w/w% fructose and
glucose, or a total of 50-90w/w% fructose and glucose, or a total of 60-90w/w% fructose and glucose.

The starting material preferably contains least 20w/w% mannose and fructose, such as, a total of 30-90w/w% fructose and mannose, e.g. 40-90w/w% fructose and
mannose, or a total of 50-90w/w% fructose and mannose, or a total of 60-90w/w% fructose and mannose.

As the compositions used as starting materials in the methods of the present invention in many cases may be obtained from natural sources, e.g. biomass, they may
also contain other components than fructose and/or glucose and/or mannose including other saccharides. For example the compositions used as starting material in
the methods of the present invention may comprise 0-10w/w% oligosaccharides.

The choice of starting material may to some extent affect the combination of steps in a method of the present invention. Furthermore, the starting compositions used in
the methods or processes of the present invention may as described above comprise other saccharides than fructose, glucose and mannose.

For example if a composition comprises a relative high amount of fructose it may be used directly as a starting material for the dehydration process of fructose to HMF.
In this context a "relative high amount of fructose" may typically be a composition wherein at least 40w/w% of the total amount of saccharides in the composition is
fructose or that fructose constitutes at least 40w/w% of the total amount of saccharides in the composition.

Thus the compositions used in the present invention, i.e. a composition comprising fructose, a composition comprising fructose and mannose, and a composition
comprising fructose and glucose, and a composition comprising fructose, glucose and mannose may in a particular embodiment be a composition wherein 40-100w/w%
of the total amount of saccharides in the composition is fructose. More particularly 45-100w/w% of the total amount of saccharides may be fructose, or 45-95w/w% of
the total amount of saccharides may be fructose, or 50-95w/w% of the total amount of saccharides may be fructose.

Examples of compositions wherein fructose constitutes more than 40w/w% of the total amount of saccharides present in the composition include but are not limited to
HFCS

(high fructose corn syrup), invert sugar, inulin and compositions which have been purified with respect to fructose.

HFCS typically comprise 40-60w/w% fructose of the total amount of saccharides.

Moreover, the ratio of fructose to glucose in HFCS is typically between 40:60 and 60:40, such as a ratio between 44:56 and 46:54, more particularly a ratio of 45:55. In
some cases the ratio of fructose to glucose in HFCS may be in the range of 53:47 to 59:41 , or in the range of 40:60 to 44:56.

Invert sugar also known as inverted sugar syrup, arise from hydrolysis of sucrose and invert sugar therefore typically comprises fructose and glucose in a ratio of
approximately between 48:52 and 52:48, such as a ratio between 49:51 and 51 :49, more particularly a ratio of 50:50. Thus fructose typically constitute 48-52w/w% of the
total amount of saccharides in invert sugar, in particular 49-51w/w% of the total amount of saccharides is fructose, even more particularly 50w/w% of the total amount of
saccharides is fructose.

Glucose similarly constitute 48-52w/w% of the total amount of saccharides in invert sugar, in particular 49-51 w/w% of the total amount of saccharides in invert sugar is
glucose, even more particularly 50w/w% of the total amount of saccharides in invert sugar is glucose. Inulins are polymers that mainly comprises fructose units joined by
a β(2→1 ) glycosidic bond and which typically have a terminal glucose units. Hydrolysis of inulin typically results in a composition wherein approximately 90w/w%, e.g. in
the range of 85- 95w/w%, of the total amount of saccharides is fructose and approximately 10w/w%, e.g. in the range of 5-15 w/w%, of the total amount of saccharides is
glucose.

If on the other hand a composition comprising a relative high concentration of glucose or mannose, and a relative low concentration of fructose is used as a starting
material in a method of the present invention it is an advantage to include a step of increasing the amount of fructose relative to the amount of glucose or mannose, prior
to using it in the dehydration step of the present invention. Methods of increasing the amount of fructose in a composition are described above but it may also involve
other methods such as purification of fructose. In this context a "relative high concentration of glucose or mannose" means a composition wherein 60-100w/w% of the
total amount of saccharides is glucose or mannose, such as 60-95w/w% of the total amount of saccharides is glucose or mannose.

Furthermore, in this context the term "relative low concentration of fructose" means a composition wherein fructose constitutes 40w/w% or less than 40w/w% of the total
amount of saccharides, i.e. wherein 0-40w/w% of the total amount of saccharides is fructose.

Examples of such compositions comprising a high concentration of glucose and a low concentration of fructose include but are not limited to glucose obtained from any
source of starch, such as but not limited to corn, wheat and potatoes, glucose obtained from cellulosic biomass, e.g. fibres, stovers, wheat, or straw. The glucose may
also be obtained from other sources of starch or biomass known to a person skilled in the art.

Glucose obtained from starch typically results in a composition wherein approximately 92-98w/w% of the total amount of saccharides is glucose.

Converting glucose to fructose by an enzymatic reaction catalyzed by glucose isomerase typically results in a composition wherein approximately 43-47w/w% of the total
amount of saccharides is fructose and approximately 53-57w/w% of the total amount of saccharides is glucose. Thus the ratio of fructose to glucose in these
compositions may typically be in range of 43:57 and 47:53, such as in the range of 44:56 and 46:54, or approximately 45:55.

Examples of compositions comprising a high concentration of mannose and a low concentration of fructose include but are not limited to palm kernel cake.

Mannose may in a particular embodiment be converted to fructose by an enzymatic reaction catalyzed by mannose isomerase.

Reaction mixture The processes of converting fructose or glucose or mannose to HMF take place in a reaction mixture that is a mixture of an aqueous solution and one
or more organic solvents that are fully miscible with water, the mixture forming a one phase system at standard conditions of 20°C and 1 atm. absolute pressure. Thus
the reaction mixture of the present invention comprises a single phase system which typically may be liquid due to the nature of the components involved and the
dehydration process. I n the context of the present invention the term "phase" refers to the solubility of the aqueous solution in the one or more organic solvent and vice
versa. Thus in the context of the present invention it means that the solubility of the aqueous solution in the organic solvent and vice versa is so high that the reaction
mixture comprises only one single distinct phase; i.e. a mixture of the aqueous solution and the one or more organic solvents.

The reaction mixture of the present invention may comprise more than or less than 50v/v% organic solvent. Hence the amount of other solvents than water in the
reaction mixture may in particular be in the range of 50-100v/v% organic solvent or 0-50v/v% organic solvent. In some embodiments, the reaction mixture comprises
greater than 50v/v% organic solvent, such as greater than 60v/v%, 65v/v%, 70v/v%, 75v/v%, 80v/v%, 85v/v%, 90v/v%, or 95v/v% organic solvent. In some embodiments,
the reaction mixture may be in the range of 50-100v/v%, such as 55-90v/v%, 60-80v/v%, or 65-70v/v% organic solvent. I n other embodiments, the reaction mixture
comprises less than 50v/v% organic solvent, such as less than 45v/v%, 40v/v%, 35v/v%, 30v/v%, 25v/v%, 20v/v%, 15v/v%, 10v/v%, or 5v/v% organic solvent.
As described herein, the inventors of the present invention have surprisingly found that the presence of salt in the reaction mixture is capable of catalyzing dehydration of
fructose to HMF. In the context of the present invention the term "salt" is to be understood as an ionic compound composed of cations (positively charged ions) and
anions (negative ions) so that the product is electrically neutral (without a net charge). These component ions can be inorganic such as chloride (Cl~), as well as organic
such as acetate (CH3COO~) and monoatomic ions such as fluoride (F~), as well as polyatomic ions such as sulfate (S04 2~), or monovalent ions, such as Na+, or divalent

ions, such as Mg2+. There are several varieties of salts. Salts that produce hydroxide ions when dissolved in water are basic salts and salts that produce hydronium ions
in water are acid salts. Neutral salts are those that are neither acid nor basic salts. Zwitterions contain an anionic center and a cationic center in the same molecule but
are not considered to be salts. Examples include amino acids, many metabolites, peptides and proteins. When salts are dissolved in water, they are called electrolytes,
and are able to conduct electricity, a property that is shared with molten salts.

The salt present in the aqueous phase may in particular be an inorganic salt, such as a salt selected from the group consisting of but not limited to metal halides, metal
sulphates, metal sulphides, metal phosphates, metal nitrates, metal acetates, metal sulphites and metal carbonates. Examples of such salts include but are not limited to
sodium chloride (NaCI), sodium sulphite (Na2S03), magnesium chloride (MgCI2), lithium chloride (LiCI), potassium chloride (KCI), calcium chloride (CaCI2), cesium
chloride (CsCI), sodium sulphate (Na2S04), potassium sulphate (K2S04), lithium bromide (LiBr), sodium bromide (NaBr), potassium bromide (KBr), lithium nitrate (LiN03),
sodium nitrate (NaN03), potassium nitrate (KN03) and potassium iodine (Kl). The salt may in particular be a metal halide, such as NaCI, MgCI2, LiCI, KCI, CaCI2, CsCI, LiBr,
NaBr, KBr or Kl.

The concentration of salt may depend on the choice of salt, however it may for many or most salts be in the range of 0.1 -30w/w%, such as in the range of 0.5-30w/w%, or
in the range of 1 -30w/w%, or in the range of 0.1 -25w/w%, or in the range of 0.5-25w/w%, or in the range of 1 -25w/w%, or in the range of 0.1 -20w/w%, or in the range of
0.5-20w/w%, or in the range of 1 -20w/w%, or in the range of 0.5-15w/w%, or in the range of 0.5-10w/w%, or in the range of 0.5-7.5w/w%, or in the range of 1 -10w/w%, or
in the range of 1 -7.5w/w%, or in the range of 1 -5w/w%, or in the range of 2-10w/w%, or in the range of 2-7.5w/w%, or in the range of 2-5w/w%.

The inventors of the present invention have shown that by combining the salt with a weak acid, such as boric acid, the HMF yield and fructose conversion is increased
even further.

Without being bound by any theory, the inventors of the present invention are of the opinion that the combination of the sugars (e.g. fructose or glucose) and salt may
affect the acidic effect of the weak acid causing it to behave more acidic than without the presence of sugar and salt. Hence, in a particular embodiment the aqueous
phase may comprise a weak acid.

In the context of the present invention a weak acid is an acid with a pKa-value which is 1 or higher than 1 (pKa(weak acid) ≥ 1 ). Examples of such acids include boric acid
(B(OH)3). The amount of weak acid, e.g. boric acid, in the aqueous phase may typically be in the range of 0.1 -200 g/L, such as in the range of 5-200 g/L, or in the range
of, 10-200 g/L, or in the range of 10-150 g/L, or in the range of 25-150 g/L, or in the range of 50-150 g/L, or in the range of 50-125 g/L, or in the range of 75-125 g/L, such
as 100 g/L.

Addition of a weak acid such as boric acid to the reaction mixture does not decrease the pH as much as when using a strong acid as a catalyst. Thus the advantages of
using salt as catalyst compared to using a strong acid also applies to using a combination of salt and a weak acid, such as boric acid, or a strong acid, such as
hycrochloric acid, as a catalyst.

For the process of dehydrating fructose to HMF, the reaction mixture may in a particular embodiment have a pH in the range of pH 1.0 to 10, such as in the range of pH 1
.5-10, or in the range of pH 1 .6-10, or in the range of pH 1.7-10, or in the range of pH 1 .8- 10, or in the range of pH 1 .9-10, or in the range of pH 2.0-10, or in the range of
2.1 -10, or in the range of pH 2.2-10, or in the range of pH 2.3-10, or in the range of pH 2.4-10, or in the range of pH 2.5-10, or in the range of pH 2.6-10, or in the range of
pH 2.7-10, or in the range of pH 2.8-10, or in the range of pH 2.9-10, or in the range of pH 3 to 10, or in the range of pH 3 to 9, or in the range of pH 3.5 to 9, or in the range
of pH 3 to 8, or in the range of pH 3.5 to 8, or in the range of 4 to 9, or in the range of pH 4 to 8.5, or in the range of pH 4 to 8, or in the range of pH 4.5 to 10, or in the range
of pH 4.5 to 9, or in the range of pH 4.5 to 8.5, or in the range of pH 4.5 to 8, or in the range of pH 5 to 10, or in the range of pH 5 to 9, or in the range of pH 5 to 8.5, or in
the range of pH 5 to 8, or in the range of pH 5.5 to 10, or in the range of pH 5.5 to 9, or in the range of pH 5.5 to 8.5, or in the range of pH 5.5 to 8, or in the range of pH 6 to
10, or in the range of pH 6 to 9, or in the range of pH 6 to 8.5, or in the range of pH 6 to 8.

For the process of dehydrating glucose to HMF, the pH of the reaction mixture may in particular be in the range of 1 to 9, such as a pH in the range of 1 to 8, or in the
range of 1 to 7, or in the range of 1 to 6, or in the range of 1 to 5, or in the range of 1 to 4, or in the range of 1 .5 to 8, or in the range of 1 .5 to 7, or in the range of 1 .5 to 6,
or in the range of 1 .5 to 5, or in the range of 1.5 to 4.

The dehydration of glucose and/or fructose and/or mannose to HMF takes place in the reaction mixture and the process may create by-products. Some of these by-
products are acidic and they may therefore cause the pH of the aqueous phase to fall, as the dehydration of glucose and/or fructose and/or mannose to HMF takes
place. Thus in the context of the present invention the pH range of the reaction mixture refers to t0 of the dehydration process. In other words, it is the pH of the reaction
mixture at that point in time, where all components are present, but prior to any actual dehydration of fructose or glucose or mannose to HMF.

For example, if the method of the present invention is run as a continuous process on an industrial scale, the pH of a composition comprising fructose, glucose,
mannose, fructose and glucose, fructose and mannose, mannose and glucose, or all three fructose, glucose and mannose may be the same as the pH of the reaction
mixture at t0, when no acidic catalysts are added to the reaction mixture.

For example, if the starting material, i.e. the composition comprising fructose, fructose and mannose, or fructose and glucose, used for the dehydration of fructose to
HMF, has been obtained from conversion of glucose to fructose, or mannose to fructose, by an enzymatic reaction catalyzed by a glucose isomerase or mannose
isomerase, the pH of the composition obtained from this conversion will typically be in the range of 6.5-7.5. As glucose isomerase currently is used on an industrial basis
in the form of columns to which the glucose isomerase is immobilized, this means that the pH of the composition leaving the glucose isomerase may typically be in the
range of 6.5-7.5. It may of course be possible to adjust the pH of this composition before it enters the dehydration process.

In alternative embodiment, the reaction mixture for the process of dehydrating fructose to HMF does not contain an acidic catalyst or does not comprise a strong acid. In
the context of the present invention "does not contain an acidic catalyst" means that no acidic catalyst has been added to the reaction mixture. An "acidic catalyst" may in
particular be an acid which has a pKa-value below 5, such as a pKa-value below 4, or a pKa-value below 3, or a pKa-value below 2, or have a pKa-value between 1 -5, such
as between 1 -4, or between 1 -3 or between 1 -2, or between 1 -1 .5, or between 2-4, such as between 2-3, or between 2.5-3.5; or between 1 .5-4, such as between 1 .5-3,
or between 1 .5-2.5; or between 3-5, such as between 3.5-4.5 or between 3-4, or between 4-5. An "acidic catalyst" may in particular be a "strong acid", wherein a strong
acid is an acid with a pKa-value below 1 . A "strong acid" in the context of the present invention is to be understood as an acid with a pKa-value which is lower than 1
(pKa(strong acid)<1 ). Examples of such acidic catalysts include but are not limited to mineral acids, such as HCI, HN03, H2S04, H3P04, sulfonic acid, sulfonic acid resins,
zeolites, acid-functionalized Mobil composition materials (MCM's), sulphated zirconia, heteropolyacids, phosphates such as NbOP04, vanadium phosphate, solid silica-
and silica-alumina, Br0ndsted or Lewis acid catalyst.
The inventors of the present invention has surprisingly found out that the salt present in the reaction mixture is able to function as catalyst for the dehydration of fructose
to HMF, making it unnecessary to use other catalysts such as acidic catalysts which have previously been used.

Hence, in a particular embodiment the reaction mixture of the present invention does not comprise an acidic catalyst or does not comprise a strong acid. Although the
inventors of the present invention found out that it is not necessary to use an acidic catalyst for the dehydration of fructose to HMF, such catalysts may still be present in
the reaction mixture, for example, in small amounts. Thus any of the above mentioned catalysts may be present in the reaction mixture.

Furthermore, for the process of dehydration of glucose to HMF, or mannose to HMF, it may also be an advantage to include an acidic catalyst, such as AICI3 to minimize
the production of unwanted side-products. The optimal reaction conditions for the dehydration of fructose, mannose and glucose, respectively, to HMF are not the same.

The reaction mixture also comprises an organic solvent. A suitable organic solvent is a solvent which is miscible with the aqueous solution of the reaction mixture at
standard conditions of 20°C or higher and 1 atm. absolute pressure. Examples of such organic solvents include in particular but are not limited to alcohols, ketones, or
combinations thereof. In a particular embodiment the organic solvent may be acetone. Other examples of useful organic solvents include but are not limited to low-
molecular weight alcohols (e.g., fusel oil, isoamyl alcohol, butanol or isopentyl alcohol, straight or branched alcohols, such as pentanol, tertbutyl alcohol or 1 -butanol,
straight or branced alkanones, such as butanone, pentanone, hexanone, heptanone, diisobutylketone).

EXAMPLES

Flow reactor for dehydration of sugars

Dehydrations were carried out in a continuous flow reactor setup, where organic solvents and aqueous solutions of sugars and catalyst were separately pumped through
a tube reactor using HPLC pumps with pressure indicators (Smartline 100, Knauer, Berlin, Germany). The reactor tubes consisted of stainless steel tubing coil (outer
diameter (OD): 1/8"; inner diameter (ID): 0.07"), of which some were in-lined with PTFE tubing (OD. 1/16", ID. 1 mm). The coiled reactors were submerged in an oil bath,
which was heated and stirred on a magnetic stirrer/heating plate with temperature control (RCT basic, I KA, Staufen, Germany). The outlet tubing was connected to an in-
line filter, consisting of a stainless steel column filled with cotton and submerged in a water bath for fast cooling of the reaction mixture. The outlet of the filter was
connected to a fixed pressure regulator (IDEX, Washington, U.S.A.), for maintaining a fixed pressure in the reactor tube. Collected samples were filtered through a syringe
filter and analyzed by HPLC on an Aminex HPX-87H (Biorad, Hercules, CA) column at 60°C with 0.6 mL/min 0.005 M aqueous sulphuric acid as eluent. Compounds were
quantified using a refractive index detector by external calibration with authentic compounds.

The results presented in examples are calculated in the following way:

Yield of HMF:

„ _ CHMF

^0,Fructose

Conversion of fructose:

r_r

V ^0,Fructose ^Fructose

f ~ r ^0,Fructose

Selectivity of HMF from fructose:

CHMF

' HMF, f rue — r _ r

^0,Fructose ^Fructose

The residence time: Volume

volumetric flow

Example 1. Impact of solvent on the pressure build-up in the reactor system

Fructose and glucose/fructose mixtures were dehydrated in the above-mentioned flow reactor system, using both acetone and MIBK as solvent. It was found that when
acetone was used as solvent and the reactor coil was in-lined with PTFE tubing, only little pressure increase was observed (1 -7 bar). When MIBK was used as solvent
and/or when the reactor tubes were not in-lined with PTFE tubing, then a significant increase in pressure over time was observed, due to clogging of the reactor system
with insoluble polymeric materials.

Example 2. Dehydration of fructose using acetone as solvent

Aqueous solutions of fructose, with hydrochloric acid and/or sodium chloride as dehydration catalyst were dehydrated in the above reactor using acetone as organic
solvent. The reaction conditions and results are found in Table 1 . The results show, that fructose is converted to HMF with high selectivity at high conversions using both
NaCI/HCI (Table 1 , entry 1 -2), HCI (Table 1 , entry 3-7) and NaCI (Table 1 , entry 8) as catalyst. The reaction rate was found to significantly increase in the presence of
sodium chloride, as indicated by twice as fast reaction rate when using sodium chloride in combination with hydrochloric acid (Table 1 , entry 2 vs. entry 7).

Table 1 . Results for the dehydration of fructose in the presence of acetone

2:1 fructose

Example 3. Selective dehydration of fructose/glucose mixture using acetone as solvent

An aqueous solution of 128 g/L fructose, 172 g/L glucose, 50 g/L sodium chloride, and 0.01 M hydrochloric acid was dehydrated in the above flow reactor using two
volumes of acetone as solvent at different temperatures and residence times. Results are shown in Table 2.

Table 2. Results of dehydration of HFCS in the presence of acetone.

Example 4. Introduction of preheater

A preheater may be introduced to preheat the substrate mixture and solvent separately. In one experiment, the substrate mixture consisted of 128 g/L fructose and 172
g/L glucose, and the acetone solvent was separately mixed with 10 mM HCI. The preheater (HC stainless steel O.D. 1/8" I.D. 0.07" with in-lined Teflon tubing O.D 1/16" I.D.
0.1 mm) was then introduced after the bypass security valves and before the reactor as shown in Figure 2.

The preheater reached temperatures of 170-190 °C for both lines before entry into a mixer at a volumetric ratio of 2:1 for solvent:substrate. The mixture was hereafter led
to the reactor wherein dehydration occurred at 180-200 °C. Results are shown in Table 3.

Table 3. Results of dehydration of HFCS in the presence of acetone using a preheater

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Concepts

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Name Image Sections Count Query match

Fructose title,claims,abstract,description 316 0.000
O OH

HO OH

OH OH

Fructose title claims abstract description 157 0 000


Fructose title,claims,abstract,description 157 0.000

Hydroxymethylfurfural title,claims,abstract,description 59 0.000

O
O
OH

organic solvent title,claims,abstract,description 44 0.000

manufacturing process title,description 8 0.000

method claims,abstract,description 54 0.000

aqueous solution claims,abstract,description 26 0.000

D-Glucose OH
claims,description 105 0.000
HO O
OH

HO OH

glucose claims,description 105 0.000

β-D-glucose claims,description 82 0.000

OH

HO O
OH

HO OH

mixture claims,description 75 0.000

D-mannopyranose OH
claims,description 64 0.000
HO O
OH

HO OH

acetone claims,description 43 0.000

O

reaction mixture claims,description 43 0.000

sodium chloride claims,description 38 0.000

salts claims,description 33 0.000

carbohydrates claims,description 32 0.000

dehydration reaction claims,description 32 0.000

acid claims,description 30 0.000

Isomerases claims,description 21 0.000

Isomerases claims,description 21 0.000

such as claims,description 21 0.000

product claims,description 13 0.000

EC 5.3.1.7 claims,description 12 0.000

acid catalyst claims,description 11 0.000

polytetrafluoroethylene claims,description 11 0.000

solution claims,description 11 0.000

lithium bromide claims,description 10 0.000

L i +Br-

sodium bromide claims,description 10 0.000

+ -
NaBr

polytetrafluoroethylene claims,description 9 0.000

Boric acid claims,description 8 0.000

HO OH
B

OH

boric acid claims,description 7 0.000

material claims,description 7 0.000

potassium bromide claims,description 6 0.000

K+ Br-

EtOH claims,description 5 0.000

OH

Fluorinated ethylene propylene claims,description 4 0.000

Fluorinated ethylene propylene claims,description 4 0.000

Perfluoroether claims,description 4 0.000

Sulfuric acid claims,description 4 0.000

O
OH
S
HO
O

acetonitrile claims,description 4 0.000

carbohydrates claims,description 4 0.000

ethene;prop-1-ene claims,description 4 0.000

heat treatment claims,description 4 0.000

metal halide claims,description 4 0.000

metal halides claims,description 4 0.000

methanol claims,description 4 0.000

OH

tetrahydrofuran claims,description 4 0.000

humin claims,description 3 0.000

iso-propanol claims,description 3 0.000

OH
 OH

1,4-dioxane O claims,description 2 0.000

chemical reaction product claims,description 2 0.000

distillation claims,description 2 0.000

propanol claims,description 2 0.000

OH

solubilization claims,description 2 0.000

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