‫وزارة التعليم العالي والبحث العلمي‬

‫كلية المصطفى الجامعة‬

‫قسم الصيدلة‬
‫الدراسة \ صباحي‬
‫المرحلة الرابعة‬

‫‪Biopharmaceutics‬‬

‫مرتضى احمد فندي غضب‬

 Q/ A 70-kg male subject was given 225 mg of a drug by IV injection. Blood
samples were removed and assayed for intact drug . Regard the subject one
compartment then calculate CL,t1/2(by trapezoidal method) Cp0 found equal
to 1.05 mg/ml ,kel 0.01min-1
 Calculation

CL=Dos/Auc
❖To calculate CL, we need to find the Auc
Auc = (Cp1+Cp2) (T2-T1)/2
Auc0 extrapolated = (1.05 + 0.892) (24-0) / 2 =
23304mg.min / ml
Auc1= (0.892 + 0.5X (144-24) / 2 = 83.52 mg.min / ml
Auc2 = (0.5 + 0.336X240-144) / 2 = 40.128 mg.min / ml
Auc3 = (0.336) + 0.16 (480-240) / 2 = 59.52 mg.min / ml
Auc4 = (0.16 + 0.108) (720-480) / 2 = 32.16 mg.min / ml
Auc Last = 0.108 / 0.01 = 10.8 mg.min / ml
Auc = 23304 + 83.52 + 40.128 + 59.52 + 32.16 + 10.8 =
249.432 mg.min / ml
CL = Dose / Aus
= 225 / 249.432 = 0.90204946 ml / min
T1 / 2 = 0.693 / Kel
= 0.693 / 0.01 = 69.3